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ACNP AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY

44th

ANNUAL MEETING

GENERAL PROGRAM WAIKOLOA, HAWAII HILTON WAIKOLOA VILLAGE

DECEMBER 11-15, 2005

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Table of Contents Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Council . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Program Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Dates and Location . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Book of Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Program Book . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Abstracts-On-Line . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Abstracts-On-CD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Executive Office . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Continuing Medical Education (CME) . . . . . . . . . . . . . . . . . . . . . 4 Meeting Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Scientific Program Videotaping Sessions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Teaching Day . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Hot Topics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Oakley Ray History Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 President’s Plenary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Distinguished Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Issues in Ethics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Panels (times and dates) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Study Groups (times and dates) . . . . . . . . . . . . . . . . . . . . . . . . . 7 Posters Sessions (times and dates) . . . . . . . . . . . . . . . . . . . . . . . 7 Registration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Hotel Facilities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Insurance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Refreshments Breaks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Buffet Meals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Reception . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Special Events . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 College Meetings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Committee/Task Force Meetings . . . . . . . . . . . . . . . . . . . . . . . . . 14 Sanctioned Meetings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

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Program Listings Sunday, December 11th Teaching Day . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Hot Topics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 Oakley Ray History Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . 28

Monday, December 12th President’s Plenary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 Distinguished Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Afternoon Panel Sessions Dopamine Beta Hydroxylase Genetics and Substance Abuse: Of Mice and Men . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Specificity of Cortical GABAergic Systems: Development and Disturbances in Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . 32 Homo- and Hetero-Dimerization of G Protein-Coupled Receptors: Drug Mechanisms and Pharmacological Diversity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Successful Aging: A Neuropsychiatric Entity . . . . . . . . . . . . . . . 34 Towards Building Translational Measures of Depression: Objective Characterizations of Depressive Phenotypes and Biomarkers in Humans and Animals . . . . . . . . . . . . . . . . . . . . . . 35 Effects of Immune Mediators on the Development of Brain Circuits Regulating Cognition and Emotion . . . . . . . . . . . 36 Genes and Brain Development in Health and Illness: The Trajectory is the Story . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 ii

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Monday, December 12th (cont’d) The Future of Phase IV Studies and Off-Label Prescribing: The Conundrum Facing Corporate Sponsors of Research, Regulators, Clinical Investigators and the Future of Psychiatric Practice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 Study Groups Developing a Consortium and Mechanism to Facilitate the Development of Radiotracers as Useful Biomarkers in Academia and Industry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 J’Accuse: COI in the News, but What of the Accused? . . . . . . . . 40

Tuesday, December 13th Morning Panel Sessions Animal Models of Schizophrenia: Making Progress or Just a Delusion? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Noradrenergic and Dopaminergic Modulation of Prefrontal Cognition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Steroid Hormones and Addiction: From Genes to Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Drug Development: Biomarkers in Alzheimer’s Disease: Early Diagnostic and Treatment Implications . . . . . . . . . . . . . . . 44 The Prefrontal Cortex and Cognitive Flexibility . . . . . . . . . . . . . 45 Stress, Pain and Emotions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 New Neuroimaging Findings in the Pathophysiology and Treatment of Panic Disorder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 iii

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Tuesday, December 13th (cont’d) ECNP Panel: Bipolar Disorders: European Contributions . . . . . . 48 Issues in Ethics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Afternoon Panel Sessions Lipid Rafts, Caveolin-Related Proteins and Neuronal Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 JSNP Panel: Molecular Mechanisms of Drug Dependence Induced by Amphetamine and Related Drugs . . . . . . . . . . . . . . . 51 What Does Dopamine Say: Clues from Computational Modeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 The Role of Feeding Neuropeptides in Alcohol and Drug Dependence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 Drug Development: Development of Novel Metabotropic Glutamate Receptor Agents for the Treatment of Schizophrenia and Anxiety-Related Disorders . . . . . . . . . . . . . . . 54

Drug Development: Practical Clinical Trials of Antipsychotic Drugs in Schizophrenia . . . . . . . . . . . . . . . . . . . . . 55 Corticolimbic Changes in Bipolar Disorder: A Developmental Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 Novel Pharmacological Approaches to the Treatment of Drug Addiction: Animal and Human Studies . . . . . . . . . . . . . . . . 57

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Wednesday, December 14th Morning Panel Sessions The Warrior/Worrier Paradox: Varying Allelic Effects and Counter Balancing Selection of Phenotypes . . . . . . . . . . . . . . . . 58 Subregions in the Medial Temporal Lobe: Implications for Normal and Disordered Cognition . . . . . . . . . . . . . . . . . . . . . 59

Drug Development: GSK-3: A Novel Target for Improved Therapeutics for Severe Neuropsychiatric Diseases . . . . . . . . . . 60 Validation of Screening Models for Medications Development to Alcoholism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 Is it Worth the Risks? Treating the Elderly with Antipsychotics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 Neuregulin and Schizophrenia: From Genetic Sequence to Pathogenic Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 Animal Models of Deficient Sensorimotor Gating: A New Role for the Corticotropin-Releasing Factor System? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 Afternoon Panel Sessions Molecular Mechanisms of Synaptic Alterations Associated with Neuropsychiatric Disorders and Addiction . . . . . . . . . . . . . 65 Tourette Syndrome-A Window into Neurochemistry and Neuropharmacology of Many Comorbid Neuropsychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66

Drug Development: Advances in Neurotensin Neurobiology: Implications for Novel Treatments for Psychosis and Drug Abuse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 v

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Wednesday, December 14th (cont’d) Cortical Dopaminergic Neurotransmission and Cognition: Neuroimaging and Physiologic Studies . . . . . . . . . . . . . . . . . . . . 68 Protein Trafficking and Therapeutic Mechanisms for Mood Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 5-HT6 Receptors: New Targets for Neuropsychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 Stress in Addiction Relapse: Are There Viable Treatment Targets? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71

Thursday, December 15th Morning Panel Sessions Selecting Animal Models to Predict Pro-Cognitive Effects in Human Populations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 Synaptic Plasticity: Focus on the Mechanisms and Clinical Implications of Long-Term Depression . . . . . . . . . . . . . . . . . . . . 73 Advances in Functional Neuroanatomy and Neurochemistry of Resilience . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 If You Prick Them, Do They not Bleed? Emotion Recognition and Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . . . 75 Clock Genes, Melatonin and Affective Disorders . . . . . . . . . . . . 76 The Endocannabinoid System as Target for Drug Discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 A Noradrenergic Focus on Attention and Attention-Deficit Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 vi

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Thursday, December 15th (cont’d) Teaching Neuropsychopharmacology . . . . . . . . . . . . . . . . . . . 79 Afternoon Panel Sessions Plastic Changes in the Addicted Brain: A Glimpse at the Next Generation of Pharmacotherapies . . . . . . . . . . . . . . . . . . . . 80 Neural Changes in Adolescence and Onset of Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 Neuregulin 1 - ErbB4 Signaling in Schizophrenia . . . . . . . . . . . . 82

Drug Development: Novel Insights into the Neurobiology and Treatment of Autism Spectrum Disorders . . . . . . . . . . . . . . . 83 Neural Mechanisms of Extinction: Translating from Rats to Humans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 Sex Differences in the Action of Opioids . . . . . . . . . . . . . . . . . . . 85 Whole Genome Association Studies: New Promise for Psychiatric Genetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86

Poster Sessions Poster Session I . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Poster Session II . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111 Poster Session III . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134

Nonmember Participants List . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 Hotel Map . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 222 Future ACNP Annual Meetings . . . . . . . . . . . . . . Inside Back Cover Summary Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Back Cover vii

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ACKNOWLEDGMENTS The American College of Neuropsychopharmacology gratefully acknowledges the following companies in support of the 44th ACNP Annual Meeting:

Bristol-Myers Squibb Company Cyberonics, Inc. Eli Lilly and Company Forest Laboratories GlaxoSmithKline Janssen Pharmaceutica Products, L.P. Otsuka Maryland Research Pfizer Pharmaceuticals Wyeth Pharmaceuticals

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COUNCIL Officers and Council President President-Elect Secretary Treasurer

Daniel R. Weinberger Kenneth L. Davis Oakley S. Ray Irwin J. Kopin

Council

William T. Carpenter, Jr. Dennis S. Charney Michael Davis Ellen Frank Raquel Gur Mary Jeanne Kreek Eric J. Nestler Carol A. Tamminga

PROGRAM COMMITTEE 2005 Program and Scientific Communications Committee Chair Co-Chair Council Liaison

Trey Sunderland Larry Siever Raquel Gur

Members Lori Altshuler Nancy Andreasen Jay Baraban Karen Berman Jacqueline Crawley John Csernansky Steven DeKosky David Goldman Suzanne Haber Dilip Jeste Edward Jones John Krystal Pat Levitt

Edythe London Helen Mayberg Bruce McEwen Charles Nemeroff Daniel Pine Judith Rapoport Perry Renshaw Lorna Role Gary Small Rita Valentino Elizabeth Young George Zubenko

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GENERAL INFORMATION Dates and Location Dates Location

Sunday, December 11, 2005 - Thursday, December 15, 2005 Hilton Waikoloa Village, Waikoloa, Hawaii

Book of Abstracts The abstracts presented at the Annual Meeting will be archival. All scientific registrants will receive a copy of Neuropsychopharmacology, Volume 30, Supplement 1, December 2005 as part of their registration material. Additional copies may be purchased from Nature Publishing Group (http://www.nature.com/npp) for $30.00 each.

Program Book All scientific registrants will receive a Program Book as part of their registration material. The Program Book is also available on the ACNP website, www.acnp.org.

Abstracts-On-Line All scientific registrants will be able to access the 44th ACNP Annual Meeting Abstracts-On-Line at www.acnp.org.

Abstracts-On-CD All scientific registrants will receive the 44th ACNP Annual Meeting Abstracts-on-CD as part of their registration material.

ACNP Executive Office ACNP Executive Office 545 Mainstream Drive, Suite 110 Nashville, Tennessee 37228 Phone: 615-324-2360 Fax: 615-324-2361 E-mail: acnp@acnp.org

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Continuing Medical Education The 2005 ACNP Annual Meeting is jointly sponsored by the ACNP and Vanderbilt University School of Medicine. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for CME (ACCME) through the joint sponsorship of Vanderbilt University School of Medicine and ACNP. Vanderbilt University School of Medicine is accredited by the Accreditation Council for CME to sponsor continuing medical education for physicians. Vanderbilt School of Medicine designates this educational activity for up to 42.0 Category 1 credits toward the AMA Physician’s Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity. There is no charge for scientific registrants to obtain CME credits. Current guidelines of the Accreditation Council for CME require that participants in CME activities must be made aware of any affiliation or financial relationship that might influence a speaker’s presentation(s). To meet these guidelines, each speaker was required to complete a “Financial Disclosure Form.” Information that speakers provide on these forms is included in the appendix of the Program Book. The 2005 ACNP Annual Meeting has been planned to meet the educational needs of the membership of the American College of Neuropsychopharmacology. Invited guests of members and trainees may also attend. Learning Objectives: After participating in the 2005 ACNP Annual Meeting, ACNP members should be able to describe and discuss: • recent theories about the treatment of mental and addictive disorders • recent advances in basic neurosciences that affect the development of new treatments • recent progress in the molecular genetics and molecular biology of mental and addictive disorders • anatomical areas of the brain that are involved in the medication of behavioral states • functional and anatomical brain abnormalities observed in recent studies of mental and addictive disorders CME forms and instructions are included in the meeting registration tote bag.

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Meeting Evaluation All meeting attendees are urged to complete an evaluation of the meeting. Attendees who are requesting CME credit for the meeting a re re q u i red to complete the evaluation. You may complete the evaluation in the ACNP Computer Center in Kona 2 or on-line at www.acnp.org (click Annual Meeting). All evaluations must be completed by January 15, 2006.

SCIENTIFIC PROGRAM VIDEOTAPING SESSIONS Attendees may not videotape, audiotape, or photograph (camera or camera phone) presentations at the Annual Meeting without prior permission from the panel chair.

PLENARY SESSIONS TEACHING DAY. Teaching Day is organized and chaired by Kenneth Davis, the President-Elect. The topic this year is “Total Glia.” Sunday, December 11th

8:00 a.m. - 12:30 p.m.

This session is located in the Monarchy Ballroom. HOT TOPICS. Each presentation should last about ten minutes with a fiveminute period for questions and open discussion. There are two categories: Basic/Translational topics & Clinical topics. The two sessions will be concurrent. Sunday, December 11th

2:30 p.m. - 5:00 p.m.

Basic Clinical

Kona 5 Kona 4

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OAKLEY RAY HISTORY LECTURE. This will be the first year of the biennial Oakley Ray History Lecture. This lecture will be chaired by Carl Salzman, the History Committee Chair. Andrea Tone will be speaking on “Fifty Years After Miltown: Tranquilizers, History, and Psychiatry.” Sunday, December 11th

7:00 p.m. - 8:00 p.m.

This session is located in Kona 4. PRESIDENT’S PLENARY. This year’s President's Plenary, chaired by ACNP President, Daniel Weinberger, is titled “The Complexity of Complex Genetics: Beyond Genes and Environment.” Monday, December 12th

8:00 a.m. - 11:30 a.m.

This session is located in the Monarchy Ballroom. DISTINGUISHED LECTURE. This plenary is chaired by Daniel Weinberger. The lecture will be presented by Ronald McKay. The title of his talk is, “Stem Cells Today and Stem Cells Tomorrow.” Monday, December 12th

1:00 p.m. - 2:15 p.m.

This session is located in the Monarchy Ballroom. ISSUES IN ETHICS. This year’s topic is “Rethinking Risk in Clinical Research” and is co-chaired by David Rubinow and David Braff. The speakers this year include Paul Andreason, David Brent, James Harris, Lydia Lewis, Jane Pearson, and Donald Rosenstein. Tuesday, December 13th

12:00 p.m. - 2:30 p.m.

This session is located in the Monarchy Ballroom.

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CONCURRENT SESSIONS PANELS. The title and location of each Panel is indicated in the Program. The presentations in each session are scheduled at approximately 30-minute intervals, allowing for 20-minute presentations and 10-minute discussion periods. A thirty-minute general discussion period is scheduled after the last presenter in each session. Panels are scheduled: Monday, December 12th

2:30 p.m. - 5:00 p.m.

Tuesday, December 13th

8:00 a.m. - 10:30 a.m. 2:30 p.m. - 5:00 p.m.

Wednesday, December 14th

8:00 a.m. - 10:30 a.m. 2:30 p.m. - 5:00 p.m.

Thursday, December 15th

8:00 a.m. - 10:30 a.m. 2:30 p.m. - 5:00 p.m.

STUDY GROUPS. This year will be the first year of Issue Oriented Study Groups. There are two study groups scheduled for Monday evening. The title and location of each Study Group is indicated in the Program. They are: Monday, December 12th

7:45 p.m. - 9:00 p.m.

POSTER SESSIONS POSTERS. Poster presentations are grouped by general topic area. Topic areas are sometimes repeated. All three Poster Sessions are located in the Kohala Ballroom. Monday, December 12th

5:30 p.m. - 7:30 p.m. Poster Session I Welcoming Reception

Tuesday, December 13th

5:30 p.m. - 7:30 p.m. Poster Session II Reception

Wednesday, December 14th

5:30 p.m. - 7:30 p.m. Poster Session III Reception

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REGISTRATION ON-SITE REGISTRATION PERIODS Date

Time

Location

Saturday, December 10th

10:00 a.m. - 6:00 p.m.

Kona 3

Sunday, December 11th

7:00 a.m. - 5:00 p.m.

Kona 3

Monday, December 12th

7:00 a.m. - 5:00 p.m.

Kona 3

Tuesday, December 13th

7:30 a.m. - 5:00 p.m.

Kona 3

Wednesday, December 14th

7:30 a.m. - 5:00 p.m.

Kona 3

Thursday, December 15th

7:30 a.m. - 3:00 p.m.

Kona 3

ON-SITE REGISTRATION FEES Categories

On-Site Fee

Members of ACNP Members of ECNP, CINP, CCNP, JSNP (on list) Emeritus Corporate Representatives Non-Member Program Participant 2005 Travel Awardees Trainee* Invited Guest Past Travel Awardee (2003-2004) Optional Journal Subscription for non-ACNP members** Accompanying Person***

$450 $450 $250 $650 Waived Waived $250 $650 $250 $100 $125

*A Trainee is a person in a training position and not a full-time, permanent position. A Trainee can be a M.D., Ph.D., Postdoctoral Fellow, or a Resident Research Fellow. Trainees have all the rights and privileges of Invited Guests. **Non-ACNP members may pay $100 extra and receive a 1-year subscription (calendar year 2006) to Neuropsychopharmacology. This is a substantial discount from the normal non-member rate of $245.

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***An accompanying person is a spouse, relative, or significant other who accompanies an attendee. An accompanying person may only attend the social functions of the meeting, which includes the networking breakfast, morning buffets, lunches, and the closing reception dinner. Accompanying persons are also allowed to attend the poster sessions. Registration fee for scientific registrants includes: - Meeting refreshment breaks - Admission to Teaching Day, Hot Topics, Issues in Ethics Session, President’s Plenary, the Distinguished Lecture, Oakley Ray History Lecture, Teaching Neuropsychopharmacology, all panel & study group sessions - Admission to poster sessions - Admission to the Buffet Luncheons on Monday, Tuesday, Wednesday - Meeting Abstract Book, Program Book, and Abstracts-On-CD - Registration packet containing CME instructions, other meeting materials - Thursday Evening Reception

Pre-paid registration will be outside of Waikoloa 1.

Hotel Facilities The Hilton Waikoloa Village guest rooms, common areas, and transportation services are in compliance with the public accommodation requirements of the Americans with Disabilities Act. These facilities will be accessible to and usable by individuals with disabilities who attend and participate in the Annual Meeting. Meeting and activity rooms have been designated smoke-free for the duration of the Annual Meeting.

Insurance It is highly recommended that all participants carry the proper travel and health insurance as the ACNP cannot accept liability for any accidents or injuries that may occur at the meeting.

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SERVICES ACNP Service Center The “Office Away from the Office” is provided for the convenience of meeting attendees. The Service Center will feature a message center, fax transmissions, and photocopying. Kona 3:

Saturday (registration only) Sunday-Monday Tuesday-Wednesday Thursday

10:00 a.m. - 6:00 p.m. 7:00 a.m. - 5:00 p.m. 7:30 a.m. - 5:00 p.m. 7:30 a.m. - 5:30 p.m.

ACNP Computer Center The ACNP Computer Center is provided this year for the convenience of meeting attendees. The computers will available for the following: abstractson-CD, e-mail, internet access, and meeting evaluation. Kona 2:

Sunday through Wednesday Thursday

7:30 a.m. - 9:00 p.m. 7:30 a.m. - 5:00 p.m.

Speaker Ready Room A speaker ready room will be available in Kona 1. The speaker ready room will be open Sunday - Thursday, 6:30 a.m. - 6:00 p.m.

Travel Information Desk The Travel Information Desk is located outside of Queen’s 4 and is staffed by Sailair Travel, Inc., the official travel agency for the ACNP. Participants can obtain travel, tour, and car rental information, purchase tickets, and make a variety of other tour and travel arrangements at this desk.

REFRESHMENT BREAKS All registered individuals are invited. Coffee and light pastries for registered individuals will be available in Lagoon Lanai the following times: Sunday, Monday, Tuesday, Thursday: Wednesday:

7:00 a.m. 6:45 a.m. 10

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BUFFET MEALS All registered individuals are invited. Date: Monday, December 12th Time: 11:30 a.m. - 12:45 p.m. Place: Lagoon Lanai Date: Tuesday, December 13th Time: 11:00 a.m. - 12:00 p.m. Place: Lagoon Lanai Date: Wednesday, December 14th Time: 12:00 p.m. - 1:00 p.m. Place: Lagoon Lanai

ACNP RECEPTION All registered individuals are invited. Date: Thursday, December 15th Time: 7:30 p.m. - 10:30 p.m. Place: Monarchy Ballroom

SPECIAL EVENTS Saturday, December 10, 2005 Travel Award Breakfast (by invitation only) Time: 6:00 p.m. - 7:30 p.m. Place: Water’s Edge Ballroom

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Sunday, December 11, 2005 Travel Award Breakfast (by invitation only) Time: 7:00 a.m. - 8:00 a.m. Place: Water’s Edge Ballroom Past Presidents’ Luncheon (by invitation only) Time: 12:30 p.m. - 2:00 p.m. Place: Water’s Edge Boardroom

Monday, December 12, 2005 Informal Networking Session for Spouses/Guests of Attendees See flyer in registration tote bag Time: 9:00 a.m. - 11:00 a.m. Place: Kona 5 Media Training Session Time: 7:30 p.m. - 10:00 p.m. Place: Queen’s 6

Wednesday, December 14, 2005 Town Hall Meeting: Clinical Trials Registry & U.S. Drug Surveillance System Time: 7:00 a.m. - 8:00 a.m. Place: Kona 4 Travel Award Luncheon (by invitation only) Time: 12:00 p.m. - 2:00 p.m. Place: Water’s Edge Ballroom Memorial Symposium Time: 1:00 p.m. - 2:15 p.m. Place: Queen’s 6

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Thursday, December 15, 2005 Teaching Neuropsychopharmacology Time: 12:30 p.m. - 2:00 p.m. Place: Kona 5

COLLEGE MEETINGS Monday, December 12, 2005 Neuropsychopharmacology Editorial Board Time: 11:30 a.m. - 12:45 p.m. Place: Kona 4 Tuesday, December 13, 2005 Corporate Liaison Meeting Time: 11:00 a.m. - 12:00 p.m. Place: Water’s Edge Ballroom Wednesday, December 14, 2005 Annual Business Meeting (ACNP Scientific Members only) Chair: Daniel Weinberger Time: 10:45 a.m. - 11:45 a.m. Place: Kona 4

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Council Meetings Council is involved in many activities during the Annual Meeting. The official Council meetings are listed below: Saturday, December 10, 2005 ACNP Council Time: 8:00 a.m. - 3:00 p.m. Place: Water’s Edge Ballroom Tuesday, December 13, 2005 2005 Committee Chairs - Reports to Council Time: 6:00 p.m. - 11:00 p.m. Place: Water’s Edge Ballroom Thursday, December 15, 2005 2006 Committee Chairs & ACNP Council Time: 11:00 a.m. - 1:00 p.m. Place: Water’s Edge Ballroom

COMMITTEE/TASK FORCE MEETINGS Meetings listed below are as scheduled by the Committee Chairs. Committee meetings, Task Force meetings, and activities not listed here will be posted at the ACNP Registration Desk. Saturday, December 10, 2005 Credentials Committee Time: 8:15 a.m. - 5:30 p.m. Place: Kona 5 Animal Committee Time: 10:00 a.m. – 12:00 p.m. Place: Waikoloa 3 Constitution & Rules Committee Time: 10:30 a.m. - 11:30 a.m. Place: Waikoloa 2

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Saturday, December 10, 2005 (cont’d) Ethics Committee Time: 1:00 p.m. - 3:00 p.m. Place: Queen’s 6 Medication Development Task Force Time: 1:30 p.m. - 3:00 p.m. Place: Queen’s 5 Advocacy Committee/Advocacy Affiliates/Coalition for Mental Health Research Time: 2:00 p.m. - 3:30 p.m. Place: Kohala 2 Human Research Committee Time: 2:00 p.m. - 4:00 p.m. Place: Waikoloa 2 Liaison Committee Time: 3:00 p.m. - 5:00 p.m. Place: Kohala 1 Publications Committee Time: 3:30 p.m. - 5:00 p.m. Place: King’s 3 Finance Committee Time: 3:30 p.m. - 5:30 p.m. Place: King’s 2 Education & Training Committee Time: 4:00 p.m. - 6:00 p.m. Place: Kona 4 Public Information Committee Time: 4:30 p.m. - 6:30 p.m. Place: Queen’s 4

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Sunday, December 11, 2005 2006 Nominating Committee Time: 12:30 p.m. - 2:30 p.m. Place: TBA

Monday, December 12, 2005 Program Committee Time: 11:30 a.m. - 12:45 p.m. Place: Water’s Edge Ballroom

The History Task Force will be video taping interviews by appointment in Waikoloa 3.

ACNP SANCTIONED MEETINGS (These Sanctioned Meetings are closed meetings.) TURNS SOU Compound Selection Meeting Date: Saturday, December 10, 2005 Time: 8:00 a.m. - 5:00 p.m. Place: Water’s Edge Boardroom NIDA Workshop Date: Saturday, December 10, 2005 Time: 8:30 a.m. - 5:00 p.m. Place: Kohala 3 CDI Booster Session Date: Saturday, December 10, 2005 Time: 1:30 p.m. - 6:00 p.m. Place: Kohala 4 Date: Sunday, December 11, 2005 Time: 12:30 p.m. - 2:30 p.m. Place: Kohala 4 16

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SBP

Council Date: Saturday, December 10, 2005 Time: 4:00 p.m. - 9:00 p.m. Place: King’s 1 P rogram Committee Date: Wednesday, December 14, 2005 Time: 11:45 a.m. - 1:30 p.m. Place: Monarchy Ballroom (dancefloor area) Emory-GSK-NIMH Steering Committee Date: Sunday, December 11, 2005 Time: 12:30 p.m. - 2:30 p.m. Place: Waikoloa 2 Duke Clinical Research Institute Private Function Date: Sunday, December 11, 2005 Time: 8:00 p.m. - 10:00 p.m. Place: Waikoloa 2 Date: Monday, December 12, 2005 Time: 9:00 p.m. - 11:00 p.m. Place: Waikoloa 2 Date: Wednesday, December 14, 2005 Time: 7:00 p.m. - 11:00 p.m. Place: Water’s Edge Boardroom Academic Consortium Meeting Date: Wednesday, December 14, 2005 Time: 12:00 p.m. - 1:15 p.m. Place: Waikoloa 2

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In Memoriam Ernest Sigg October 12, 2004 Julius Axelrod December 29, 2004 Peter Stokes January 22, 2005 C. Jelleff Carr February 15, 2005 David Segal August 23, 2005 Mogens Schou September 29, 2005 Frederic Quikin October 9, 2005

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ACNP 44th Annual Meeting Scientific Program Legends for tabs PA-Panel PL-Plenary Session SG-Study Group

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8:00 AM - 12:30 PM Teaching Day Monarchy Ballroom

Teaching Day

Su PL

Total Glia Chair:

Kenneth L. Davis

8:00 a.m.

Welcome and Introduction Kenneth L. Davis

8:10 a.m.

Glial Cells of Mammalian CNS James E. Goldman

8:50 a.m.

Neuron-Glia Metabolic Coupling and its Relevance for Functional Brain Imaging in Neuropsychiatry Pierre J. Magistretti

9:30 a.m.

Oligodendrocytes and Myelination Bruce D. Trapp

10:10 a.m.

Break

10:30 a.m.

Involvement of Glial Cells in the Pathophysiology and Treatment of Severe Mood Disorders Husseini K. Manji

11:10 a.m.

White Matter Abnormalities in Schizophrenia Joseph D. Buxbaum

11:50 a.m.

Derivation of High Purity Neural Lineages from Human Embryonic Stem Cells Hans Keirstead

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2:30 - 5:00 PM Hot Topics - Basic Kona 5

Su

Hot Topics

PL Basic/Translational Chair:

Larry Siever

2:30 p.m.

Distinct Roles for Different Homer1 Isoforms in Behaviors Associated with Prefrontal Cortex Function in vivo Karen Szumlinski

2:45 p.m.

Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer’s Disease Are Reversed by Inhibition of Gamma Secretase Menelas Pangalos

3:00 p.m.

Insulin And Igf-1 Reverse Mitochondrial, Energy Metabolism, Proteasome, And Neuronal Plasticity Gene Decreases Of Schizophrenia In An Mrna-Based Screen For Antischizophrenia Agents C. Altar

3:15 p.m.

Casein Kinase 1 Epsilon Modulates Sensitivity to Stimulant Drugs in Both Mice and Humans: A Translational Genetic Study Abraham Palmer

3:30 p.m.

Histone Hyper-Acetylation Enhances Memory Storage and Facilitates Synaptic Plasticity via the Transcription Factor CREB Ted Abel

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2:30 - 5:00 PM Hot Topics - Basic Kona 5

Hot Topics

Su PL

Basic/Translational Chair:

Larry Siever

3:45 p.m.

Neural Correlates of Anxiety in Serotonin 1A Receptor-Deficient Mice Joshua Gordon

4:00 p.m.

MUTED (6p24.3), a Protein That Binds to Dysbindin (DTNBP1, 6p22.3), Is Strongly Associated with Schizophrenia and Exhibits Statistical Epistasis with COMT Richard Straub

4:15 p.m.

Electroconvulsive Seizures Increase Cell Proliferation in the Adult Monkey Cortex Tarique Perera

4:30 p.m.

COMT Inhibition Enhances Neuregulin-Induced Cell Migration in B Lymphoblasts Elizabeth Tunbridge

4:45 p.m.

Engraftment of a Monoaminergic Cell Line within Affective Neural Circuitry Miles Cunningham

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2:30 - 5:00 PM Hot Topics - Clinical Kona 4

Su

Hot Topics

PL Clinical Chair:

Trey Sunderland

2:30 p.m.

Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle

2:45 p.m.

Early Postnatal Brain Structure and Development in Humans: Sexual Dimorphism and Cerebral Asymmetry are Present at Birth John Gilmore

3:00 p.m.

Oxytocin Increases Social Cognition in Autism Eric Hollander

3:15 p.m.

Influence of Low and High Dose Hydrocortisone Infusion on Hemodynamic Response in Amygdala While Viewing Emotional Faces Kristine Erickson

3:30 p.m.

Distribution of [11C]PIB in a Nondemented Population: Implication for Use as an Antecedent Marker of Alzheimer’s Disease Mark Mintun

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2:30 - 5:00 PM Hot Topics - Clinical Kona 4

Hot Topics

Su PL

Clinical Chair:

Trey Sunderland

3:45 p.m.

Glutamate Transporter Gene (SLC1A1) Associated with Obsessive Compulsive Disorder Paul Arnold

4:00 p.m.

Frontal Dopamine D2 Receptor Binding in Neuroleptic-Naive First-Episode Schizophrenic Patients Correlates with Positive Psychotic Symptoms and Predicts Treatment Outcome Birte Glenthoj

4:15 p.m.

The Trajectory is The Story: Cortical Gray Matter Changes During Adolescence In Childhood Onset Schizophrenia Evolve Into The Adult Pattern By Age 25 Nitin Gogtay

4:30 p.m.

Corollary Discharge Failure in Schizophrenia is Related to Severity of Auditory Hallucinations: fMRI Evidence Judith Ford

4:45 p.m.

Robust, Rapid and Relatively Sustained Antidepressant Effects with a Single-Dose of an NMDA Antagonist in Treatment-Resistant Major Depression: A DoubleBlind Placebo-Controlled Study Carlos Zarate

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7:00 - 8:00 PM Oakley Ray History Lecture Kona 4

Su PL

Oakley Ray History Lecture Fifty Years After Miltown: Tranquilizers, History, and Psychiatry Chair:

Carl Salzman

Presented by Andrea Tone Canada Research Chair in the Social History of Medicine Social Studies of Medicine & Department of History McGill University

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8:00 - 11:30 AM President’s Plenary Monarchy Ballroom

President's Plenary Welcoming Remarks and Moment of Silence Daniel Weinberger President

Mo PL

Presentation of Honorific Awards and Media Award Carol Tamminga Chair, Honorific Awards Committee The Complexity of Complex Genetics: Beyond Genes and Environment Chair:

Daniel Weinberger

8:30 a.m.

Lessons from Mendelian Genetics About the Mistakes Not to Make Michael Dean

9:15 a.m.

Genetics of Addictions: From Behavior to Genetic Architecture, and Back David Goldman

10:00 a.m.

Imaging Genetics: Mapping the Mechanisms from Genes to Circuits to Behavior Andreas Meyer-Lindenberg

10:45 a.m.

The Long Term Neurobiological Consequences of Stress in Early Life: Gene-Environment Interactions in the Real World Charles Nemeroff

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1:00 - 2:15 PM Distinguished Lecture Monarchy Ballroom

Mo PL

Distinguished Lecture Stem Cells Today and Stem Cells Tomorrow Chair:

Daniel Weinberger

Presented by Ronald D.G. McKay Chief, Laboratory of Molecular Biology National Institute of Neurological Disorders and Stroke National Institutes of Health

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2:30 - 5:00 PM Dopamine Beta Hydroxylase & Substance Abuse King’s 2

Dopamine Beta Hydroxylase Genetics and Substance Abuse: Of Mice and Men Chair: Co-Chair: 2:30 p.m.

Joseph Cubells Thomas Kosten

Human Genetics of Plasma DBH Activity in Cocaine Dependence Joseph Cubells

Mo PA

3:00 p.m.

Dopamine Beta-Hydroxylase Knockout Mice Have Alterations in Dopamine Signaling and Are Hypersensitive to Cocaine Locomotion, Reward, and Aversion David Weinshenker

3:30 p.m.

DBH Genotype and Human Self-Administration of Cocaine Robert Malison

4:00 p.m.

Norepinephrine in Opiate Reward, Locomotion, and Withdrawal: Evidence for Distinct Contributions by the Locus Coeruleus and the Nucleus Tractus Solitarius Valerie Olson

4:30 p.m.

Discussion

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2:30 - 5:00 PM Cortical GABAergic Systems in Schizophrenia Kona 4

Specificity of Cortical GABAergic Systems: Development and Disturbances in Schizophrenia Chair: Co-Chair:

David Lewis John Krystal

2:30 p.m.

Fate Determination of Cortical Interneurons. It Is Who You Are, Not How You Get There Stewart Anderson

3:00 p.m.

Regulation of Axon Growth and Inhibitory Synapses Formation by GAD67-Mediated GABA Signaling: Implications in Schizophrenia Pathogenesis Z. Josh Huang

3:30 p.m.

Differential Vulnerability of Specific Cortical GABA Systems in Schizophrenia David Lewis

4:00 p.m.

New Clinical Evidence Implicating GABA Systems in Psychosis and Cognition: Implications for Schizophrenia John Krystal

4:30 p.m.

Discussion

Mo PA

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2:30 - 5:00 PM G Protein-Coupled Receptors King’s 1

Homo- and Hetero-Dimerization of G Protein-Coupled Receptors: Drug Mechanisms and Pharmacological Diversity Chair: 2:30 p.m.

3:00 p.m.

Jonathan Javitch

Functional and Pharmacological Consequences of Oligomeric Assemblies in G-Protein-Coupled Receptor Signalling Mo Michel Bouvier PA Hetero-Dimerization of CNS Expressed G ProteinCoupled Receptors: Implications for Drug Function Graeme Milligan

3:30 p.m.

Role of GPCR Oligomerization in Regulating Receptors by Endocytic Membrane Trafficking Mark von Zastrow

4:00 p.m.

Crosstalk in G Protein-Coupled Receptors: Changes at the Transmembrane Homodimer Interface Determine Activation Jonathan Javitch

4:30 p.m.

Discussion

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2:30 - 5:00 PM Successful Aging King’s 3

Successful Aging: A Neuropsychiatric Entity Chair: Co-Chair: 2:30 p.m. Mo

Dilip Jeste Trey Sunderland

A Psycho-Bio-Social Study of Successful Aging Among Community-Dwelling Seniors Dilip Jeste

PA 3:00 p.m.

Genome Survey for Loci that Influence Successful Aging George Zubenko

3:30 p.m.

Neurodegeneration and Regeneration in the Aging Nervous System Laura Dugan

4:00 p.m.

Effects of a 14-Day Healthy Aging Lifestyle Program on Brain Function Gary Small

4:30 p.m.

Discussion

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2:30 - 5:00 PM Translational Measures of Depression Kona 5

Towards Building Translational Measures of Depression: Objective Characterizations of Depressive Phenotypes and Biomarkers in Humans and Animals Chair: Co-Chair: 2:30 p.m.

Athina Markou Diego Pizzagalli

Objective Measures of Core Cognitive Symptoms of Depression Barbara Sahakian

3:00 p.m.

Laboratory Measures of Anhedonia in Humans: A Signal Detection Approach Diego Pizzagalli

3:30 p.m.

Measuring Anhedonia in Animals: Reversal by Antidepressant Treatments Athina Markou

4:00 p.m.

Long-Term Neurobehavioural Effects of Early Life Adversity in Rats and Monkeys with Relevance to Depression Joram Feldon

4:30 p.m.

Discussion

35

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2:30 - 5:00 PM Immune Mediators on Brain Circuits Queen’s 4

Effects of Immune Mediators on the Development of Brain Circuits Regulating Cognition and Emotion Chair: Co-Chair:

Lois Winsky Mark Geyer

2:30 p.m.

The Effects of Prenatal Infection on Mechanisms Critical for Cortical Development John Gilmore

3:00 p.m.

Sensorimotor Gating Deficits in Rodent Developmental Models Related to Psychotic Disorders Mark Geyer

3:30 p.m.

The Impact of Infection Early in Life on the Formation of Long-Term Memories in Adulthood Steven Maier

4:00 p.m.

Maternal Influenza Infection Leads to Neuropathology and Behavioral Abnormalities in Adult Offspring Paul Patterson

4:30 p.m.

Discussion

Mo PA

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2:30 - 5:00 PM Genes and Brain Development Queen’s 6

Genes and Brain Development in Health and Illness: The Trajectory is the Story Chair: Co-Chair: 2:30 p.m.

Jay Giedd Judith Rapoport

The Genetics of Cerebral Cortex Development in the Mouse Susan McConnell

Mo PA

3:00 p.m.

Searching for the Cause of Dyslexia: To Gel and Bac Albert Galaburda

3:30 p.m.

Trajectories of Anatomic Brain Development in Children and Adolescents Jay Giedd

4:00 p.m.

Genes, Brain Development and Clinical Outcome in Children with Attention Deficit/Hyperactivity Disorder (ADHD) Philip Shaw

4:30 p.m.

Discussion

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2:30 - 5:00 PM Phase IV Studies & Off-Label Prescribing Queen’s 5

The Future of Phase IV Studies and Off-Label Prescribing: The Conundrum Facing Corporate Sponsors of Research, Regulators, Clinical Investigators and the Future of Psychiatric Practice Chair: Co-Chair:

2:30 p.m. Mo PA 3:00 p.m.

Roger Meyer Alexander Glassman

Dealing with the Challenging Legal Environment for Phase IV Clinical Trials and Off-Label Prescribing Sandra Johnson The Changing Legal Environment Around Phase IV Studies: The Industry Response Dave Ceryak & Doug Snyder

3:30 p.m.

Reporting of Phase 4 Studies in Scholarly Journals Richard Glass

4:00 p.m.

The Future of Phase IV Studies and Off-Label Prescribing: The Conundrum Facing Corporate Sponsors of Research, Regulators, Clinical Investigators and the Future of Psychiatric Practice David Meltzer

4:30 p.m.

Discussion/Response Panel: Paul Andreason, Donald Klein, Charles O’Brien

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7:45 - 9:00 PM Development of Radiotracers as Useful Biomarkers Queen’s 4

Developing a Consortium and Mechanism to Facilitate the Development of Radiotracers as Useful Biomarkers in Academia and Industry Chair:

Dean F. Wong

Co-Chairs:

Linda Brady Robert Innis

Participants: Donald Burns Lars Farde Colin Fish Richard Frank Paul Gaylo Hartmuth Kolb Timothy McCarthy Steven Paul William Potter Mark Schmidt Jill Sorensen

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7:45 - 9:00 PM J’Accuse: COI in the News, but What of the Accused? Queen’s 5

J’Accuse: COI in the News, but What of the Accused? Chair:

Mo

Daniel R. Weinberger

Participants: Alan Breier William Carpenter Ezekiel Emanuel Jack Gorman Robert Muse Jamie Talan Daniel Weinberger

SG

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8:00 - 10:30 AM Animal Models of Schizophrenia Kona 4

Animal Models of Schizophrenia: Making Progress or Just a Delusion? Chair: Co-Chair:

8:00 a.m.

8:30 a.m.

Barbara Lipska Shitij Kapur

Morphological and Molecular Changes in the Prefrontal Cortex of Rats Following Neonatal Ventral Hippocampus Damage Lalit Srivastava Genetic Animal Models of Psychosis: The Dopamine/Glutamate Interaction Marc Caron

9:00 a.m.

New Genetic Mouse Models of Schizophrenia: Mimicking Cognitive Dysfunction by Altering Susceptibility Gene Expression Jingshan Chen

9:30 a.m.

