CURRICULUM VITAE Hans-Martin JÄCK, Ph.D. Professor of Immunology
Hans-Martin JÄCK, Ph.D. Division of Molecular Immunology Department of Internal Medicine III Friedrich-Alexander University Erlangen-Nürnberg Glückstrasse 6, D-91054 Erlangen, Germany Telephone: ++49 (9131) 8535912 Telefax: ++49 (9131) 8539343
[email protected] E-mail:
EDUCATION 1988
Ph.D. in Immunology, University of Tübingen, Germany (summa cum laude)
1984
Diplom (M.Sc. equivalent) in Biochemistry, University of Tübingen, Germany
1980
Vordiplom (B.Sc. equivalent) in Biochemistry, University of Tübingen, Germany
PROFESSIONAL APPOINTMENTS AND RESEARCH EXPERIENCE 1997 - present
Division Head & Professor
1997 - present
Lecturer
1996 -1997
Associate Professor
1990 - 1996
Assistant Professor
1988 - 1990
Postdoctoral Fellow
1984 - 1988
Research Assistant (Ph.D. student) Research Assistant (Ph.D. student) Research Assistant (Ph.D. student) Teaching Assistant
1984 - 1984 1984 - 1984 1979 - 1984
Division of Molecular Immunology Department of Internal Medicine III University of Erlangen-Nürnberg, Germany Loyola University Chicago Medical Center Department of Microbiology & Immunology Loyola University Chicago Medical Center Department of Microbiology & Immunology Loyola University Chicago Medical Center Department of Microbiology & Immunology, University of California, San Francisco Department of Microbiology & Immunology University of California, San Francisco Laboratory of Radiobiology Basel Institute for Immunology, Basel, Switzerland Max-Planck Institute, Tübingen, Germany Institute of Biochemistry, Tübingen, Germany
RESEARCH OBJECTIVES (Molecular Biology of B Lymphocytes) My overall research activities concentrate on molecular aspects of the humoral immune response. In particular, my lab is interested in signaling pathways and cellular factors that control early maturation and selection of normal B lymphocytes as well as terminal differentiation into antibody-secreting plasma cells. In addition, we investigate the mechanism by which aberrant mRNA, so-called nonsense mRNA, is degraded and whether this process is important in order to control VDJ recombination and thus the monospecificity of B lymphocytes. • Molecular control of B cell development (Structure, function and signal-transducing capabilities of the immunoglobulin-like pre-B cell receptor, role of microRNA, Ig class switch) • Nonsense codon-mediated degradation (NMD) of non-functional Ig mRNA (mRNA Surveillance) • Molecular mechanism of plasma cell differentiation and tumorigenesis • Role of endogenous retroelements in autoimmune diesease
RESEARCH FUNDING
Pending applications for extramural funding None
Current Extramural Funding 06/13 - 05/17
01/10 – 03/15
German Research Community (DFG) Transregio TRR130: B cells in immunity and autoimmunity Project 9: "microRNA-controlled generation and maintenance of humoral memory" Positive evaluation, decision May 2014 Principal Investigator: Hans-Martin Jäck German Research Community (DFG) Training Grant GRK1660 (project C4) “Role of miRNA in plasma cell differentiation” Principal Investigator: Hans-Martin Jäck
Previous Funding 10/09 – 06/13
BayImmuNet , Hightec initiative State of Bavaria “The Mighty Mouse: An in vivo factory to produce human antibodies” Principial investigator: Hans-Martin Jäck & Jürgen Wittmann
02/07 – 05/13
German Research Community (DFG)
Research Group FOR 832/1: Regulators of Humoral Immunity: (project 2, JA968/5-2) “Mechanism of pre-B cell receptor mediated selection of the antibody repertoire” Principal Investigator: Hans-Martin Jäck 09/06 – 08/11
Interdisciplinary Center Grant in Clinical Research (IZKF) “Role of microRNA in B cell maturation and B leukemogenesis” (Project D5) Principal Investigators: Hans-Martin Jäck & Jürgen Wittmann
01/09 – 01/11
German Research Community (DFG) Individual grant JA 968/6-1 “Current Concepts in Immunology” (Support for Autumn School in Immunology) Principal Investigator: Hans-Martin Jäck
2009-2010
Hiege-Stiftung gegen Hautkrebs, Hamburg "Evaluation of diagnostic and therapeutic options of microRNAs (miRNAs) in malignant melanoma" Principal Investigators: J. Wittmann, H.-M. Jäck and G. Schuler
09/07 – 08/10
Interdisciplinary Center Grant in Clinical Research (IZKF) “Molecular characterization of signaling complexes in anergic, autoreactive and normal B lymphocytes“ (Project A7) Principal Investigators: Hans-Martin Jäck & Dirk Mielenz
05/00 - 04/09
German Research Community (DFG) Training Grant GRK592 (project A1) “Mechanism of pre-B cell receptor mediated signal transduction” Principal Investigator: Hans-Martin Jäck
01/02 - 09/07
German Research Community (DFG) Individual Research Grant (project JA 968/2) “Structure and function of the pre-B cell receptor” Principal Investigator: Hans-Martin Jäck
06/06 – 05/07
ELAN Fonds (Intramural, FAU Erlangen-Nürnberg) “Role of the transcriptions factor KLF2 in B cell maturation” Principal investigators: Wolfgang Schuh & Hans-Martin Jäck
2005 – 2006
ELAN Fonds (Intramural, FAU Erlangen-Nürnberg) “Role of micro-RNA in early B cell maturation” Principal investigators: Jürgen Wittmann & Hans-Martin Jäck
2000 - 2004