Modelling Antipsychotic Action - Convergence from Studies of Mice and Men Shitij Kapur

10:00 a.m.

Discussion

41

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8:00 - 10:30 AM Noradrenergic & Dopaminergic of Cognition Kona 5

Noradrenergic and Dopaminergic Modulation of Prefrontal Cognition Chair: Co-Chair:

Larry Siever Daniel Weinberger

8:00 a.m.

Amygdala Modulation of Conditioning within the Prefrontal Cortex is Dependent on Cannabinoid and Dopamine D4 Receptor Activation Anthony Grace

8:30 a.m.

Relative Roles for Dopamine and Norepinephrine in Attentional Function and the Behavioral Effects of Methylphenidate and Other Therapeutic Agents for ADHD Trevor Robbins

9:00 a.m.

Noradrenergic and Dopaminergic Interventions in the Schizophrenia Larry Siever

9:30 a.m.

COMT in Prefrontal Cortex and Beyond: Genetic Studies of Cortical DA Signaling Daniel Weinberger

10:00 a.m.

Discussion

Tu PA

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8:00 - 10:30 AM Steroid Hormones & Addiction King’s 2

Steroid Hormones and Addiction: From Genes to Behavior Chair: Co-Chair:

Daniel Dorsa Jill Becker

8:00 a.m.

Effects of Estrogen in the Brain: Roles of ER Alpha and Beta in Neurons and Glia Daniel Dorsa

8:30 a.m.

Sex Differences and Influences of Steroid Hormones in Drug Abuse Jill Becker

Tu PA

9:00 a.m.

Steroid Hormones, DARPP-32 and Signal Integration Mechanisms in Brain and Behavior Shaila Mani

9:30 a.m.

Anabolic Steroid Addiction? Insights from Animal Studies Ruth Wood

10:00 a.m.

Discussion

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8:00 - 10:30 AM Biomarkers in Alzheimer’s Disease King’s 3

Drug Development Biomarkers in Alzheimer’s Disease: Early Diagnostic and Treatment Implications Chair: Co-Chair:

Trey Sunderland George Zubenko

8:00 a.m.

D10S1423 Identifies Susceptibility Locus AD7 for Alzheimer’s Disease in a Prospective, Longitudinal, Double-Blind Study of Asymptomatic Individuals George Zubenko

8:30 a.m.

Cerebrospinal Fluid Peptides as Biomarkers for Presymptomatic AD in “At Risk” Controls Trey Sunderland

9:00 a.m.

Antecedent Biomarkers for Alzheimer’s Disease John Morris

9:30 a.m.

CSF Biomarkers Add to Delayed Recall and Hippocampal Volume in Diagnosing MCI Mony de Leon

10:00 a.m.

Discussion

Tu PA

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8:00 - 10:30 AM Prefrontal Cortex & Cognitive Flexibility King’s 1

The Prefrontal Cortex and Cognitive Flexibility Chair: Co-Chair:

Daniel Pine Ellen Leibenluft

8:00 a.m.

Reversal Learning in Primates: A Neuroanatomical, Neurochemical and Behavioral Analysis Angela Roberts

8:30 a.m.

The Primate Prefrontal Cortex and the Executive Control of Attention Leslie Ungerleider

9:00 a.m.

The Prefrontal Cortex and Cognitive Flexibility Cameron Carter

9:30 a.m.

Response Flexibility in Bipolar Disorder: A Developmental Perspective Ellen Leibenluft

10:00 a.m.

Discussion

45

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8:00 - 10:30 AM Stress, Pain and Emotions Queen’s 5

Stress, Pain and Emotions Chair: Co-Chair:

Charles Nemeroff Emeran Mayer

8:00 a.m.

Brain Systems Regulating the Organism’s Response to Stress: Preclinical and Clinical Studies Charles Nemeroff

8:30 a.m.

Chronic Pain and Depression Alan Schatzberg

9:00 a.m.

Irritable Bowel Syndrome: Brain Mechanisms Involved in the Generation of Chronic Visceral Pain and How Emotions and Cognitions Can Alter Normal Processing of Visceral Stimuli Emeran Mayer

9:30 a.m.

Fibromyalgia: Brain Mechanisms Involved in the Generation of Chronic Somatic Pain and How Somatic Pain Processing is Altered in the Setting of Altered Mood and Cognitions Daniel Clauw

10:00 a.m.

Discussion

Tu PA

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8:00 - 10:30 AM Neuroimaging Findings & Panic Disorder Queen’s 4

New Neuroimaging Findings in the Pathophysiology and Treatment of Panic Disorder Chair: Co-Chair:

Scott Rauch Jack Gorman

8:00 a.m.

Functional Magnetic Resonance Imaging Studies of Amygdalo-Cortical Function in Panic Disorder Scott Rauch

8:30 a.m.

Functional Magnetic Resonance Imaging of Attention and Emotion Recognition in Panic Disorder Srinivasan Pillay

9:00 a.m.

fMRI Studies of Fronto-Limbic Fear Circuitry in Panic Tu Disorder David Silbersweig PA Regional Metabolic Brain Activation in Patients with Panic Disorder During Doxapram Infusion Jack Gorman

9:30 a.m.

10:00 a.m.

Discussion

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8:00 - 10:30 AM Bipolar Disorders: European Contributions Queen’s 6

ECNP Panel Bipolar Disorders: European Contributions Chair: Co-Chair:

David Nutt Guy Goodwin

8:00 a.m.

Exploring the Endophenotype in Bipolar Disorder Guy Goodwin

8:30 a.m.

Diagnosis of Bipolar Disorder in Children and Adults (A European Perspective) Jan Buitelaar

9:00 a.m.

A Critical Analysis of the Value of Psychoeducation in Bipolar Disorder Eduard Vieta

Tu PA 9:30 a.m.

10:00 a.m.

The Treatment of Depression in Bipolar Disorder (An European Perspective) Heinz Grunze Discussion

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12:00 - 2:30 PM Issues in Ethics Monarchy Ballroom

Issues in Ethics Rethinking Risk in Clinical Research Chair: Co-Chair:

David Rubinow David Braff

Donald Rosenstein Acting Clinical Director National Institute of Mental Health National Institutes of Health Jane Pearson Acting Deputy Director Division of Services and Intervention Research National Institute of Mental Health National Institutes of Health Lydia Lewis President The Depression and Bipolar Support Alliance James Harris Director, Developmental Neuropsychiatry Johns Hopkins University School of Medicine David Brent Academic Chief Child and Adolescent Psychiatry Western Psychiatric Institute and Clinic Paul Andreason Acting Deputy Director Division of Psychiatric Products Food and Drug Administration

49

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2:30 - 5:00 PM Lipid Rafts, Caveolae & Signal Transduction King’s 3

Lipid Rafts, Caveolin-Related Proteins and Neuronal Signaling Chair: Co-Chair:

Bryan Roth Mark Rasenick

2:30 p.m.

Caveolin: A Novel Regulator of GPCR Signaling Bryan Roth

3:00 p.m.

Caveolin-1 Interacts with Metabotropic Glutamate Receptors and Participates in Receptor Trafficking Anna Francesconi

3:30 p.m.

Agonist-Induced Lipid Raft Trafficking and Subsequent Internalization of G alpha s Regulates cAMP Signaling Mark Rasenick

Tu PA 4:00 p.m.

4:30 p.m.

Lipid Rafts and Neural Cell Adhesion Molecules in Axon Growth Vance Lemmon Discussion

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2:30 - 5:00 PM Molecular Mechanisms of Drug Dependence Queen’s 4

JSNP Panel Molecular Mechanisms of Drug Dependence Induced by Amphetamine and Related Drugs Chair: Co-Chair:

Toshitaka Nabeshima Edward Domino

2:30 p.m.

Overview

2:35 p.m.

Candidate Gene Analysis of MethamphetamineRelated Disorders Hiroshi Ujike

3:00 p.m.

Brain Imaging Reveals Corticolimbic Dysregulation in Methamphetamine Abusers Tu Edythe London

3:25 p.m.

Mesolimbic Dopamine D2/D3 Receptor-Mediated Signaling in Methamphetamine-Sensitized Rats Jin-Chung Chen

3:50 p.m.

The Role of Tissue Plasminogen Activator in Methamphetamine-Related Reward and Sensitization Kiyofumi Yamada

4:15 p.m.

Serotonin Modulation of the Effects of Amphetamine and Phencyclidine: Locomotor Hyperactivity and Prepulse Inhibition Studies in Rats Maarten van den Buuse

4:40 p.m.

Question and Answer

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2:30 - 5:00 PM Dopamine & Computational Modeling King’s 1

What Does Dopamine Say: Clues from Computational Modeling Chair: Co-Chair:

Tu

Steven Grant Jonathan Cohen

2:30 p.m.

The Role of Dopamine in the Temporal Difference Model of Reinforcement Learning Read Montague

3:00 p.m.

Dopamine Encodes a Quantiative Reward Prediction Error for Reinforcement Learning Paul Glimcher

3:30 p.m.

Implications of the Temporal Difference Reinforcement Learning Model for Addiction and Relapse A. David Redish

4:00 p.m.

Dopamine-Norepinephrine Interactions: Exploitation versus Exploration Jonathan Cohen

4:30 p.m.

Discussion

PA

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2:30 - 5:00 PM Feeding Neuropeptides & Drug Dependence Queen’s 6

The Role of Feeding Neuropeptides in Alcohol and Drug Dependence Chair: Co-Chair:

Michael Lewis George Koob

2:30 p.m.

Galanin and Opioid Peptides in Relation to Alcohol Intake and Dietary Fat: Possible Positive Feedback Mechanisms Sarah Leibowitz

3:00 p.m.

Neuropeptide Y and Melanocortin Neuropeptides Regulate Alcohol Intake and Feeding: Are Overlapping Pathways Involved? Todd Thiele

3:30 p.m.

Not Your Mother’s CRF: Type 2 Urocortins, Selective CRF2 Receptor Agonists, Reduce Excessive Ethanol Drinking and Overeating George Koob

4:00 p.m.

Sugar Bingeing Produces Effects on Opioid and Dopamine Systems: Possible Roles in Drug Abuse Bartley Hoebel

4:30 p.m.

Discussion

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2:30 - 5:00 PM Novel Metabotropic Glutamate Receptor Agents Kona 5

Drug Development Development of Novel Metabotropic Glutamate Receptor Agents for the Treatment of Schizophrenia and Anxiety-Related Disorders Chair: Co-Chair:

Athina Markou Anne Lesage

2:30 p.m.

Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5: A New Generation of Antipsychotics? Vincent Mutel

3:00 p.m.

Description of a Clinically Validated Anxiolytic with mGlu5 Antagonist Properties Richard Porter

Tu PA 3:30 p.m.

Anxiolytic and Cognitive Properties of the mGlu1 Receptor Negative Allosteric Modulator JNJ16259685 Anne Lesage

4:00 p.m.

mGluR7: A Novel Therapeutic Target for StressRelated Disorders John F. Cryan

4:30 p.m.

Discussion

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2:30 - 5:00 PM Practical Clinical Trials of Antipsychotic Drugs Kona 4

Drug Development Practical Clinical Trials of Antipsychotic Drugs in Schizophrenia Chair: Co-Chair:

Jeffrey Lieberman Susan Essock

2:30 p.m.

First Generation versus Second Generation (non-clozapine) Antipsychotic Drugs versus Clozapine in Schizophrenia: The CUtLASS Trials Shon Lewis

3:00 p.m.

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia: Primary Efficacy and Safety Outcomes of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Tu Trial Jeffrey Lieberman PA

3:30 p.m.

Effectiveness of Antipsychotic Drugs in Unresponsive and Intolerant Patients Joseph McEvoy

4:00 p.m.

Cost-Effectiveness of Atypical Antipsychotics in the CATIE Schizophrenia Trial Robert Rosenheck

4:30 p.m.

Discussion

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2:30 - 5:00 PM Corticolimbic Changes in Bipolar Disorder King’s 2

Corticolimbic Changes in Bipolar Disorder: A Developmental Perspective Chair: Co-Chair:

Tu

Caleb Adler Stephen Strakowski

2:30 p.m.

Prefrontal-Amygdalar Abnormalities in Pediatric Bipolar Disorder Kiki Chang

3:00 p.m.

Progression of Anterior Limbic Dysfunction in Adolescent Bipolar Disorder Melissa DelBello

3:30 p.m.

Multimodality Magnetic Resonance Imaging Evidence for Abnormalities in Cortico-limbic Structural and Functional Connectivity in Bipolar Disorder Hilary Blumberg

4:00 p.m.

Complementary Morphometric and Functional Corticolimbic Changes in Adult Bipolar Patients Caleb Adler

4:30 p.m.

Discussion

PA

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2:30 - 5:00 PM Drug Addiction: Novel Pharmacological Approaches Queen’s 5

Novel Pharmacological Approaches to the Treatment of Drug Addiction: Animal and Human Studies Chair: Co-Chair:

Charles O’Brien Laura Peoples

2:30 p.m.

The Differential Neuroplasticity and Differential Inhibition Hypotheses of Drug Addiction: Empirical Evidence and Implications for Treatment Laura Peoples

3:00 p.m.

Novel Pharmacological Targets for Relapse Prevention: Animal Studies Friedbert Weiss

3:30 p.m.

Regulating Glutamate Homeostasis in Treating Cocaine Addiction Peter Kalivas

4:00 p.m.

Translating Data from Animal Models to New Treatments for Addiction Charles O’Brien

4:30 p.m.

Discussion

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8:00 - 10:30 AM The Warrior/Worrier Paradox King’s 1

The Warrior/Worrier Paradox: Varying Allelic Effects and Counter Balancing Selection of Phenotypes Chair: Co-Chair: 8:00 a.m.

The 5HTTLPR Low Versus High Activity Alleles are Associated with High Versus Low Aggressive Behaviour, But Not Suicidality James Kennedy

8:30 a.m.

CNS Serotonergic Functioning, Alcohol, Genotype X by Rearing Interactions and Violence Using a Nonhuman Primate Model James Higley

9:00 a.m.

Variation in Allelic Expression of Genes Associated with Aggression Larry Siever

9:30 a.m.

Novel Functional Variation in the Serotonin Transporter and Tryptophan Hydroxylase Genes and Linkage to Complex Behavioral Phenotypes David Goldman

10:00 a.m.

Discussion

We PA

Larry Siever David Goldman

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8:00 - 10:30 AM Subregions Medial Temporal Lobe & Cognition King’s 2

Subregions in the Medial Temporal Lobe: Implications for Normal and Disordered Cognition Chair: Co-Chair:

Terry Goldberg Stephan Heckers

8:00 a.m.

The Hippocampus and Episodic Memory: Cognitive and Neural Mechanisms Howard Eichenbaum

8:30 a.m.

Binding Processes and Structures in Working Memory and Long-Term Memory: Interaction of Hippocampal and Neocortical Areas Jaap Murre

9:00 a.m.

Hippocampal Contribution to the Novel Use of Relational Information in Declarative Memory John Gabrieli

9:30 a.m.

Hippocampal Dysfunction in Psychiatric Disorders Stephan Heckers

10:00 a.m.

Discussion

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8:00 - 10:30 AM GSK-3: A Novel Target for Severe Neuropsychiatric Diseases Kona 5

Drug Development GSK-3: A Novel Target for Improved Therapeutics for Severe Neuropsychiatric Diseases Chair: Co-Chair:

We

Marc Caron Husseini Manji

8:00 a.m.

Involvement of an Akt/β-arrrestin2/PP2A Signaling Complex in the Actions of Dopamine Marc Caron

8:30 a.m.

Targeting Glycogen Synthase Kinase-3 as a Treatment for Bipolar Disorder Todd Gould

9:00 a.m.

GSK-3 as a Target of Lithium Action in Bipolar Disorder and Alzheimer’s Disease Peter Klein

9:30 a.m.

Genetic Analysis of GSK-3·α and β in Conditional Knockout Mice and Stem Cells Jim Woodgett

10:00 a.m.

Discussion

PA

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8:00 - 10:30 AM Screening Models for Alcoholism Medications King’s 3

Validation of Screening Models for Medications Development to Alcoholism Chair: Co-Chair:

Robert Swift Raye Litten

8:00 a.m.

High Throughput Pharmacological Screening for Lead Compounds at Molecular Targets of Relevance to Alcohol Dependence John Littleton

8:30 a.m.

Development of Animal Models of Excessive Drinking, Protracted Abstinence, and Cue-Induced Relapse for Medications Development George Koob

9:00 a.m.

Application of Functional Genomics to Animal Models of Alcoholism for Target Discovery and Validation Markus Heilig

9:30 a.m.

Development and Validation of Human Laboratory Models for the Prediction of Medication Efficacy in Clinical Trials Barbara Mason

10:00 a.m.

Discussion

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8:00 - 10:30 AM Treating the Elderly with Antipsychotics Queen’s 4

Is it Worth the Risks? Treating the Elderly with Antipsychotics Chair: Co-Chair:

We

Lon Schneider Pierre Tariot

8:00 a.m.

What Are the Risks? Lon Schneider

8:30 a.m.

Long-Term Adverse Effects: Old and New? Dilip Jeste

9:00 a.m.

What About Efficacy? Pierre Tariot

9:30 a.m.

Cost-Effectiveness of Atypical Antipsychotics in the CATIE Alzheimers Disease Trial Robert Rosenheck

10:00 a.m.

Discussion

PA

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8:00 - 10:30 AM Neuregulin and Schizophrenia Queen’s 5

Neuregulin and Schizophrenia: From Genetic Sequence to Pathogenic Mechanisms Chair:

Daniel Weinberger

8:00 a.m.

The Relevance of NRG1-erbB Signaling in Oligodendrocytes to Schizophrenia Gabriel Corfas

8:30 a.m.

Neuregulin, Nicotine and Schizophrenia David Talmage

9:00 a.m.

Neuregulin mRNA and Protein in Patients with Schizophrenia Cynthia Weickert

9:30 a.m.

SNPing Away at NRG1 and ErbB4 Gene Expression in Schizophrenia We Amanda Law

10:00 a.m.

Discussion

PA

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8:00 - 10:30 AM Sensorimotor Gating: A New Role for the CRF System Queen’s 6

Animal Models of Deficient Sensorimotor Gating: A New Role for the Corticotropin-Releasing Factor System? Chair: Co-Chair:

\We

Mark Geyer Vaishali Bakshi

8:00 a.m.

CRF1 and CRF2 Receptor Modulation of Information Processing Victoria Risbrough

8:30 a.m.

Is Dopamine to Blame for CRF-Induced Sensorimotor Gating Deficits in Rats? Ronald Hammer

9:00 a.m.

Effects of Antipsychotics and Manipulations of the Serotonin System on the Corticotropin-Releasing Factor-Induced Decrease in PPI in Rats Lisa Conti

9:30 a.m.

Acute and Long-Term Effects of Stress and CRF on Prepulse Inhibition Vaishali Bakshi

10:00 a.m.

Discussion

PA

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2:30 - 5:00 PM Synaptic Alterations in Neuropsychiatric Disorders & Addiction King’s 1

Molecular Mechanisms of Synaptic Alterations Associated with Neuropsychiatric Disorders and Addiction Chair: Co-Chair:

Lorna Role Jonathan Pollock

2:30 p.m.

Synapse Assembly in the Developing Brain: The Active Role of the Adhesion Molecule SynCAM Thomas Biederer

3:00 p.m.

Identification and Analysis of a Rac1 Regulator That Mediates Dendritic Pruning Peter Scheiffele

3:30 p.m.

Developmental Synapse Elimination is Mediated by the Complement Cascade Ben Barres

4:00 p.m.

Synapse to Nucleus Signaling During Long-term Synaptic Plasticity: A Role for the Classical Active Nuclear Import Kelsey Martin

4:30 p.m.

Discussion

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2:30 - 5:00 PM Tourette Syndrome: Neuropsychiatric Disorders King’s 3

Tourette Syndrome-A Window into Neurochemistry and Neuropharmacology of Many Comorbid Neuropsychiatric Disorders Chair: Co-Chair:

We

Dean Wong Anthony Grace

2:30 p.m.

Striatal Biology and Tourette Syndrome Roger Albin

3:00 p.m.

Tics and Tourette Syndrome in Children: Genetics and Public Health Impact Lawrence Scahill

3:30 p.m.

Abnormalities of the Dopamine and Serotonin Systems Associated with Tourette Syndrome Dean Wong

4:00 p.m.

Treatment of Tourette Syndrome and Co-Occurring Conditions John Walkup

4:30 p.m.

Discussion

PA

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2:30 - 5:00 PM Advances in Neurotensin Neurobiology Queen’s 4

Drug Development Advances in Neurotensin Neurobiology: Implications for Novel Treatments for Psychosis and Drug Abuse Chair: Co-Chair: 2:30 p.m.

Elliott Richelson Charles Nemeroff

Viral Vector-Induced Overexpression of the NT1 Receptor in the Nucleus Accumbens: Further Evidence for Antipsychotic Effects of Increased NTergic Neurotransmission Charles Nemeroff

3:00 p.m.

Neurotensin Regulation of Corticostriatal Function: Implications for Schizophrenia Ariel Deutch

3:30 p.m.

The Role of Neurotensin in Estrous Cycle Regulation of Prepulse Inhibition of Acoustic Startle We Becky Kinkead PA NT69L: A Neurotensin Receptor Agonist for Treatment of Neuropsychiatric Diseases Elliott Richelson

4:00 p.m.

4:30 p.m.

Discussion

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2:30 - 5:00 PM Cortical Dopaminergic Neurotransmission & Cognition Kona 5

Cortical Dopaminergic Neurotransmission and Cognition: Neuroimaging and Physiologic Studies Chair: Co-Chair:

We

Robert Innis Karen Berman

2:30 p.m.

Dopamine Modulation of Glutamate and GABA Responses in the Rat Prefrontal Cortex Patricio O’Donnell

3:00 p.m.

The Cortical D1 Receptor: A Biomarker for Cortical Dopamine Transmission? Anissa Abi-Dargham

3:30 p.m.

PET Imaging of Dopamine Metabolism and Receptors in Cortex: Relation to Cognitive Function in Parkinson’s Disease Robert Innis

4:00 p.m.

Interactions of Prefrontal Function and Dopamine: Multimodal Neuroimaging of Genetic Modulation Andreas Meyer-Lindenberg

4:30 p.m.

Discussion

PA

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2:30 - 5:00 PM Protein Trafficking & Therapeutic Mechanisms Queen’s 6

Protein Trafficking and Therapeutic Mechanisms for Mood Disorders Chair: Co-Chair:

Mark Rasenick Maurizio Popoli

2:30 p.m.

G Protein Trafficking and its Relevance to Depression and Antidepressant Therapy Mark Rasenick

3:00 p.m.

Regulation of G Protein-Coupled Receptors by Endocytosis Mark von Zastrow

3:30 p.m.

Modulation of AMPA Glutamate Receptor Trafficking by Antimanic Agents New Avenues for Drug Development Jing Du

4:00 p.m.

Leveling Glutamate Release: A Presynaptic Path Toward Antidepressant Action Maurizio Popoli

4:30 p.m.

Discussion

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2:30 - 5:00 PM 5-HT6 Receptors & Neuropsychiatric Disorders King’s 2

5-HT6 Receptors: New Targets for Neuropsychiatric Disorders Chair: Co-Chair: 2:30 p.m.

John Neumaier Theresa Branchek

The 5-HT6 Receptor: Filled with Promise or Promises Unfilled? David Nelson

3:00 p.m.

5-HT6 Receptors in Striatum Inhibit RewardMotivated Learning John Neumaier

3:30 p.m.

Selective Serotonin 5-HT6 Receptor Antagonist(s) for the Treatment of Obesity Patrizia Caldirola

We 4:00 p.m. PA 4:30 p.m.

A 14 Day, Dose Escalation, Double Blind, Randomized, Placebo-Controlled Study of SGS518 in Adult Patients with Schizophrenia Ann Neale Discussion

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2:30 - 5:00 PM Stress in Addiction Relapse & Treatment Targets Queen’s 5

Stress in Addiction Relapse: Are There Viable Treatment Targets? Chair: Co-Chair:

Charles O’Brien Rajita Sinha

2:30 p.m.

Novel Pharmacological Treatment Targets to Address Stress-Induced Relapse: Insights from Animal Models Friedbert Weiss

3:00 p.m.

The Role of Stress in Smoking Relapse: That’s So Yesterday Saul Shiffman

3:30 p.m.

Lofexidine Attenuates Stress Induced Drug Craving and Arousal to Improve Stress-Induced Relapse Outcomes Rajita Sinha

4:00 p.m.

Stress and Drug Cues Motivate Smoking Relapse: Are We There Neurobiological Substrates That Account for This Association? PA Raymond Niaura

4:30 p.m.

Discussion

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8:00 - 10:30 AM Animal Models to Predict Pro-Cognitive Effects King’s 1

Selecting Animal Models to Predict Pro-Cognitive Effects in Human Populations Chair: Co-Chair:

Th

John Csernansky Mark Geyer

8:00 a.m.

Predictive Validity of Rodent Models of Learning and Memory John Csernansky

8:30 a.m.

Neuropsychopharmacological Models of Attentional Dysfunction and Their Translation to the Clinic Trevor Robbins

9:00 a.m.

Evaluating Sensorimotor Gating Measures in Animals as Predictors of Pro-Cognitive Effects in Humans Mark Geyer

9:30 a.m.

Serotonergic Neuromodulation of Behavioral and Cognitive Functions in Humans Franz Vollenweider

10:00 a.m.

Discussion

PA

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8:00 - 10:30 AM Synaptic Plasticity & Long-Term Depression King’s 2

Synaptic Plasticity: Focus on the Mechanisms and Clinical Implications of Long-Term Depression Chair: Co-Chair:

Robert Malenka Mark Bear

8:00 a.m.

Regulation of AMPA Receptor Function and Synaptic Plasticity Richard Huganir

8:30 a.m.

Distinct Triggering and Expression Mechanisms Underlie LTD of AMPA Receptor and NMDA Receptor Synaptic Responses Robert Malenka

9:00 a.m.

Long-Term Synaptic Plasticity at Excitatory and Inhibitory Synapses on Dopamine Neurons of the VTA Julie Kauer

9:30 a.m.

The mGluR Theory of Fragile X Mental Retardation Mark Bear

10:00 a.m.

Discussion

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8:00 - 10:30 AM Functional Neuroanatomy & Neurochemistry of Resilience Kona 5

Advances in Functional Neuroanatomy and Neurochemistry of Resilience Chair: Co-Chair:

Rachel Yehuda Dennis Charney

8:00 a.m.

Neural Substrates of Stress Inoculation Determined in vivo by Brain Imaging in Monkeys David Lyons

8:30 a.m.

Neuroanatomic and Neuroendocrine Alterations in Trauma Survivors Associated with Coping and PTSD Risk Factors Rachel Yehuda

9:00 a.m.

Levels of Emotional Awareness and Alexithymia in Traumatized Subjects with and Without PTSD: Implications for Resilience Ruth Lanius

9:30 a.m. Th

The Psychobiology of Human Resilience to Stress Dennis Charney

PA 10:00 a.m.

Discussion

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8:00 - 10:30 AM Emotion Recognition & Schizophrenia King’s 3

If You Prick Them, Do They not Bleed? Emotion Recognition and Schizophrenia Chair: Co-Chair:

Daniel Javitt Pamela Butler

8:00 a.m.

Hear No Evil: Early-Stage Auditory Processing and Emotion Recognition Deficits in Schizophrenia Daniel Javitt

8:30 a.m.

See No Evil: Early-Stage Visual Processing and Emotion Recognition Deficits in Schizophrenia Pamela Butler

9:00 a.m.

Fear No Evil: Top-Down and Bottom-Up Processing of Emotions in Schizophrenia Investigated with Blocked and Event-Related fMRI Ruben Gur

9:30 a.m.

To Thine Own Self Be True: Consummatory vs. Appetitive Pleasure in Schizophrenia William Horan

Th

Discussion

PA

10:00 a.m.

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8:00 - 10:30 AM Clock Genes, Melatonin & Affective Disorders Queen’s 4

Clock Genes, Melatonin and Affective Disorders Chair: Co-Chair:

Alfred Lewy William Bunney

8:00 a.m.

Melatonin Receptors As Targets For Modulation Of Circadian Rhythms Margarita Dubocovich

8:30 a.m.

In Winter Depression (SAD), the Sweet Spot for the 10 pg/ml Plasma Dim Light Melatonin Onset (DLMO) is Six Hours Before Mid-Sleep Alfred Lewy

9:00 a.m.

The Role of Per Genes in Addiction and Depression Rainer Spanagel

9:30 a.m.

The Molecular Clock as a Target in the Treatment of Bipolar Disorder Francesco Benedetti

Th 10:00 a.m.

Discussion

PA

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8:00 - 10:30 AM Endocannabinoid System: Target for Drug Discovery Queen’s 5

The Endocannabinoid System as Target for Drug Discovery Chair:

Alexandros Makriyannis

8:00 a.m.

Overview of the Endocannabinoid System, CB1 Receptor Antagonists Alexandros Makriyannis

8:30 a.m.

Neuroprotection Through Direct and Indirect Activation of Cannabinoid CB1 Receptors Ben Bahr

9:00 a.m.

Progress Towards the Development of a PET Radioligand for Cannabinoid CB1 Receptors Samuel Gatley

9:30 a.m.

“Gone to Pot”: Emerging Pharmacological Evidence Implicating Cannabinoid Receptor Function in Cognition and Psychosis - Implications for Medications Development Deepak D’Souza

10:00 a.m.

Discussion

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8:00 - 10:30 AM Noradrenergic Focus: Attention-Deficit Disorders Queen’s 6

A Noradrenergic Focus on Attention and Attention-Deficit Disorders Chair: Co-Chair:

Randy Blakely Maureen Hahn

8:00 a.m.

Norepinephrine Transporters: Genetic Variants and their Impact on Transporter Function and Regulation Maureen Hahn

8:30 a.m.

Molecular Control of Noradrenergic Gene Expression and the Impact of Polymorphisms on Attention Disorders Kwang-Soo Kim

9:00 a.m.

Role for Norepinephrine in Attention, Learning and Memory: Insights from Knockout Mice Steven Thomas

9:30 a.m. Th

Noradrenergic Pharmacotherapies in Attention Deficit Hyperactivity Disorder Thomas Spencer

PA 10:00 a.m.

Discussion

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12:30 - 2:00 PM Teaching Neuropsychopharmacology Kona 5

Teaching Neuropsychopharmacology The Neglected Constituencies: Can Teaching About Psychopharmacology Change Attitudes and Practices? Fifth Annual Teaching Session 12:30 p.m.

Introduction Ira Glick

12:35 p.m.

Medical Students – What is Relevant and How Much to Cover? Murray Raskind

12:50 p.m.

NIMH – Intramural and Extramural Psychopharmacology: Education in a Research Setting Donald Rosenstein

1:05 p.m.

Primary Care Physicians & Other Mental Health Providers – Where Does Psychopharmacology Fit In? Sidney Zisook Th

1:20 p.m.

Industry – The Challenge of Teaching at the Academic- PL Industry Interface Terence Ketter & Ira Glick

1:35 p.m.

The Public & Media – Education in the Context of “Stigma” Among Other Issues Ellen Frank

1:45 p.m.

General Discussion

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2:30 - 5:00 PM Plastic Changes in the Addicted Brain Kona 5

Plastic Changes in the Addicted Brain: A Glimpse at the Next Generation of Pharmacotherapies Chair: Co-Chair:

Th

Susan Weiss Ruben Baler

2:30 p.m.

Neuroadaptations in Proteins in the Postsynaptic Density and Cocaine Addiction Peter Kalivas

3:00 p.m.

Role of Amygdala ERK in Incubation of Cocaine Craving Yavin Shaham

3:30 p.m.

The Endogenous Brain Cannabinoid System and the Motivational Control of Reinforced Behavior Steven Goldberg

4:00 p.m.

Why Are Drugs That Enter the Brain Rapidly Potentially the Most Addictive? Terry Robinson

4:30 p.m.

Discussion

PA

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2:30 - 5:00 PM Neural Changes in Adolescence & Schizophrenia King’s 2

Neural Changes in Adolescence and Onset of Schizophrenia Chair:

Patricio O’Donnell

2:30 p.m.

Structural MRI of Typical Adolescent Brain Development Jay Giedd

3:00 p.m.

Changes in Prefrontal Dopamine Function During Adolescence and in a Developmental Animal Model of Schizophrenia Patricio O’Donnell

3:30 p.m.

Differential Expression in Schizophrenic Brain of a DISC1 Molecular Pathway and Association with DISC1 SNPs Barbara Lipska

4:00 p.m.

Brain Development in Childhood Onset Schizophrenia and their Healthy Siblings Judith Rapoport

4:30 p.m.

Discussion

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2:30 - 5:00 PM Neuregulin 1 - ErbB4 Signaling in Schizophrenia King’s 1

Neuregulin 1 - ErbB4 Signaling in Schizophrenia Chair: Co-Chair:

Steven Arnold Chang-Gyu Hahn

2:30 p.m.

Neuregulin/ErbB Signaling in Schizophrenia: An Overview Cary Lai

3:00 p.m.

Neuregulin 1- ErbB Signaling During Neuronal Migration in the Developing and Adult Cerebral Cortex Eva Anton

3:30 p.m.

Regulation of Synaptic Plasticity by the NRG-1/ErbB Signaling Pathway: Possible Implications for Schizophrenia Andres Buonanno

4:00 p.m.

ErbB4 Signaling is Altered in Schizophrenia Chang-Gyu Hahn

4:30 p.m.

Discussion

Th PA

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2:30 - 5:00 PM Autism Spectrum Disorders: Neurobiology & Treatment King’s 3

Drug Development Novel Insights into the Neurobiology and Treatment of Autism Spectrum Disorders Chair: Co-Chair:

Larry Young Husseini Manji

2:30 p.m.

Neuropeptides and the Social Brain: The Value of Comparative Studies in Autism Research Larry Young

3:00 p.m.

Molecular Mechanisms of Fragile X Syndrome Reveal Potential Therapeutic Approaches Stephen Warren

3:30 p.m.

Clues From Basic Neurodevelopment For New Treatment Targets in Autism Pat Levitt

4:00 p.m.

Pharmacological Treatment of Behavioral Symptoms in Autism Christopher McDougle

4:30 p.m.

Discussion

Th PA

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2:30 - 5:00 PM Neural Mechanisms of Extinction Queen’s 6

Neural Mechanisms of Extinction: Translating from Rats to Humans Chair: Co-Chair:

Gregory Quirk Scott Rauch

2:30 p.m.

Extinction Training Initiated Shortly After Trauma May Reduce Spontaneous Recovery, Renewal and Reinstatement: Implications for Exposure-Based Psychotherapy Michael Davis

3:00 p.m.

Retention of Fear Extinction in Rats Depends on Infralimbic Prefrontal Cortex Plasticity Gregory Quirk

3:30 p.m.

Neural Mechanisms of Long- and Short-Term Fear Extinction in Humans Fred Helmstetter

4:00 p.m.

Magnetic Resonance Imaging Studies of Extinction Retention in Human Subjects Scott Rauch

4:30 p.m.

Discussion

Th PA

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2:30 - 5:00 PM Sex Differences in the Action of Opioids Queen’s 4

Sex Differences in the Action of Opioids Chair: Co-Chair:

Jon-Kar Zubieta Anne Murphy

2:30 p.m.

Opioid Drugs: Where Sex Makes a Difference Christopher Evans

3:00 p.m.

Sex Differences in Opiate Pharmacological Effects in Humans James Zacny

3:30 p.m.

Sex Differences in the Antihyperalgesic Actions of Morphine Anne Murphy

4:00 p.m.

Sex Differences and Gonadal Steroid Influences on Mu-Opioid Receptor Neurotransmission in Humans Jon-Kar Zubieta

4:30 p.m.

Discussion

Th PA

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2:30 - 5:00 PM Whole Genome Association Studies Queen’s 5

Whole Genome Association Studies: New Promise for Psychiatric Genetics Chair: Co-Chair:

John Kelsoe Elliot Gershon

2:30 p.m.

Linkage and Association Findings in Bipolar Disorder and Schizophrenia Elliot Gershon

3:00 p.m.

Whole Genome Association: Technologies and Strategies for Application to Psychiatric Illness John Kelsoe

3:30 p.m.

Dissecting Neuropsychiatric Traits Through WholeGenome Association Analysis Dietrich Stephan

4:00 p.m.

Analysis Techiniques for Whole Genome Association Studies David Cutler

4:30 p.m.

Discussion

Th PA

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POSTERS

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Poster Session I—Monday 1.

Statistical and Pharmacoeconomic Issues for Annual Alzheimer Screening J W. Ashford*, Jared R. Tinklenberg, Helena C. Kraemer, Javaid Sheikh, Ruth O’Hara, Joy Taylor, Jerome A. Yesavage

2.

Alterations in Brain CRF and SRIF in a Transgenic Mouse Model of Alzheimer’s Disease (Tg2576) Following Treatment with a High Fat Diet Garth Bissette*, Katherine Ketchum, Jennifer Horgan

3.

Participation in Alzheimer’s Disease Clinical Trials: A Focus on African American Caregivers Warachal E. Faison*

4.

Guanfacine Augmentation of Donepezil In The Treatment of Alzheimer’s Disease Joseph I. Friedman*, Hillel Grossman, Maureen Fusco, Kristin Swedish, Jessica Stern, Mary Sano, Kenneth Davis

5.

Anxiolytic Actions of an Estrogen Receptor Beta Agonist in Aged Female Rats Robert J. Handa*, T. John Wu, Trent D. Lund

6.

The Neuroanatomical Patterns Associated With Neuropsychiatric Symptoms In Older Adults With And Without Cognitive Impairment: An MRI Study Helen Lavretsky*, Ling Zheng, Michael Weiner, Dan Mungas, Bruce Reed, Joel Kramer, William Jagust, Helena Chui, Wendy J. Mack

7.

Deficit in the GABAergic Neuroactive Steroid Allopregnanolone in Alzheimer’s Dementia and Relevance to Neuropathological Disease Stage: Investigations in Temporal Cortex Christine E. Marx*, David C. Steffens, Dan G. Blazer, Marian I. Butterfield, Christine Hulette, John Ervin, Jeffrey A. Lieberman, Lawrence J. Shampine

89

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8.

The Allosteric Potentiation of Nicotinic Acetylcholine Receptors by Galantamine Ameliorates the Cognitive Dysfunction in the AmyloidTreated Mice: Involvement of Dopaminergic Systems Yukihiro Noda*, Yuan Zhou, Dayong Wang, Akihiro Mouri, Hiroyuki Mizoguchi, Toshitaka Nabeshima

9.

Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer’s Disease Are Reversed by Inhibition of Gamma Secretase Menelas N. Pangalos*, J S. Jacobsen, Thomas A. Comery, Chi-Cheng Wu, Jeffrey M. Redwine, Robert Arias, Robert Martone, Susan Aschmies, Kevin P. Atchinson, John H. Morrison, Karen Marquis, Bloom E. Floyd, Peter H. Reinhart

10.

Frontal, Parietal, and Callosal Degradation in Aging: A Quantitative DTI Fiber Tracking Study Adolf Pfefferbaum*, Edith V. Sullivan

11.

Subjective Cognitive Impairment: The Pre-Mild Cognitive Impairment Stage of Brain Degeneration: Longitudinal Outcome After a Mean of 7 Years Follow-Up Barry Reisberg*, Steven Ferris, Mony J. De Leon, Carol Torossian, Sridhar Kadiyala, Wei Zhu

12.

Effect of Catechol-O-Methyl Transferase val 158 Met Polymorphism on Information Processing in the Prefrontal Cortex during Working Memory in the Elderly Fabio Sambataro*, Elesha Kingshott, Saumitra Das, Bhaskar S. Kolachana, Christie Russo, Allan F. Mirsky, Terry Goldberg, Michael F. Egan, Andreas Meyer-Lindenberg, Joseph H. Callicott, Daniel R. Weinberger, Venkata S. Mattay

13.

Serotonin Modulates Longevity and Global Gene Expression in the Mammalian Brain Etienne Sibille*, Jing Su, Samuel Leman, A.M. Le Guisquet, Rene Hen, Catherine Belzung

14.

PET Studies of Cholinergic Modulation of Serotonin in Alzheimer Disease (AD) Gwenn Smith*, Elisse Kramer, Carol Hermann, Yilong Ma, Margaret Kirshner, David Eidelberg, Bruce Pollock

90

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15.

Stress History and Breast Cancer Recurrence Oxana Palesh, Lisa D. Butler, Cheryl Koopman, Helena C. Kraemer, Robert Carlson, David Spiegel*

16.

Benefits of Memantine/Donepezil Treatment on Behavior in Moderate to Severe AD Using Factor-Analytically Derived Subscales Pierre Tariot*, Jeffrey Cummings, Jason Olin

17.

Is Translational Research Monkey Business: The Journey of a Novel AMPAKINE (CX 717) from Primate to a Human Phase 1B Study with a Cognitive Impairment Model Gary Tollefson*, Hank Mansbach, Samuel Deadwyler

18.

Cholinergic Receptor Systems in Cocaine-Addicted Subjects: Alterations in Regional Cerebral Blood Flow Bryon Adinoff*, Mark J. Williams, Susan E. Best, Tanya Zielinski, Thomas S. Harris, Erica R. Schreffler, Michael D. Devous

19.

C-fos Activation Correlates with Cocaine Preference in Adolescent Rats Susan L. Andersen*, Lucinda Kussmaul, Lee Napierata

20.

A Primer on Multivariate Methods for Pharmacoepidemiology: Cocaine Dependence Illustration James C. Anthony*

21.

Extinction-Induced Up-Regulation in AMPA Receptors Attenuates Sensitization to Cocaine and D2 Receptor Stimulation Ryan K. Bachtell*, Lisa Monteggia, Rachael L. Neve, David W. Self

22.

Comparative Molecular Field Analyses of Amphetamine, Cocaine, and Antidepressant Recognition at Serotonin Transporter Mutants Reveals Contributions of Transmembrane Helix III to Ligand Binding Eric L. Barker*, Crystal C. Walline

23.

Effects of Standard Dopaminergics and Comparison of D3 and D2 Receptor Ligands on Choice Between Concurrently Available Cocaine and Food in Rats Andrew C. Barrett*, S S. Negus, Amy H. Newman, Peter Grundt, S B. Caine

91

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24.

Behavioral And Neurochemical Effects Of Chronic Exposure To D2 Agonist Treatment In Monkeys Jack Bergman*, Walter Tornatzky, Frank Tarazi

25.

Neurotensin System Genes and Susceptibility to Cocaine-induced Psychosis Elisabeth B. Binder*, Yilang Tang, Charles B. Nemeroff, Joseph F. Cubells

26.

Relationships Between State Policies and the Availability of Services for HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs Lawrence S. Brown*, Steven Kritz, John Rotrosen, Sherryl Baker, Jim Robinson

27.

N-3 Polyunsaturated Fatty Acids Decrease Feelings Of Anger In A Population Of Substance Abusers Laure Buydens*, Marc Branchey, Alec Roy

28.

Reduced Cocaine Self-Administration in Muscarinic M5 Acetylcholine Receptor-Deficient Mice Morgane Thomsen, David P. Woldbye, Gitta Woertwein, Anders FinkJensen, Juergen Wess, Simon B. Caine*

29.

Decreased CNS Serotonin Turnover, Early-life Stress, and Initial Response to Ethanol are Predictors of Ethanol Consumption in Adolescent Rhesus Macaques Scott A. Chen*, Christina S. Barr, Melanie L. Schwandt, Stephen G. Lindell, Daniel Hommer, Susan Shoaf, Stephen J. Suomi, Markku Linnoila, J D. Higley

30.

Pain and Opioid Addiction: Complex Relationship Wilson M. Compton*, Yonette Thomas, Kevin P. Conway, Marc D. Brodsky

31.

Attenuation of Ethanol and Sucrose-Seeking and Intake Following Chronic Acamprosate or Naltrexone Treatment Cristine Czachowski*, Michael DeLory

92

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32.

Insulin And Amphetamine: What’s Up With Dat? Lynette Daws*, W A. Owens, Adrian K. France, Rajkumar Sevak, Aurelio Galli, Charles P. France

33.

Stress, Alcohol, and Fluvoxamine: Composing the Score for a Dissonant ConSERT Nicole L. Baganz Strode, Jaclyn L. Munn, Janel M. Boyce-Rustay, Andrew Holmes, Lynette Daws*

34.

An Association Study of Adenosine Receptor Gene Polymorphisms and Acute Responses to Caffeine in Light- or Non-Caffeine Users Harriet De Wit*, Emma Childs, Christa Hohoff, Jurgen Deckert

35.

Dual Diagnosis and Drinking Behaviors in an Outpatient Treatment Seeking Sample of Adolescents with Alcohol Use Disorders Deborah Deas*, Himanshu Upadhyaya, Suzanne Thomas

36.

A Double Blind Placebo Controlled Trial of Bupropion Added to Nicotine Patch and Cognitive Behavioral Therapy in Smokers with Current or Past Unipolar Depressive Disorder A. Eden Evins*, Jonathan E. Alpert, Joel Pava, Timothy J. Petersen, Amy H. Farabaugh, Maurizio Fava

37.

Genomic Screen for Loci Associated with Marijuana, Stimulant and Drug Dependence in Mission Indians: Relation to Body Mass Index Cindy L. Ehlers*, Kirk C. Wilhelmsen

38.

The Effects of Exogenous Progesterone on Cocaine Self-Administration in Women Suzette M. Evans*, Richard W. Foltin

39.

Differences in the Dopamine System Correspond to Individual Differences in Pavlovian Conditioned Approach Behavior Shelly B. Flagel*, Tracy Simmons, Stanley J. Watson, Terry Robinson, Huda Akil

93

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40.

Differential Roles for the Basolateral Amygdala and Medial Prefrontal Cortex in Extinction and Cue-Induced Reinstatement of Food-Seeking Behavior Ryan J. McLaughlin, Stan B. Floresco*

41.

The Role of the Basolateral Amygdala in Consolidation of StimulusReward Associations and Subsequent Conditioned Cued-Reinstatement of Cocaine Seeking Rita A. Fuchs*, Matthew W. Feltenstein, Ronald E. See

42.

Regulation of Alcohol-Heightened Aggression by Dorsal Raphe and Prefrontal Cortical 5-HT1B Receptors: Evidence from Microinjection and Microdialysis Studies in Mice Sara P. Faccidomo, Makoto Bannai, Jeremy Maggin, Klaus A. Miczek*

43.

Evidence of White Matter Pathology in First-Episode Manic Adolescents with Bipolar Disorder: A Diffusion Tensor Imaging Study Caleb M. Adler*, John Adams, Melissa P. DelBello, Scott K. Holland, Vince Schmithorst, Ari Levine, Kelly Jarvis, Stephen M. Strakowski

44.

Quetiapine Efficacy in Bipolar Adolescents with Depressive Symptoms Drew H. Barzman, Caleb M. Adler*, Melissa P. DelBello, Kevin E. Stanford, Robert A. Kowatch, Stephen M. Strakowski

45.

Measurement of Brain Betabolites in Type 2 Diabetes and Depression Using Proton Magnetic Resonance Spectroscopy Olu Ajilore*, E Haroon, C Darwin, N Binesh, A Thomas, S Kumaran, J Miller, A Kumar

46.

Escitalopram Responders Have Higher Quality of Life Scores Than Placebo Responders George Alexopoulos*, Andrew Korotzer, Anjana Bose, Khalil Saikali

47.

Gender Differences in Sleep Regulation in Depressed Adults and Healthy Controls Roseanne Armitage*, Robert Hoffmann

94

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48.

Glutamate Transporter Gene (SLC1A1) Associated with Obsessive Compulsive Disorder Paul D. Arnold*, Tricia Sicard, Eliza Burroughs, Margaret A. Richter, James L. Kennedy

49.

A Study of Long-Acting, Injectable Risperidone in Frequently Relapsing Bipolar Disorder: Preliminary Findings Earle Bain*, Georges Gharabawi, Julie Locklear, Ibrahim Turkoz, Deborah Yurgelun-Todd

50.

Association of an Ancient CRH Gene Haplotype with HPA Axis Activity in Rhesus Macaques Christina S. Barr*, Timothy K. Newman, Stephen J. Suomi, Robert Lipsky, David Goldman, J D. Higley

51.

Regional Cerebral Metabolism and Anxiety Symptoms in Bipolar Depression: Effects of Levothyroxine Michael Bauer*, Edythe D. London, Steven M. Berman, Natalie Rasgon, Mark A. Mandelkern, Bradley Voytek, Peter C. Whybrow

52.

Duloxetine: Meta-Analyses of Suicidal Behaviors and Thoughts in Clinical Trials for Major Depressive Disorder Nayan V. Acharya, Amy S. Rosen, John P. Polzer, Deborah N. DSouza, David G. Perahia, Patrizia A. Cavazzoni, Charles M. Beasley*, Ross J. Baldessarini

53.

Generalized Anxiety and Pain: Associations and Implications Katja Beesdo*, Frank Jacobi, Hans-Ulrich Wittchen

54.

Brain Regional α-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive Compulsive Disorder Alexandre Berney, Marco Leyton, Paul Gravel, Pedro Rosa-Neto, C Todorov, Debbie Sookman, Gilbert Pinard, Pierre Blier, Mirko Diksic, Chawki Benkelfat*

55.

Antidepressant Drug Combination from Treatment Initiation to Improve Therapeutic Response in Major Depression Richard Bergeron*, Philippe Tremblay, Herbert E. Ward, Chantal Hebert, Pierre Blier

95

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56.

Subjective Evaluation of the Long-Term Cognitive Effects of Electroconvulsive Therapy Robert M. Berman*, Joan Prudic, Mark Olfson, Harold A. Sackeim

57.

Pharmacological Dissection of the Effect of Risperidone on SSRI-Induced Changes of Norepinephrine Neuronal Firing Pierre Blier*, Eliyahu Dremencov, Mostafa El Mansari

58.

Activity of a Selective Galanin-3 Receptor (GAL3) Antagonist In Acute and Chronic Behavioral Models of Anxiety and Depression Thomas P. Blackburn, Chad J. Swanson, Toni D. Wolinsky, Michael J. Konkel, Mary M. Walker, Margaret Durkin, Roman P. Artymyshyn, Kelli E. Smith, Kenneth A. Jones, Douglas A. Craig, Christophe P. Gerald, Theresa A. Branchek*

59.

Attention Bias to Threat in Bipolar Children With or Without Comorbid Anxiety Disorders Melissa A. Brotman*, Brendan A. Rich, Mariana Schmajuk, Christopher S. Monk, Karin Mogg, Brendan P. Bradley, Daniel S. Pine, Ellen Leibenluft

60.

Post-Retrieval Propranolol Weakens Longstanding Traumatic Memories Alain Brunet*, Scott P. Orr, Jacques Tremblay, Karim Nader, Roger K. Pitman

61.

Serotonin Transporter Polymorphism Association with Neuroticism and Depression: A Controversy Evaluated Margit Burmeister*, Srijan Sen, Debashis Ghosh

62.

A Pilot Controlled Trial of Bupropion vs. Es-Citalopram in Generalized Anxiety Disorder (GAD) Alexander Bystritsky*, Lauren Kerwin, Samuel Eiduson, Tanya Vapnik

63.

Serotonin Transporter Binding in Unmedicated Bipolar Disorder Subjects using [Carbon-11] DASB and Positron Emission Tomography Dara M. Cannon*, Masahiro Ichise, Stephem Fromm, Allison C. Nugent, Denise Rollis, Shilpa K. Gandhi, Wayne C. Drevets

96

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64.

Depressive-Like Effects of the Kappa-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats William A. Carlezon*, Cecile Beguin, Jennifer A. DiNieri, Michael H. Baumann, Michele R. Richards, Mark S. Todtenkopf, Richard B. Rothman, Zhongze Ma, David Y. Lee, Bruce M. Cohen

65.

Prefrontal Neurometabolite Changes Following Lamotrigine Treatment in Adolescents with Bipolar Depression Kiki Chang*, Kim Gallelli, Meghan Howe, Kirti Saxena, Christopher Wagner, Daniel Spielman, Allan Reiss

66.

The ERK Pathway in Left Anterior Cingulate Cortex Modulates Locomotive and Hedonic Activities Guang Chen*, Thomas Creson, YanLei Hao, Sharon Engel, Husseini K. Manji

67.

Glucocorticoid Modulation of TPH2 Protein in Raphe Nuclei and Frontal Cortical 5-HTP Levels in C57/Bl6 Mice Janet Clark*, Lee-Yuh Pai, Rachel Conley, Rosemarie B. Flick, Ildiko Szalayova, Eva Mezey, Peter H. Hutson, Ariel Deutch, Susan P. Rohrer, Osvaldo Flores

68.

Ontogeny of Individual Differences in Emotional Reactivity Sarah Clinton*, John D. Stead, Sue Miller, Delia Vasquez, Stanley Watson, Huda Akil

69.

A Pilot Study of the Effect of Omega-3 Fatty Acids on Heart Rate Variability in Anxiety Disorders Kathryn M. Connor*, Wei Zhang, Victoria Payne, Lana Watkins, Jonathan Davidson

70.

Adjunctive Eszopiclone and Fluoxetine in Major Depressive Disorder and Insomnia: Effects on Sleep and Depression Mark Corrigan*, W V. McCall, Maurizio Fava, Robert Rubens, Thomas Wessel, Judy Caron, David Amato, Thomas Roth

71.

Engraftment of a Monoaminergic Cell Line within Affective Neural Circuitry Miles G. Cunningham*, Rachael Donalds, William Carlezon, Susan Anderson, Lee Napierata, Kwang-Soo Kim, Dong-Wook Kim 97

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72.

Cardiovascular Effects of Duloxetine: Preclinical and Clinical Findings Michael J. Detke*, Smriti Iyengar, Judith W. Henck, Frank Bymaster, John T. Callaghan, Mary Pat Knadler, Joachim F. Wernicke, Michael E. Thase

73.

A Psychosocial Approach to Depression in Parkinson’s Disease Roseanne D. Dobkin*, Lesley A. Allen, Matthew Menza

74.

Serotonin Attenuates Mating-Induced Glutamate Activity in the Medial Preoptic Area: Implications for Impaired Libido Resulting from SSRIs Juan M. Dominguez*, Mario Gil, Jessica H. Brann, Elaine M. Hull

75.

Association of the Functional -1019C/G 5-HT1A Polymorphism with Decreased Prefrontal Cortex Activation Measured with 3T fMRI in Panic Disorder Katharina E. Domschke*, Miriam Braun, Patricia Ohrmann, Thomas Suslow, Harald Kugel, Jochen Bauer, Christa Hohoff, Anette Kersting, Almut Engelien, Volker Arolt, Walter Heindel, Juergen Deckert

76.

Membrane Localization of the G protein Gsα is Altered in Post-Mortem Brain of Depressed Suicide Victims: Possible Disruption of Plasma Membrane Rafts Robert Donati*, Justin Brown, Xinguo Ren, Yogesh Dwivedi, Robert Conley, Ghanshyam Pandey, Mark M. Rasenick

77.

Lithium Normalizes Dendritic Localization of Val66met Polymorphism of Brain-Derived Neurotrophic Factor (BDNFmet): Therapeutic Implications Jing Du*, Kastuji Suzuki, Guhan Nagappan, Yun Wang, Bai Lu, Husseini Manji

78.

Serotonin Transporter Activity Modulates 5-HT1B-Induced Alterations in Prepulse Inhibition and Locomotion: Implications for Obsessive Compulsive Disorder and Panic Disorder Stephanie C. Dulawa*, Kerri A. Holick, Mark S. Ansorge, Rene Hen, Jay A. Gingrich

79.

Underdiagnosis of Psychotic Symptoms in Patients with Bipolar Mania David L. Dunner*, Carla M. Canuso, Cynthia A. Bossie, Young Zhu

98

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80.

Olanzapine/Fluoxetine Combination Versus Lamotrigine in the Long-Term Treatment of Bipolar I Depression Eileen Brown, David Dunner*, David Adams, Elisabeth Degenhardt, Mauricio Tohen, Douglas Williamson, John Houston

81.

A Comparison of ETRANK, MMRM and LOCF Analyses of Eighteen Placebo-Controlled Venlafaxine Clinical Trials for the Treatment of Major Depressive Disorder Richard Entsuah*, David V. Sheehan, Michael E. Thase, Ying Zhang

82.

Children of Depressed Mothers in an Urban Primary Care Population Adriana Feder*, Min Tang, Virginia Warner, Angelique Alonso, Eva Barranco, Daniel J. Pilowsky, Helena Verdeli, Priya Wickramaratne, Myrna M. Weissman

83.

The DID Anhedonia Rating Scale: Results of the First Validation Study James M. Ferguson*, Ken Evans, Terry Sills, Heather McDonald

84.

Passive Avoidance Learning and Response Reversal During Tryptophan Depletion Elizabeth Finger*, Abigail Marsh, Niveen Kamel, Karina Peschardt, Meena Vythilingam, Daniel Pine, James Blair

85.

Cognitive Performance in Bipolar Disorder: A Processing Efficiency Account David E. Fleck*, Paula K. Shear, Robert A. Kowatch, Stephen M. Strakowski

86.

A Pilot Trial of Escitalopram for Depression in Perimenopausal Women Marlene P. Freeman*, Rebecca Hill, Barbara H. Brumbach, Alan J. Gelenberg

87.

Modafinil in the Treatment of Bipolar Depression: A Placebo-Controlled Trial Mark A. Frye*

88.

Epigenetic Determinants of GAD1/GAD67 (2q31.1) Expression in Human Prefrontal Cortex Hsien-Sung Huang, Schahram Akbarian*

99

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89.

Asenapine, a Novel Psychotherapeutic Agent with Efficacy in Positive and Negative Symptoms During Acute Episodes of Schizophrenia: A Randomized, Placebo- and Risperidone-Controlled Trial Steven G. Potkin, Miriam Cohen, Ross A. Baker, Anil S. Jina, Steven Nettler, Larry Alphs*, John Panagides

90.

Training for Assessment of Negative Symptoms of Schizophrenia Across Languages and Cultures Utilizing the Negative Symptom Assessment Scale Larry Alphs*, David G. Daniel, Dawn Velligan, John Bartko, John Panagides, John Davis

91.

Insulin And Igf-1 Reverse Mitochondrial, Energy Metabolism, Proteasome, And Neuronal Plasticity Gene Decreases Of Schizophrenia In An MrnaBased Screen For Antischizophrenia Agents C. A. Altar*, Rachel A. Hunt, Jurata W. Jurata, Eric Derby, Paul Gallagher, Andrew Lemire, Pascal Laeng

92.

A Double-Blind Randomized Trial of a Single Dose of Placebo, Haloperidol, and Risperidone in Healthy Volunteers Celso Arango*, Juan Francisco Artaloytia, Adrienne Lahti, Javier Sanz, Ana Pascual, Pedro Cubero, David Prieto, Tomas Palomo

93.

Corticotropin-Releasing Factor (CRF) Impairs Sensorimotor Gating In The Sprague-Dawley Rat: Reversal By Clozapine And Raclopride Isabel C. Arrillaga-Romany*, Ronald P. Hammer

94.

Type of Symptom Remission and Treatment Outcomes in the Long-Term Treatment of Patients with Schizophrenia Haya Ascher-Svanum*, Baojin Zhu, Douglas Faries, Bruce J. Kinon, John M. Kane

95.

PCP-Disrupted Social Interaction Paradigm in Rats: Differential Effects of Typical and Atypical Antipsychotics: Putative Role of α2-Adrenoceptor Antagonism? Louisa Douglas, Nicole Golembo, Hilde Duytschaever, Barbara Biemans, Sahana Nayak, David Ashton*

100

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96.

Predictors of Patient Satisfaction with Medication in Patients with Schizophrenia A G. Awad*, Andrew Greenspan, Colette Kosik-Gonzalez, Young Zhu, Cynthia A. Bossie, Amir H. Kalali, Georges M. Gharabawi, Michael Davidson

97.

Targeting the Cystine-Glutamate Antiporter to Attenuate the Behavioral and Neurochemical Effects in the Phencyclidine Rodent Model of Schizophrenia David Baker*, Aric Madayag, Eric Haschke, Rostian Akpor-Mensah

98.

NRG-1 Protein Levels in Patients with Schizophrenia, Bipolar Disorder and Major Depression Senda Beltaifa*, Maree J. Webster, Cynthia Shannon Weickert

99.

Alterations of Postsynaptic AMPA Receptor Trafficking in the Anterior Cingulate Cortex in Elderly Schizophrenics Monica Beneyto*, Arjune K. Rama, Vahram Haroutunian, James H. Meador-Woodruff

100.

AVE1625, a Cannabinoid CB1 Antagonist, as a Co-Treatment for Schizophrenia: Improvement in Cognitive Function and Reduction of Antipsychotic-Side Effects in Animal Models Beth Borowsky*, Rachel Stevens, Black Mark, Senyah Yaw, Nancy Rogacki, Odessa Giardino, Odile Piot-Grosjean, Jeremy Pratt, Robert Lenox

101.

Divergence of PPI Deficits and P50 Suppression Deficits in Schizophrenia Patients Point to Two Dissociable Endophenotypes: Implications for Genetic Analyses in the COGS Project David Braff*, Gregory Light, Kristin Cadenhead, Joyce Sprock, Neal Swerdlow

102.

Elevated Prenatal Homocysteine as a Risk Factor for Schizophrenia Alan S. Brown*, Teodoro Bottiglieri, Catherine A. Schaefer, Charles P. Quesenberry, Liyan Liu, Michaeline Bresnahan, Ezra S. Susser

101

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103.

Evidence That a DTNBP1 Risk Haplotype is Associated with Negative Symptoms and Cognitive Dysfunction in Patients with Schizophrenia Katherine E. Burdick*, Pamela DeRosse, Birgit Funke, Todd Lencz, Philip R. Szeszko, John M. Kane, Raju Kucherlapati, Anil K. Malhotra

104.

Hypometabolic Medial-Frontal Effects of Chronic Intermitent PCP Exposure in Rats Assessed with High Resolution Magic Angle Spin 11.7T Proton Magnetic Resonance Spectroscopy Juan R. Bustillo*, Nora Perrone-Bizzozero, Rodrigo Paz, Gayle Griffith, Matthew Galloway

105.

The Eyes Don’t Have It: Face Processing in Schizophrenia Pamela D. Butler*, Arielle Tambini, Yovel Galit, Maria Jalbrzikowski, Rachel Ziwich, Nancy Kanwisher, Uriel Heresco, Shlomo Bentin, Daniel C. Javitt

106.

Neurocognitive Deficits in Prodromal and First Episode Schizophrenia are Stable and Predictive of Social Functioning Kristin Cadenhead*, Angela Eastvold, David Braff, Robert Heaton

107.

The Consortium on the Genetics of Schizophrenia (COGS): Recruitment and Assessment Methods in a Multi-Site Collaboration ME Calkins*, DJ Dobie, KS Cadenhead, A Olincy, DL Braff

108.

Prefrontal Cortex Inefficiency During Working Memory in Unaffected Siblings of Patients with Schizophrenia: A Replication Joseph H. Callicott*, Steven Sust, Hao-Yang Tan, Venkata S. Mattay, Joshua Buckholtz, Michael F. Egan, Daniel R. Weinberger

109.

Promoter Specific Alterations of BDNF mRNA in Frontal Cortex in Patients with Schizophrenia Hope L. Cassano*, Thomas M. Hyde, Amy Deep-Soboslay, Joel E. Kleinman, Cynthia Shannon Weickert

110.

Trait vs. State Markers for Schizophrenia: the Case of Visual Motion Processing Yue Chen*, L Cinnamon Bidwell, Philip Holzman

102

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111.

Identification and Characterization of Behavioral Plasticity Genes in Drosophila William Cho*, Fred Wolf, Ulrike Heberlein

112.

Confirmation of the Association of 10 Genes with Atypical Anti-Psychotic Treatment Emergent Weight Gain in a Cohort with an Obesity Phenotype Sandra Close Kirkwood*, Richard D. Hockett, Nitai D. Mukhopadhyay, Dong-Jing Fu, R. Arlen Price, John Blanchard, Dennis Ballinger, David R. Cox, Alan Breier

113.

Patient-Reported and Clinician-Rated Depressive Symptoms in the Treatment of Schizophrenia Robert Conley*, Haya Ascher-Svanum, Baojin Zhu, Douglas Faries, Bruce Kinon

114.

Investigating Cortical Inhibition as a Potential Mechanism of Atypicality in the Antipsychotic Clozapine Using Transcranial Magnetic Stimulation Zafiris J. Daskalakis*, Sarah I. Fountain, Robert Chen

115.

Null Mutation of the Alpha-2A Adrenoceptor in Mice Fails to Alter Visuospatial Attention or the Performance Enhancing Effects of Guanfacine J David Jentsch*

116.

Ziprasidone Dosing Study in Pediatric Patients with Bipolar Disorder, Schizophrenia, or Schizoaffective Disorder Mark Versavel, Melissa P. DelBello*, Kathleen Ice, Robert Kowatch, David Keller, Jeffrey Miceli

117.

Brain Structural and Functional Deficits in Subjects at High Genetic Risk for Schizophrenia Lynn E. DeLisi*, Kamila Szulc, Hilary C. Bertisch, Kyle Brown, Magda Majcher, Sarah Branch, David Mack, Raj Sangoi, Matthew Hoptman, Craig Branch

118.

Population Pharmacokinetic Analysis of Drug-Drug Interactions Among Risperidone, Bupropion, and Sertraline in CF-1 Mice Lindsay DeVane*, Jun-Sheng Wang, Brian Gibson, Jennifer Donovan, John Markowitz, Haojie Zhu

103

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119.

A Data-Driven Approach for Understanding the Stages of Schizophrenia John Docherty*, Stephen Rodriguez, Colette Kosik-Gonzalez, Cyndi Bossie, Georges Gharabawi, Sam Siris

120.

Deficits in PFC Activity in Schizophrenia Patients During the Maintenance and Response Selection Phases of Working Memory Naomi R. Driesen*, Hoi-Chung Leung, R. T. Constable, Pawel Skudlarski, Patricia S. Goldman-Rakic, John H. Krystal

121.

Reduced Hospitalisation in Patients with Schizophrenia Initiated with Risperidone Long-Acting Injection (LAI): 3 Month Follow-Up from the eSTAR Database Dieter Naber, Harry Hustig, Dominique Rosillon, Lennart Wetterberg, Sue Caleo, Mike Ingham, Bo Eriksson*, An Jacobs

122.

Natural Prepulse Inhibition Deficits in Brattleboro Rats Respond to Valproic Acid Augmention of Clozapine: Further Support for the Predictive Validity of this Animal Model David Feifel*, Paul Shilling, Gilia Melendez

123.

Corollary Discharge Failure in Schizophrenia is Related to Severity of Auditory Hallucinations: fMRI Evidence Judith M. Ford*, May Gray, Gary Glover, William O. Faustman, Susan L. Whitfield, Daniel H. Mathalon

124.

Mice Deficient for an Immediate Early Gene Show a Heightened Response to Environmental Stressors Consistent with a Schizophrenia Phenotype Amelia Gallitano-Mendel*, David Wozniak, Maureen Boyle, Louis Muglia, Jeffrey Milbrandt

125.

A Pilot Study Assessing the Effects of Dar-0100 (A Dopamine D1 Full Agonist) on Regional Brain Activity and Task-Specific Activation in Patients with Schizophrenia Mark S. George*, Ziad Nahas, Berry Anderson, F. A. Kozel, Qiwen Mu, Chris Molnar, Michael Knable, Prabhavathi Fernandes, David Nichols, Richard Mailman

104

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126.

Neuropsychological Deficits in Non-Smokers with Schizophrenia: Effects of a Nicotinic Antagonist Tony P. George*, Kristi A. Sacco

127.

Exploring the Evidence for a Relationship Between Symptomatic Remission and Improvement in Functioning in Patients With Schizophrenia Georges Gharabawi*, Cyndi Bossie, Steve Rodriguez, Ibrahim Turkoz, George Simpson

128.

Appraising Neurocognitive Endophenotypes for Schizophrenia David C. Glahn*, Laura Almasy, Jaun Manuel Peralta, Gary M. Burk, Jose Estrada, Naxhielli Meyenberg, Mariana Pereira Castro, Humberto Nicolini, Henriette Raventos, Michael A. Escamilla

129.

Placebo-Controlled, Add-On Trial of CX516 (Ampakine) in Schizophrenia Donald C. Goff*, J. S. Lamberti, Alexander Miller, Jayendra K. Patel, Theo Manschreck, Oliver Freudenreich, Michael F. Green, Andrew Leon, Steven Johnson

130.

The Trajectory is The Story: Cortical Gray Matter Changes During Adolescence In Childhood Onset Schizophrenia Evolve Into The Adult Pattern By Age 25 Nitin Gogtay*, Deanna Greenstein, Jay Giedd, Liv Clasen, Alexandra Sporn, Marge Lenane, Jason Lerch, Alan Evans, Judith Rapoport

131.

Reelin (RELN) Promoter Hypermethylation In Gaba Neurons In Schizophrenia Dennis R. Grayson*, Ying Chen, Rajiv P. Sharma, Alessandro Guidotti, Erminio Costa

132.

The Consortium on the Genetics of Schizophrenia (COGS): Preliminary Heritability Analyses of Endophenotypic Measures for Schizophrenia Tiffany A. Greenwood*, David L. Braff, Neal R. Swerdlow, Michael F. Green, Keith Nuechterlein, Allen D. Radant, William S. Stone, Ann Olincy, Raquel Gur, Nicholas J. Schork

133.

Convergence of Cognitive Improvement with Development of Clinical Remission in Schizophrenia Philip D. Harvey*, Antony Loebel, Christopher R. Bowie

105

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134.

Cognitive and Functional Improvement with Long Term Treatment with Long-acting Risperidone Philip D. Harvey*, Gahan Pandina, Robert M. Bilder, Steven Rodriguez, Ibo Turkoz, Georges Gharabawai

135.

Cognitive Coping and Illusion of Control Can Both Modulate Hypothalamic-Pituitary-Adrenal Response to Pharmacological Activation James L. Abelson*, Samir Khan, Israel Liberzon, Hedieh Briggs, Elizabeth A. Young

136.

Mifepristone for the Prevention of Olanzapine-Induced Weight Gain in Rats Katherine L. Beebe*, Thaddeus Block, Charles DeBattista, Christine Blasey, Alan F. Schatzberg

137.

Ovarian Steroids Suppress the Apoptosis-Inducing Protein JNK1 in the Dorsal Raphe Region of Macaques Cynthia L. Bethea*, Lisa J. Smith

138.

Effects of Left Prefrontal rTMS on Laboratory, Neuropathic and PostOperative Pain Jeffrey J. Borckardt*, A. R. Smith, Mitchell Weinstein, Scott T. Reeves, Stephen Gibert, Audrey Barry, F. A. Kozel, Mark S. George

139.

Indiplon Dose-Response Analyses For Objective and Subjective Measures of Sleep Brian Corrigan*, Raymond Miller, Phillip B. Chappell, Robert Farber, Danielle Ouellet, Dimitri E. Grigoriadis

140.

Plasma L-Tryptophan Depletion and Loading Time-Course and Side-Effect Comparison of 50 and 100g Formulations Donald M. Dougherty*, D.M. Marsh, C.W. Mathias, M.A. Addicott, A.A. Jagar, C.J. Morgan, A.A-B. Badawy

141.

Prevalence of Intact Decision-Making Capacity for Research Among People with Schizophrenia Using Two Standards Laura B. Dunn*, Barton W. Palmer, Dilip V. Jeste

106

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142.

Methamphetamine-Induced Dopamine Complex Formation: A Role For Reactive Oxygen Species and Dopamine Receptors Anthony J. Baucum, Kamisha L. Johnson-Davis, Glen A. Cook, Glen R. Hanson, Annette Fleckenstein*

143.

Response to Methylphenidate in Symptoms of Most Concern to Parents of Preschool Children with Developmental Disorders Jaswinder K. Ghuman*, Rick Cruz, Ron Wright, Harinder S. Ghuman, Alan Gelenberg

144.

Inhibition of Dopamine Transporter Activity by Cannabinoids Andrea Giuffrida*, David A. Price, Lynette C. Daws, W A. Owens, Georgianna G. Gould, Alan Frazer, Alexander Seillier, James L. Roberts

145.

Differences in Cognitive Function and Acute Sedative Effects of Risperidone and Quetiapine Among Individuals with Stable Bipolar I Disorder Howard A. Hassman*, Steven J. Glass, Luella Engelhart, Lian Mao, Stephen Rodriguez, Georges Gharabawi, Robert Bilder, David G. Krefetz, Maria Pinho, Harbans Lal

146.

Family Study of Binge Eating Disorder James I. Hudson*, Justine K. Lalonde, Cynthia M. Bulik, Scott J. Crow, Susan L. McElroy, Nan M. Laird, Ming T. Tsuang, B. T. Walsh, Norman R. Rosenthal, Harrison G. Pope

147.

Duloxetine: Summary of Time to Response in a Preclinical and a Clinical Model of Neuropathic Pain Smriti Iyengar*, Yili L. Pritchett, Jerry A. Hall, Amy S. Chappell, Joachim F. Wernicke, David J. Goldstein, Rosa M. Simmons, Michael J. Detke, Shuyi Shen, Deborah N. DSouza, Michael J. Robinson

148.

Seizure Risk Among Patients Participating in Psychopharmacology Clinical Trials Arif Khan*, Kenneth Alper, Kelly Schwartz, Russell Kolts, Walter Brown

107

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149.

Early Life Stress Impairs Memory and Produces Hippocampal Degeneration in Adult Rats Therese A. Kosten*, David A. Karanian, Colin N. Haile, Thomas R. Kosten, Jeansok J. Kim, Priscilla Kehoe, Ben A. Bahr

150.

The Role Of Postsynaptic Alpha-2 Noradrenergic Receptors In The Modulation Of Cortical Activity Antonieta Lavin*, Glenn D. Andrews

151.

Effects of Childhood Trauma and Acute Lorazepam on Fear-Related Cortico-Limbic Brain Reactivity: A Pilot Pharmacological fMRI Study Royce Lee*, Kin L. Phan, Michael Angstadt, Daniel A. Fitzgerald, Allan Klock, Michael S. McCloskey, Emil F. Coccaro

152.

Trophic Factors and Adrenergic Function Dona Lee Wong*, T.C. Tai, David C. Wong-Faull, Robert Claycomb

153.

Functional Outcomes in Adults with Attention-Deficit/Hyperactivity Disorder Following Treatment with Atomoxetine vs. Placebo Louise Levine*, Roy N. Tamura, Douglas K. Kelsey, Darryle D. Schoepp, Albert J. Allen

154.

Abnormal Glutamate and Dopamine Receptor Function in the Striatum of Alpha-Synuclein Overexpressing Mice Michael S. Levine*, Nan-Ping Wu, Carlos Cepeda, Eliezer Masliah

155.

Asenapine Preferentially Increases Dopamine (DA) and Acetylcholine (ACh) Efflux in Rat Medial Prefrontal Cortex (mPFC) and Hippocampus (HIP) Zhu Li*, Mohammed Shahid, Herbert Y. Meltzer

156.

Topiramate for the Treatment of Moderate to Severe Binge Eating Disorder Associated with Obesity A Double-Blind, Placebo-Controlled Study Susan McElroy*, James I. Hudson, Julie A. Capece, Karen Beyers, Alan C. Fisher, Norman R. Rosenthal

157.

Effect of Risperidone and Olanzapine on Measures Associated with the Insulin Resistance Syndrome Herbert Y. Meltzer*, Yuejin Chen, Karu Jayathilake

108

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158.

Multiple Novel Polymorphisms in the Rhesus Macaque DRD4 5’ UTR are Associated with Impulsive Behavior Timothy K. Newman*, Christina S. Barr, Rachel E. Holston, Nicole Y. Davis, Stephen J. Suomi, David Goldman, J D. Higley

159.

Metabolic Profile in Children and Adolescents with Disruptive Behavior Disorders Treated with Risperidone Magali Reyes, Gahan J. Pandina*, Ilse Augustyns, Robert L. Findling

160.

The Association of Fatigue with Poor Virologic Response in Patients Receiving Interferon-Alpha Plus Ribavirin for the Treatment of Hepatitis C Charles L. Raison*, Carmine M. Pariante, Lucile Capuron, Bin Chen, Bobbi J. Woolwine, Paul M. Plotsky, Ira M. Jacobson, Andrew H. Miller

161.

Randomized, Double-Blind, Placebo-Controlled Study of Armodafinil for the Treatment of Excessive Sleepiness Associated With Chronic Shift Work Sleep Disorder Thomas Roth*, Charles A. Czeisler, James K. Walsh, Keith A. Wesnes, Michael Williams, Gwendolyn E. Niebler, Sanjay Arora

162.

A Complementary Strategy to Approach the Genetics of Schizophrenia Dan Rujescu*, Ina Giegling, Annette Hartmann, Just Genius, Christoph Mulert, Ulrich Hegerl, Heinz Grunze, Pierandrea Mulia, Claire Birell, Andreas Ruppert, Thomas Meitinger, Martin Keck, Frauke Ohl, Manfred Ackenheil, Hans-Jurgen Moller

163.

Serotonin Transporter Polymorphism Influences the Prolactin Response to Tryptophan and Stress Cynthia M. Kuhn, Kishore Gadde, Saul M. Schanberg*, Douglas A. Marchuk, Ilene C. Siegler, Richard S. Surwit, Redford B. Williams

164.

5-HT6 Receptor Stimulation Induces Neuroprotective Properties In Vitro and In Vivo Lee E. Schechter*, Margaret Zaleska, Mark Bowlby, Danni Liu, Shi Liang, John A. Harvey, Al Robichaud, Ron Bernotas, Derek Cole, Kevin Pong

109

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165.

Onset of Antidepressant Action and Acute Efficacy and Safety of Duloxetine Versus Escitalopram and Placebo in the Treatment of Major Depressive Disorder AA Nierenberg*, JH Greist, CH Mallinckrodt, A Prakash, JG Watkin, A Sambunaris, GD Tollefson, MM Wohlreich

110

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Poster Session II—Tuesday 1.

Diffusion Tensor Imaging in Cocaine Dependence: Evidence for Reduced Myelin in the Anterior Corpus Callosum F. Gerard Moeller*, Khader M. Hassan, Joel L. Steinberg, Ignacio Valdes, Larry Kramer, Ponnada A. Narayana, Alan C. Swann

2.

Effects of Self-Administered and Passive Cocaine Infusions on Dopamine, Norepinephrine and Corticosterone Concentrations in the Medial Prefrontal Cortex Nicholas E. Goeders*, Gennady N. Smagin, Marie F. Lanfranco, Patricia K. Seitz, Mary L. Thomas, Kathryn A. Cunningham, Vitaly S. Palamarchouk

3.

Decreased Corticolimbic Responset To Monetary Reward in Cocaine Addiction: Association with Motivation and Self-Control Rita Z. Goldstein*, Dardo Tomasi, Nelly Alia-Klein, Lisa A. Cottone, Lei Zhang, Thomas Maloney, Frank Telang, Elisabeth C. Caparelli, James M. Swanson, Nora D. Volkow

4.

Interactions Between Nalbuphine, Mood and Hypothalamic-Pituitary-Axis (HPA) Hormones Nathalie V. Goletiani*, Jack H. Mendelson, Michelle B. Sholar, Arthur J. Siegel, Alicja Skupny, Nancy K. Mello

5.

Aripiprazole Decreases Alcohol Drinking in Syrian Golden Hamsters David T. Chau, Alan I. Green*

6.

Time-Dependent Dissociation Between Accumbal and Amygdalar Mediation of Cue-Induced Cocaine Seeking Jeffrey W. Grimm*, Meghan Manaois, Dan Osincup, Amber Fyall, Barbara Wells

7.

Effects of Baclofen on Cocaine Self-Administration: Opioid-Dependent and Non-Opioid Dependent Volunteers Margaret Haney*, Carl Hart, Richard W. Foltin

111

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8.

Modafinil Attenuates Disruptions in Performance and Mood During Simulated Night Shift Work Carl L. Hart*, Margaret Haney, Suzanne K. Vosburg, Sandra D. Comer, Erik Gunderson, Richard W. Foltin

9.

Psychiataric Symptoms Among Outpatients in an Open-Label Trial of Risperidone for Methamphetamine Dependence Craig Jaffe*, Andrew J. Saxon, Charles W. Meredith

10.

Gender Differences in Substance Use by Healthcare Professionals in a State Sample George A. Kenna*, Robert M. Swift

11.

Intravenous Nicotine Self-Administration in C57BL6/J Mice Paul J. Kenny*, Athina Markou

12.

Behavioral Pharmacology and Pharmacokinetics of Cocaine Analogs in Rhesus Monkeys Heather L. Kimmel*, S S. Negus, Sarah B. Ewing, John R. Votaw, Mark M. Goodman, F I. Carroll, Nancy K. Mello, Leonard L. Howell

13.

Synergistic Interactions Between “Club Drugs”: Gamma-Hydroxybutyrate and N-Methyl-D-Aspartate Antagonists Wouter Koek*, Mandar Khanal, Charles P. France

14.

Six-Month Trial of Bupropion with Contingency Management for Cocaine Dependence Thomas R. Kosten*, James Poling, Alison Oliveto, Kishor Gonsai, Mehmet Sofuoglu, Gerardo Gonzalez, Bridget Martell

15.

Naltrexone and Fluoxetine for Relapse to Heroin Dependence in St. Petersburg, Russia Evgeny M. Krupitsky*, Edwin E. Zvartau, Elena V. Verbitskaya, Charles P. O’Brien, George E. Woody

16.

Are Adolescent Rats Addiction-Prone and Hyperresponsive to Stimulants Because They Are Hypodopaminergic? Quentin D. Walker, Joseph M. Caster, Lauren Gerlach, Sarah Parylak, Sarah Morris, Cynthia M. Kuhn*

112

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17.

Ethanol Does Not Affect Discriminative Stimulus Effects of Nicotine in Rats Bernard Le Foll*, Steven R. Goldberg

18.

Blockade of D2/D3 Dopamine Receptors Selectively Impairs Reversal Learning, but not New Learning, in Monkeys Performing a Visual Discrimination Task Buyean Lee*, Edythe D. London, J. D. Jentsch

19.

Endocrine Challenge of the HPA Axis Differentially Modulates Plasma Deoxycortisosterone and Pregnenolone Levels in Cynomolgus Monkeys A. Leslie Morrow*, Patrizia Porcu, Laura S. Rogers, Kathleen A. Grant

20.

The Effect of Dopamine Precursor Depletion on Alcohol SelfAdministration in Men: Individual Differences Sean P. Barrett, Robert O. Pihl, Chawki Benkelfat, Caroline Brunelle, Simon N. Young, Marco Leyton*

21.

Examining White Matter Abnormalities in Cocaine Dependence with T2 Relaxography Kelvin O. Lim*, Bryon A. Mueller, Sheila M. Specker, Jeffrey R. Wozniak

22.

Variation in the rhNPY Promoter Is Associated with Differences in CSF Levels of NPY and Alcohol Consumption Christina S. Barr, Stephen G. Lindell*, Stephen J. Suomi, David Goldman, J D. Higley

23.

The Effects of CRH-1 Antagonist Antalarmin on Cocaine SelfAdministration and Discrimination Nancy K. Mello*, S S. Negus, Kenner C. Rice, Jack H. Mendelson

113

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24.

The Effects of ‘Binge’ Cigarette Smoking on Hypothalamic-PituitaryAdrenal Axis Hormones and Mood in Men Jack H. Mendelson*, Nathalie V. Goletiani, Michelle B. Sholar, Arthur J. Siegel, Nancy K. Mello

25.

Dose-Dependent Effects of Topiramate on Alcohol Cue Reactivity and the Subjective Effects of Drinking: Preliminary Data Robert Miranda*, Peter Monti, Robert Swift, James MacKillop, Jennifer Tidey, Chad Gwaltney, Damaris Rohsenow

26.

5-HT1B Receptors in Nucleus Accumbens Efferents Can Increase both Rewarding and Aversive Effects of Cocaine John F. Neumaier*, Sabiha Barot

27.

Factor Analysis of the Y-BOCS in Autistic Disorder Evdokia Anagnostou*, William Chaplin, Dryden Watner, Jeremy Silverman, Eric Hollander

28.

Decreased Cortisol Response to the Trier Social Stress Test in Healthy Adults with Significant Childhood Adversity Linda L. Carpenter*, Audrey R. Tyrka, John P. Carvalho, Lauren Wier, Gerard G. Gagne, Andrea F. Mello, Marcelo F. Mello, George M. Anderson, Lawrence H. Price

29.

Variable Foraging Demand (VFD) Exposure of Primate Maternal-Infant Dyads and Impaired Insulin Action in Juvenile Offspring Jeremy D. Coplan*, Daniel Kaufman, Igor Shorman, Eric L. Smith, Michael J. Owens, Charles B. Nemeroff, Leonard A. Rosenblum, John G. Kral, MaryAnn Banerji

30.

Early Postnatal Brain Structure and Development in Humans: Sexual Dimorphism and Cerebral Asymmetry are Present at Birth John Gilmore*, Christopher Looney, Yethiraja Vesta, J. K. Smith, Weili Lin, Jeffery A. Lieberman, Guido Gerig

114

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31.

Oxytocin Increases Social Cognition in Autism Eric Hollander*, William Chaplin, Ann Phillips, Jennifer Sumner, Latha Soorya, Evdokia Anagnostou, Stacey Wasserman

32.

Individual Differences in Physiological Regulation and Early Development of African-American Infants Living in Poverty Suma Jacob*, Kate Keenan

33.

Developmental Regulation of NCAM in Human Frontal Cortex L. F. Jarskog*, Patricia F. Maness, Karissa L. Gable, Anthony-Samuel LaMantia, Jeffrey A. Lieberman, John H. Gilmore

34.

Gender-Specific Longitudinal Changes in Cortical Thickness in Children and Adolescents Rhoshel Lenroot*, Philip Shaw, Kristin Taylor, Dede Greenstein, Liv Clasen, Alan Evans, Jay N. Giedd

35.

Behavioral and Electrophysiological Characterization of the Role of MeCP2 in the Brain Lisa Monteggia*, Erika Nelson, Terry Gemelli, Olivier Berton, Linda Perrotti, Rudolf Jaenisch, Ege Kavalali

36.

A Prospective, Open-Label Study of Atomoxetine for ADHD Symptoms Associated with Higher-Functioning Pervasive Developmental Disorders David J. Posey*, Ryan E. Wiegand, Wilkerson Jennifer, Melissa Maynard, Kimberly A. Stigler, Christopher J. McDougle

37.

Relationship Between Behavior and Neurochemical Changes in Rhesus Macaques During a Separation Paradigm Simona Spinelli*, Melanie Schwandt, Kristine Erickson, Stephen Lindell, Jay Schulkin, Philip Gold, Stephen J. Suomi, J. D. Higley

38.

Dysfunction of Critical Regulators of Serotonergic Signaling Confers Autism Susceptibility James S. Sutcliffe*, Ryan J. Delahanty, Harish C. Prasad, Qiao Han, Lan Jiang, Randy D. Blakely

115

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39.

Cortical and Amygdala Overgrowth in Autism Associated With 5-HTTLPR Thomas H. Wassink*, Heather Cody, Matthew Mosconi, Eric Epping, Joseph Piven

40.

The Sp4 Transcription Factor Gene is Critical for Postnatal Development of Dentate Gyrus in Mice and Associated with Bipolar Disorder in Humans Xianjin Zhou*, John Kelsoe, Mark A. Geyer

41.

Genetic Correlates of Cortico-Limbic Activity and Connectivity in Major Depression Amit Anand*, Yu Li, Yang Wang, Sujuan Gao, Jingwei Wu, Mark J. Lowe, Thomas Talavage, John I. Nurnberger, David Goldman, Jill Murrell

42.

Comparison of the Effects of Tolcapone and Entacapone on Cognition and fMRI in Normal Volunteers Jose A. Apud*, Venkata Mattay, Jingshan Chen, Kolachana S. Bhaskar, Joseph H. Callicott, Guilna Alce, Jennifer Iudicello, Natkai Akbar, Michael F. Egan, Terry E. Goldberg, Daniel R. Weinberger

43.

Altered Serotonin Transporter Binding After Recovery from Anorexia Nervosa Using PET and [11C]McN5652 Ursula F. Bailer*, Guido F. Frank, Shannan E. Henry, Julie C. Price, Carolyn C. Meltzer, Angela Wagner, Claire W. McCohana, Chester A. Mathis, Walter H. Kaye

44.

CBT vs Sertraline in OCD: Effects on Brain Regional Serotonin Synthesis Index Igor Sibon, Marco Leyton, Paul Gravel, Debbie Sookman, Gilbert Pinard, Mirko Diksic, Chawki Benkelfat*

45.

The Neural Correlates of Social Decision-Making: An Event-Related fMRI Study Joshua W. Buckholtz*, Qiang Chen, Steven Sust, Emily M. Drabant, Beth A. Verchinski, Giuseppe Blasi, Fabio Sambataro, Venkata S. Mattay, Daniel R. Weinberger, Joseph H. Callicott

116

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46.

Role of Medial Prefrontal Cortex in Intention Deficit in Schizophrenia Margaret A. Cato*, Bruce A. Crosson, Eric L. Granholm, Gregory G. Brown

47.

Amygdala Hyperactivity to Angry Faces in Patients with Intermittent Explosive Disorder Emil F. Coccaro*, Michael S. McCloskey, Daniel A. Fitzgerald, K. Luan Phan

48.

Prefrontal Neurochemical Abnormalities in Adolescent Bipolar Disorder Melissa P. DelBello*, Kim Cecil, Cal Adler, Stephen M. Strakowski

49.

Low Frequency Oscillations of Oxy-Hemoglobin in Brain: A NearInfrared-Spectroscopic Feasibility Study Adriana Di Martino*, PaoloEmilio Barbano, Michael Milham, Christopher Hyde, F. Xavier Castellanos

50.

Neural Activation During Encoding of Emotional Faces in Pediatric Bipolar Disorder Daniel P. Dickstein*, Brendan A. Rich, Roxann Roberson-Nay, Deborah T. Vinton, Lisa H. Berghorst, Daniel S. Pine, Ellen Leibenluft

51.

Altered Dorsal or Ventral Prefrontal Morphology May Differentiate Risk for Schizophrenia or Bipolar Disorder: Preliminary Evidence from in vivo MRI studies Vaibhav A. Diwadkar*, Boris Birmaher, Jeffrey J. Nutche, Diana Dworakowski, David Axelson, David Brent, Debra M. Montrose, Matcheri S. Keshavan

52.

Emotional Numbing in PTSD: fMRI Neuroimaging of Reward Circuitry Igor Elman*, Blaise Frederick, Dan Ariely, Steven Dunlap, John Rodolico, David Penetar, Nina Mazar, Jeannette Cohan, Roger Pitman, Scott Lukas

117

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53.

Influence of Low and High Dose Hydrocortisone Infusion on Hemodynamic Response in Amygdala While Viewing Emotional Faces Kristine Erickson*, Maura L. Furey, Jay Schulkin, Suzanne E. Wood, Linda Mah, Allison C. Nugent, Wayne C. Drevets

54.

Schematic Faces Evoke Exaggerated Regional Activation Within the Amygdala in Social Anxiety Disorder Karleyton Evans*, Christopher I. Wright, Michelle M. Wedig, Mark H. Pollack, Scott L. Rauch

55.

Medial Prefrontal Cortical Maturation: An fMRI Study of Interference Processing in Healthy Children Kate D. Fitzgerald*, Hannah F. Chua, Robert C. Welsh, Stephan F. Taylor

56.

Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Guido K. Frank*, Ursula F. Bailer, Wayne C. Drevets, Carolyn C. Meltzer, Julie C. Price, Walter H. Kaye

57.

PET Imaging of the Serotonin 2a Receptor (5-HT2a) and Sertonin Transporter (SERT) in Personality Disordered Subjects with Impulsive Aggressivity WG Frankle*, PS Talbot, Y Huang, L Iskander, M Goodman, AS New, D-R Hwang, A Abi-Dargham, M Laruelle, LJ Siever

58.

Subcortical Asymmetries in Bipolar and Attention Deficit/Hyperactivity Disorders Jean A. Frazier*, Janis L. Breeze, Nikos Makris, Martha R. Herbert, David N. Kennedy, Steven M. Hodge, Megan E. Dieterich, Joseph Biederman, Verne S. Caviness

59.

Increased GABAergic Activity Modulates MR-Visible Glutamate and Glutamine: Studies with High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HR-MAS 1H-MRS) Matthew P. Galloway*, Navid Seraji-Bozorgzad, Kerry L. Murphy, Shonagh K. O’Leary Moore, Kristen M. Haubenreich, George M. McKelvey, Aliaksei Pustavoitau, John H. Hannigan, Harold M. Marsh

118

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60.

Computational Anatomy to Assess Growth Pattern of Early Brain Development in Healthy and Disease Populations Guido Gerig*, John H. Gilmore, Matthieu Jomier, Sarang Joshi, Joseph Piven

61.

Altered Pain Processing in Veterans with Posttraumatic Stress Disorder Elbert Geuze*, Anja Jochims, Christian Schmahl, Herman Westenberg, Eric Vermetten

62.

Frontal Dopamine D2 Receptor Binding in Neuroleptic-Naive FirstEpisode Schizophrenic Patients Correlates with Positive Psychotic Symptoms and Predicts Treatment Outcome Birte Y. Glenthoj*, Hans Rasmussen, Torben Mackeprang, Claus Svarer, William Baare, Lars Pindborg, Lars Friberg, Ralf Hemmingsen, Charlotte Videbaek

63.

White Matter Integrity in Kleptomania: A Pilot Study Jon Grant*, Stephen Correia, Thea Brennan-Krohn

64.

Prevention of Relapse in MDD: An Investigation of the Neural Basis of Self-Regulation of Emotion Merida M. Grant*, Steven D. Hollon, Richard C. Shelton, Elizabeth Stringer

65.

What Is the “Therapeutic Window” of Risperidone Long-Acting Injectable (RLAI)? A Meta-Analysis of Published and Unpublished Data Gerhard Grunder*, Erik Mannaert, Dean F. Wong, Rossella Medori

66.

MAOA Polymorphism Affects BOLD Responses During Behavioral and Emotional Regulation Mary Heitzeg*, Zucker A. Robert, Elzbieta Sliwerska, Margit Burmeister, Jon-Kar Zubieta

119

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67.

Brain Glycine Increases Detected During Oral Glycine Supplementation with TE-Averaged Proton Spectroscopy Marc J. Kaufman*, Andrew P. Prescot, Dost Ongur, A. Eden Evins, Tanya Barros, Julie Covell, Liqun Wang, John Brown, Maurizio Fava, Perry F. Renshaw

68.

DTI of Cerebellar and Basal Ganglia Pathways in OCD Yijun Liu*, Wayne K. Goodman

69.

The Old Drug Scopolamine Offers New Promise as a Potent Antidepressant Agent: A Randomized, Placebo-Controlled Clinical Trial Maura L. Furey*, Wayne C. Drevets

70.

Genetic Analysis of Dorsal Raphe Tph2 Expression: Potential Interaction with Antidepressant Responsive Gene Kf1 (Rnf103) Steven J. Garlow*, Ericka Boone, Wei Li

71.

Genetic Analysis of Dorsal Raphe 5-HT1A, SERT and Glucocorticoid Receptor Expression: Potential Shared Genetic Regulation Ericka Boone, Wei Li, Steven J. Garlow*

72.

Glucocorticoid Receptor Transgenic Mice as Models for Depression Peter Gass*, Sabine Chourbaji, Stephanie Ridder, Rainer Hellweg, Alexandre Urani, Christiane Zacher, Wolfgang Schmid, Mathias Zink, Heide Hortnagl, Herta Flor, Gunther Schutz, Fritz A. Henn

73.

Integration of Emotion-Laden and Working Memory-Related Information in the Prefrontal Cortex Aaron L. Goldman*, Lukas Pezawas, Gang Chen, Andreas MeyerLindenberg, Terry E. Goldberg, Ziad S. Saad, Venkata S. Mattay, Daniel R. Weinberger

74.

Neural Correlates of Anxiety in Serotonin 1A Receptor-Deficient Mice Joshua A. Gordon*, Clay O. Lacefield, Clifford G. Kentros, Rene Hen

120

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75.

Mouse Strain Differences in Single Dose Lithium Attenuation of Amphetamine Hyperactivity Todd D. Gould*, Alyssa M. Picchini, Kelley C. O’Donnell, Robert J. Schloesser, Husseini K. Manji

76.

Prevalence of Metabolic Syndrome in Partial Responders to Selective Serotonin Reuptake Inhibitors with Major Depressive Disorder Tracy L. Greer*, Madhukar H. Trivedi, Timothy S. Church, Bruce D. Grannemann, Daniel I. Galper, Prabha Sunderajan

77.

Surinabant, a New CB1 Receptor Antagonist, Displays Efficacy in Animal Models of Attention Deficit/Hyperactivity Disorder Caroline Louis, Jean-Paul Terranova, Michel Decobert, Jean-Charles Bizot, Dominique Francon, Craig Karson, Richard Alonso, Caroline Cohen, Guy Griebel*

78.

The Dexamethasone/CRF Test in Men with Major Depression: Role of Childhood Trauma Christine Heim*, Tanja Mletzko, David Purselle, Dominique L. Musselman, Charles B. Nemeroff

79.

Regulation of 5-HT1A Receptor Function in Inducible BDNF Knock-Out Mice Following Administration of Fluoxetine or Corticosterone Julie G. Hensler*, Lisa M. Monteggia

80.

Demonstration on PET of a Widespread Deficiency in Serotonin Transporter Binding in Bipolar Depression Maria A. Oquendo, Ramin S. Hastings, Yung-yu Huang, Norman Simpson, R Todd Ogden, Ronald L. Van Heertum, J John Mann*, Ramin V. Parsey

81.

Anxiolytic-Like Effects of a DNA Enzyme Targeting the CorticotropinReleasing Factor 2(a) Receptor (CRF2(a)) in the Rat Lateral Septum Steve A. Nanda, Ned H. Kalin*, Dimitri E. Grigoriadis, Patrick H. Roseboom

121

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82.

A Randomized Placebo-Controlled Trial of Risperidone Augmentation for Patients with Difficult-to-Treat Unipolar, Nonpsychotic Major Depression G I. Keitner*, P T. Ninan, C E. Ryan, S Garlow, D A. Solomon, C B. Nemeroff, M B. Keller

83.

Placebo-Controlled Trial of Venlafaxine ER in Prevention of Recurrence in Patients with Recurrent Unipolar Major Depression Martin B. Keller*, Bing Yan, Saeed Ahmed, Erika Parker-Zavod, Ron Pedersen

84.

Rapid Cycling Differentially Exacerbates Bipolar II Compared to Bipolar I Disorder: Implications for Adjunctive Antidepressant Therapy Terence A. Ketter*, Joseph Calabrese, Charles Bowden, Lauren Marangell, Laszlo Gyulai, Andrew Nierenberg, Stephen Wisniewski, Gary Sachs

85.

The REVAMP Medication Algorithm for Chronic Depression: Preliminary Results James H. Kocsis*, Martin B. Keller, Daniel N. Klein, Philip T. Ninan, Alan F. Schatzberg, Michael E. Thase, Madhukar H. Trivedi, Steven Wisniewski, Alan J. Gelenberg

86.

Olanzapine in the Treatment of Acute Mania in Adolescents with Bipolar I Disorder: A 3-Week Randomized Double-Blind Placebo-Controlled Study Mauricio Tohen, Ludmila Kryzhanovskaya, Gabrielle Carlson, Melissa DelBello, Janet Wozniak, Robert Kowatch*, Karen Wagner, Robert Findling, Daniel Lin, Carol Robertson-Plouch, Wen Xu, Xiaohong Huang, Ralf Dittman, Joe Biederman

87.

Paroxetine-Induced Increase in LDL Cholesterol Levels Jean-Michel Le Melledo*, Kevin Mailo, Maria Castillo Abadia, Lucas Gil, Nathalie Lara, Stephen Newman, Glen Baker, Stephen Archer, Mickael Van Ameringen

88.

Reduced Brain Docosahexaenoic Acid Content After a Single Reproductive Cycle in Female Rats Maintained on a Diet Deficient in n-3 Polyunsaturated Fatty Acids Beth Levant*, Jeffery D. Radel, Susan E. Carlson

122

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89.

Pooled Analysis of Response and Remission Rates with Venlafaxine ER in Social Anxiety Disorder Michael Liebowitz*, Jonathan R. Davidson, Carlos Blanco, Raj Tummala, Qin Jiang

90.

Randomized Controlled Trial of the Cognitive Side Effects of Magnetic Seizure Therapy and Electroconvulsive Shock Sarah H. Lisanby*, Tammy D. Moscrip, Bruce Luber, Matthew Truesdale, Niko Reyes, Louis Trotman, Herbert S. Terrace

91.

The Familial Aggregation Anxiety Disorders Ascertained from the Community versus Clinics Nancy C. Low*, Lihong Cui, Kathleen R. Merikangas

92.

Increased Neurogenesis in CREB-Deficient Mice is Associated with Antidepressant-Like Behavior Jessica E. Malberg*, Alana C. C. Conti, Anita J. Bescholt, Irwin Lucki, Julie A. Blendy

93.

Lithium Increases Gray Matter in the Prefrontal and Subgenual Prefrontal Cortices in Treatment Responsive Bipolar Disorder Patients Gregory J. Moore, Bernadette M. Cortese, Debra A. Glitz, Caroline Zajac-Benitez, Jorge A. Quiroz, Thomas W. Uhde, Wayne C. Drevets, Husseini Manji*

94.

Vagus Nerve Stimulation for the Treatment of Rapid Cycling Bipolar Disorder Lauren Marangell*, Trisha Suppes, Holly Zboyan, Grace Fischer, James Martinez, Diane Snow, Suresh Sureddi

95.

A Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose, Trial of Augmentation with OROS Methylphenidate in Treatment Resistant Depression Prakash S. Masand*, Ashwin A. Patkar, Kathleen Peindl, Christa Hooper-Wood, Patrick E. Ciccone, Daniel Blazer

123

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96.

A Genome-by-Genome Interaction Linkage Scan of Bipolar Disorder Melvin McInnis*, Peter Zandi, Anjene Addington, Carl Langefeld, John Nurnberger, Bill Byerley, Elliot Gershon, John Kelsoe, John Rice, Bill Scheftner, Bill Coryell, Wade Berrettini, Francis McMahon

97.

Behavioral and Anatomical Interactions Between Dopamine and Corticotropin-Releasing Factor (CRF) Edward G. Meloni*, Lyle P. Gerety, Allison T. Knoll, Bruce M. Cohen, William A. Carlezon

98.

Amyloid PET Imaging with Pittsburgh Compound-B in Late Life Depression with Cognitive Impairment Carolyn C. Meltzer*, Meryl A. Butters, William E. Klunk, Chester A. Mathis, Julie C. Price, Brian J. Lopresti, Scott K. Ziolko, Jessica A. Hoge, Charles F. Reynolds, Steven T. DeKosky

99.

Familial Patterns of Comorbidity of Migraine and Affective Disorders Kathleen R. Merikangas*, Nancy C. Low, Lihong Cui

100.

Emergence of Anhedonia in Laboratory Rats During Continuous Subordination Stress: Relevance to Antidepressants and Stimulant Abuse Klaus A. Miczek*, Herbert E. Covington, Artur K. Kieres, Jasmine J. Yap, Ella M. Nikulina

101.

The Anxiolytic Opipramol Affects Calcium Signalling via Sigma Receptors Walter E. Muller*, Bettina Henke, Kristina Treiber

102.

Antidepressant Prescribing Trends Pre and Post-Black Box Warning: A Review of the Medicaid Database Meera Narasimhan*, Richard Rech, Richard Harding

103.

Cognitive Function in Patients with Resistant Depression: Effects of Antidepressant Monotherapy and Risperidone Augmentation Philip D. Harvey, Robert Bilder, Georges M. Gharabawi, Carla M. Canuso, Gahan J. Pandina, Ibrahim Turkoz, Charles Nemeroff*

124

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104.

Alterations of Cortico-Limbic Responsiveness to Emotional Valenced Stimuli in Alpha2CDel322-325 Carriers with Depression and Controls Alexander Neumeister*, Wayne C. Drevets, David Luckenbaugh, David Goldman, Inna Belfer, Peter Herscovitch, Dennis S. Charney

105.

Fluoxetine and Triiodothyronine Reduce 5-HT1A and 5-HT1B Receptor Activites and mRNA Levels in Male but Not in Female Rats Michael E. Newman*, Ronen Segman, Tsuri Lifschytz, Galit Shalom, Tanya Golzer, Eitan Gur, Bernard Lerer

106.

Sleep EEG Response to Metyrapone May be a Measure of Hypothalamic CRF Activity: A Study of Women with and Without Posttraumatic Stress Disorder Thomas Neylan*, Christian Otte, Rachel Yehuda, Charles Marmar

107.

CSF 5-HIAA, Suicide Intent and Hopelessness in the Prediction of Suicide in High Risk Suicide Attempters Peter Nordstrom*, Jussi Jokinen, Mats Samuelsson, Anna-Lena Nordstrom, Marie Asberg

108.

Association of the Down-Regulation of the Norepinephrine Transporter in Rat Brain with the Persistent Behavioral Effects Observed Following Repeated Treatment with Desipramine James M. O’Donnell*, Alicia M. Crissman, Zaorui Zhao

109.

Transmission of Mood Disorders to the Offspring of Parents with Bipolar Disorder and Major Depressive Disorder Maria A. Oquendo*, Boris Birmaher, Adrienne Tin, Jamie Zelazny, Barbara H. Stanley, Nadine Melhem, Laurence Greenhill, Steven P. Ellis, David Kolko, Beth S. Brodsky, J. John Mann, David A. Brent

110.

Brain Derived Neurotrophic Factor (BDNF) is Decreased in Platelets and Lymphocytes of Pediatric Patients with Bipolar Disorder Ghanshyam N. Pandey*, Yogesh Dwivedi, Hooriyah S. Rizavi, Xinguo Ren, Amal C. Mondal, Mani Pavuluri

125

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111.

Resolution of Sleepiness and Fatigue in the Treatment of Major Depressive Disorder: A Comparison of Bupropion and the Selective Serotonin Reuptake Inhibitors George I. Papakostas*, David J. Nutt, Vivan L. Tucker, Alok Krishen, Maurizio Fava

112.

Proton Magnetic Resonance Spectroscopy Study of the Effects of Lithium on Myo-Inositol in Bipolar Depressed Adolescents Nick C. Patel*, Melissa P. DelBello, Kim M. Cecil, Holly S. Bryan, Caleb M. Adler, Kevin E. Stanford, Stephen M. Strakowski

113.

Electroconvulsive Seizures Increase Cell Proliferation in the Adult Monkey Cortex Tarique D. Perera*, Michael Persky, Michele Insanally, Alexander Sackeim, Jeremy Coplan, Andrew Dwork, Harold Sacheim

114.

Pharmacological Characterization of the Novel 5-HT2C Agonist SCA-136: Antidepressant-Like Effects Sharon Rosenzweig-Lipson*, Jack Bergman, John Dunlop, Karen Marquis, Jean Zhang, Siva Ramamoorthy, Jessica Malberg, Claudine Pulicicchio, Hossein Mazandarani, Steve Grauer, Paul J. Mitchell, Boyd Harrison, Menelas N. Pangalos, Lee Schechter, Gary Stack

115.

Constitutive Activation of the G-Protein Subunit G αs Causes Behavioral and Biochemical Deficits Due to a PKA-Dependent Upregulation of PDE Activity Michele Kelly, Michael Esposito, Jan Tokarczyk, Steve Siegel, Steve Kanes, Ted Abel*

116.

Does Maintenance Treatment with Atypical Antipsychotics Worsen Quality of Life Among Stable Patients with Schizophrenia? Charles M. Beasley, Jr.*, Virginia K. Sutton, Cindy Taylor, Gopalan Sethuraman, Martin Dossenbach, Dieter Naber, David Pickar

117.

Dopaminergic Modulation of Excitatory and Inhibitory Transmission in the Basolateral Amygdala-Prefrontal Cortex Pathway Stan B. Floresco*, Maric T. Tse

126

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118.

Schizophrenia, Diabetic Ketoacidosis and Atypical Antipsychotic Agents David C. Henderson*, Enrico Cagliero, Paul M. Copeland, Pearl M. Louie, Christina P. Borba, Donald C. Goff

119.

DISC1 Polymorphism in Schizophrenia: Associations with Cognition and MRI Brain Morphology Beng-Choon Ho*, Thomas H. Wassink

120.

Temporal and Prefrontal Cortex Gray Matter Abnormalities in Patients with Schizophrenia and Their Unaffected Siblings; An Optimized VoxelBased Morphometry Study Robyn A. Honea*, Andreas Meyer-Lindenburg, Katherine Hobbs, Lukas Pezawas, Beth A. Verchinski, Aaron L. Goldman, Venkata S. Mattay, Daniel R. Weinberger, Joseph H. Callicott

121.

Identification of a Novel Genetic Locus at 7q36.1 in Strong LD with Schizophrenia and the Differential Expression of the Flanking Genes, NOS3 and KCNH2 Stephen J. Huffaker*, Daniel R. Weinberger

122.

Allelic Variations in NRG1 Affect Region-Specific Expression of Low Affinity Nicotinic Acetylcholine Receptors in the Human Brain Thomas M. Hyde*, Shiny V. Mathew, Barbara K. Lipska, Shruti N. Mitkus, Radhakrishna Vakkalanka, Richard E. Straub, Daniel R. Weinberger, Joel E. Kleinman

123.

Treatment of Patients with Acute Schizophrenia Using Paliperidone Extended-Release Tablets: A 6-Week Placebo-Controlled Study John M. Kane*, Michelle Kramer, Lisa Ford, Christiana GassmannMayer, Pilar Lim, Marielle Eerdekens

124.

A Comparison of the Effects of Olanzapine, Quetiapine, and Risperidone on Neurocognitive Function in First-Episode Psychosis Richard Keefe*, Hongbin Gu, Diana Perkins, Joseph McEvoy, Robert Hamer, Jeffrey Lieberman

127

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125.

Relationship of Paternal Age to N-Acetyl-Aspartate in the Prefrontal Cortex in Schizophrenia Lawrence S. Kegeles*, Dikoma C. Shungu, Xiangling Mao, Raymond Goetz, Charles B. Mikell, Anissa Abi-Dargham, Marc Laruelle, Dolores Malaspina

126.

Cardiac-Related Mortality in People with Schizophrenia Deanna L. Kelly*, Robert R. Conley, Robert P. McMahon, Raymond C. Love, Yang Yu, Tara Wagner

127.

Cognitive Remediation and Social Cognition in Early Schizophrenia: Preliminary fMRI Data Matcheri S. Keshavan*, Vaibhav A. Diwadkar, Jeffrey J. Nutche, Gerald E. Hogarty

128.

Factorial Structure of the Schedule for Deficit Syndrome in Schizophrenia David Kimhy*, Scott Yale, Raymond R. Goetz, Lynn Marcinko McFarr, Cheryl Corcoran, Dolores Malaspina

129.

Association of Depressive Symptoms and Discontinuation from Schizophrenia Treatment: A Post-hoc Pooled Analysis of 4 Controlled Atypical Antipsychotic Treatment Trials Adam Meyers, David Adams, Haya Ascher-Svanum, Richard Mohs, Bruce Kinon*

130.

Increased Brain Activation During Eye Gaze Discrimination in Schizophrenia Christian G. Kohler*, James Loughead, Kosha Ruparel, Tim Indersmitten, Ruben C. Gur

131.

Abnormal Expression of NMDA Receptor Subunits and Interacting PSD Molecules in the Endoplasmic Reticulum in Schizophrenia Lars V. Kristiansen*, Vahram Haroutunian, James H. MeadorWoodruff

128

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132.

Functional Effects of Haloperidol and Olanzapine over a 6-Week Treatment Period: Relation to Clinical Response Adrienne C. Lahti*, Henry H. Holcomb, Carol A. Tamminga, Martin A. Weiler

133.

Prefrontal Cortical“UP” States in Adult Rat Brain Slice: Role of Glutamate Spillover and 5-HT2A Receptors Evelyn K. Lambe*, George K. Aghajanian

134.

Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S. Kegeles, Gordon W. Frankle, Raj Narendran, Roberto Gil, Peter S. Talbot, Dah-Ren Hwang, Yiyun Huang, Thomas Cooper, Slifstein Mark, Anissa Abi-Dargham

135.

DRD2 Promoter Region Variation Predicts Sustained Response to Antipsychotic Medication in First Episode Schizophrenia Todd Lencz*, Delbert G. Robinson, Ke Xu, Jenny Ekholm, Serge Sevy, Handan Gunduz-Bruce, Margaret G. Woerner, John M. Kane, David Goldman, Anil K. Malhotra

136.

Clozapine Effects on Memory Function are Reversed by Hippocampal Damage Edward D. Levin*

137.

Synergetic Effects of Quetiapine and Venlafaxine in Preventing the Decrease in Cell Proliferation and BDNF Expression in Rat Hippocampus Caused by Chronic Restraint Stress Xin-Min Li*, Haiyun Xu

138.

Remission in Schizophrenia: A Comparison of 2 Dose Regimens of Ziprasidone versus Haloperidol Treatment in a 3-Year Double-Blind Extension Study Jeffrey Lieberman*, Lewis Warrington, Antony Loebel, Cynthia Siu

139.

Probing the Cognitive, Clinical, and Functional Impairments of Schizophrenia Patients with Mismatch Negativity Gregory A. Light*, Katrin Meyer-Gomes, Joyce Sprock, David L. Braff

129

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140.

Role of Catechol-O-Methyltransferase Val/Met Polymorphism on P50 Sensory Gating in Schizophrenia Brett Y. Lu*, Kimberly Martin, Ashley K. Smith, Stephen F. Lewis, Gregory A. Miller, Jose M. Canive

141.

The Prospective Study of Cannabis Use, Symptoms and Functioning in Patients Prodromal to Psychosis Cheryl Corcoran, David Kimhy, Yadira Sanchez, Jessica MacDonald, Herbert Kleber, Dolores Malaspina*

142.

Symptomatic Remission in Schizophrenia Patients Treated with Aripiprazole or Haloperidol for up to 52 Weeks Anil Malhotra*, John Kane, David Crandall, Xiaoling Wu, William Carson, Dan Oren, Dusan Kostic, Wim Swyzen

143.

Inhibition of the Glycine Transporter (GlyT1) Potentiates the Effect of Risperidone, but Not Clozapine, on Glutamatergic Transmission in the Rat Medial Prefrontal Cortex Monica M. Marcus*, Asa Konradsson, Peter Hertel, Torgny H. Svensson, Kent E. Jardemark

144.

Efficacy and Tolerability of Two Fixed Dosages of Paliperidone ExtendedRelease Tablets in the Treatment of Acute Schizophrenia: A 6-Week Placebo-Controlled Study Stephen R. Marder*, Michelle Kramer, Lisa Ford, Els Eerdekens, Lim Pilar, Marielle Eerdekens

145.

ERP P300 and Mismatch Negativity Abnormalities in Prodromal and Early Illness Schizophrenia: Predicting Conversion to Psychosis Daniel H. Mathalon*, Thomas H. McGlashan, Tandy J. Miller, Scott W. Woods

146.

Comparison of Atypicals in First-Episode Psychosis (CAFE): A Randomized, 52-Week Comparison of Olanzapine, Quetiapine, and Risperidone Joseph P. McEvoy*, Joseph A. Lieberman, Diana Perkins, Robert M. Hamer

130

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147.

Novel Targets of Quaking: A Gene Essential for Myelination That is Severely Reduced in Schizophrenia Lynne A. McInnes*, Sean Ryder

148.

Comparison of Clozapine and High Dose Olanzapine in Treatment Resistant Schizophrenia in a Double Blind, Randomized, 6 Month Clinical Trial Karu Jayathilake, David O. Meltzer*, Joyce Small, Herbert Y. Meltzer

149.

Comparative Effects of Ziprasidone and Olanzapine on Markers of Insulin Resistance: Results of a 6-Week Randomized Study in Patients with Acute Schizophrenia Jonathan Meyer*, Antony Loebel, Henry Nasrallah

150.

Aripiprazole Effects on Highly Agitated Patients with Alzheimers’s Disease and Associated Psychosis Jacobo Mintzer*, Lindsay DeVane, Britt West, Joseph Pultz, Andrei Pikalov, Ronald Marcus, Rolando Gutierrez-Esteinou, David Crandall

151.

A New Approach to Assessing Objective Functional Outcomes in Schizophrenia: A Validation Study Richard Mohs*, S Dube, L Bowman, B Kinon, L. Kleinman, L. Frank, D Revicki, Y Zhao

152.

Error Feedback Negativity During a Learning Task in Schizophrenia Sarah E. Morris*, Erin A. Heerey, Benjamin M. Robinson, James M. Gold

153.

Prefrontal Activity in Schizophrenia: An Interleaved TMS/fMRI Study Ziad Nahas*, Chris Molnar, Dave Ramsey, John Walker, Jejo Koola, Kevin Johnson, Richard Holt, Michael Horner, Frank A. Kozel, Stewart Denslow, Daryl Bohning, Mark S. George

154.

Low Rates of Treatment for Metabolic Disorders in the CATIE Schizophrenia Trial at Baseline Henry A. Nasrallah*

131

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155.

An Integrative Approach to Investigate Molecular Mechanisms Underlying Schizophrenia Using both Rat and Drosophila Melanogaster Charles Nichols*, Elaine Sanders-Bush

156.

Association of the 5HT2C Gene Polymorphism and Antipsychotic-Induced Weight Gain Charles Nnadi*, Christoph U. Correll, Katherine E. Burdick, Jenny M. Ekholm, John M. Kane, Anil K. Malhotra

157.

Genetic Analysis Supports a Primary Abnormality in Oligodendrocyte Function in Schizophrenia Michael O’Donovan*, Lyudmila Georgieva, George Kirov, Vahram Haroutunian, Kenneth L. Davis, Joseph D. Buxbaum, Michael Owen

158.

The Consortium on the Gentics of Schizophrenia (COGS): The P50 Auditory Evoked Potential as an Endophenotype in a Large Multi-Site Study Ann Olincy*, Jamey Ellis, Robert Freedman

159.

Learning to Relax with MRS: Altered NAA T2 Relaxation Times in Schizophrenia David P. Olson*, Joseph Coyle, Yong Ke, Staci A. Gruber, Isabelle Rosso, Marisa Silveri, Perry F. Renshaw, Deborah A. Yurgelun-Todd

160.

Sleep Spindle Abnormalities in Schizophrenia Michael J. Peterson*, Fabio Ferrarelli, Reto Huber, Marcello Massimini, Steve K. Esser, Adam Watson, Giulio Tononi

161.

A Double-Blind Placebo Controlled Trial of Modafinil for Negative Symptoms in Schizophrenia Joseph M. Pierre*, John H. Peloian, Donna A. Wirshing, William C. Wirshing, Stephen R. Marder

162.

PCP- and Cocaine- Induced Changes in White Matter- Comparison with DTI Findings in Schizophrenia and Cocaine Dependence Jay Nierenberg*, David G. Guilfoyle, Matthew J. Hoptman, Daniel C. Javitt

132

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163.

A Post-Marketing Observational Study of the Effects of Donepezil on Patients with Alzheimer Disease Jared R. Tinklenberg*, Helena C. Kraemer, Kristine Yaffe, Leslie Ross, J W. Ashford, Javaid Sheikh, Jerome A. Yesavage, Joy L. Taylor

164.

Alterations in Sensorimotor Processing in Mice with Hyperdopaminergic or Hypomonoaminergic Tone William C. Wetsel*, Ramona M. Rodriguiz, Marc G. Caron

165.

Candidate Gene Polymorphisms and Birth Weight (BW) in the National Longitudinal Study of Adolescent Health (Add Health) Redford Williams*, Melanie Kail, Marcy Speer, Beverly Brummett, Stephan Zuchner, Ilene Siegler, John Barefoot, Geeta Swamy, Haywood Brown, Marie L. Miranda, Allison Ashley-Koch

133

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Poster Session III—Wednesday 1.

Design, Synthesis and Application of Novel Tropane-Based Photoaffinity Labels Toward the Identification of Binding Domains on the Dopamine Transporter Amy H. Newman*, Mu-Fa Zou, Jianjing Cao, Joo H. Cha, John R. Lever, Theresa Kopajtic, Jonathan L. Katz, M. L. Parnas, Roxanne Vaughan

2.

White Matter Changes in Cocaine Dependence Jay Nierenberg*, Laurie Nash, Matthew J. Hoptman, Jan Hrabe, Babak A. Ardekani, Gregory Bunt, Kelvin O. Lim, John Rotrosen

3.

Prediction of Alcohol Problems Using A Prospective Longitudinal Design Including Genotype John I. Nurnberger*, R Wiegand, L Bierut, K Bucholz, T Foroud, H Edenberg, E T. Meyer, J Kramer, D Dick, W Reich, S Kuperman, V Hesselbrock, A Goate, B Porjesz, H Begleiter

4.

Casein Kinase 1 Epsilon Modulates Sensitivity to Stimulant Drugs in Both Mice and Humans: A Translational Genetic Study Abraham A. Palmer*, Jeremy Veenstra-Vander Weele, Miguel Verbitsky, Rathi Suresh, Asfia Qaadir, Helen M. Kamens, John K. Belknap, T C. Gilliam, Edwin H. Cook, Tamara J. Phillips, Harriet De Wit

5.

Cerebellar Vermis Participation in Cocaine-Related Behaviors Carl M. Anderson, Luis C. Maas, Blaise D. Frederick, Jacob T. Bendor, Thomas J. Spencer, Eli Livni, Scott E. Lukas, Alan J. Fischman, Bertha K. Madras, Perry F. Renshaw*, Marc J. Kaufman

6.

Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in AlcoholDependent Self-Administering Rats Heather Richardson*, Laura E. O’Dell, Soon Y. Lee, George F. Koob, Catherine L. Rivier

134

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7.

Sensitization-Prone C57BL/6J Mice Exhibit Reduced Dopamine D3 Receptor-Mediated Inhibition Relative to Sensitization-Resistant DBA/2J Mice Robert K. McNamara, Beth Levant, Benjamin Taylor, Rebecca Ahlbrand, Amy Liu, Kevin Stanford, Neil M. Richtand*

8.

Rats Maintain Ethanol Self-Administration into the Posterior Ventral Tegmental Area (VTA) Despite the Aversive Effects of Bicuculline Zachary A. Rodd*, Scott M. Oster, Jamie E. Toalston, James M. Murphy, Richard L. Bell, Ting-Kai Li, William J. McBride

9.

Exposure to Cues Associated with Palatable Food Increases ImmediateEarly Gene (IEG) mRNA and Proenkephalin (PENK) premRNA Expression in the Rat Brain Craig A. Schiltz*, Ann E. Kelley, Charles F. Landry

10.

Ontogeny of the HPA-Axis and Monoamine Response to Acute Ethanol Challenge in Male and Female Adolescent Rhesus Macaques Melanie L. Schwandt*, Christina S. Barr, Stephen J. Suomi, James D. Higley

11.

Aripiprazole Attenuates Cocaine-Seeking Behavior in an Animal Model of Relapse Ronald E. See*, Matthew W. Feltenstein, C. A. Altar

12.

Chronic, but Not Acute, Desipramine Treatment Prevented Nicotine Withdrawal and Decreased Nicotine Self-Administration in Rats Svetlana Semenova*, Neil E. Paterson, Athina Markou

13.

Positron Emission Tomographic Study of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and Without Comorbid Alcohol Dependence Leo Sher*, Matthew S. Milak, Ramin V. Parsey, Thomas B. Cooper, Juan J. Carballo, Maria A. Oquendo, J J. Mann

14.

NMDA Receptors Mediate Some of the Lingering Behavioral Deficits of Repeated Ethanol Exposure in Adolescent Rats Ratna Sircar*

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15.

Selective Enhancement of Limited Access Ethanol Intake in IsolateHoused Alcohol-Preferring (P) Rats Craig J. Slawecki*, Cindy L. Ehlers

16.

Amphetamine Effects on Amygdala Responses to Affective Pictures in Healthy Volunteers Tara L. White, Robert M. Swift*, Ronald A. Cohen, Lawrence H. Sweet

17.

The Effects of MDMA (Ecstasy) on Sleep Architecture and Mood in Humans Manuel E. Tancer*, Timothy Roehrs, Chris-Ellyn Johanson

18.

Positive and Negative Transcription Regulation of NR2B Gene in Basal and Ethanol-Induced Gene Expression in Fetal Cortical Neurons Maharaj K. Ticku*, Mei Qiang

19.

An Open Label Pilot Trial of Atomoxetine and Four-Session Motivational Interviewing for Cannabis Dependence Carlos F. Tirado*, Nathalie Maullin, Kampman Kyle, Lauren Klein, Charles O’Brien

20.

Brain Stimulation Reward Thresholds Are Altered by Viral VectorMediated Elevations of GluR Subunits Within the Nucleus Accumbens Shell Mark S. Todtenkopf*, Rachael L. Neve, William A. Carlezon

21.

The Impact of Screening, Brief Intervention, and Referral to Treatment (SBIRT) on Emergency Department(ED) Patients’ Alcohol Use Kimberly Walton*, Research Collaborative The Academic ED SBIRT, Robert E. Taylor

22.

Effects of Acute Plasma Tryptophan Depletion on Serotonin Receptor Binding Using PET in Healthy Controls: Implications for Alcoholic Brain Disease Wendol A. Williams*, Richard E. Carson, Andreas Heinz, James Bjork, Mary-Anne Enoch, Christopher Geyer, Robert Rawlings, Daniel Hommer, David Goldman, Peter Herscovitch

136

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23.

Baseline Data from CTN Study 0010: Buprenorphine/Naloxone Facilitated Psychosocial Treatment for Opioid Dependent Adolescents/Young Adults George E. Woody*, Sabrina Poole, Forman Robert, Blaine Jack

24.

A Large-Scale Approach for Identifying Vulnerability Genes to Alcoholism: A 1536 SNP Chip Ke Xu*, Qiaoping Yuan, Colin A Hodgkinson, Pei-Hong Shen, Lisa Neuhold, Zhaoxia Ren, Kenneth Warren, David Goldman

25.

Nicotinic Agonists Inhibit Reinstatement of Methamphetamine-Seeking Behavior in Rats Tsuneyuki Yamamoto*, Takato Hiranita, Kusnandar Anggadiredja

26.

Diffusion Tensor Imaging Measures Correlate with Cognitive Performance in Heavy Cannabis Smokers Staci A. Gruber, Deborah A. Yurgelun-Todd*

27.

Region and Emotion Specific Effects of Lorazepam on Neural Responses to Facial Displays of Affect K. Luan Phan*, Mike Angstadt, Daniel A. Fitzgerald, Pradeep J. Nathan, Royce Lee, Emil F. Coccaro

28.

Reproducibility of Proton Spectroscopic Imaging (H1-MRSI) at 3Tesla: Effects of Corrections for B1 Field and Partial Volume Stefano Marenco*, Douglas W. Jones, Alan S. Barnett, Jan Willem Van der Veen, Aronica Cotton, Daniel R. Weinberger

29.

Neuroticism, Extraversion and Alexithymia Are Associated with Differential Neural Activation Patterns to Emotional Stimuli Jennifer C. Britton, Brian Martis*, Shao-Hsuan Ho, Stephan F. Taylor, Israel Liberzon

30.

Magnetic Resonance Spectroscopic Imaging Twenty Years After the Emergence of Adolescent-Onset Major Depressive Disorder Sanjay J. Mathew*, Dikoma C. Shungu, Xiangling S. Mao, Heidi Fitterling, Jonathan M. Amiel, Eric L. Smith, Adriana Feder, Jeremy D. Coplan, Myrna M. Weissman

137

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31.

COMT val158met Polymorphism Impacts on Reactivity of Amygdala to Emotion Laden Stimuli Venkata S. Mattay*, Giuseppe Blasi, Guilna Alce, Saumitra Das, Joseph H. Callicott, Bhaskar S. Kolachana, Michael F. Egan, Fabio Sambataro, Andreas Meyer-Lindenberg, Ahmad R. Hariri, Daniel R. Weinberger

32.

Irritable Bowel Syndrome and Increased Anxiety in Healthy Females, but Not in Healthy Males, is Associated with Increased Size of a Midbrain Region Activated During Inescapable Pain Steven M. Berman, Joshua Bueller, Brandall Suyenobu, Edythe London, Lin Chang, Bruce D. Naliboff, Emeran A. Mayer*

33.

Increased Basal Ganglia Activity During Interferon-Alpha Therapy for Malignant Melanoma: Relationship with Neurovegetative Symptoms Lucile Capuron, Giuseppe Pagnoni, Marina Demitrashvili, David H. Lawson, Gregory S. Berns, Charles B. Nemeroff, Andrew H. Miller*

34.

Distribution of [11C]PIB in a Nondemented Population: Implication for Use as an Antecedent Marker of Alzheimer’s Disease Mark A. Mintun*, Gina N. LaRossa, Yvette I. Sheline, Sang Y. Lee, Carmen S. Dence, Mach H. Robert, William E. Klunk, Chester A. Mathis, Steven T. DeKosky, John C. Morris

35.

Positron Emission Tomography of Brain 5HT1A Receptor Binding with [11-C]WAY100635 in Postpartum Depressed and Nondepressed Women Eydie L. Moses-Kolko*, Katherine L. Wisner, Julie C. Price, Sarah L. Berga, Chester Mathis, Wayne C. Drevets, Andrea L. Confer, Carl Becker, Carolyn C. Meltzer

36.

The Sensitivity of the Loudness Dependence Auditory Evoked Potential (LDAEP) as a Measure of Central Serotonin Function in Humans Pradeep J. Nathan*, Barry O’Neill, Julian Simmons, Nick Allen, Matthew P. Galloway, K L. Phan, Rodney J. Croft

37.

FDG-PET in Laboratory Induced Aggression in Borderline Personality Disorder Antonia S. New*, Roanna Trisdorfer, Erin A. Hazlett, Randall E. Newmark, Monte S. Buchsbaum, Larry J. Siever

138

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38.

Acute Occupancy of Brain Serotonin Transporter by Sertraline as Measured by [11C]DASB and Positron Emission Tomography Ramin V. Parsey*, Justine M. Kent, Maria A. Oquendo, Misty Richards, Mali Pratap, Thomas Cooper, Victoria Arango, J. J. Mann

39.

Lorazepam Dose-Dependently Decreases Risk-Taking Related Activation in the Caudate Martin P. Paulus*, Estibaliz Arce, Murray B. Stein

40.

An fMRI Study of the Interface Between Affective and Cognitive Circuitry in Pediatric Bipolar Disorder Mani N. Pavuluri*, Aryal Subhash, Megan M. O’Connor, Erin Harral, Ellen Herbener, John A. Sweeney

41.

FDG and PIB PET Imaging in Alzheimer’s Disease and Mild Cognitive Impairment Julie C. Price*, Scott K. Ziolko, Lisa A. Weissfeld, William E. Klunk, Brian J. Lopresti, Jessica A. Hoge, Xueling Lu, Wenzhu Bi, Carolyn C. Meltzer, Nicholas Tsopelas, Steven T. DeKosky, Chester A. Mathis

42.

Imaging Neuroinflammation in Alzheimer Disease with [111C]Arachidonic Acid and Positron Emission Tomography Stanley I. Rapoport*, Richard E. Carson, Abesh Bhattacharjee, Mark B. Schapiro, Giuseppe Esposito, Peter Herscovitch, William C. Eckelman, Giuseppe Esposito

43.

A Voxel-Based, Whole Brain MRI Analysis of Adolescents with Psychotic Illnesses Donald C. Rojas*, David B. Arciniegas, Peter Teale, Olivia Hernandez, Martin L. Reite

44.

Localization of Increased White Matter Hyperintensities in Late Life Depression Using an Automated Voxel-Wise Method Yvette Sheline*, Robert McKinstry, Deanna Barch, Avi Snyder, Asif Moinuddin, Consuelo Wilkins, Jon Christensen, Mark Mintun

139

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45.

Effects of Lithium Treatment on Human Brain Structure Mapped Using Longitudinal MRI Alex D. Leow, Paul M. Thompson, Kiralee M. Hayashi, Carrie Bearden, Mark A. Nicoletti, Serap E. Monkul, Roberto B. Sassi, Paolo Brambilla, Alan G. Mallinger, Jair Soares*

46.

Marked Deficits in Membrane Phospholipid Precursor Levels in AttentionDeficit/Hyperactivity Disorder (ADHD) Children with Comorbid Diagnoses Jeffrey A. Stanley*, Matcheri S. Keshavan, Heidi Kipp, Erika Greisenegger, Kanagasabai Panchalingam, Jay W. Pettegrew, Oscar G. Bukstein

47.

GABRA2 Genetic Variation and Response of the Human Amygdala and Insula to Fearful Faces Murray B. Stein*, Martin P. Paulus, Joel Gelernter

48.

Diffusion Tensor Imaging: Fractional Anisotropy in White Matter, Symptom Severity, and Cognition in the Brains of Schizophrenia Patients Daniel G. Stewart*, Joseph I. Friedman, Cheuk Tang, Jack Gorman, Phil Harvey, David Carpenter, Arash Hajianpour, Johnny Ng, Patrick Hof, Monte Buchsbaum, Kenneth L. Davis

49.

Physiological Correlates of a Non-Working Memory Prefrontal Task Steven Sust*, Joshua Buckholtz, Brad Zoltick, Doug Jones, Bart Rypma, Hao Y. Tan, Venkata Mattay, Daniel R. Weinberger, Joseph Callicott

50.

The Development of Human Parent-Infant Attachment: Functional Brain Imaging During the Early Postpartum James E. Swain*, James F. Leckman, Linda C. Mayes, Ruth Feldman, Robert T. Schultz

51.

Rolling with the Punches: Emotional Resilience and Ventral Prefrontal Cortex Stephan Taylor*, Christian E. Waugh, Tor D. Wager, Douglas C. Noll, Barbara L. Fredrickson

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52.

Evidence for Sensitive Periods in the Effects of Childhood Abuse on Regional Brain Morphology Martin H. Teicher*, Susan L. Andersen, Akemi Tomoda, Ann Polcari, Evelyn Vincow, Elizabeth Valente

53.

Allelic Variation of PPP1R1B, Encoding DARPP-32, Affects Human Striatal Volume and Striatal-Prefrontal Structural Connectivity Beth A. Verchinski*, Andreas Meyer-Lindenberg, Lukas Pezawas, Richard Straub, Robyn Honea, Aaron L. Goldman, Katherine Hobbs, Joshua W. Buckholtz, Joseph H. Callicott, Bhaskar Kolachana, Venkata S. Mattay, Daniel R. Weinberger

54.

Gastric Stimulation Activates Brain Satiety Circuiy Gene-Jack Wang*

55.

123I-ADAM SPECT Study in Patients with Major Depression: Serotonin Transporter Occupancy Induced by Paroxetine and Relationship with Clinical Response Victor S. Perez*, Ana Catafau, P Plaza, JC Pascual, S Bullich, M Danus, D Puigdemont, I Corripio, MM Penengo, J Perich, E Alvarez

56.

Epistasis of SERT & BDNF: A Mechanistic Model of Depression Lukas Pezawas*, Aaron L. Goldman, Beth A. Verchinski, Venkata S. Mattay, Gang Chen, Katherine Hobbs, Robyn A. Honea, Joseph S. Callicott, Bhaskar S. Kolachana, Richard E. Straub, Michael F. Egan, Andreas Meyer-Lindenberg, Daniel R. Weinberger

57.

Associations in the Longitudinal Course of Body Dysmorphic Disorder with Major Depression, OCD, and Social Phobia Katharine A. Phillips*, Robert L. Stout

58.

Toward the Identification of Biological Markers of Bipolar Disorder: A First Stage Neuroimaging Study Mary L. Phillips*, Cecile D. Ladouceur, Stefanie Hassel, Natalie Kerr, Greg Siegle, Kate Fissell, Simon Surguladze, Michael E. Thase, David J. Kupfer

141

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59.

Shared Genetic Contributions to Pathological Gambling and Major Depression in Men Marc N. Potenza*, Hong Xian, Kamini R. Shah, Jeffrey F. Scherrer, Seth A. Eisen

60.

Adolescent Depression and Neuronal Circuits Associated with Reward Processes Uma Rao*, Anup Bidesi, Monique Ernst, Carol Tamminga

61.

Depression-Insulin Resistance Link Natalie L. Rasgon*, Margaret F. Reynolds, Laurel N. Zappert, Heather A. Kenna, M.A.

62.

Pediatric Bipolar Disorder and Face Processing: Neural and Behavioral Deficits Brendan A. Rich*, Deborah T. Vinton, Lisa Berghorst, Erin B. McClure, Daniel S. Pine, Ellen Leibenluft

63.

Role of CRF2 Receptors in Maintenance and Recovery from CRF1 Receptor-Induced Alterations in Defensive Startle Victoria B. Risbrough*, Sarah Coste, Mary Stenzel-Poore, Mark Geyer

64.

Safety and Tolerability of the Selegiline Transdermal System 20 mg for Treatment of Major Depression Donald S. Robinson*, Bryan J. Campbell, Jay D. Amsterdam

65.

Alterations in Human Amygdala Corticotropin-Releasing Factor (CRF) Receptor Binding Associated with Psychiatric Illness Patrick H. Roseboom*, Dimitri E. Grigoriadis, Susan K. Sullivan, Ryan J. Herringa, Ned H. Kalin

66.

A “Pharmacological Stressor” Model of Anxiolysis in Monkeys: Alprazolam Attenuation of the Behavioral and Physiological Effects of Yohimbine Melissa A. Birkett, Donna M. Platt, Stefan Tiefenbacher, James K. Rowlett*

142

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67.

Adjunctive Topiramate Therapy in Patients Receiving a Mood Stabilizer for Bipolar I Disorder: A Randomized, Placebo-Controlled Trial K.N. Roy Chengappa*, Lesley K. Schwarzmann, Joseph F. Hulihan, Jim Xiang, Norman R. Rosenthal

68.

Is the Association of PTSD and Poor Health Due to a Common Familial or Genetic Factor? Peter P. Roy-Byrne*, Carolyn Noonan, Niloo Afari, Dedra Buchwald, Jack Goldberg

69.

Blockade of Angiotensin II AT1 Receptors Decreases Anxiety and Prevents the Isolation Stress-Induced Decrease in Cortical CRF1 Receptors and Benzodiazepine Binding Juan M. Saavedra*

70.

Antimanic Response to Aripiprazole with High vs. Low Agitation Gary Sachs*, Jerrold Rosenbaum, Joseph Pultz, Andrei Pikalov, Christopher Breeder, Dusan Kostic, David Crandall

71.

Paroxetine Treatment of Compulsive Hoarding Sanjaya Saxena*, Arthur L. Brody, Karron M. Maidment, Lewis R. Baxter

72.

The Nucleus Accumbens as Target for Deep Brain Stimulation for Treatment Refractory Depression Thomas E. Schlaepfer*, Doris Lenartz, Caroline Frick, Volker Sturm

73.

Time Course of Depressive Symptomatology During Vagus Nerve Stimulation: Comparisons of US and European Results Caroline Frick, Stephen Brannan, Mustafa Hasdemir, Zeno Stanga, Markus Kosel, Hans-Ulrich Fisch, Thomas E. Schlaepfer*

74.

Prospective Study of Plasma Stress Hormones in PTSD Arieh Y. Shalev*, Ronen Segman, Roger K. Pitman, Yair Bannet, Rachel Yehuda

75.

Risperidone vs. Bupropion Combined with SSRIs in Treatment Resistant Unipolar Major Depression Richard C. Shelton*, Stephanie Addington, Vatsal Thakkar

143

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76.

Effects of Chronic Prednisone Therapy on Mood and Memory: A FollowUp Study E. Sherwood Brown*, Elizabeth Vera, Alan B. Frol, Dixie J. Woolston, Brandy Johnson

77.

Effect of Two Prednisone Exposures on Mood and Declarative Memory E. Sherwood Brown*, Laura Beard, Alan B. Frol

78.

In Vivo Effects of Lithium on Synaptic Plasticity and Levels of BDNF and Phospho-CREB in Hippocampus Seong Shim*, Michael Hammonds, Joseph Calabrese

79.

Efficacy and Tolerability of Low Doses of Paroxetine CR in Elderly Outpatients with Major Depression Ram K. Shrivastava*, Saraswatiben P. Shrivastava, Johanna Landinez, Cornelius D. Pitts, Desiree M. Schaefer, Alan Lipschitz, Malini Iyengar

80.

Efficacy of Ziprasidone in Dysphoric Mania: Pooled Analysis of 2 DoubleBlind Studies Stephen M. Stahl*, Illise Lombardo, Antony Loebel, Francine Mandel

81.

A Single-Blind Prospective Study of Quetiapine for the Treatment of Mood Disorders in Adolescents Who Are at High Risk for Developing Bipolar Disorder Stephen M. Strakowski*, Melissa P. DelBello, Robert Kowatch, Rachel Whitsel, Cal Adler

82.

Manic Symptoms During Bipolar Depression: Impulsivity and Suicidality Alan C. Swann*, Joel L. Steinberg, Frederick G. Moeller

83.

Galanin-Evoked Reductions in Serotonergic Neurotransmission in the Hippocampus and Dorsal Raphe Nucleus Are Attenuated by GAL3 Receptor Antagonists Chad J. Swanson*, Xuexiang Zhang, Kang Zheng, Zhi-Qing D. Xu, Tomas Hokfelt, Heidi Chen, Michael J. Konkel, Huailing Zhong, Mary M. Walker, Thomas P. Blackburn, Theresa A. Branchek, Christophe P. Gerald, Douglas A. Craig

144

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84.

Decreased Serotonin-1A Receptor Binding in Social Anxiety Disorder Rupert Lanzenberger, Christoph Spindelegger, Alexander Holik, Key Mien, Markus Mitterhauser, Wolfgang Wadsak, Nilufar Mossaheb, Trawat Attarbaschi, Julia Sacher, Nikolas Klein, Kurt Kletter, Siegfried Kasper, Johannes Tauscher*

85.

Using Symptom Improvement Patterns to Predict Remission in Depressed Outpatients Treated with Venlafaxine Extended Release (XR) or Selective Serotonin Reuptake Inhibitors (SSRI) Madhukar H. Trivedi*, Bruce D. Grannemann, Jeff Musgnung, Qin Jiang, Raj Tummala, Michael E. Thase

86.

Inhibited Temperament and HPA Axis Function in Healthy Adults Audrey R. Tyrka*, Linda Carpenter, George Anderson, Lawrence Price

87.

Antidepressant Treatment and Risk of Suicide Attempt by Adults with Major Depressive Disorder: A Propensity-Adjusted Retrospective Cohort Study Robert J. Valuck*, Anne M. Libby, Elaine H. Morrato, Maria A. Oquendo, Hendricks Brown, Robert D. Gibbons

88.

Mitochondrial Related Gene Expression In Suicide Marquis P. Vawter*, Simon J. Evans, Prabha V. Choudary, Fan Meng, Mary E. Atz, Preston Cartagena, David M. Walsh, Jun Li, Hiro Tomita, Richard M. Myers, Huda Akil, Stanley J. Watson, Edward G. Jones, William E. Bunney

89.

Altered Sensitivity of Peripheral Blood Leukocytes to Glucocorticoids in Deployment-Related Postraumatic Stress Disorder Eric Vermetten*, Carien De Kloet, Annemieke Kavelaars, Angela Bikker, Ellen Meulman, Herman G. Westenberg, Cobi J. Heijnen

90.

Evidence That SSRI Response in Depression Is Influenced by a Functional Haplotype in HTR1B and the C-1019G SNP in HTR1A Sandra M. Villafuerte*, Elizabeth A. Young, Margit Burmeister

145

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91.

The Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and Stress Gary Wand*, Rachel Chong, Lynn Oswald, Xiaoju Yang, Magdalena Uhart, Ping Lin

92.

5HTTLPR Genotypes and Environmental Stress Interact to Affect Sleep Quality Beverly Brummett, Allison Ashley-Koch, Cynthia Kuhn, Melanie Kail, Jeffery Vance, Stephan Zuchner, Ilene Siegler, John Barefoot, Redford Williams*

93.

Evidence of Increased CRH Pulsatility in Major Depression Elizabeth A. Young*, Morton B. Brown, Saulo Ribeiro

94.

Identifying the Most Sensitive Measures and Definitions of Outcome for Pediatric Bipolar Disorder Eric A. Youngstrom*, Mark D. Cooperberg, Joseph R. Calabrese, Robert L. Findling

95.

Robust, Rapid and Relatively Sustained Antidepressant Effects with a Single-Dose of an NMDA Antagonist in Treatment-Resistant Major Depression: A Double-Blind Placebo-Controlled Study Carlos A. Zarate*, Jaskaran Singh, Paul Carlson, Nancy Brutsche, Rezvan Ameli, David Luckenbaugh, Dennis S. Charney, Husseini K. Manji

96.

Responsiveness of Mice Deficient in Beta Adrenergic Receptors to Desipramine and Beta Adrenergic Agonists: Behavioral Effects Observed Using the Forced-Swim Test (FST) and Differential-Reinforcement-ofLow-Rate (DRL) Schedule Hanting Zhang*, Lisa R. Stolinski, Ying Huang, James M. O’Donnell

97.

Lithium Regulates P2X7 Receptor Expression and ATP Activation in Astrocytes: A Novel Therapeutic Target in the Treatment of Bipolar Disorder? Lei Zhang*, James E. Barrett, Husseini K. Manji

146

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98.

Abnormal Expression of Transcripts for GKAP and Shank Suggest Alterations of Interactions Between Metabotropic and Ionotropic Glutamate Receptors in Schizophrenic Brain James H. Meador-Woodruff*, Eduardo Reyes, Vahram Haroutunian, Lars V. Kristiansen

99.

Correlations Between REM Sleep EEG Spectral Analysis and CSF GABA in Clinically Stable Drug-Free Patients with Schizophrenia: A Pilot Study Julie Poulin*, Daniel P. Van Kammen, Mary E. Kelley, Roger Godbout, Thomas C. Neylan, Eric A. Nofzinger, Jeffrey L. Peters, Guochuan E. Tsai

100.

Medial Temporal Lobe Structures and RGS4 Polymorphisms in FirstEpisode Schizophrenia Konasale M. Prasad*, Kodavali V. Chowdari, Michael E. Talkowski, David A. Lewis, Vishwajit L. Nimgaonkar, Matcheri S. Keshavan

101.

The Consortium on the Genetics of Schizophrenia (COGS): Reliability and Validity of Standardized Assessement of Basic Oculomotor Function in Schizophrenia Patients, First Degree Relatives and Controls in a Multisite Study Allen D. Radant*, Dorcas J. Dobie, Monica E. Calkins, Ann Olincy, Sean P. Meichle, Debby W. Tsuang

102.

Disrupted Integration of Prefrontal and Hippocampal Activation in Schizophrenia During Word Encoding and Recognition John D. Ragland*, Dan Wolf, Mark Elliott, Jeffrey N. Valdez, Ruben C. Gur, Raquel E. Gur

103.

Bilateral Reduction of Caudate Volumes in the Young, Asymptomatic, Genetically at Risk Offspring of Patients with Schizophrenia RP Rajarethinam*, Ameet Upadhyaya, Pon Tsou, Margi Upadhyaya, Jeffrey Nutche, Matcheri Keshavan

104.

The Orexin-1 Receptor Antagonist SB-334867 Reverses the Depolarization Inactivation of A9 and A10 Dopamine Neurons Caused by Chronic Administration of Haloperidol and Olanzapine Kurt Rasmussen*, Kalpana Merchant, Yili Yang

147

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105.

Second-Generation Antipsychotic Exposure and Patterns of Change in Metabolic Adverse Effects: A Longitudinal Pharmacoepidemiology Study from 1988 to 2002 Chris Reist*, Lawrence Albers, Sandor Szabo, Mazan Jamal, Mehrtash Hashemzadeh, Vural Ozdemir

106.

MEG Gamma Band Activity Reduced in Psychotic Adolescents Keeran Maharajh, Peter Teale, Don Rojas, Martin Reite*

107.

Randomized Comparison of Olanzapine versus Risperidone for the Treatment of First Episode Schizophrenia: Four Month Outcomes Delbert G. Robinson*, Margaret Woerner, Barbara Napolitano, Raman Patel, Serge Sevy, Handan Gunduz-Bruce, Jose Soto-Perello, Alan Mendelowitz, Ali Khadivi, Rachel Miller, Joanne McCormack, Beth Lorell, Martin Lesser, Nina Schooler, John Kane

108.

Olanzapine and Clozapine Rapidly Decrease Whole-Body Insulin Sensitivity in Rats: Implications for the Diabetic Liability of Certain Antipsychotics K L. Houseknecht, A S. Robertson, E M. Gibbs, W J. Zavadoski, F M. Nedza, D E. Johnson, B K. Koe, H Rollema*

109.

Alteration of Amygdala Inputs to Entorhinal Cortex Through Dopaminergic Modulation of Voltage-Gated Ion Channels Amiel Rosenkranz*, Daniel Johnston

110.

Antipsychotic-Like Effects of SCA-136: A Novel 5-HT2C Receptor Agonist Karen L. Marquis, Nancy Ator, John Dunlop, Siva Ramamoorthy, Chad Beyer, Qian Lin, Julie Brennan, Michael Piesla, Charles Ashby, Boyd Harrison, Ron Magolda, Menelas N. Pangalos, Gary Stack, Sharon Rosenzweig-Lipson*

111.

Efficacy of Ziprasidone in Schizophrenic Subjects with Differing Levels of Agitation Nina R. Schooler*, Jacobo Mintzer, Antony Loebel, Ruoyong Yang

148

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112.

A Pharmacogenetic Test for Prediction of Vulnerability to Tardive Dyskinesia Ronnen H. Segman*, Tanya Goltser - Dubner, Fabio Macciardi, Bernard Lerer

113.

Neuregulin1-Induced Cell Migration of B Lymphoblasts: Possible Association with Schizophrenia Yoshitatsu Sei*, Renee Ren-Patterson, Zhen Li, Elizabeth M. Tunbridge, Michael F. Egan, Bhaskar S. Kolachana, Daniel R. Weinberger

114.

Differential Methamphetamine-Induced Immediate Early Gene Expression in the Prefrontal Cortex of High Versus Low Responders Paul D. Shilling*, Ronald Kuczenski, David S. Segal, Thomas B. Barrett, John R. Kelsoe

115.

Disruption of Startle Gating in Rats After Systemic D1 Blockade Is Independent of Prefrontal Cortex and Changes in Sensory Gating. Jody M. Shoemaker*, Gregory A. Light, Michelle Breier, Hubertus H. Voet, Richard L. Saint Marie, Alaina C. Neary, Neal R. Swerdlow

116.

Frequency Mismatch Negativity in Mice is Attenuated by Ketamine Steven J. Siegel*, Richard S. Ehrlichmen, Christina Maxwell, Sonalee Majumdar

117.

Metabolic Responses to Fatty Meal in Schizophrenic Patients Treated with Olanzapine or Risperidone Robert C. Smith*, Jean-Pierre Lindenmayer, Erin Kelly, Adriana Buga, Melissa Matute, Sumathi Vaidhyanathaswamy, Nabila Sheikh, Tom Viviano, Santica M. Marcovina

118.

Effects of Smoking and Nicotine Nasal Spray on Cognitive Function in Schizophrenic Smokers, Schizophrenics Non-Smokers, and Non-Psychotic Smokers Erin Kelly, Robert C. Smith*, Anantha Shekhar, Fredrick Molloy, Timothy Steadman, Nabila Sheikh, Meaghan Kuczora, Alea Khan

149

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119.

Effectiveness and Tolerability Outcomes of Risperidone Long-Acting Injection Compared to Conventional Depot Antipsychotics in a Canadian Psychiatric Hospital Mark Snaterse*, Ron Welch, Pierre Chue

120.

Evidence for Epigenetic Regulation of the 5HT2A Receptor Gene (5HT2AR). Methylation of Allele C-Specific CpG Sites in 5HT2AR Correlates with its Expression and eRobust, Rapid and Relatively Sustained Antidepressant Effects with a Single-Dose of an NMDA Antagonist in Treatment-Resistant Major Depression: A Double-Blind Placebo-Controlled Study Expression of DNA Methylase DNMT1 Oxana O. Polesskaya, Christopher Aston, Boris P. Sokolov*

121.

Deficit Syndrome and Memory Function in Schizophrenia Arielle D. Stanford*, Ronald B. Chin, Binu Thomas, Elena Ivleva, Carol A. Tamminga

122.

MUTED (6p24.3), a Protein That Binds to Dysbindin (DTNBP1, 6p22.3), Is Strongly Associated with Schizophrenia and Exhibits Statistical Epistasis with COMT Richard E. Straub*, Michael B. Mayhew, Radha K. Vakkalanka, Bhaskar Kolachana, Terry E. Goldberg, Michael F. Egan, Daniel R. Weinberger

123.

Bifeprunox: Relationship Between Antipsychotic Potential, EPS Liability and Dopamine D2 Receptor Occupancy in Rats Peter Hertel, L Brennum, L Helboe, C K Olsen, M Kreilgard, Karen Marquis, Torgny Svensson*, A H J Herremans, Mayke Hesselink

124.

Enhanced Cortical Dopamine Output and Antipsychotic-Like Effect of Raclopride by Low Dose L-Dopa Torgny Svensson*, Marie-Louise Wadenberg, Amani Eltayb

125.

Effects of Memantine on Startle Gating in Normal Adult Men Neal R. Swerdlow*, Ashley N. Sutherland, Monique P. Tillemans, Jo A. Talledo

150

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126.

Lower Anterior Cingulate Grey Matter Volume in Antipsychotic DrugNaive First-Episode Schizophrenia Patients with Cannabis Use Philip R. Szeszko*, Serge Sevy, Delbert G. Robinson, Sanjiv Kumra, Claudia I. Rupp, Julia Betensky, Todd Lencz, Manzar Ashtari, John Kane, Anil K. Malhotra, Handan Gunduz-Bruce, Barbara Napolitano, Robert M. Bilder

127.

Distinct Roles for Different Homer1 Isoforms in Behaviors Associated with Prefrontal Cortex Function in vivo Karen K. Szumlinski*, Kevin D. Lominac, Peter W. Kalivas

128.

Asenapine Displays Unique Long-Term Molecular Effects on Dopamine Receptor Subtypes Frank I. Tarazi*, Taylor Moran-Gates, Carla Massari, Erik HF Wong, Brian Henry, Mohammed Shahid

129.

A Double-Blind, Placebo-Controlled Study of Olanzapine in Adolescents with Schizophrenia Ludmila Kryzhanovskaya, Charles Schulz, Christopher J. McDougle, Jean A. Frazier, Joan Shen, Ralf Dittman, Carol Robertson-Plouch, Theresa Bauer, Wen Xu, Wei V. Wang, Janice Carlson, Sara Corya, Mauricio Tohen*

130.

COMT Inhibition Enhances Neuregulin-Induced Cell Migration in B Lymphoblasts Elizabeth Tunbridge*, R Ren-Patterson, Z Li, J Chen, J Apud, M Egan, B Kolachana, P J. Harrison, Y Sei, D R. Weinberger

131.

Chromosome 7q PTC Non-Taster Haplotype is Associated with Schizophrenia Bruce I. Turetsky*, Stephen J. Kanes, Mya E. Levy, Paul J. Moberg

132.

The COMT Val158Met Polymorphism and Cognition in Schizophrenia Elizabeth W. Twamley*, Jenille M. Narvaez, David I. Sitzer, John R. Kelsoe

133.

Identification of an Interaction Between the Dopamine D1 Receptor and Niemann-Pick C1 Protein Gabriel Vargas*, Stanford Chen, Mark Von Zastrow

151

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134.

Are Self-Reports and Physician Impressions of Adherence to Oral Antipsychotics Related to Objective Measures? Dawn I. Velligan*, Mei Wang, Desiree Castillo, Scott Bendle, Francis Lam, Larry Ereshefsky, Pamela Diamond, Alexander L. Miller

135.

Neuroscience-Guided Cognitive Training in Schizophrenia: Preliminary Data Sophia Vinogradov*, Christine Holland, Michael Merzenich

136.

Treatment of Cardiac Risk Factors in Patients with Schizophrenia and Diabetes Anthony P. Weiss*, David C. Henderson, Jeffrey B. Weilburg, Donald C. Goff, James B. Meigs, Enrico Cagliero, Richard W. Grant

137.

Aripiprazole Effects in Schizophrenia Patients with High or Low Agitation Britt West*, James Appel, Stephen Marder, Joseph Pultz, Andrei Pikalov, Ronald Marcus, Rolando Gutierrez-Esteinou, David Crandall

138.

Anterior Cingulate Bundle Abnormality in Children and Adolescents with Schizophrenia Tonya White*, Ayse T. Karagille, Stephane Leherecy, Mustafa Kendi, Canan Karatekin, Angela Guimaraes, Nicholas Davenport, S. C. Schulz, Kelvin O. Lim

139.

Altered Cerebral Processing of Reward Uncertainty in Patients with Schizophrenia While Medication-Free and on Atypical Neuroleptics Dylan Wint*, Jean-Claude Dreher, Daniella Furman, Paul Koch, Philip Kohn, Michael Egan, Daniel Weinberger, Karen F. Berman

140.

Asenapine: A Novel Psychotherapeutic Agent with a Unique Human Receptor Binding Signature Mohammed Shahid, Erik Wong*, Glenn B. Walker, Ross A. Baker, Anil S. Jina, Stevin Zorn

141.

Variation in Catecol-O-Methyltransferase and GRM3 on Working Memory Load and Prefrontal Cortical Physiology Hao Yang Tan*, Qiang Chen, Steven Sust, Joshua W. Buckholtz, Richard Straub, Venkata S. Mattay, Michael F. Egan, Daniel R. Weinberger, Joseph H. Callicott

152

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142.

Cortisol and Cytokines in Chronic and Treatment-Resistant Patients with Schizophrenia: Association with Psychopathology and Response to Antipsychotics Xiang Y. Zhang*, Dong F. Zhou

143.

BDNF Levels and Genotype Are Associated with Antipsychotic-Induced Weight Gain in Patients with Chronic Schizophrenia Xiang Y. Zhang*, Yun L. Tan, Dong F. Zhou

144.

Histone Hyper-Acetylation Enhances Memory Storage and Facilitates Synaptic Plasticity via the Transcription Factor CREB Ted Abel*, Chris Vecsey, K. Matthew Lattal, Joel Stein, Sara Fabian, Michelle Attner, Josh Hawk, Marcelo A. Wood

145.

Changes in Natural Killer Cell Function, Inflammatory Signaling and Plasma IL-6 Production During Acute Stress in Patients with Major Depression Oyetunde Alagbe*, Thaddeus Pace, Tanya Mletzko, Jerry Vogt, Charles Nemeroff, Christine Heim, Andrew Miller

146.

The Phosphodiesterase Type IV Inhibitor, Rolipram, Activates Septohippocampal Neurons Min Wu, Elena Morozova, Iryna Dumalska, Ronald S. Duman, Meenakshi Alreja*

147.

Creation of Designer Biogenic Amine Receptors via Directed Molecular Evolution Blaine Armbruster*, Bryan Roth

148.

Elevated Membrane Cholesterol Limits Metabotropic Glutamate Receptor (mGluR) Suppression of NMDA Function: A Potential Contribution to Antipsychotic Action? Andrius Baskys*, Liwei Fang, Moti L. Kashyap, Vaijinath Kamanna, Ildar T. Bayazitov

149.

Enzymes Coupled with Cyclooxygenase Are Altered in the Brain of Cyclooxygenase-1 Deficient Mice: Implications for Neuroprotection in Neuropsychiatric Disorders Sang-Ho Choi, Francesca Bosetti*

153

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150.

ERK MAP Kinase Signaling in Postmortem Brain of Suicide Subjects: Differential Regulation of Upstream Raf Kinases Raf-1 and B-Raf Yogesh Dwivedi*, Robert Conley, Ghanshyam N. Pandey

151.

Adderall® Produces Differential Dopamine Overflow When Compared to D-Amphetamine in Rat Striatum Paul E. Glaser*, B. M. Joyce, Garretson D. Epperly, Greg A. Gerhardt

152.

Distinct Roles for MT1 and MT2 Melatonin (MLT) Receptors in MLTMediated Phase Shifts of Circadian Rhythms R. L. Hudson*, I Stepien, P Ginter, M. L. Dubocovich

153.

Hippocampal Erk Signalling in Stress-Enhanced Aversive Learning Farahnaz Sananbenesi, Andre Fischer, Christina Schrick, Jelena Radulovic*

154.

Mood Stabilizers That Downregulate the Brain Arachidonic Acid Cascade Reduce AP-2 or NF-κB Transcription Factors in Rat Frontal Cortex Jagadeesh S. Rao*, Richard P. Bazinet, Ho-Joo Lee, Stanley I. Rapoport

155.

Identification and Characterization of D2 Dopamine Receptor Interacting Proteins David R. Sibley*, Lisa A. Hazelwood, R. B. Free, David M. Cabrera

156.

Protein Interactions of the Vesicular Glutamate Transporter, VGLUT1 Susan Voglmaier*, Robert H. Edwards

157.

Dexras1 Is a Novel Modulator of Neuronal Adenylyl Cyclases Chau H. Nguyen, Val J. Watts*

158.

Long-Term Efficacy of Ziprasidone in Treatment-Refractory Schizophrenia Steven G. Potkin, Antony Loebel*, John Kane, Cynthia Siu

154

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159.

Dopamine and Serotonin Receptor Occupancy of Long Acting Injectable Risperidone in Patients with Schizophrenia Steven G. Potkin*, Jogesh Mukherjee, Georges Gharabawi, Daphne Collins

160.

Adult Outcome in Children with Obsessive-Compulsive Disorder Michael H. Bloch*, Britt Craiglow, Philip Dombrowski, Katie Panza, Denis Sukhodolsky, Bradley S. Peterson, James Leckman

161.

Regulation of Apolipoprotein L2 in Human Drug Abuse Elin Lehrmann*, Carlo Colantuoni, Thomas M. Hyde, Joel E. Kleinman, Kevin G. Becker, William J. Freed

155

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NONMEMBER PARTICIPANTS

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Roger Albin Professor of Neurology University of Michigan Health System 200 Zina Pitcher Place Kresge Building 111, Rm. 4412 Ann Arbor, MI 48109-0585

Ruben Baler National Institute of Health/NIDA 6001 Executive Blvd. NSC Bldg., Room 5241 Bethesda, MD 20892 Ben Barres Stanford University School of Medicine 299 Campus Drive Fairchild Bldg., Room D235 Stanford, CA 94305-5125

Paul Andreason FDA-Division of Psychiatry Products Building 22, Room 4112 10903 New Hampshire Avenue Silver Spring, MD 20993-0002

Jill Becker University of Michigan 530 Church Street Ann Arbor, MI 48109

Stewart Anderson Box 244 1300 York Avenue New York, NY 10021

Francesco Benedetti San Raffaele Turro Via Stamira D'Ancona 20 Milano 20127 ITALY

Eva Anton University of North Carolina, Chapel Hill 105 Mason Farm Road Neuroscience Center, Room 7109B Chapel Hill, NC 27599

Thomas Biederer Yale University School of Medicine Mol Biophys & Biochem New Haven, CT 06520-8024

Ben Bahr 372 Fairfield Road Unit-2092 Storrs, CT 06269-2092

Michel Bouvier Université De Montréal Département De Biochimie Unive 2900 Edouard Montpetit Montreal, QUE H3C 3J7 CANADA

Vaishali Bakshi Wisconsin Psychiatric Institute & Clinics 6001 Research Park Blvd Dept. of Psychiatry Madison, WI 53719

Jan Buitelaar

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Andres Buonanno National Institute of Health 35 Lincoln Drive MSC 3713, Bldg 35, Room 2C1000 Bethesda, MD 20892

Jin-chung Chen Jingshan Chen National Institute of Mental Health 9000 Rockville Pike Bldg. 10, Room 4N307 Bethesda, MD 20892

Donald Burns Merck Research Labs WP44C-2, Box 4 Sumneytown Pike West Point, PA 19486

Daniel Clauw University of Michigan School of Medicine Division of Rheumatology Ann Arbor, MI 48109-0723

M. Catheine Bushnell McGill Centre for Research on Pain 3640 University Street Room M/19 Montreal H3A 2B2 CANADA

Lisa Conti University of Connecticut Health Center 263 Farmington Avenue Psychiatry, MC 1410 Farmington, CT 06030

Pamela Butler Nathan Kline Institute for Psychiatric Research 140 Old Orangeburg Road Orangeburg, NY 10962

Gabriel Corfas Harvard Medical School Dept of Neurology 300 Longwood Avenue Boston, MA 02115

Patrizia Caldirola Biovitrum Berzeliusveg 8 Stockholm 11276 SWEDEN

Rebecca Craft Washington State University Dept. of Psychology P.O. Box 644820 Pullman, WA 99164-4820

Dave Ceryak Eli Lilly and Company Law Division Lilly Corporate Center Indianapolis, IN 46285

John Cryan University College Cork School of Pharmacy Dept of Pharmacology Cork City IRELAND

Kiki Chang Stanford University Psychiatry 401 Quarry Road Stanford, CA 94305 160

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Cyril D'Souza Psychiatry Dept 20 York Street New Haven, CT 06510

Lars Farde AstraZeneca R&D Global Discovery Research Area CNS Pain Control Sodertalje SE-15185 SWEDEN

Mony De Leon New York University School of Medicine 560 First Avenue New York, NY 10016

Joram Feldon Swiss Federal Institute of Technology Zurich Schorenstrasse 16 Schwerzenbach 8603 SWITZERLAND

Michael Dean National Cancer Institute Laboratory of Genomic Diversity Bld. 560, Rm. 21-18 Frederick, MD 21702

Anna Francesconi Albert Einstein College of Medicine Dept of Neuroscience 1300 Morris Park Avenue Bronx, NY 10461

Jing Du National Institute of Mental Health 49 Convent Drive Bldg. 49, Room B1C60 Bethesda, MD 20892

John Gabrieli Stanford University School of Medicine Department of Psychology Jordan Hall Building 420, Room 300 Stanford, CA 94305

Laura Dugan UCSD 9500 Gilman Drive (0665) San Diego, CA 92093

Albert Galaburda 330 Brookline Avenue, KS-274 Boston, MA 02215

Howard Eichenbaum Boston University 2 Cummington Street Boston, MA 02215

S. Gatley 490 Bell Avenue Upton, NY 11973

Christopher Evans NPI 760 Westwood Plaza Psychiatry & Behavioral Sciences Los Angeles, CA 90024-1759

Jay Gingrich New York State Psychiatry Institute Unit 40 1051 Riverside Drive New York, NY 10032

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Richard Glass JAMA 1033 E 49th Street Chicago, IL 60615

Chang-Gyu Hahn 415 Curie Blvd 545 CRB Philadelphia, PA 19014

Paul Glimcher New York University 4 Washington Place Room 809 New York, NY 10003

Maureen Hahn Instructor Vanderbilt University Medical Center 465 21st Avenue South 7141 MRB III Nashville, TN 37232

Steven Goldberg National Institute on Drug Abuse 5500 Nathan Shock Drive Preclinical Pharmacology Baltimore, MD 21224

Ronald Hammer Tufts University School of Medicine 750 Washington Street Box 1007 Boston, MA 02111

James E. Goldman Professor of Pathology and Director, Division of Neuropathology Columbia University College of P&S 630 West 168th Street, P&S 15-420 New York, NY 10032

Stephan Heckers McLean Hospital 115 Mill Street Schizophrenia & Bipolar Disease Belmont, MA 02478

Guy Goodwin Oxford University Warneford Hospital Lane Oxford OX3 7JX UNITED KINGDOM

Markus Heilig National Institute of Health/NIAAA 10 Center Drive 10-CRC/15330 Bethesda, MD 20892-1610

Todd Gould National Institute of Mental Health Bldg. 35, Room 1C-912 9000 Rockville Pike Bethesda, MD 20892-3711

Fred Helmstetter University of Wisconsin Dept of Psychology P.O. Box 413 Milwaukee, WI 53201

Heinz Grunze Department of Psychiatry, LMU Nussbaumastrasse 7 Munich 80336 GERMANY

Bart Hoebel Princeton University Department of Psychology Princeton, NJ 08544

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William Horan UCLA Dept of Psychiatry & Biobehavioral Science 300 UCLA Medical Plaza, Suite 2240 Los Angeles, CA 90095

Kwang-Soo Kim McLean Hospital/Harvard Medical School 115 Mill Street Belmont, MA 02478 Becky Kinkead Emory University School of Medicine 101 Woodruff Circle Suite 4000 WMRB Atlanta, GA 30322

Z. Huang Beckman 220 One Bungtown Road Cold Spring Harbor, NY 11724 Richard Huganir Johns Hopkins University School of Medicine Dept of Neuroscience 725 Wolfe Street, PCTB 904A Baltimore, MD 21205

Peter Klein 415 Curie Blvd 364 Clinical Research Bldg Philadelphia, PA 19104-6140 Cary Lai Scripps Research Institute 10550 N. Torrey Pines Road La Jolla, CA 92037

Sandra Johnson St. Louis University 3700 Lindell Blvd. Saint Louis, MO 63108

Ruth Lanius University of Western Ontario 339 Windermere Road, P.O. Box 5339 Room 10N07 London, Ontario N6A 5A5 CANADA

Julie Kauer Brown University Biomedical Center, Department of MPPB PO Box G-B4 Providence, RI 02912

Amanda Law University of Oxford Warneford Hospital, Headington Dept. of Psychiatry Oxford UNITED KINGDOM

Hans Keirstead University of California, Irvine 2111 Gillespie Neuroscience Facility Irvine, CA 92697 Terence Ketter Stanford University School of Medicine Department of Psychiatry Room 2124 401 Quarry Road Stanford, CA 94305-5723

Ellen Leibenluft National Institute of Mental Health, NIH Mood & Anxiety Program Bldg. 15K, MSC 2670 Bethesda, MD 20892-2670

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Sarah Leibowitz The Rockefeller University 1230 York Avenue New York, NY 10021

John Littleton University of Kentucky Cooper and University Drive Lexington, KY 40546

Vance Lemmon University of Miami Medical School Lois Pope LIFE Center, Room 4-16 1095 NW 14th Terrace Miami, FL 33136

David Lyons Stanford University 1201 Welch Rd Psychiatry, MSLS, Room 104 Stanford, CA 94305

Anne Lesage Johnson & Johnson Pharmaceutical R&D Turnhoutseweg 30 CNS Discovery Research Beerse B2340 BELGIUM

Pierre Magistretti Director, Center for Psychiatric Neuroscience Department of Psychiatry - CHUV and University of Lausanne (UNIL), Medical School Professor of Neuroscience Brain and Mind Institute Ecole Polytechnique Federale Lausanne (EPFL) Rue du Bugnon 7, CH-1005 Lausanne SWITZERLAND

Lydia Lewis The Depression and Bipolar Support Alliance 730 N Franklin Suite 501 Chicago, IL 60610

Steven Maier University of Colorado Psychology Campus Box 345 Boulder, CO 80309

Shon Lewis G.907 Stopford Building Oxford Road Manchester M13 9PT UNITED KINGDOM

Robert Malison Yale School of Medicine Clinical Neuroscience Research Unit 34 Park Street New Haven, CT 06519

Raye Litten National Institute on Alcohol Abuse & Alcoholism 5635 Fishers Lane Room 2041 Bethesda, MD 20892-9304

Shaila Mani Baylor School of Medicine One Baylor Plaza 123D Houston, TX 77030

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Kelsey Martin UCLA, Brain Research Institute, Gonda Bldg. Department of Psychiatry 695 Charles Young Drive South Los Angeles, CA 90095-1761

David Meltzer University of Chicago 5841 S Maryland MC 2007 Chicago, IL 60637 Graeme Milligan University of Glasgow Davidson Building University Avenue Glasgow G12 8QQ UNITED KINGDOM

Emeran Mayer UCLA/GLA VA HS Bldg 115/Room 223 11301 Wilshire Blvd Los Angeles, CA 90073 Susan McConnell Stanford University Herrin Labs 115 385 Serra Mall Stanford, CA 94305-5020

Pendleton Montague Baylor College of Medicine Center for Theoretical Neuroscience Division of Neuroscience 1 Baylor Plaza Houston, TX 77030

Joseph McEvoy Duke University Medical Center/John Umstead Hospital 1003 12th Street Bldg. 32 Butner, NC 27509

Anne Murphy Center for Behavioral Neuroscience P.O. Box 4010 Atlanta, GA 30302 Jaap Murre Roeterstraat 15 Amsterdam 1018 NETHERLANDS

Ronald McKay NINDS, Laboratory of Molecular Biology Porter Neurosciences Research Center Building 35, Room 3A-201 35 Covent Drive, MSC 3703 Bethesda, MD 20892-4157

Robert Muse Stein, Mitchell & Mezines 1100 Connecticut Avenue, NW Suite 1100 Washington, DC 20036

Michael Meaney Douglas Hospital Research Center 6875 LaSalle Blvd Montreal, Quebec H4H 1R3 CANADA

Vincent Mutel Addex Pharmaceuticals, Ltd. 12, Chemin Des Aulx Plan Les Ouates CH-1228 SWITZERLAND

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Toshitaka Nabeshima Professor & Director Nagoya University Graduate School of Medicine Dept of Neuropsychopharmacol & Hosp Phar 65 Touruma-cho, Showa-Ku Nagoya 486-8560 JAPAN

Paul Patterson California Institute of Technology Div Biol 216-76 Pasadena, CA 91125 Jane Pearson Assoc Dir Preventive Interventions NIMH Div of Services & Intervention Research 6001 Executive Blvd, Rm 7160 MSC 9635 Bethesda, MD 20892-9635

Ann Neale 60 Stone Pine Road Suite 200 Half Moon Bay, CA 94019

Laura Peoples University of Pennsylvania Department of Psychology 3720 Walnut Street Philadelphia, PA 19104-6196

David Nelson Eli Lilly and Company Lilly Corporate Center Drop Code 0510 Indianapolis, IN 46285

Srinivasan Pillay McLean Hospital 115 Mill Street Brain Imaging Center Belmont, MA 02478

Raymond Niaura Brown Medical School 345 Blackstone Blvd. Psychiatry Providence, RI 02906

Diego Pizzagalli Harvard University Dept of Psychology 1220 William James Hall 33 Kirkland Street Cambridge, MA 02138

David Nutt University of Bristol Psychopharmacology Unit Whitson Street Bristol BS1 3NY UNITED KINGDOM

Jonathan Pollock National Institute on Drug Abuse Division of Neuroscience & Behavioral Research 6001 Executive Blvd., Room 4282 MCS9555 Bethesda, MD 20892-9555

Valerie Olson Acting Assistant Professor University of Washington VA Puget Sound Health Care System Dept of Psychiatry & Behavioral Science 1660 S. Columbia Way Seattle, WA 98108 166

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Maurizio Popoli University of Milano Center of Neuropharmacology Dept. of Pharmacology Sci., Via Balza Milano 20133 ITALY

Donald Rosenstein Office of the Clinical Director National Institute of Mental Health Bldg 10-CRC, Room 6-5340 10 Center Drive Bethesda, MD 20892

Richard Porter Hoffmann La Roche Bldg. 69-452 Basel SWITZERLAND

Barbara Rothbaum Emory University School of Medicine Psychiatry, The Emory Clinic 1365 Clifton Road Atlanta, GA 30322

A. Redish University of Minnesota 6-145 Jackson Hall 321 Church Street Minneapolis, MN 55455

Barbara Sahakian University of Cambridge School of Clinical Medicine Department of Psychiatry, Box 189 Audenbrookes Hospital Cambridge, Eng CB22QQ UNITED KINGDOM

Victoria Risbrough University of California, San Diego 9500 Gilman Drive Psychiatry MC0804 La Jolla, CA 92093

Larry Scahill Yale Child Study Center 230 South Frontage Road P O Box 207900 New Haven, CT 06520-7900

Angela Roberts University of Cambridge Dept. of Anatomy Downing Street Cambridge CB2 3DY UNITED KINGDOM

Peter Scheiffele Columbia University Dept of Physiol & Cell Biophys 630 West 168th St P&S 11-511, MC22 New York, NY 10032

Robert Rosenheck VA Connecticut Healthcare System NEPEC #182, Bldg. 8 950 Campbell Avenue West Haven, CT 06516

Yavin Shaham IRP/NIDA 5500 Nathan Shock Drive Baltimore, MD 21044

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Philip Shaw National Institute of Mental Health 10 Center Drive, MSC 1600 Bldg. 10, Room 3N202 Bethesda, MD 20892

Dietrich Stephan The Translational Genomics Research Institute 445 North Fifth Street Phoenix, AZ 85004

Saul Shiffman Smoking Research Group 130 N. Bellefield Avenue Suite 510 Pittsburgh, PA 15213

David Talmage Columbia University Institute of Human Nutrition 701 W 168th Street New York, NY 10032

David Silbersweig Weill Medical College of Cornell Univ. New York Presbyterian Hospital 1300 York Avenue Box 140, Room F1303 New York, NY 10021

Todd Thiele University of North Carolina Dept. of Psychology CB 3270 Chapel Hill, NC 27599 Steven Thomas University of Pennsylvania 3620 Hamilton Walk 103 John Morgan Bldg. Philadelphia, PA 19104-6084

Rajita Sinha Yale University School of Medicine 34 Park Street Room S110 New Haven, CT 06519

Andrea Tone Professor & Director of Graduate Studies McGill University 3647 Peel Street Faculty of Medicine Montreal H3A 1X1 CANADA

Rainier Spanagel J5 Mannheim 68159 GERMANY Thomas Spencer Massachusetts General Hospital 55 Fruit Street YAW 6900 Boston, MA 02114

Bruce Trapp Cleveland Clinic 9500 Euclid Avenue Dept. of Neuroscience NC30 Cleveland, OH 44195

Lalit Srivastava McGill University Verdun, Quebec H4H 1R3 CANADA

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Hiroshi Ujike Okayama Graduate School of Medicine 2-5-1 Shikata-cho Okayama 700-8558 JAPAN

John Walkup Johns Hopkins Hospital CMSC 314 600 N. Wolfe Street Baltimore, MD 21287-3325

Leslie Ungerleider National Institute of Mental Health 10 Center Drive Bldg. 10, MSC-1366 Bethesda, MD 20892-1366

Stephen Warren Emory University School of Medicine Dept of Human Genetics Atlanta, GA 30322 Cynthia Weickert National Institute of Mental Health 10 Center Drive Bldg. 10, Room 3N234 Bethesda, MD 20892-1276

Maarten Van Den Buuse Mental Health Research Institute Behavioral Neuroscience Laboratory 155 Oak Street Parkville 3052 AUSTRALIA

David Weinshenker Assistant Professor Emory University Whitehead Building, Suite 301 615 Michael Street Atlanta, GA 30322

Marquis Vawter University of California, Irvine Gillespie, Room 2119 Irvine, CA 92697-1675 Eduard Vieta University of Barcelona, Hospital Clinic Villarroel 170, Rossello 140 Barcelona, NJ 08036 SPAIN Franz Vollenweider University Hospital of Psychiatry University of Zurich Lenggstrasse 31 PO Box 68 Zurich CH-8032 SWITZERLAND

Lois Winsky National Institute of Mental Health Division of Neurosci MSC 9641 Room 7184 6001 Executive Blvd Bethseda, MD 20892-9641 Ruth Wood Keck of Medicine of USC 1333 San Pablo Street BMT 408A Los Angeles, CA 90033

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James Woodgett Princess Margaret Hospital 610 University Avenue 10th Floor, Room 622 Toronto, ON M5G 2M9 CANADA Kiyofumi Yamada Kanazawa University Graduate School of Natural Science Kakuma-Machi Kanazawa JAPAN Larry Young Associate Professor Emory University Dept. of Psychiatry Yerkes Research Center 954 Gatewood Road Atlanta, GA 30322 James Zacny University of Chicago 5841 S. Maryland Avenue MC4028 Chicago, IL 60637 Sidney Zisook University of California, San Diego 9500 Gilman Drive 0603R La Jolla, CA 92093

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APPENDIX

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Disclosure Statement

It is the policy of Vanderbilt University School of Medicine that the information presented at Vanderbilt CME activities will be unbiased and based on scientific evidence. To help readers of this enduring material make judgments about the presence of bias, disclosure of the financial relationships of speakers and Vanderbilt with commercial entities that produce or market products or services related to the content of this CME activity, if any, are listed below: Anissa Abi-Dargham Honorarium: Bristol-Myers Squibb, Otsuka, Sanofi-Aventis Grant/Research Support: Bristol-Myers Squibb Steven Arnold Consultant: Esai, Merck Gary Aston-Jones Consultant: Sanofi Aventis Speaker’s Bureau: Sanofi Aventis Mark Bear Consultant: Seaside Therapeutics Hilary Blumberg Honorarium: Abbott, Lilly Theresa Branchek Stock Shareholder: Lundbeck Jan Buitelaar Honorarium: Eli Lilly, Janssen Cilag BV Consultant: Abbott, Eli Lilly, Janssen Cilag BV, Medice, Shire William Bunney, Jr. Consultant: Thuris Corporation Stock Shareholder: Thuris Corporation H. Donald Burns Stock Shareholder: Merck Other, Employee: Merck

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William Carpenter Consultant: Janssen, Pfizer, Solvay, Wyeth Dave Ceryak Stock Shareholder: Eli Lilly and Company Other, Employee: Eli Lilly and Company Kiki Chang Honorarium: Abbott Labs, AstraZeneca, GlaxoSmithKline, Lilly, Shire US Grant/Research Support: Abbott Labs, AstraZeneca, GlaxoSmithKline, Otsuka Pharmaceuticals Consultant: Abbott Labs, AstraZeneca, GlaxoSmithKline, Lilly, Shire US Daniel Clauw Consultant: Cypress Biosciences Stock Shareholder: Cypress Biosciences John F. Cryan Other, Employee: Novartis Pharma AG John Csernansky Honorarium: Bristol-Myers Squibb, Janssen Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Forest Pharmaceuticals, Pfizer Consultant: Aventis Sanofi Mony de Leon Grant/Research Support: Forest Labs, Janssen Ariel Deutch Grant/Research Support: Eli Lilly, Pfizer Consultant: Eli Lilly Speaker’s Bureau: Eli Lilly Margarita Dubocovich Honorarium: Pfizer Consultant: Shire Pharmaceuticals Group Lars Farde Stock Shareholder: AstraZeneca

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Colin Fish Stock Shareholder: GlaxoSmithKline Other, Employee: GlaxoSmithKline Richard Frank Other, Employee: GE Healthcare Paul Gaylo Stock Shareholder: Eli Lilly & Company Other, Employee: Eli Lilly & Company Mark Geyer Consultant: Abbott, Acadia, Addex, Avera, Cenomed, Lilly, Nura, Repligen, Serono, Solvay, Vertex Grant/Research Support: GlaxoSmithKline, Repligen Stock Shareholder: San Diego Instruments Richard Glass Other, Employee: Deputy Editor of JAMA, American Medical Association Alexander Glassman Consultant: AstraZeneca, GlaxoSmithKline, Lilly, Ono Pharma, Pfizer Speaker’s Bureau: AstraZeneca, GlaxoSmithKline, Pfizer Ira Glick Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Lilly, Pfizer, Shire, Solvay Consultant: AstraZeneca, Bristol-Myers Squibb, Lilly, Pfizer Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, Janssen, Lilly, Pfizer Stock Shareholder: Janssen Guy Goodwin Honorarium: AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Lilly, Lundbeck, Sanofi-Aventis Grant/Research Support: Sanofi-Aventis, Servier Consultant: Bristol-Myers Squibb, GlaxoSmithKline, Sanofi-Aventis, Servier, Wyeth

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Anthony Grace Consultant: Novartis, Servier, Taisho Heinz Grunze Grant/Research Support: Novartis Germany, UCB Belgium Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Pfizer Ruben Gur Grant/Research Support: Merck Consultant: Brain Resource Center Sydney, CogTest LTD London, Eli Lilly Chang-Gyu Hahn Consultant: Pfizer Pharmaceuticals Richard Huganir Consultant: Intra-cellular Therapeutics Inc, Saegis Other, Royalties: Upstate Biotechnology Jonathan Javitch Consultant: Novasite Pharmaceuticals Dilip Jeste Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Solvay, Wyeth Grant/Research Support: Janssen Ned Kalin Grant/Research Support: Dana Foundation, NIH, Stanley Foundation Consultant: Bristol-Myers Squibb, Corcept, Cyberonics, Cypress, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica, Neurocrine Inc, Novartis, Otsuka America Pharmaceutical Inc, Sanofi-Synthelabo, Somerset Pharmaceuticals, Wyeth Pharmaceuticals Speaker’s Bureau: Janssen Pharmaceuticals, Wyeth Pharmaceuticals Stock Shareholder: Corcept, Neurocrine Inc. Other, Owner: Promoter Neurosciences, LLC Shitij Kapur Grant/Research Support: AstraZeneca, Eli Lilly, EMD, Janssen, Neuromolecul Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Gla Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Gla 176

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Ira Katz Grant/Research Support: Janssen Consultant: AstraZeneca, Janssen, Lilly John Kelsoe Speaker’s Bureau: GlaxoSmithKline Stock Shareholder: Psynomics, Inc. James Kennedy Consultant: GlaxoSmithKline Terrence Ketter Honorarium: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eli Lilly & Company, GlaxoSmithKline, Janssen Pharmaceutica Products, Novartis Pharmaceuticals Corporation, Pfizer, Shire Pharmaceuticals Group Grant/Research Support: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eisai, Elan Pharmaceuticals, Eli Lilly & Company, GlaxoSmithKline, Janssen Pharmaceutica Products, Novartis Pharmaceuticals Corporation, Shire Pharmaceuticals Group, Solvay Pharmaceuticals, Wyeth Pharmaceuticals Consultant: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Cephalon Inc, Corcept Therapeutics, Elan Pharmaceuticals, Eli Lilly & Company, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica Products, Jazz Pharmaceuticals, Novartis Pharmaceuticals Corporation, Pfizer, Shire Pharmaceuticals Group, Solvay Pharmaceuticals, UCB Pharmaceuticals, Wyeth Pharmaceuticals Becky Kinkead Grant/Research Support: Bristol-Myers-Squibb, Merck, NIMH, Pfizer Pharmaceuticals, Solvay Donald Klein Consultant: Vela Pharmaceutical, Vivometrics Hartmuth Kolb Other, Employee: Siemens Molecular Imaging George Koob Consultant: Alkermes, Forest Laboratories, Merck/Lipha

177

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Anne Lesage Other, Employee: Johnson&Johnson Pharmaceutical R & D David Lewis Grant/Research Support: Lilly, Merck, Pfizer Consultant: Lilly, Merck, Pfizer Shon Lewis Honorarium: Astra Zenica, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Lilly, Lundbeck, Novartis, Pfizer, Wyeth Alfred Lewy Other, Patents: OHSU Jeffrey Lieberman Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Pfizer Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Pfizer Other, Advisory Board: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Pfizer John Littleton Honorarium: Forest Laboratories Grant/Research Support: Merck s.a. Consultant: Forest Laboratories, Merck s.a. Speaker’s Bureau: Forest Laboratories Stock Shareholder: Naprogenix Inc Athina Markou Grant/Research Support: Novartis Barbara Mason Consultant: Forest, Somaxon Speaker’s Bureau: Forest Other, Medication Supply: Pfizer Pharmaceuticals Emeran Mayer Consultant: Allergan, Amgen, AstraZeneca, Avera, GSK, Lilly Consultant: J&J, Merck, Novartis, Solvay Grant/Research Support: Novartis, GSK, Lilly

178

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Christopher McDougle Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Co, Janssen Pharmaceutica, PediaMed Consultant: Bristol-Myers Squibb, Eli Lilly and Co, Janssen Pharmaceutica, PediaMed Speaker’s Bureau: Bristol-Myers Squibb, Janssen Pharmaceutica Joseph McEvoy Honorarium: AstraZeneca, Bristol-Myers, Janssen, Lilly, Pfizer Grant/Research Support: AstraZeneca, Bristol-Myers, Janssen, Lilly, Pfizer David Meltzer Grant/Research Support: Merck Roger Meyer Grant/Research Support: Forest, Sepracor, Star Scientific Consultant: Best Practice Management Inc., Cephalon, Memory Pharmaceuticals, NABI, Neurim, Ovation, Sanofi, Sepracor, Solvay, Star Scientific Stock Shareholder: Best Practice Management Inc Other, Company Contract: Abbott Pharmaceuticals, AstraZeneca, BristolMyers Squibb, DAS, GlaxoSmithKline, Janssen, J & J Research, Eli Lilly, M’s Science, Novartis, Pfizer, Prestwick Pharmaceuticals, Takeda Graeme Milligan Grant/Research Support: Cara Therapeutics, Pfizer Consultant: Amersham Biosciences, Boehringer Ingelheim, Cara Therapeutics, Novasite Pharmaceuticals John Morris Grant/Research Support: Elan, Wyeth Consultant: Amgen, Axonyx, Bristol-MyersSquibb, Elan, Forest Labs, GlaxoSmithKline, Johnson & Johnson, Neurochem, Novartis, SanofiAventis Speaker’s Bureau: Forest Labs Ann Neale Other, Employee: Saegis Pharmaceuticals David Nelson Other, Employee: Eli Lilly and Company

179

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Charles Nemeroff Grant/Research Support: Abbott Laboratories; AFSP; AstraZeneca; BristolMyers-Squibb; Forest Laboratories; GlaxoSmithKline; Janssen Pharmaceutica; NARSAD; NIMH; Pfizer Pharmaceuticals; Stanley Foundation/NAMI; Wyeth-Ayerst Consultant: Abbott Laboratories; Acadia Pharmaceuticals; Bristol-MyersSquibb; Corcept; Cypress Biosciences; Cyberonics; Forest Laboratories; GlaxoSmithKline; Janssen Pharmaceutica; Otsuka; Pfizer Pharmaceuticals; Quintiles; Wyeth-Ayerst Speaker’s Bureau: Abbott Laboratories; GlaxoSmithKline; Janssen Pharmaceutica; Pfizer Pharmaceuticals Stock Shareholder: Corcept; Cypress Biosciences; Neurocrine Biosciences; Acadia Pharmaceuticals Other, Board of Directors: American Foundation for Suicide Prevention (AFSP); American Psychiatric Institute for Research and Education (APIRE); George West Mental Health Foundation; Novadel Pharmaceuticals Other, Equity: Reevax; BMC-JR LLC; CeNeRx Other, Patents: method and devices for transdermal delivery of lithium (US 6,375,990 B1); method to estimate serotonin and norepinephrine transporter occupancy after drug treatment using patient or animal serum (provisional filing April, 2001) Raymond Niaura Consultant: GlaxoSmithKline David J. Nutt Grant/Research Support: AstraZeneca, GlaxoSmithKline, Janssen, Merck Sharp & Dohme, Organon, Wyeth Consultant: AstraZeneca, GlaxoSmithKline, Janssen, Merck Sharp & Dohme, Organon, Wyeth Speaker’s Bureau: AstraZeneca, GlaxoSmithKline, Janssen, Merck Sharp & Dohme, Organon, Wyeth Stock Shareholder: GlaxoSmithKline Charles O'Brien Grant/Research Support: Pfizer Consultant: Alkermes, Forest, McNeil Steven Paul Stock Shareholder: Eli Lilly & Company Other, Employee: Eli Lilly & Company 180

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Richard Porter Grant/Research Support: Roche Other, Employee: Roche William Potter Other, Employee: Merck Research Labs Mark Rasenick Grant/Research Support: Genzyme, NIH, Pfizer Murray Raskind Consultant: Bristol-Myers Squibb, Forest Laboratories, Ortho-McNeil Neurologics Speaker’s Bureau: Bristol-Myers Squibb, Forest Laboratories, Ortho-McNeil Neurologics Trevor Robbins Honorarium: Lundbeck, Pfizer, Roche Grant/Research Support: Cephalon, Merck Sharp & Dohme Consultant: Cambrideg Cognition, Eli Lilly Speaker’s Bureau: Lundbeck, Pfizer, Roche Stock Shareholder: CENES plc Robert Rosenheck Honorarium: Janssen Consultant: Bristol Myers Squibb Barbara Rothbaum Stock Shareholder: Virtually Better Barbara Sahakian Consultant: Cambridge Cognition Ltd (UK) Lawrence Scahill Consultant: Bristol-Myers Squibb, Janssen, Pfizer

181

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Alan Schatzberg Honorarium: Lilly Grant/Research Support: Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Somerset, Wyeth Consultant: Abbott, Aventis, BrainCells, Bristol-Myers Squibb, Corcept, Eli Lilly, Forest Labs, GlaxoSmithKline, Innapharma, Janssen, Neuronetics, Organon, Pfizer, Somerset, Somaxon, Wyeth Speaker’s Bureau: Abbott, Aventis, BrainCells, Bristol-Myers Squibb, Corcept, Eli Lilly, Forest Labs, GlaxoSmithKline, Innapharma, Janssen, Neuronetics, Organon, Pfizer, Somerset, Somaxon, Wyeth Other, Equity: BrainCells, Corcept, Elan, Merck, Organon, Pfizer, Somaxon Lon Schneider Grant/Research Support: Bristol-Myers Squibb, Janssen, Pfizer Consultant: AstraZeneca, Bristol-Myers Squibb, Janssen, Pfizer Saul Shiffman Consultant: GlaxoSmithKline Inc Other, Ownership: Invivodata, inc Gary Small Other, Patent: FDDNP-PET: Siemens Thomas Spencer Honorarium: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Grant/Research: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Consultant: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Speaker’s Bureau: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Stephen Strakowski Grant/Research Support: AstraZeneca, Forest, Janssen, Lilly Consultant: OMP, Pfizer Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, Forest, Janssen, Lilly, OMP, Pfizer Trey Sunderland Honorarium: Lundbeck, Pfizer Consultant: AstraZeneca, Pfizer 182

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Robert Swift Grant/Research Support: Bristol-Myers Squibb, Forest Laboratories, OrthoMcNeil, Pfizer Inc Consultant: Alkermes, Forest Laboratories, Pfizer Inc Speaker’s Bureau: Forest Laboratories Pierre Tariot Grant/Research Support: AstraZeneca, Forest, Janssen, Lilly, Pfizer Consultant: AstraZeneca, Forest, Lilly, Pfizer Speaker’s Bureau: AstraZeneca, Forest, Pfizer Eduard Vieta Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen-Cilag Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen-Cilag John Walkup Grant/Research Support: Abbott, Lilly, Pfizer Consultant: Lilly Speaker’s Bureau: Janssen, Lilly, Pfizer Stephen Warren Other, Chair, SAB: Seaside Therapeutics Dean Wong Grant/Research Support: Acadia, Eli Lilly, Janssen, McNeil, Merck, Pfizer, Phillip Morris Consultant: AstraZeneca, Aventis, Eli Lilly, Janssen, McNeil, Merck, Pfizer, Pharmacia, Sumitomo

183

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The following individuals had nothing to disclose: Caleb M. Adler Roger Albin Susan Andersen Stewart A. Anderson Paul Andreason Eva S. Anton Ben A. Bahr Vaishali P. Bakshi Ruben Baler Ben Barres Jill B. Becker Francesco Benedetti Karen Berman Thomas Biederer Randy Blakely Michel Bouvier Linda Brady David Brent Andres Buonanno M. Catherine Bushnell Pamela D. Butler Joseph Buxbaum Patrizia Caldirola Marc G. Caron Cameron S. Carter Dennis Charney Jin-Chung Chen Jingshan Chen Jonathan D. Cohen Lisa H. Conti Gabriel Corfas Rebecca Craft Joseph F. Cubells David J. Cutler Deepak Cyril D'Souza Kenneth Davis Michael Davis Michael Dean Melissa P. DelBello Edward Domino Daniel Dorsa Jing Du

Laura L. Dugan Howard Eichenbaum Ezekiel Emanuel Susan Essock Christopher Evans Joram Feldon Anna Francesconi Ellen Frank John Gabrieli Albert Galaburda Samuel John Gatley Elliot S. Gershon John H. Gilmore Jay Gingrich Paul W. Glimcher Steven R. Goldberg Terry Goldberg David Goldman James Goldman Jack M. Gorman Todd Gould Steven Grant Michael F. Green Maureen K. Hahn Ronald P. Hammer James Harris Stephan Heckers Markus Heilig Fred J. Helmstetter James Dee Higley Bartley G. Hoebel William Horan Z. Josh Huang Robert Innis Daniel C. Javitt Sandra H. Johnson Peter Kalivas Julie A. Kauer Hans Keirstead Kwang-Soo Kim Peter S. Klein George F. Koob

184

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The following individuals had nothing to disclose: Thomas Kosten John Harrison Krystal Cary Lai Ruth Lanius Amanda Jayne Law Ellen Leibenluft Sarah Leibowitz Vance Lemmon Pat Levitt Michael Lewis Barbara K. Lipska Raye Litten Edythe D. London David M. Lyons Pierre Magistretti Steven Maier Alexandros Makriyannis Robert Malenka Robert Malison Shaila Mani Husseini Manji Kelsey Martin Susan K. McConnell Ronald McKay Andreas Meyer-Lindenberg Read Montague Anne Z. Murphy Jaap Murre Vincent Mutel Toshitaka Nabeshima John F. Neumaier Patricio O'Donnell Valerie Olson Paul H. Patterson Jane Pearson Laura Peoples Srinivasan S. Pillay Daniel Pine Diego A. Pizzagalli Jonathan Pollock Maurizio Popoli Gregory J. Quirk

Judith L. Rapoport Scott L. Rauch A. David Redish Elliott Richelson Victoria Risbrough Angela Roberts Terry Robinson Lorna Role Donald Rosenstein Bryan L. Roth Peter Scheiffele Peter Schmidt Yavin Shaham Philip Shaw Anantha Shekhar Larry J. Siever David Silbersweig Rajita Sinha Rainer Spanagel Lalit Srivastava Dietrich Stephan Jamie Talan David A. Talmage Todd E. Thiele Steven A. Thomas Andrea Tone Bruce Trapp Hiroshi Ujike Leslie G. Ungerleider Maarten van den Buuse Marquis Vawter Frank Vocci Nora Volkow Franz X. Vollenweider Mark von Zastrow Cynthia Shannon Weickert Daniel R. Weinberger David Weinshenker Friedbert Weiss Susan Weiss Lois Winsky Ruth I. Wood

185

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The following individuals had nothing to disclose: Jim Woodgett Kiyofumi Yamada Rachel Yehuda Larry James Young James P. Zacny George S. Zubenko Jon-Kar Zubieta

186

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The following participants intend to discuss an unapproved/investigative (“off-label”) use of a product: Susan Andersen Paul Andreason Steven Arnold Ruben Baler William Bunney, Jr. H. Donald Burns M. Catherine Bushnell Joseph Buxbaum William Carpenter Dave Ceryak Kiki Chang Joseph F. Cubells Michael Dean Edward Domino Ezekiel Emanuel Susan Essock Lars Farde Colin Fish Richard Frank Paul Gaylo Ira Glick Guy M. Goodwin Anthony Grace Steven Grant Michael F. Green Heinz Grunze Markus Heilig Jonathan Javitch Dilip V. Jeste Ned Kalin Peter Kalivas Ira Katz Hans Keirstead Terrence Ketter Donald Klein Hartmuth Kolb Thomas Kosten John Krystal Raye Litten Antony Loebel Husseini Manji

Athina Markou Barbara J. Mason Christopher J. McDougle Joseph McEvoy Ann C. Neale David Nutt Charles O’Brien Jane Pearson Daniel Pine Jonathan Pollock Murray Raskind Trevor W. Robbins Donald Rosenstein Barbara Rothbaum Barbara Sahakian Alan Schatzberg Peter Schmidt Lon S. Schneider Larry J. Siever Thomas J. Spencer Stephen Strakowski Robert Swift Pierre N. Tariot Frank Vocci John T. Walkup Daniel R. Weinberger Dean F. Wong

187

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Author Index

11/17/05

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Page 189

AUTHOR INDEX

Author Index

11/17/05

7:49 AM

Page 190

Author Index

11/17/05

7:49 AM

Abadia, Maria Castillo Abel, Ted 153 Abelson, James L. Abi-Dargham, A. Abi-Dargham, Anissa 129 Acharya, Nayan V. Ackenheil, Manfred Adams, David Adams, John Addicott, M.A. Addington, Anjene Addington, Stephanie Adinoff, Bryon Adler, Cal Adler, Caleb Adler, Caleb M. Afari, Niloo Aghajanian, George K. Ahlbrand, Rebecca Ahmed, Saeed Ajilore, Olu Akbar, Natkai Akbarian, Schahram Akil, Huda 145 Akpor-Mensah, Rostian Alagbe, Oyetunde Albers, Lawrence Albin, Roger Alce, Guilna Alexopoulos, George Alia-Klein, Nelly Allen, D. Radant Allen, Albert J. Allen, Lesley A. Allen, Nick Almasy, Laura Alonso, Angelique Alonso, Richard Alper, Kenneth Alpert, Jonathan E. Alphs, Larry Alreja, Meenakshi

Page 191

122 24, 126,

Altar, C. Altar, C. A. Alvarez, E. Amato, David Ameli, Rezvan Amiel, Jonathan M. Amsterdam, Jay D. Anagnostou, Evdokia Anand, Amit Andersen, Susan L. Anderson, Berry Anderson, Carl M. Anderson, George Anderson, George M. Anderson, Stewart Anderson, Susan Andreason, Paul Andrews, Glenn D. Anggadiredja, K. Angstadt, Michael Angstadt, Mike Ansorge, Mark S. Anthony, James C. Anton, Eva Appel, James Apud, J. Apud, Jose A. Arango, Celso Arango, Victoria Arce, Estibaliz Archer, Stephen Arciniegas, David B. Ardekani, Babak A. Arias, Robert Ariely, Dan Armbruster, Blaine Armitage, Roseanne Arnold, Paul Arnold, Paul D. Arnold, Steven Arolt, Volker Arora, Sanjay Arrillaga-Romany, I. C. Artaloytia, J. F. Artymyshyn, Roman P.

106 118 68, 128, 95 109 99, 128 94 106 124 143 91 117, 144 56 94, 126 143 129 135 122 94 116 99 93, 97, 101 153 148 66 116, 138 94 111 147 108 98 138 105 99 121 107 93 100 153

191

24 100, 135 141 97 146 137 142 114, 115 116 91, 141 104 134 145 114 32 97 38, 49 108 137 108 137 98 91 82 152 151 116 100 139 139 122 139 134 90 117 153 94 27 95 82 98 109 100 100 96

Author Index

11/17/05

7:49 AM

Asberg, Marie Ascher-Svanum, Haya 103, 128 Aschmies, Susan Ashby, Charles Ashford, J. W. Ashley-Koch, Allison Ashtari, Manzar Ashton, David Aston, Christopher Atchinson, Kevin P. Ator, Nancy Attarbaschi, Trawat Attner, Michelle Atz, Mary E. Augustyns, Ilse Awad, A. G. Axelson, David Baare, William Bachtell, Ryan K. Badawy, A.A-B. Bahr, Ben Bahr, Ben A. Bailer, Ursula F. Bain, Earle Baker, David Baker, Glen Baker, Ross A. Baker, Sherryl Bakshi, Vaishali Baldessarini, Ross J. Baler, Ruben Ballinger, Dennis Banerji, MaryAnn Bannai, Makoto Bannet, Yair Barbano, PaoloEmilio Barch, Deanna Barefoot, John Barker, Eric L. Barnett, Alan S. Barot, Sabiha Barr, Christina S. 109, 113, 135 Barranco, Eva

Page 192

125 100,

Barres, Ben Barrett, Andrew C. Barrett, James E. Barrett, Sean P. Barrett, Thomas B. Barros, Tanya Barry, Audrey Bartko, John Barzman, Drew H. Baskys, Andrius Baucum, Anthony J. Bauer, Jochen Bauer, Michael Bauer, Theresa Baumann, Michael H. Baxter, Lewis R. Bayazitov, Ildar T. Bazinet, Richard P. Bear, Mark Beard, Laura Bearden, Carrie Beasley, Jr., Charles M. Becker, Carl Becker, Jill Becker, Kevin G. Beebe, Katherine L. Beesdo, Katja Begleiter, H. Beguin, Cecile Belfer, Inna Belknap, John K. Bell, Richard L. Beltaifa, Senda Belzung, Catherine Bendle, Scott Bendor, Jacob T. Benedetti, Francesco Beneyto, Monica Benkelfat, Chawki 116 Bentin, Shlomo Berga, Sarah L. Bergeron, Richard Berghorst, Lisa Berghorst, Lisa H.

90 148 89 133, 146 151 100 150 90 148 145 153 145 109 101 117 119 91 106 77 108 116, 118 95 101 122 100, 152 92 64 95 80 103 114 94 143 117 139 133, 146 91 137 114 92, 95, 99

192

65 91 146 113 149 120 106 100 94 153 107 98 95 151 97 143 153 154 73 144 140 95, 126 138 43 155 106 95 134 97 125 134 135 101 90 152 134 76 101 95, 113, 102 138 95 142 117

Author Index

11/17/05

7:49 AM

Bergman, Jack Berman, Karen Berman, Karen F. Berman, Robert M. Berman, Steven M. Berney, Alexandre Bernotas, Ron Berns, Gregory S. Berrettini, Wade Bertisch, Hilary C. Berton, Olivier Bescholt, Anita J. Best, Susan E. Betensky, Julia Bethea, Cynthia L. Beyer, Chad Beyers, Karen Bhaskar, Kolachana S. Bhattacharjee, Abesh Bi, Wenzhu Bidesi, Anup Bidwell, L. Cinnamon Biederer, Thomas Biederman, Joe Biederman, Joseph Biemans, Barbara Bierut, L. Bikker, Angela Bilder, Robert Bilder, Robert M. Binder, Elisabeth B. Binesh, N. Birell, Claire Birkett, Melissa A. Birmaher, Boris Bissette, Garth Bizot, Jean-Charles Bjork, James Blackburn, Thomas P. Blair, James Blakely, Randy Blakely, Randy D. Blanchard, John Blanco, Carlos Blasey, Christine

Page 193

92, 126 68 152 96 95, 138 95 109 138 124 103 115 123 91 151 106 148 108 116 139 139 142 102 65 122 118 100 134 145 107, 124 106, 151 92 94 109 142 117, 125 89 121 136 96, 144 99 78 115 103 123 106

Blasi, Giuseppe Blazer, Dan G. Blazer, Daniel Blendy, Julie A. Blier, Pierre Bloch, Michael H. Block, Thaddeus Blumberg, Hilary Bohning, Daryl Boone, Ericka Borba, Christina P. Borckardt, Jeffrey J. Borowsky, Beth Bose, Anjana Bosetti, Francesca Bossie, Cyndi Bossie, Cynthia A. Bottiglieri, Teodoro Bouvier, Michel Bowden, Charles Bowie, Christopher R. Bowlby, Mark Bowman, L. Boyce-Rustay, Janel M. Boyle, Maureen Bradley, Brendan P. Brady, Linda Braff, David 102 Braff, David L. Braff, DL Brambilla, Paolo Branch, Craig Branch, Sarah Branchek, Theresa Branchek, Theresa A. Branchey, Marc Brann, Jessica H. Brannan, Stephen Braun, Miriam Breeder, Christopher Breeze, Janis L. Breier, Alan Breier, Michelle Brennan, Julie

193

116, 138 89 123 123 95, 96 155 106 56 131 120 127 106 101 94 153 104, 105 98, 101 101 33 122 105 109 131 93 104 96 39 49, 101, 105, 129 102 140 103 103 70 96, 144 92 98 143 98 143 118 40, 103 149 148

Author Index

11/17/05

7:49 AM

Brennan-Krohn, Thea Brennum, L. Brent, David Brent, David A. Bresnahan, Michaeline Briggs, Hedieh Britton, Jennifer C. Brodsky, Beth S. Brodsky, Marc D. Brody, Arthur L. Brotman, Melissa A. Brown, Alan S. Brown, E. Sherwood Brown, Eileen Brown, Gregory G. Brown, Hendricks Brown, John Brown, Justin Brown, Lawrence S. Brown, Morton B. Brown, Walter Brown, Kyle Brumbach, Barbara H. Brummett, Beverly Brunelle, Caroline Brunet, Alain Brutsche, Nancy Bryan, Holly S. Bucholz, K. Buchsbaum, Monte Buchsbaum, Monte S. Buchwald, Dedra Buckholtz, Joshua Buckholtz, Joshua W. 152 Bueller, Joshua Buga, Adriana Buitelaar, Jan Bukstein, Oscar G. Bulik, Cynthia M. Bullich, S. Bunney, William Bunney, William E. Bunt, Gregory Buonanno, Andres

Page 194

119 150 49, 117 125 101 106 137 125 92 143 96 101 144 99 117 145 120 98 92 146 107 103 99 133, 146 113 96 146 126 134 140 138 143 102, 140 116, 141,

Burdick, Katherine E. Burk, Gary M. Burmeister, Margit 145 Burns, Donald Burroughs, Eliza Bustillo, Juan R. Butler, Pamela Butler, Pamela D. Butterfield, Marian I. Butters, Meryl A. Buxbaum, Joseph D. Buydens, Laure Byerley, Bill Bymaster, Frank Bystritsky, Alexander Cabrera, David M. Cadenhead, Kristin Cadenhead, KS Cagliero, Enrico Caine, S. B. Caine, Simon B. Calabrese, Joseph Calabrese, Joseph R. Caldirola, Patrizia Caleo, Sue Calkins, ME Calkins, Monica E. Callaghan, John T. Callicott, Joseph Callicott, Joseph H. 116, 127, 138, 141, 152 Callicott, Joseph S. Campbell, Bryan J. Canive, Jose M. Cannon, Dara M. Canuso, Carla M. Cao, Jianjing Caparelli, Elisabeth C. Capece, Julie A. Capuron, Lucile Carballo, Juan J. Carlezon, William Carlezon, William A. 136

138 149 48 140 107 141 76 145 134 82

194

102, 132 105 96, 119, 39 95 102 75 102 89 124 23, 132 92 124 98 96 154 101, 102 102 127, 152 91 92 122, 144 146 70 104 102 147 98 140 90, 102, 141 142 130 96 98, 124 134 111 108 109, 138 135 97 97, 124,

Author Index

11/17/05

7:49 AM

Carlson, Gabrielle Carlson, Janice Carlson, Paul Carlson, Robert Carlson, Susan E. Caron, Judy Caron, Marc Carpenter, David Carpenter, Linda Carpenter, Linda L. Carpenter, William Carroll, F. I. Carson, Richard E. Carson, William Cartagena, Preston Carter, Cameron Carvalho, John P. Cassano, Hope L. Castellanos, F. Xavier Caster, Joseph M. Castillo, Desiree Castro, Mariana Pereira Catafau, Ana Cato, Margaret A. Cavazzoni, Patrizia A. Caviness, Verne S. Cecil, Kim Cecil, Kim M. Cepeda, Carlos Ceryak, Dave Cha, Joo H. Chang, Kiki Chang, Lin Chang-Gyu Hahn Chaplin, William Chappell, Amy S. Chappell, Phillip B. Charney, Dennis Charney, Dennis S. Chau, David T. Chen, Bin Chen, Gang Chen, Guang Chen, Heidi Chen, Jin-Chung

Page 195

122 151 146 91 122 97 41, 60 140 145 114 40 112 136, 139 130 145 45 114 102 117 112 152 105 141 117 95 118 117 126 108 38 134 56, 97 138 82 114, 115 107 106 74 125, 146 111 109 120, 141 97 144 51

Chen, Jingshan Chen, Qiang Chen, Robert Chen, Scott A. Chen, Stanford Chen, Ying Chen, Yue Chen, Yuejin Chen, J. Chengappa, K.N. Roy Childs, Emma Chin, Ronald B. Cho, William Choi, Sang-Ho Chong, Rachel Choudary, Prabha V. Chourbaji, Sabine Chowdari, Kodavali V. Christensen, Jon Chua, Hannah F. Chue, Pierre Chui, Helena Church, Timothy S. Ciccone, Patrick E. Clark, Janet Clasen, Liv Clauw, Daniel Claycomb, Robert Clinton, Sarah Coccaro, Emil F. 137 Cody, Heather Cohan, Jeannette Cohen, Bruce M. Cohen, Caroline Cohen, Jonathan Cohen, Miriam Cohen, Ronald A. Colantuoni, Carlo Cole, Derek Collins, Daphne Comer, Sandra D. Comery, Thomas A. Compton, Wilson M. Confer, Andrea L.

195

41, 116 116, 152 103 92 151 105 102 108 151 143 93 150 103 153 146 145 120 147 139 118 150 89 121 123 97 105, 115 46 108 97 108, 117, 116 117 97, 124 121 52 100 136 155 109 155 112 90 92 138

Author Index

11/17/05

7:49 AM

Conley, Rachel Conley, Robert 154 Conley, Robert R. Connor, Kathryn M. Constable, R. T. Conti, Alana C. C. Conti, Lisa Conway, Kevin P. Cook, Edwin H. Cook, Glen A. Cooper, Thomas Cooper, Thomas B. Cooperberg, Mark D. Copeland, Paul M. Coplan, Jeremy Coplan, Jeremy D. Corcoran, Cheryl Corfas, Gabriel Correia, Stephen Correll, Christoph U. Corrigan, Brian Corrigan, Mark Corripio, I. Cortese, Bernadette M. Corya, Sara Coryell, Bill Costa, Erminio Coste, Sarah Cotton, Aronica Cottone, Lisa A. Covell, Julie Covington, Herbert E. Cox, David R. Coyle, Joseph Craig, Douglas A. Craiglow, Britt Crandall, David 143, 152 Creson, Thomas Crissman, Alicia M. Croft, Rodney J. Crosson, Bruce A. Crow, Scott J. Cruz, Rick

Page 196

97 98, 103,

Cryan, John F. Csernansky, John Cubells, Joseph Cubells, Joseph F. Cubero, Pedro Cui, Lihong Cummings, Jeffrey Cunningham, Kathryn A. Cunningham, Miles Cunningham, Miles G. Cutler, David Czachowski, Cristine Czeisler, Charles A. D’Souza, Deepak Daniel, David G. Danus, M. Darwin, C. Das, Saumitra Daskalakis, Zafiris J. Davenport, Nicholas Davidson, Jonathan Davidson, Jonathan R. Davidson, Michael Davis, John Davis, Kenneth Davis, Kenneth L. 140 Davis, Michael Davis, Nicole Y. Daws, Lynette Daws, Lynette C. De Kloet, Carien De Leon, Mony J. De Wit, Harriet Deadwyler, Samuel Dean, Michael Deas, Deborah DeBattista, Charles Deckert, Juergen Deckert, Jurgen Decobert, Michel Deep-Soboslay, Amy Degenhardt, Elisabeth DeKosky, Steven T. 139

128 97 104 123 64 92 134 107 129, 139 135 146 127 126 114, 137 128, 130 63 119 132 106 97 141 123 151 124 105 142 137 111 120 124 103 132 96, 144 155 130, 131, 97 125 138 117 107 107

196

54 72 31 92 100 123, 124 91 111 25 97 86 92 109 77 100 141 94 90, 138 103 152 97 123 101 100 89 23, 132, 84 109 93 107 145 44, 90 93, 134 91 29 93 106 98 93 121 102 99 124, 138,

Author Index

11/17/05

7:49 AM

Delahanty, Ryan J. DelBello, Melissa DelBello, Melissa P. 117, 126, 144 DeLisi, Lynn E. DeLory, Michael Demitrashvili, Marina Dence, Carmen S. Denslow, Stewart Derby, Eric DeRosse, Pamela Detke, Michael J. Deutch, Ariel DeVane, Lindsay Devous, Michael D. Di Martino, Adriana Diamond, Pamela Dick, D. Dickstein, Daniel P. Dieterich, Megan E. Diksic, Mirko DiNieri, Jennifer A. Dittman, Ralf Diwadkar, Vaibhav A. Dobie, DJ Dobie, Dorcas J. Dobkin, Roseanne D. Docherty, John Dombrowski, Philip Dominguez, Juan M. Domino, Edward Domschke, Katharina E. Donalds, Rachael Donati, Robert Donovan, Jennifer Dorsa, Daniel Dossenbach, Martin Dougherty, Donald M. Douglas, Louisa Drabant, Emily M. Dreher, Jean-Claude Dremencov, Eliyahu Drevets, Wayne C. 120, 123, 125, 138 Driesen, Naomi R.

Page 197

115 56, 122 94, 103,

DSouza, Deborah N. 95, 107 Du, Jing 69, 98 Dube, S. 131 Dubocovich, M. L. 154 Dubocovich, Margarita 76 Dugan, Laura 34 Dulawa, Stephanie C. 98 Dumalska, Iryna 153 Duman, Ronald S. 153 Dunlap, Steven 117 Dunlop, John 126, 148 Dunn, Laura B. 106 Dunner, David 99 Dunner, David L. 98 Durkin, Margaret 96 Duytschaever, Hilde 100 Dwivedi, Yogesh 98, 125, 154 Dworakowski, Diana 117 Dwork, Andrew 126 Eastvold, Angela 102 Eckelman, William C. 139 Edenberg, H. 134 Edwards, Robert H. 154 Eerdekens, Els 130 Eerdekens, Marielle 127, 130 Egan, M. 151 Egan, Michael 152 Egan, Michael F. 90, 102, 116, 138, 141, 149, 150, 152 Ehlers, Cindy L. 93, 136 Ehrlichmen, Richard S. 149 Eichenbaum, Howard 59 Eidelberg, David 90 Eiduson, Samuel 96 Eisen, Seth A. 142 Ekholm, Jenny 129 Ekholm, Jenny M. 132 El Mansari, Mostafa 96 Elliott, Mark 147 Ellis, Jamey 132 Ellis, Steven P. 125 Elman, Igor 117 Eltayb, Amani 150 Emanuel, Ezekiel 40

103 92 138 138 131 100 102 98, 107 67, 97 103, 131 91 117 152 134 117 118 95, 116 97 122, 151 117, 128 102 147 98 104 155 98 51 98 97 98 103 43 126 106 100 116 152 96 96, 118, 104

197

Author Index

11/17/05

7:49 AM

Engel, Sharon Engelhart, Luella Engelien, Almut Enoch, Mary-Anne Entsuah, Richard Epperly, Garretson D. Epping, Eric Ereshefsky, Larry Erickson, Kristine 118 Eriksson, Bo Ernst, Monique Ervin, John Escamilla, Michael A. Esposito, Giuseppe Esposito, Michael Esser, Steve K. Essock, Susan Estrada, Jose Evans, Alan Evans, Christopher Evans, Karleyton Evans, Ken Evans, Simon J. Evans, Suzette M. Evins, A. Eden Ewing, Sarah B. Fabian, Sara Faccidomo, Sara P. Faison, Warachal E. Fang, Liwei Farabaugh, Amy H. Farber, Robert Farde, Lars Faries, Douglas Faustman, William O. Fava, Maurizio 120, 126 Feder, Adriana Feifel, David Feldman, Ruth Feldon, Joram Feltenstein, Matthew W. Ferguson, James M. Fernandes, Prabhavathi

Page 198

97 107 98 136 99 154 116 152 26, 115,

Ferrarelli, Fabio Ferris, Steven Findling, Robert Findling, Robert L. Finger, Elizabeth Fink-Jensen, Anders Fisch, Hans-Ulrich Fischer, Andre Fischer, Grace Fischman, Alan J. Fish, Colin Fisher, Alan C. Fissell, Kate Fitterling, Heidi Fitzgerald, Daniel A. 137 Fitzgerald, Kate D. Flagel, Shelly B. Fleck, David E. Fleckenstein, Annette Flick, Rosemarie B. Flor, Herta Flores, Osvaldo Floresco, Stan B. Floyd, Bloom E. Foltin, Richard W. 112 Ford, Judith Ford, Judith M. Ford, Lisa Foroud, T. Fountain, Sarah I. France, Adrian K. France, Charles P. Francesconi, Anna Francon, Dominique Frank, Ellen Frank, Guido F. Frank, Guido K. Frank, L. Frank, Richard Frankle, Gordon W. Frankle, WG Frazer, Alan Frazier, Jean A.

104 142 89 105 139 126 132 55 105 105, 115 85 118 99 145 93 93, 120 112 153 94 89 153 93 106 39 100, 103 104 93, 97, 99, 137 104 140 35 94, 135 99 104

198

132 90 122 109, 146 99 92 143 154 123 134 39 108 141 137 108, 117, 118 93 99 107 97 120 97 94, 126 90 93, 111, 27 104 127, 130 134 103 93 93, 112 50 121 79 116 118 131 39 129 118 107 118, 151

Author Index

11/17/05

7:49 AM

Frederick, Blaise Frederick, Blaise D. Fredrickson, Barbara L. Free, R. B. Freed, William J. Freedman, Robert Freeman, Marlene P. Freudenreich, Oliver Friberg, Lars Frick, Caroline Friedman, Joseph I. Frol, Alan B. Fromm, Stephem Frye, Mark A. Fu, Dong-Jing Fuchs, Rita A. Funke, Birgit Furey, Maura L. Furman, Daniella Fusco, Maureen Fyall, Amber Gable, Karissa L. Gabrieli, John Gadde, Kishore Gagne, Gerard G. Galaburda, Albert Galit, Yovel Gallagher, Paul Gallelli, Kim Galli, Aurelio Gallitano-Mendel, Amelia Galloway, Matthew Galloway, Matthew P. Galper, Daniel I. Gandhi, Shilpa K. Gao, Sujuan Garlow, S. Garlow, Steven J. Gass, Peter Gassmann-Mayer, C. Gatley, Samuel Gaylo, Paul Gelenberg, Alan Gelenberg, Alan J. Gelernter, Joel

Page 199

117 134 140 154 155 132 99 105 119 143 89, 140 144 96 99 103 94 102 118, 120 152 89 111 115 59 109 114 37 102 100 97 93 104 102 118, 138 121 96 116 122 120 120 127 77 39 107 99, 122 140

Gemelli, Terry Genius, Just George, Mark S. 131 George, Tony P. Georgieva, Lyudmila Gerald, Christophe P. Gerety, Lyle P. Gerhardt, Greg A. Gerig, Guido Gerlach, Lauren Gershon, Elliot Geuze, Elbert Geyer, Christopher Geyer, Mark 142 Geyer, Mark A. Gharabawai, Georges Gharabawi, Georges 105, 107, 155 Gharabawi, Georges M. Ghosh, Debashis Ghuman, Harinder S. Ghuman, Jaswinder K. Giardino, Odessa Gibbons, Robert D. Gibbs, E. M. Gibert, Stephen Gibson, Brian Giedd, Jay 105 Giedd, Jay N. Giegling, Ina Gil, Lucas Gil, Mario Gil, Roberto Gilliam, T. C. Gilmore, John 114 Gilmore, John H. Gingrich, Jay A. Ginter, P. Giuffrida, Andrea Glahn, David C. Glaser, Paul E.

199

115 109 104, 106, 105 132 96, 144 124 154 114, 119 112 86, 124 119 136 36, 64, 72, 116 106 95, 104, 101, 124 96 107 107 101 145 148 106 103 37, 81, 115 109 122 98 129 134 26, 36, 115, 119 98 154 107 105 154

Author Index

11/17/05

7:49 AM

Page 200

Glass, Richard 38 Glass, Steven J. 107 Glassman, Alexander 38 Glenthoj, Birte 27 Glenthoj, Birte Y. 119 Glick, Ira 79 Glimcher, Paul 52 Glitz, Debra A. 123 Glover, Gary 104 Goate, A. 134 Godbout, Roger 147 Goeders, Nicholas E. 111 Goetz, Raymond 128 Goetz, Raymond R. 128 Goff, Donald C. 105, 127, 152 Gogtay, Nitin 27, 105 Gold, James M. 131 Gold, Philip 115 Goldberg, Jack 143 Goldberg, Steven 80 Goldberg, Steven R. 113 Goldberg, Terry 59, 90 Goldberg, Terry E. 116, 120, 150 Goldman, Aaron L. 120, 127, 141 Goldman, David 29, 58, 95, 109, 113, 116, 125, 129, 136, 137 Goldman, James E. 23 Goldman-Rakic, P. S. 104 Goldstein, David J. 107 Goldstein, Rita Z. 111 Golembo, Nicole 100 Goletiani, Nathalie V. 111, 114 Goltser-Dubner, Tanya 149 Golzer, Tanya 125 Gonsai, Kishor 112 Gonzalez, Gerardo 112 Goodman, M. 118 Goodman, Mark M. 112 Goodman, Wayne K. 120 Goodwin, Guy 48 Gordon, Joshua 25 Gordon, Joshua A. 120

200

Gorman, Jack 140 Gould, Georgianna G. Gould, Todd Gould, Todd D. Grace, Anthony Granholm, Eric L. Grannemann, Bruce D. Grant, Jon Grant, Kathleen A. Grant, Merida M. Grant, Richard W. Grant, Steven Grauer, Steve Gravel, Paul Gray, May Grayson, Dennis R. Green, Alan I. Green, Michael F. Greenhill, Laurence Greenspan, Andrew Greenstein, Deanna Greenstein, Dede Greenwood, Tiffany A. Greer, Tracy L. Greisenegger, Erika Greist, JH Griebel, Guy Griffith, Gayle Grigoriadis, Dimitri E. 142 Grimm, Jeffrey W. Grossman, Hillel Gruber, Staci A. Grunder, Gerhard Grundt, Peter Grunze, Heinz Gu, Hongbin Guidotti, Alessandro Guilfoyle, David G. Guimaraes, Angela Gunderson, Erik Gunduz-Bruce, H. 151 Gur, Eitan

40, 47, 107 60 121 42, 66 117 121, 145 119 113 119 152 52 126 95, 116 104 105 111 105 125 101 105 115 105 121 140 110 121 102 106, 121, 111 89 132, 137 119 91 48, 109 127 105 132 152 112 129, 148, 125

Author Index

11/17/05

7:49 AM

Page 201

Gur, Raquel 105 Gur, Raquel E. 147 Gur, Ruben 75 Gur, Ruben C. 128, Gutierrez-Esteinou, R. 131, Gwaltney, Chad 114 Gyulai, Laszlo 122 Hahn, Chang-Gyu 82 Hahn, Maureen 78 Haile, Colin N. 108 Hajianpour, Arash 140 Hall, Jerry A. 107 Hamer, Robert 127 Hamer, Robert M. 130 Hammer, Ronald 64 Hammer, Ronald P. 100 Hammonds, Michael 144 Han, Qiao 115 Handa, Robert J. 89 Haney, Margaret 111, Hannigan, John H. 118 Hanson, Glen R. 107 Hao, YanLei 97 Harding, Richard 124 Hariri, Ahmad R. 138 Haroon, E 94 Haroutunian, Vahram 101, 132, 147 Harral, Erin 139 Harris, James 49 Harris, Thomas S. 91 Harrison, Boyd 126, Harrison, P. J. 151 Hart, Carl 111 Hart, Carl L. 112 Hartmann, Annette 109 Harvey, John A. 109 Harvey, Phil 140 Harvey, Philip D. 105, 124 Haschke, Eric 101 Hasdemir, Mustafa 143 Hashemzadeh, Mehrtash 148 Hassan, Khader M. 111 Hassel, Stefanie 141

Hassman, Howard A. Hastings, Ramin S. Haubenreich, Kristen M. Hawk, Josh Hayashi, Kiralee M. Hazelwood, Lisa A. Hazlett, Erin A. Heaton, Robert Heberlein, Ulrike Hebert, Chantal Heckers, Stephan Heerey, Erin A. Hegerl, Ulrich Heijnen, Cobi J. Heilig, Markus Heim, Christine Heindel, Walter Heinz, Andreas Heitzeg, Mary Helboe, L. Hellweg, Rainer Helmstetter, Fred Hemmingsen, Ralf Hen, Rene 120 Henck, Judith W. Henderson, David C. Henke, Bettina Henn, Fritz A. Henry, Brian Henry, Shannan E. Hensler, Julie G. Herbener, Ellen Herbert, Martha R. Heresco, Uriel Hermann, Carol Hernandez, Olivia Herremans, A. H. J. Herringa, Ryan J. Herscovitch, Peter 139 Hertel, Peter Hesselbrock, V Hesselink, Mayke

147 152

112

128,

148

106,

201

107 121 118 153 140 154 138 102 103 95 59 131 109 145 61 121, 153 98 136 119 150 120 84 119 90, 98, 98 127, 152 124 120 151 116 121 139 118 102 90 139 150 142 125, 136, 130, 150 134 150

Author Index

11/17/05

7:49 AM

Higley, J. D. 109, 113, 115 Higley, James Higley, James D. Hill, Rebecca Hiranita, Takato Ho, Beng-Choon Ho, Shao-Hsuan Hobbs, Katherine Hockett, Richard D. Hodge, Steven M. Hodgkinson, Colin A. Hoebel, Bartley Hof, Patrick Hoffmann, Robert Hogarty, Gerald E. Hoge, Jessica A. Hohoff, Christa Hokfelt, Tomas Holcomb, Henry H. Holick, Kerri A. Holik, Alexander Holland, Christine Holland, Scott K. Hollander, Eric 115 Hollon, Steven D. Holmes, Andrew Holston, Rachel E. Holt, Richard Holzman, Philip Hommer, Daniel Honea, Robyn Honea, Robyn A. Hooper-Wood, Christa Hoptman, Matthew Hoptman, Matthew J. Horan, William Horgan, Jennifer Horner, Michael Hortnagl, Heide Houseknecht, K. L. Houston, John Howe, Meghan Howell, Leonard L.

Page 202

92, 95,

Hrabe, Jan Huang, Hsien-Sung Huang, Xiaohong Huang, Y. Huang, Ying Huang, Yiyun Huang, Yung-yu Huang, Z. Josh Huber, Reto Hudson, James I. Hudson, R. L. Huffaker, Stephen J. Huganir, Richard Hulette, Christine Hulihan, Joseph F. Hull, Elaine M. Hunt, Rachel A. Hustig, Harry Hutson, Peter H. Hwang, D-R Hwang, Dah-Ren Hyde, Christopher Hyde, Thomas M. 155 Ice, Kathleen Ichise, Masahiro Indersmitten, Tim Ingham, Mike Innis, Robert Insanally, Michele Iskander, L. Iudicello, Jennifer Ivleva, Elena Iyengar, Malini Iyengar, Smriti Jack, Blaine Jacob, Suma Jacobi, Frank Jacobs, An Jacobsen, J. S. Jacobson, Ira M. Jaenisch, Rudolf Jaffe, Craig Jagar, A.A. Jagust, William

58 135 99 137 127 137 127, 141 103 118 137 53 140 94 128 124, 139 93, 98 144 129 98 145 152 94 26, 114, 119 93 109 131 102 92, 136 141 127, 141 123 103 132, 134 75 89 131 120 148 99 97 112

202

134 99 122 118 146 129 121 32 132 107, 108 154 127 73 89 143 98 100 104 97 118 129 117 102, 127, 103 96 128 104 39, 68 126 118 116 150 144 98, 107 137 115 95 104 90 109 115 112 106 89

Author Index

11/17/05

7:49 AM

Jalbrzikowski, Maria Jamal, Mazan Jardemark, Kent E. Jarskog, L. F. Jarvis, Kelly Javitch, Jonathan Javitt, Daniel Javitt, Daniel C. Jayathilake, Karu Jennifer, Wilkerson Jentsch, J. David Jentsch, J. D. Jeste, Dilip Jeste, Dilip V. Jiang, Lan Jiang, Qin Jina, Anil S. Jochims, Anja Johanson, Chris-Ellyn Johnson, Brandy Johnson, D. E. Johnson, Kevin Johnson, Sandra Johnson, Steven Johnson-Davis, K. L. Johnston, Daniel Jokinen, Jussi Jomier, Matthieu Jones, Doug Jones, Douglas W. Jones, Edward G. Jones, Kenneth A. Joshi, Sarang Joyce, B. M. Jurata, Jurata W. Kadiyala, Sridhar Kail, Melanie Kalali, Amir H. Kalin, Ned H. Kalivas, Peter Kalivas, Peter W. Kamanna, Vaijinath Kamel, Niveen Kamens, Helen M.

Page 203

102 148 130 115 94 33 75 102, 132 108, 131 115 103 113 34, 62 106 115 123, 145 100, 152 119 136 144 148 131 38 105 107 148 125 119 140 137 145 96 119 154 100 90 133, 146 101 121, 142 57, 80 151 153 99 134

Kane, John 151, 154 Kane, John M. 127, 129, 132 Kanes, Stephen J. Kanes, Steve Kanwisher, Nancy Kapur, Shitij Karagille, Ayse T. Karanian, David A. Karatekin, Canan Karson, Craig Kashyap, Moti L. Kasper, Siegfried Katz, Jonathan L. Kauer, Julie Kaufman, Daniel Kaufman, Marc J. Kavalali, Ege Kavelaars, Annemieke Kaye, Walter H. Ke, Yong Keck, Martin Keefe, Richard Keenan, Kate Kegeles, Lawrence S. Kehoe, Priscilla Keirstead, Hans Keitner, G. I. Keller, David Keller, Martin B. Kelley, Ann E. Kelley, Mary E. Kelly, Deanna L. Kelly, Erin Kelly, Michele Kelsey, Douglas K. Kelsoe, John 124 Kelsoe, John R. Kendi, Mustafa Kenna, George A. Kenna, Heather A. Kennedy, David N. Kennedy, James

203

130, 148, 100, 102, 151 126 102 41 152 108 152 121 153 145 134 73 114 120, 134 115 145 116, 118 132 109 127 115 128, 129 108 23 122 103 122 135 147 128 149 126 108 86, 116, 149, 151 152 112 142 118 58

Author Index

11/17/05

7:49 AM

Kennedy, James L. Kenny, Paul J. Kent, Justine M. Kentros, Clifford G. Kerr, Natalie Kersting, Anette Kerwin, Lauren Keshavan, Matcheri Keshavan, Matcheri S. 140, 147 Ketchum, Katherine Ketter, Terence Ketter, Terence A. Khadivi, Ali Khan, Alea Khan, Arif Khan, Samir Khanal, Mandar Kieres, Artur K. Kim, Dong-Wook Kim, Jeansok J. Kim, Kwang-Soo Kimhy, David Kimmel, Heather L. Kingshott, Elesha Kinkead, Becky Kinon, B. Kinon, Bruce Kinon, Bruce J. Kipp, Heidi Kirkwood, Sandra Close Kirov, George Kirshner, Margaret Kleber, Herbert Klein, Daniel N. Klein, Donald Klein, Lauren Klein, Nikolas Klein, Peter Kleinman, Joel E. 155 Kleinman, L. Kletter, Kurt Klock, Allan

Page 204

95 112 139 120 141 98 96 147 117, 128,

Klunk, William E. 139 Knable, Michael Knadler, Mary Pat Knoll, Allison T. Koch, Paul Kocsis, James H. Koe, B. K. Koek, Wouter Kohler, Christian G. Kohn, Philip Kolachana, B. S. 141, 149, 150, 151 Kolb, Hartmuth Kolko, David Kolts, Russell Konkel, Michael J. Konradsson, Asa Koob, George Koob, George F. Koola, Jejo Kopajtic, Theresa Korotzer, Andrew Kosel, Markus Kosik-Gonzalez, Colette Kosten, Therese A. Kosten, Thomas Kosten, Thomas R. Kostic, Dusan Kowatch, Robert 144 Kowatch, Robert A. Kozel, F. A. Kozel, Frank A. Kraemer, Helena C. Kral, John G. Kramer, Elisse Kramer, J. Kramer, Joel Kramer, Larry Kramer, Michelle Krefetz, David G. Kreilgard, M. Krishen, Alok Kristiansen, Lars V.

89 79 122 148 149 107 106 112 124 97 108 78, 97 128, 130 112 90 67 131 103, 128 100 140 103 132 90 130 122 38 136 145 60 102, 127, 131 145 108

204

124, 138, 104 98 124 152 122 148 112 128 152 90, 138, 39 125 107 96, 144 130 53, 61 134 131 134 94 143 101, 104 108 31 108, 112 130, 143 103, 122, 94, 99 104, 106 131 89 114 90 134 89 111 127, 130 107 150 126 128, 147

Author Index

11/17/05

7:49 AM

Kritz, Steven Krupitsky, Evgeny M. Krystal, John Krystal, John H. Kryzhanovskaya, Ludmila Kucherlapati, Raju Kuczenski, Ronald Kuczora, Meaghan Kugel, Harald Kuhn, Cynthia Kuhn, Cynthia M. Kumar, A. Kumaran, S. Kumra, Sanjiv Kuperman, S. Kupfer, David J. Kussmaul, Lucinda Kyle, Kampman Lacefield, Clay O. Ladouceur, Cecile D. Laeng, Pascal Lahti, Adrienne Lahti, Adrienne C. Lai, Cary Laird, Nan M. Lal, Harbans Lalonde, Justine K. Lam, Francis LaMantia, A. S. Lambe, Evelyn K. Lamberti, J. S. Landinez, Johanna Landry, Charles F. Lanfranco, Marie F. Langefeld, Carl Lanius, Ruth Lanzenberger, Rupert Lara, Nathalie LaRossa, Gina N. Laruelle, M. Laruelle, Marc 129 Lattal, K. Matthew Lavin, Antonieta Lavretsky, Helen

Page 205

92 112 32 104 122, 151 102 149 149 98 146 109, 112 94 94 151 134 141 91 136 120 141 100 100 129 82 107 107 107 152 115 129 105 144 135 111 124 74 145 122 138 118 26, 128,

Law, Amanda Lawson, David H. Le Foll, Bernard Le Guisquet, A.M. Le Melledo, Jean-Michel Leckman, James Leckman, James F. Lee, Buyean Lee, David Y. Lee, Ho-Joo Lee, Royce Lee, Sang Y. Lee, Soon Y. Leherecy, Stephane Lehrmann, Elin Leibenluft, Ellen 117, 142 Leibowitz, Sarah Leman, Samuel Lemire, Andrew Lemmon, Vance Lenane, Marge Lenartz, Doris Lencz, Todd 151 Lenox, Robert Lenroot, Rhoshel Leon, Andrew Leow, Alex D. Lerch, Jason Lerer, Bernard Lesage, Anne Lesser, Martin Leung, Hoi-Chung Levant, Beth Lever, John R. Levin, Edward D. Levine, Ari Levine, Louise Levine, Michael S. Levitt, Pat Levy, Mya E. Lewis, David Lewis, David A. Lewis, Lydia

153 108 89

205

63 138 113 90 122 155 140 113 97 154 108, 137 138 134 152 155 45, 96, 53 90 100 50 105 143 102, 129, 101 115 105 140 105 125, 149 54 148 104 122, 135 134 129 94 108 108 83 151 32 147 49

Author Index

11/17/05

7:49 AM

Lewis, Michael Lewis, Shon Lewis, Stephen F. Lewy, Alfred Leyton, Marco 116 Li, Jun Li, Ting-Kai Li, Wei Li, Xin-Min Li, Yu Li, Z. Li, Zhen Li, Zhu Liang, Shi Libby, Anne M. Liberzon, Israel Lieberman, Jeffery A. Lieberman, Jeffrey 129 Lieberman, Jeffrey A. Lieberman, Joseph A. Liebowitz, Michael Lifschytz, Tsuri Light, Gregory Light, Gregory A. Lim, Kelvin O. 152 Lim, Pilar Lin, Daniel Lin, Ping Lin, Qian Lin, Weili Lindell, Stephen Lindell, Stephen G. Lindenmayer, J-P Linnoila, Markku Lipschitz, Alan Lipska, Barbara Lipska, Barbara K. Lipsky, Robert Lisanby, Sarah H. Litten, Raye Littleton, John Liu, Amy

Page 206

53 55 130 76 95, 113,

Liu, Danni Liu, Liyan Liu, Yijun Livni, Eli Locklear, Julie Loebel, Antony 131, 144, 148, 154 Lombardo, Illise Lominac, Kevin D. London, Edythe London, Edythe D. Looney, Christopher Lopresti, Brian J. Lorell, Beth Loughead, James Louie, Pearl M. Louis, Caroline Love, Raymond C. Low, Nancy C. Lowe, Mark J. Lu, Bai Lu, Brett Y. Lu, Xueling Luber, Bruce Luckenbaugh, David Lucki, Irwin Lukas, Scott Lukas, Scott E. Lund, Trent D. Lyons, David Ma, Yilong Ma, Zhongze Maas, Luis C. Macciardi, Fabio MacDonald, Jessica Mack, David Mack, Wendy J. Mackeprang, Torben MacKillop, James Madayag, Aric Madras, Bertha K. Maggin, Jeremy Magistretti, Pierre J. Magolda, Ron Mah, Linda

145 135 120 129 116 151 149 108 109 145 106 114 55, 127, 89, 115 130 123 125 101 129, 149 113, 134, 127 122 146 148 114 115 92, 113 149 92 144 41, 81 127 95 123 61 61 135

206

109 101 120 134 95 105, 129, 144 151 51, 138 95, 113 114 124, 139 148 128 127 121 128 123, 124 116 98 130 139 123 125, 146 123 117 134 89 74 90 97 134 149 130 103 89 119 114 101 134 94 23 148 118

Author Index

11/17/05

7:49 AM

Maharajh, Keeran Maidment, Karron M. Maier, Steven Mailman, Richard Mailo, Kevin Majcher, Magda Majumdar, Sonalee Makris, Nikos Makriyannis, Alexandros Malaspina, Dolores Malberg, Jessica Malberg, Jessica E. Malenka, Robert Malhotra, Anil Malhotra, Anil K. 132, 151 Malison, Robert Mallinckrodt, CH Mallinger, Alan G. Maloney, Thomas Manaois, Meghan Mandel, Francine Mandelkern, Mark A. Maness, Patricia F. Mani, Shaila Manji, Husseini 123 Manji, Husseini K. 121, 146 Mann, J. J. Mann, J. John Mannaert, Erik Mansbach, Hank Manschreck, Theo Mao, Lian Mao, Xiangling Mao, Xiangling S. Marangell, Lauren Marchuk, Douglas A. Marcovina, Santica M. Marcus, Monica M. Marcus, Ronald Marder, Stephen Marder, Stephen R. Marenco, Stefano

Page 207

148 143 36 104 122 103 149 118 77 128, 130 126 123 73 130 102, 129, 31 110 140 111 111 144 95 115 43 60, 83, 98, 23, 97, 135, 139 121,125 119 91 105 107 128 137 122, 123 109 149 130 131, 152 152 130, 132 137

207

Mark, Black Mark, Slifstein Markou, Athina 112, 135 Markowitz, John Marmar, Charles Marquis, Karen 150 Marquis, Karen L. Marsh, Abigail Marsh, D.M. Marsh, Harold M. Martell, Bridget Martin, Kelsey Martin, Kimberly Martinez, James Martis, Brian Martone, Robert Marx, Christine E. Masand, Prakash S. Masliah, Eliezer Mason, Barbara Massari, Carla Massimini, Marcello Mathalon, Daniel H. Mathew, Sanjay J. Mathew, Shiny V. Mathias, C.W. Mathis, Chester Mathis, Chester A. 138, 139 Mattay, Venkata S. 116, 120, 127, 138, 140, Matute, Melissa Maullin, Nathalie Maxwell, Christina Mayer, Emeran Mayer, Emeran A. Mayes, Linda C. Mayhew, Michael B. Maynard, Melissa Mazandarani, Hossein Mazar, Nina McBride, William J. McCall, W. V.

101 129 35, 54, 103 125 90, 126, 148 99 106 118 112 65 130 123 137 90 89 123 108 61 151 132 104, 130 137 127 106 138 116, 124, 90, 102, 141, 152 149 136 149 46 138 140 150 115 126 117 135 97

Author Index

11/17/05

7:49 AM

McCarthy, Timothy McCloskey, Michael S. McClure, Erin B. McCohana, Claire W. McConnell, Susan McCormack, Joanne McDonald, Heather McDougle, Christopher McDougle, C. J. McElroy, Susan McElroy, Susan L. McEvoy, Joseph McEvoy, Joseph P. McFarr, Lynn Marcinko McGlashan, Thomas H. McInnes, Lynne A. McInnis, Melvin McKay, Ronald D.G. McKelvey, George M. McKinstry, Robert McLaughlin, Ryan J. McMahon, Francis McMahon, Robert P. McNamara, Robert K. Meador-Woodruff, J. H. 147 Medori, Rossella Meichle, Sean P. Meigs, James B. Meitinger, Thomas Melendez, Gilia Melhem, Nadine Mello, Andrea F. Mello, Marcelo F. Mello, Nancy K. 113, 114 Meloni, Edward G. Meltzer, Carolyn C. 124, 138, 139 Meltzer, David Meltzer, David O. Meltzer, Herbert Y. Mendelowitz, Alan Mendelson, Jack H. 114

Page 208

39 108, 117 142 116 37 148 99 83 115, 151 108 107 55, 127 130 128 130 131 124 30 118 139 94 124 128 135 101, 128,

Meng, Fan 145 Menza, Matthew 98 Merchant, Kalpana 147 Meredith, Charles W. 112 Merikangas, Kathleen R. 123, 124 Merzenich, Michael 152 Meulman, Ellen 145 Meyenberg, Naxhielli 105 Meyer, E. T. 134 Meyer, Jonathan 131 Meyer, Roger 38 Meyer-Gomes, Katrin 129 Meyer-Lindenberg, A. 29, 68, 90, 120, 138, 141 Meyer-Lindenburg, A. 127 Meyers, Adam 128 Mezey, Eva 97 Miceli, Jeffrey 103 Miczek, Klaus A. 94, 124 Mien, Key 145 Mikell, Charles B. 128 Milak, Matthew S. 135 Milbrandt, Jeffrey 104 Milham, Michael 117 Miller, Alexander 105 Miller, Alexander L. 152 Miller, Andrew 153 Miller, Andrew H. 109, 138 Miller, Gregory A. 130 Miller, J. 94 Miller, Rachel 148 Miller, Raymond 106 Miller, Sue 97 Miller, Tandy J. 130 Milligan, Graeme 33 Mintun, Mark 26, 139 Mintun, Mark A. 138 Mintzer, Jacobo 131, 148 Miranda, Robert 114 Mirsky, Allan F. 90 Mitchell, Paul J. 126 Mitkus, Shruti N. 127 Mitterhauser, Markus 145 Mizoguchi, Hiroyuki 90 Mletzko, Tanja 121

119 147 152 109 104 125 114 114 111, 112, 124 116, 118, 38 131 108, 131 148 111, 113,

208

Author Index

11/17/05

7:49 AM

Mletzko, Tanya Moberg, Paul J. Moeller, F. Gerard Moeller, Frederick G. Mogg, Karin Mohs, Richard Moinuddin, Asif Moller, Hans-Jurgen Molloy, Fredrick Molnar, Chris Mondal, Amal C. Monk, Christopher S. Monkul, Serap E. Montague, Read Monteggia, Lisa Monteggia, Lisa M. Monti, Peter Montrose, Debra M. Moore, Gregory J. Moore, Shonagh K. O’Leary Moran-Gates, Taylor Morgan, C.J. Morozova, Elena Morrato, Elaine H. Morris, John Morris, John C. Morris, Sarah Morris, Sarah E. Morrison, John H. Morrow, A. Leslie Mosconi, Matthew Moscrip, Tammy D. Moses-Kolko, Eydie L. Mossaheb, Nilufar Mouri, Akihiro Mu, Qiwen Mueller, Bryon A. Muglia, Louis Mukherjee, Jogesh Mukhopadhyay, Nitai D. Mulert, Christoph Mulia, Pierandrea Muller, Walter E. Mungas, Dan Munn, Jaclyn L.

Page 209

153 151 111 144 96 128, 131 139 109 149 104, 131 125 96 140 52 91, 115 121 114 117 123 118 151 106 153 145 44 138 112 131 90 113 116 123 138 145 90 104 113 104 155 103 109 109 124 89 93

Murphy, Anne Murphy, James M. Murphy, Kerry L. Murre, Jaap Murrell, Jill Muse, Robert Musgnung, Jeff Musselman, Dominique L. Mutel, Vincent Myers, Richard M. Naber, Dieter Nabeshima, Toshitaka Nader, Karim Nagappan, Guhan Nahas, Ziad Naliboff, Bruce D. Nanda, Steve A. Napierata, Lee Napolitano, Barbara Narasimhan, Meera Narayana, Ponnada A. Narendran, Raj Narvaez, Jenille M. Nash, Laurie Nasrallah, Henry Nasrallah, Henry A. Nathan, Pradeep J. Nayak, Sahana Neale, Ann Neary, Alaina C. Nedza, F. M. Negus, S. S. 113 Nelson, David Nelson, Erika Nemeroff, C. B. Nemeroff, Charles 124, 153 Nemeroff, Charles B. 121, 138 Nettler, Steven Neuhold, Lisa Neumaier, John Neumaier, John F. Neumeister, Alexander

209

85 135 118 59 116 40 145 121 54 145 104, 126 51, 90 96 98 104, 131 138 121 91, 97 148, 151 124 111 129 151 134 131 131 137, 138 100 70 149 148 91, 112, 70 115 122 29, 46, 67, 92, 114, 100 137 70 114 125

Author Index

11/17/05

7:49 AM

Neve, Rachael L. New, Antonia S. New, AS Newman, Amy H. Newman, Michael E. Newman, Stephen Newman, Timothy K. Newmark, Randall E. Neylan, Thomas Neylan, Thomas C. Ng, Johnny Nguyen, Chau H. Niaura, Raymond Nichols, Charles Nichols, David Nicoletti, Mark A. Nicolini, Humberto Niebler, Gwendolyn E. Nierenberg, AA Nierenberg, Andrew Nierenberg, Jay Nikulina, Ella M. Nimgaonkar, Vishwajit L. Ninan, P. T. Ninan, Philip T. Nnadi, Charles Noda, Yukihiro Nofzinger, Eric A. Noll, Douglas C. Noonan, Carolyn Nordstrom, Anna-Lena Nordstrom, Peter Nuechterlein, Keith Nugent, Allison C. Nurnberger, John Nurnberger, John I. Nutche, Jeffrey Nutche, Jeffrey J. Nutt, David Nutt, David J. O’Brien, Charles 136 O’Brien, Charles P. O’Connor, Megan M. O’Dell, Laura E.

Page 210

91, 136 138 118 91, 134 125 122 95, 109 138 125 147 140 154 71 132 104 140 105 109 110 122 132, 134 124 147 122 122 132 90 147 140 143 125 125 105 96, 118 124 116, 134 147 117, 128 48 126 38, 57, 71, 112 139 134

210

O’Donnell, James M. O’Donnell, Kelley C. O’Donnell, Patricio O’Donovan, Michael O’Hara, Ruth O’Neill, Barry Ogden, R. Todd Ohl, Frauke Ohrmann, Patricia Olfson, Mark Olin, Jason Olincy, A. Olincy, Ann 147 Oliveto, Alison Olsen, C. K. Olson, David P. Olson, Valerie Ongur, Dost Oquendo, Maria A. 135, 139, 145 Oren, Dan Orr, Scott P. Osincup, Dan Oster, Scott M. Oswald, Lynn Otte, Christian Ouellet, Danielle Owen, Michael Owens, Michael J. Owens, W. A. Ozdemir, Vural Pace, Thaddeus Pagnoni, Giuseppe Pai, Lee-Yuh Palamarchouk, Vitaly S. Palmer, Abraham Palmer, Abraham A. Palmer, Barton W. Palomo, Tomas Panagides, John Panchalingam, K. Pandey, Ghanshyam Pandey, Ghanshyam N. Pandina, Gahan

125, 146 121 68, 81 132 89 138 121 109 98 96 91 102 105, 132, 112 150 132 31 120 121, 125, 130 96 111 135 146 125 106 132 114 93, 107 148 153 138 97 111 24 134 106 100 100 140 98 125, 154 106

Author Index

11/17/05

7:49 AM

Pandina, Gahan J. Pangalos, Menelas Pangalos, Menelas N. 148 Panza, Katie Papakostas, George I. Pariante, Carmine M. Parker-Zavod, Erika Parnas, M. L. Parsey, Ramin V. 139 Parylak, Sarah Pascual, Ana Pascual, JC Patel, Jayendra K. Patel, Nick C. Patel, Raman Paterson, Neil E. Patkar, Ashwin A. Patterson, Paul Paul, Steven Paulus, Martin P. Pava, Joel Pavuluri, Mani Pavuluri, Mani N. Payne, Victoria Paz, Rodrigo Pearson, Jane Pedersen, Ron Peindl, Kathleen Peloian, John H. Penengo, MM Penetar, David Peoples, Laura Perahia, David G. Peralta, Jaun Manuel Perera, Tarique Perera, Tarique D. Perez, Victor S. Perich, J. Perkins, Diana Perrone-Bizzozero, Nora Perrotti, Linda Persky, Michael Peschardt, Karina

Page 211

109, 124 24 90, 126,

Peters, Jeffrey L. Petersen, Timothy J. Peterson, Bradley S. Peterson, Michael J. Pettegrew, Jay W. Pezawas, Lukas 141 Pfefferbaum, Adolf Phan, K. L. Phan, K. Luan Phan, Kin L. Phillips, Ann Phillips, Katharine A. Phillips, Mary L. Phillips, Tamara J. Picchini, Alyssa M. Pickar, David Pierre, Joseph M. Piesla, Michael Pihl, Robert O. Pikalov, Andrei 152 Pilar, Lim Pillay, Srinivasan Pilowsky, Daniel J. Pinard, Gilbert Pindborg, Lars Pine, Daniel Pine, Daniel S. 142 Pinho, Maria Piot-Grosjean, Odile Pitman, Roger Pitman, Roger K. Pitts, Cornelius D. Piven, Joseph Pizzagalli, Diego Platt, Donna M. Plaza, P. Plotsky, Paul M. Polcari, Ann Polesskaya, Oxana O. Poling, James Pollack, Mark H. Pollock, Bruce

155 126 109 122 134 121, 135, 112 100 141 105 126 148 135 123 36 39 139, 140 93 125 139 97 102 49 122 123 132 141 117 57 95 105 25 126 141 141 127, 130 102 115 126 99

211

147 93 155 132 140 120, 127, 90 138 117, 137 108 115 141 141 134 121 126 132 148 113 131, 143, 130 47 99 95, 116 119 45, 99 96, 117, 107 101 117 96, 143 144 116, 119 35 142 141 109 141 150 112 118 90

Author Index

11/17/05

7:49 AM

Page 212

Pollock, Jonathan 65 Polzer, John P. 95 Pong, Kevin 109 Poole, Sabrina 137 Pope, Harrison G. 107 Popoli, Maurizio 69 Porcu, Patrizia 113 Porjesz, B. 134 Porter, Richard 54 Posey, David J. 115 Potenza, Marc N. 142 Potkin, Steven G. 100, 154, 155 Potter, William 39 Poulin, Julie 147 Prakash, A. 110 Prasad, Harish C. 115 Prasad, Konasale M. 147 Pratap, Mali 139 Pratt, Jeremy 101 Prescot, Andrew P. 120 Price, David A. 107 Price, Julie C. 116, 118, 124, 138, 139 Price, Lawrence 145 Price, Lawrence H. 114 Price, R. Arlen 103 Prieto, David 100 Pritchett, Yili L. 107 Prudic, Joan 96 Puigdemont, D. 141 Pulicicchio, Claudine 126 Pultz, Joseph 131, 143, 152 Purselle, David 121 Pustavoitau, Aliaksei 118 Qaadir, Asfia 134 Qiang, Mei 136 Quesenberry, Charles P. 101 Quirk, Gregory 84 Quiroz, Jorge A. 123 Radant, Allen D. 105 Radel, Jeffery D. 122 Radulovic, Jelena 154 Ragland, John D. 147

Raison, Charles L. Rajarethinam, RP Rama, Arjune K. Ramamoorthy, Siva Ramsey, Dave Rao, Jagadeesh S. Rao, Uma Rapoport, Judith 105 Rapoport, Stanley I. Rasenick, Mark Rasenick, Mark M. Rasgon, Natalie Rasgon, Natalie L. Raskind, Murray Rasmussen, Hans Rasmussen, Kurt Rauch, Scott Rauch, Scott L. Raventos, Henriette Rawlings, Robert Rech, Richard Redish, A. David Redwine, Jeffrey M. Reed, Bruce Reeves, Scott T. Reich, W. Reinhart, Peter H. Reisberg, Barry Reiss, Allan Reist, Chris Reite, Martin Reite, Martin L. Ren, Xinguo Ren, Zhaoxia Ren-Patterson, R. Ren-Patterson, Renee Renshaw, Perry F. 134 Revicki, D. Reyes, Eduardo Reyes, Magali Reyes, Niko Reynolds, Charles F. Reynolds, Margaret F.

212

109 147 101 126, 148 131 154 142 37, 81, 139, 154 50, 69 98 95 142 79 119 147 47, 84 118 105 136 124 52 90 89 106 134 90 90 97 148 148 139 98, 125 137 151 149 120, 132, 131 147 109 123 124 142

Author Index

11/17/05

7:49 AM

Ribeiro, Saulo Rice, John Rice, Kenner C. Rich, Brendan A. 142 Richards, Michele R. Richards, Misty Richardson, Heather Richelson, Elliott Richtand, Neil M. Richter, Margaret A. Ridder, Stephanie Risbrough, Victoria Risbrough, Victoria B. Rivier, Catherine L. Rizavi, Hooriyah S. Robbins, Trevor Roberson-Nay, Roxann Robert, Forman Robert, Mach H. Robert, Zucker A. Roberts, Angela Roberts, James L. Robertson, A. S. Robertson-Plouch, Carol Robichaud, Al Robinson, Benjamin M. Robinson, Delbert G. 151 Robinson, Donald S. Robinson, Jim Robinson, Michael J. Robinson, Terry Rodd, Zachary A. Rodolico, John Rodriguez, Stephen Rodriguez, Steve Rodriguez, Steven Roehrs, Timothy Rogacki, Nancy Rogers, Laura S. Rohrer, Susan P. Rohsenow, Damaris Rojas, Don Rojas, Donald C.

Page 213

146 124 113 96, 117,

Role, Lorna Rollema, H. Rollis, Denise Rosa-Neto, Pedro Roseboom, Patrick H. Rosen, Amy S. Rosenbaum, Jerrold Rosenblum, Leonard A. Rosenheck, Robert Rosenkranz, Amiel Rosenstein, Donald Rosenthal, Norman R. 143 Rosenzweig-Lipson, S. Rosillon, Dominique Rosso, Isabelle Roth, Bryan Roth, Thomas Rothman, Richard B. Rotrosen, John Rowlett, James K. Roy, Alec Roy-Byrne, Peter P. Rubens, Robert Rubinow, David Rujescu, Dan Ruparel, Kosha Rupp, Claudia I. Ruppert, Andreas Russo, Christie Ryan, C. E. Ryder, Sean Rypma, Bart Saad, Ziad S. Saavedra, Juan M. Sacco, Kristi A. Sacheim, Harold Sacher, Julia Sachs, Gary Sackeim, Alexander Sackeim, Harold A. Sahakian, Barbara Saikali, Khalil Saint Marie, Richard L. Salzman, Carl

97 139 134 67 135 95 120 64 142 134 125 42, 72 117 137 138 119 45 107 148 122, 151 109 131 129, 148, 142 92 107 80, 93 135 117 104, 107 105 106 136 101 113 97 114 148 139

213

65 148 96 95 121, 142 95 143 114 55, 62 148 49, 79 107, 108, 126, 148 104 132 50, 153 97, 109 97 92, 134 142 92 143 97 49 109 128 151 109 90 122 131 140 120 143 105 126 145 122, 143 126 96 35 94 149 28

Author Index

11/17/05

7:49 AM

Sambataro, Fabio 138 Sambunaris, A. Samuelsson, Mats Sananbenesi, Farahnaz Sanchez, Yadira Sanders-Bush, Elaine Sangoi, Raj Sano, Mary Sanz, Javier Sassi, Roberto B. Saxena, Kirti Saxena, Sanjaya Saxon, Andrew J. Scahill, Lawrence Schaefer, Catherine A. Schaefer, Desiree M. Schanberg, Saul M. Schapiro, Mark B. Schatzberg, Alan Schatzberg, Alan F. Schechter, Lee Schechter, Lee E. Scheftner, Bill Scheiffele, Peter Scherrer, Jeffrey F. Schiltz, Craig A. Schlaepfer, Thomas E. Schloesser, Robert J. Schmahl, Christian Schmajuk, Mariana Schmid, Wolfgang Schmidt, Mark Schmithorst, Vince Schneider, Lon Schoepp, Darryle D. Schooler, Nina Schooler, Nina R. Schork, Nicholas J. Schreffler, Erica R. Schrick, Christina Schulkin, Jay Schultz, Robert T. Schulz, Charles Schulz, S. C.

Page 214

90, 116,

Schutz, Gunther Schwandt, Melanie Schwandt, Melanie L. Schwartz, Kelly Schwarzmann, Lesley K. See, Ronald E. Segal, David S. Segman, Ronen Segman, Ronnen H. Sei, Y. Sei, Yoshitatsu Seillier, Alexander Seitz, Patricia K. Self, David W. Semenova, Svetlana Sen, Srijan Seraji-Bozorgzad, Navid Sethuraman, Gopalan Sevak, Rajkumar Sevy, Serge 151 Shah, Kamini R. Shaham, Yavin Shahid, Mohammed 152 Shalev, Arieh Y. Shalom, Galit Shampine, Lawrence J. Sharma, Rajiv P. Shaw, Philip Shear, Paula K. Sheehan, David V. Sheikh, Javaid Sheikh, Nabila Shekhar, Anantha Sheline, Yvette Sheline, Yvette I. Shelton, Richard C. Shen, Joan Shen, Pei-Hong Shen, Shuyi Sher, Leo Shiffman, Saul Shilling, Paul Shilling, Paul D.

110 125 154 130 132 103 89 100 140 97 143 112 66 101 144 109 139 46 106, 122 126 109 124 65 142 135 143 121 119 96 120 39 94 62 108 148 148 105 91 154 115, 118 140 151 152

214

120 115 92, 135 107 143 94, 135 149 125, 143 149 151 149 107 111 91 135 96 118 126 93 129, 148, 142 80 108, 151, 143 125 89 105 37, 115 99 99 89 149 149 139 138 119, 143 151 137 107 135 71 104 149

Author Index

11/17/05

7:49 AM

Shim, Seong Shoaf, Susan Shoemaker, Jody M. Sholar, Michelle B. Shorman, Igor Shrivastava, Ram K. Shrivastava, S. P. Shungu, Dikoma C. Sibille, Etienne Sibley, David R. Sibon, Igor Sicard, Tricia Siegel, Arthur J. Siegel, Steve Siegel, Steven J. Siegle, Greg Siegler, Ilene Siegler, Ilene C. Siever, Larry 58 Siever, Larry J. Siever, LJ Silbersweig, David Sills, Terry Silveri, Marisa Silverman, Jeremy Simmons, Julian Simmons, Rosa M. Simmons, Tracy Simpson, George Simpson, Norman Singh, Jaskaran Sinha, Rajita Sircar, Ratna Siris, Sam Sitzer, David I. Siu, Cynthia Skudlarski, Pawel Skupny, Alicja Slawecki, Craig J. Sliwerska, Elzbieta Smagin, Gennady N. Small, Gary Small, Joyce Smith, A. R.

Page 215

144 92 149 111, 114 114 144 144 128, 137 90 154 116 95 111, 114 126 149 141 133, 146 109 24, 25, 42, 138 118 47 99 132 114 138 107 93 105 121 146 71 135 104 151 129, 154 104 111 136 119 111 34 131 106

215

Smith, Ashley K. Smith, Eric L. Smith, Gwenn Smith, J. K. Smith, Kelli E. Smith, Lisa J. Smith, Robert C. Snaterse, Mark Snow, Diane Snyder, Avi Snyder, Doug Soares, Jair Sofuoglu, Mehmet Sokolov, Boris P. Solomon, D. A. Sookman, Debbie Soorya, Latha Sorensen, Jill Soto-Perello, Jose Spanagel, Rainer Specker, Sheila M. Spencer, Thomas Spencer, Thomas J. Spiegel, David Spielman, Daniel Spindelegger, Christoph Spinelli, Simona Sporn, Alexandra Sprock, Joyce Srivastava, Lalit Stack, Gary Stahl, Stephen M. Stanford, Arielle D. Stanford, Kevin Stanford, Kevin E. Stanga, Zeno Stanley, Barbara H. Stanley, Jeffrey A. Stead, John D. Steadman, Timothy Steffens, David C. Stein, Joel Stein, Murray B. Steinberg, Joel L. Stenzel-Poore, Mary

130 114, 137 90 114 96 106 149 150 123 139 38 140 112 150 122 95, 116 115 39 148 76 113 78 134 91 97 145 115 105 101, 129 41 126, 148 144 150 135 94, 126 143 125 140 97 149 89 153 139, 140 111, 144 142

Author Index

11/17/05

7:49 AM

Stephan, Dietrich Stepien, I. Stern, Jessica Stevens, Rachel Stewart, Daniel G. Stigler, Kimberly A. Stolinski, Lisa R. Stone, William S. Stout, Robert L. Strakowski, Stephen Strakowski, Stephen M. 117, 126, 144 Straub, Richard 152 Straub, Richard E. 150 Stringer, Elizabeth Strode, Nicole L. Baganz Sturm, Volker Su, Jing Subhash, Aryal Sukhodolsky, Denis Sullivan, Edith V. Sullivan, Susan K. Sumner, Jennifer Sunderajan, Prabha Sunderland, Trey 44 Suomi, Stephen J. 109, 113, 115, 135 Suppes, Trisha Sureddi, Suresh Suresh, Rathi Surguladze, Simon Surwit, Richard S. Suslow, Thomas Susser, Ezra S. Sust, Steven 140, 152 Sutcliffe, James S. Sutherland, Ashley N. Sutton, Virginia K. Suyenobu, Brandall Suzuki, Kastuji Svarer, Claus

Page 216

86 154 89 101 140 115 146 105 141 56 94, 99, 25, 141, 127, 141, 119 93 143 90 139 155 90 142 115 121 26, 27, 34, 92, 95, 123 123 134 141 109 98 101 102, 116, 115 150 126 138 98 119

216

Svensson, Torgny Svensson, Torgny H. Swain, James E. Swann, Alan C. Swanson, Chad J. Swanson, James M. Swedish, Kristin Sweeney, John A. Sweet, Lawrence H. Swerdlow, Neal Swerdlow, Neal R. 150 Swift, Robert Swift, Robert M. Swyzen, Wim Szabo, Sandor Szalayova, Ildiko Szeszko, Philip R. Szulc, Kamila Szumlinski, Karen Szumlinski, Karen K. Tai, T.C. Talan, Jamie Talavage, Thomas Talbot, Peter S. Talbot, PS Talkowski, Michael E. Talledo, Jo A. Talmage, David Tambini, Arielle Tamminga, Carol Tamminga, Carol A. Tamura, Roy N. Tan, Hao Y. Tan, Hao Yang Tan, Hao-Yang Tan, Yun L. Tancer, Manuel E. Tang, Cheuk Tang, Min Tang, Yilang Tarazi, Frank Tarazi, Frank I. Tariot, Pierre Tauscher, Johannes

150 130 140 111, 144 96, 144 111 89 139 136 101 105, 149, 61, 114 112, 136 130 148 97 102, 151 103 24 151 108 40 116 129 118 147 150 63 102 29, 142 129, 150 108 140 152 102 153 136 140 99 92 92 151 62, 91 145

Author Index

11/17/05

7:49 AM

Taylor, Benjamin Taylor, Cindy Taylor, Joy Taylor, Kristin Taylor, Robert E. Taylor, Stephan Taylor, Stephan F. Teale, Peter Teicher, Martin H. Telang, Frank Terrace, Herbert S. Terranova, Jean-Paul Thakkar, Vatsal Thase, Michael E. 122, 141, 145 Thiele, Todd Thomas, A. Thomas, Binu Thomas, Mary L. Thomas, Steven Thomas, Suzanne Thomas, Yonette Thompson, Paul M. Thomsen, Morgane Ticku, Maharaj K. Tidey, Jennifer Tiefenbacher, Stefan Tillemans, Monique P. Tin, Adrienne Tinklenberg, Jared R. Tirado, Carlos F. Toalston, Jamie E. Todorov, C. Todtenkopf, Mark S. Tohen, Mauricio 151 Tokarczyk, Jan Tollefson, Gary Tollefson, GD Tomasi, Dardo Tomita, Hiro Tomoda, Akemi Tone, Andrea Tononi, Giulio Tornatzky, Walter

Page 217

135 126 89 115 136 140 118, 137 139, 148 141 111 123 121 143 98, 99,

Torossian, Carol Trapp, Bruce D. Treiber, Kristina Tremblay, Jacques Tremblay, Philippe Trisdorfer, Roanna Trivedi, Madhukar H. 145 Trotman, Louis Truesdale, Matthew Tsai, Guochuan E. Tse, Maric T. Tsopelas, Nicholas Tsou, Pon Tsuang, Debby W. Tsuang, Ming T. Tucker, Vivan L. Tummala, Raj Tunbridge, Elizabeth Tunbridge, Elizabeth M. Turetsky, Bruce I. Turkoz, Ibo Turkoz, Ibrahim 124 Twamley, Elizabeth W. Tyrka, Audrey R. Uhart, Magdalena Uhde, Thomas W. Ujike, Hiroshi Ungerleider, Leslie Upadhyaya, Ameet Upadhyaya, Himanshu Upadhyaya, Margi Urani, Alexandre Vaidhyanathaswamy, S. Vakkalanka, Radha K. Vakkalanka, R. Valdes, Ignacio Valdez, Jeffrey N. Valente, Elizabeth Valuck, Robert J. Van Ameringen, Mickael Van Den Buuse, M. Van der Veen, Jan W. Van Heertum, Ronald L.

53 94 150 111 78 93 92 140 92 136 114 142 150 125 89 136 135 95 97, 136 99, 122, 126 91 110 111 145 141 28 132 92

217

90 23 124 96 95 138 121, 122, 123 123 147 126 139 147 147 107 126 123, 145 25, 151 149 151 106 95, 105, 151 114, 145 146 123 51 45 147 93 147 120 149 150 127 111 147 141 145 122 51 137 121

Author Index

11/17/05

7:49 AM

Van Kammen, Daniel P. Vance, Jeffery Vapnik, Tanya Vargas, Gabriel Vasquez, Delia Vaughan, Roxanne Vawter, Marquis P. Vecsey, Chris Veenstra-Vander Weele, J. Velligan, Dawn Velligan, Dawn I. Vera, Elizabeth Verbitskaya, Elena V. Verbitsky, Miguel Verchinski, Beth A. 141 Verdeli, Helena Vermetten, Eric Versavel, Mark Vesta, Yethiraja Videbaek, Charlotte Vieta, Eduard Villafuerte, Sandra M. Vincow, Evelyn Vinogradov, Sophia Vinton, Deborah T. Viviano, Tom Voet, Hubertus H. Voglmaier, Susan Vogt, Jerry Volkow, Nora D. Vollenweider, Franz Von Zastrow, Mark 151 Vosburg, Suzanne K. Votaw, John R. Voytek, Bradley Vythilingam, Meena Wadenberg, Marie-Louise Wadsak, Wolfgang Wager, Tor D. Wagner, Angela Wagner, Christopher Wagner, Karen Wagner, Tara

Page 218

147 146 96 151 97 134 145 153 134 100 152 144 112 134 116, 127,

Walker, Glenn B. 152 Walker, John 131 Walker, Mary M. 96, 144 Walker, Quentin D. 112 Walkup, John 66 Walline, Crystal C. 91 Walsh, B. T. 107 Walsh, David M. 145 Walsh, James K. 109 Walton, Kimberly 136 Wand, Gary 146 Wang, Dayong 90 Wang, Gene-Jack 141 Wang, Jun-Sheng 103 Wang, Liqun 120 Wang, Mei 152 Wang, Wei V. 151 Wang, Yang 116 Wang, Yun 98 Ward, Herbert E. 95 Warner, Virginia 99 Warren, Kenneth 137 Warren, Stephen 83 Warrington, Lewis 129 Wasserman, Stacey 115 Wassink, Thomas H. 116, 127 Watkin, JG 110 Watkins, Lana 97 Watner, Dryden 114 Watson, Adam 132 Watson, Stanley 97 Watson, Stanley J. 93, 145 Watts, Val J. 154 Waugh, Christian E. 140 Webster, Maree J. 101 Wedig, Michelle M. 118 Weickert, Cynthia 63 Weickert, C. S. 101, 102 Weilburg, Jeffrey B. 152 Weiler, Martin A. 129 Weinberger, Daniel 29, 30, 40, 42, 63, 152 Weinberger, Daniel R. 40, 90, 102, 116, 120, 127, 137, 138, 140, 141, 149, 150, 151, 152

99 119, 145 103 114 119 48 145 141 152 117, 142 149 149 154 153 111 72 33, 69, 112 112 95 99 150 145 140 116 97 122 128

218

Author Index

11/17/05

7:49 AM

Weiner, Michael Weinshenker, David Weinstein, Mitchell Weiss, Anthony P. Weiss, Friedbert Weiss, Susan Weissfeld, Lisa A. Weissman, Myrna M. Welch, Ron Wells, Barbara Welsh, Robert C. Wernicke, Joachim F. Wesnes, Keith A. Wess, Juergen Wessel, Thomas West, Britt Westenberg, Herman Westenberg, Herman G. Wetterberg, Lennart White, Tara L. White, Tonya Whitfield, Susan L. Whitsel, Rachel Whybrow, Peter C. Wickramaratne, Priya Wiegand, R. Wiegand, Ryan E. Wier, Lauren Wilhelmsen, Kirk C. Wilkins, Consuelo Williams, Mark J. Williams, Michael Williams, Redford Williams, Redford B. Williams, Wendol A. Williamson, Douglas Winsky, Lois Wint, Dylan Wirshing, Donna A. Wirshing, William C. Wisner, Katherine L. Wisniewski, Stephen Wisniewski, Steven Wittchen, Hans-Ulrich Woerner, Margaret

Page 219

89 31 106 152 57, 71 80 139 99, 137 150 111 118 98, 107 109 92 97 131, 152 119 145 104 136 152 104 144 95 99 134 115 114 93 139 91 109 133, 146 109 136 99 36 152 132 132 138 122 122 95 148

Woerner, Margaret G. Woertwein, Gitta Wohlreich, MM Woldbye, David P. Wolf, Dan Wolf, Fred Wolinsky, Toni D. Wong, Dean Wong, Dean F. Wong, Dona Lee Wong, Erik Wong, Erik HF Wong-Faull, David C. Wood, Marcelo A. Wood, Ruth Wood, Suzanne E. Woodgett, Jim Woods, Scott W. Woody, George E. Woolston, Dixie J. Woolwine, Bobbi J. Wozniak, David Wozniak, Janet Wozniak, Jeffrey R. Wright, Christopher I. Wright, Ron Wu, Chi-Cheng Wu, Jingwei Wu, Min Wu, Nan-Ping Wu, T. John Wu, Xiaoling Xian, Hong Xiang, Jim Xu, Haiyun Xu, Ke Xu, Wen Xu, Zhi-Qing D. Yale, Scott Yamada, Kiyofumi Yamamoto, Tsuneyuki Yan, Bing Yang, Ruoyong Yang, Xiaoju Yang, Yili

219

129 92 110 92 147 103 96 66 39, 119 108 152 151 108 153 43 118 60 130 112, 137 144 109 104 122 113 118 107 90 116 153 108 89 130 142 143 129 129, 137 122, 151 144 128 51 137 122 148 146 147

Author Index

11/17/05

7:49 AM

Yap, Jasmine J. Yaw, Senyah Yehuda, Rachel 143 Yesavage, Jerome A. Young, Elizabeth A. 146 Young, Larry Young, Simon N. Youngstrom, Eric A. Yu, Yang Yuan, Qiaoping Yurgelun-Todd, Deborah Yurgelun-Todd, D. A. Zacher, Christiane Zacny, James Zajac-Benitez, Caroline Zaleska, Margaret Zandi, Peter Zappert, Laurel N. Zarate, Carlos Zarate, Carlos A. Zavadoski, W. J. Zboyan, Holly Zelazny, Jamie Zhang, Hanting Zhang, Jean Zhang, Lei Zhang, Wei Zhang, Xiang Y. Zhang, Xuexiang Zhang, Ying Zhao, Y. Zhao, Zaorui Zheng, Kang Zheng, Ling Zhong, Huailing Zhou, Dong F. Zhou, Xianjin Zhou, Yuan Zhu, Baojin Zhu, Haojie Zhu, Wei Zhu, Young Zielinski, Tanya

Page 220

124 101 74, 125,

Zink, Mathias Ziolko, Scott K. Zisook, Sidney Ziwich, Rachel Zoltick, Brad Zorn, Stevin Zou, Mu-Fa Zubenko, George Zubieta, Jon-Kar Zuchner, Stephan Zvartau, Edwin E.

89 106, 145, 83 113 146 128 137 95 132, 137 120 85 123 109 124 142 27 146 148 123 125 146 126 111, 146 97 153 144 99 131 125 144 89 144 153 116 90 100, 103 103 90 98, 101 91

220

120 124, 139 79 102 140 152 134 34, 44 85, 119 133, 146 112

MAPS 2006.qxp

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Page 221

MAP

69' x 36'

Kohala 1

BOARDROOM

Lagoon

Lagoon Lanai

35' x 55'

28' x 36'

Kona 2 Kona 3 21' x 36'

222 Waikoloa Suites

Waikoloa 1 Waikoloa 2 Waikoloa 3 31' x 23' 31' x 23' 31' x 23'

30' x 36'

Kona 1

80' x 36'

Kona 4

80' x 36'

Kona 5

Kona Ballroom

Grand Staircase

up

To Main Lobby

7:50 AM

LOUNGE

Queen's 4

35' x 55'

36' x 55'

King's 1

Queen's 5

37' x 55'

Queen's 6

36' x 55'

Grand Promenade

95' x 134'

King's 2

37' x 55'

Monarchy

Function and Meeting Space

11/17/05

69' x 36'

Kohala 2

69' x 36'

Water’s Edge Ballroom

King's 3

120' x 206'

69' x 36'

Kohala 3

Grand Ballroom

HILTON WAIKOLOA VILLAGE

Kohala 4

Kohala Ballroom

MAPS 2006.qxp Page 222

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223

MAPS 2006.qxp

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Future ACNP Annual Meetings Dates

Hotel

Location

December 3 - 7, 2006 December 9 - 13, 2007 December 7 - 11, 2008

The Westin Diplomat Boca Raton Resort & Club The Fairmont Scottsdale Princess

Hollywood, Florida Boca Raton, Florida Scottsdale, Arizona

Summary Program Event

Time

Location

Saturday, December 10, 2005 On-Site Registration Pre-Paid Registration

10:00 am - 6:00 pm 10:00 am - 6:00 pm

Kona 3 Outside Waikoloa 1

Sunday, December 11, 2005 On-Site Registration Pre-Paid Registration Teaching Day Hot Topics Oakley Ray History Lecture

7:00 am 7:00 am 8:00 am 2:30 pm 7:00 pm -

5:00 pm 5:00 pm 12:30 pm 5:00 pm 8:00 pm

Kona 3 Outside Waikoloa 1 Monarchy Ballroom Kona 4 & Kona 5 Kona 4

Monday, December 12, 2005 On-Site Registration Pre-Paid Registration Awards Presentation President’s Plenary Poster Viewing Distinguished Lecture Panel Sessions Poster Session I Issue Oriented Study Groups

7:00 am 7:00 am 8:00 am 8:30 am 10:30 am 1:00 pm 2:30 pm 5:30 pm 7:45 pm -

5:00 pm 5:00 pm 8:30 am 11:30 am 4:30 pm 2:15 pm 5:00 pm 7:30 pm 9:00 pm

Kona 3 Outside Waikoloa 1 Monarchy Ballroom Monarchy Ballroom Kohala Ballroom Monarchy Ballroom See Program Book Kohala Ballroom See Program Book

Tuesday, December 13, 2005 On-Site Registration Pre-Paid Registration Panel Sessions Poster Viewing Issues in Ethics Panel Sessions Poster Session II

7:30 am - 5:00 pm 7:30 am - 5:00 pm 8:00 am - 10:30 am 10:30 am - 4:30 pm 12:00 pm - 2:30 pm 2:30 pm - 5:00 pm 5:30 pm - 7:30 pm

Kona 3 Outside Waikoloa 1 See Program Book Kohala Ballroom Monarchy Ballroom See Program Book Kohala Ballroom

Wednesday, December 14, 2005 Town Hall: Clinical Trials Registry Registration Panel Sessions Poster Viewing Business Meeting (Members Only) Memorial Symposium Panel Sessions Poster Session III

7:00 am 7:30 am 8:00 am 10:30 am 10:45 am 1:00 pm 2:30 pm 5:30 pm -

Kona 4 Kona 3 See Program Book Kohala Ballroom Kona 4 Queen’s 6 See Program Book Kohala Ballroom

Thursday, December 15, 2005 Registration Panel Sessions Teaching Neuropsychopharmacology Panel Sessions Reception

7:30 am - 3:00 pm 8:00 am - 10:30 am 12:30 pm - 2:00 pm 2:30 pm - 5:00 pm 7:30 pm - 10:30 pm

Kona 3 See Program Book Kona 5 See Program Book Monarchy Ballroom

ACNP Service Center Saturday (registration only) Sunday-Monday Tuesday-Wednesday Thursday

10:00 am 7:00 am 7:30 am 7:30 am -

6:00 pm 5:00 pm 5:00 pm 5:30 pm

Kona 3 Kona 3 Kona 3 Kona 3

ACNP Computer Center Sunday-Wednesday Thursday

7:30 am - 9:00 pm 7:30 am - 5:00 pm

Kona 2 Kona 2

8:00 am 5:00 pm 10:30 am 4:30 pm 11:45 am 2:15 pm 5:00 pm 7:30 pm

ACNP Executive Office • 545 Mainstream Drive, Suite 110 • Nashville, TN 37228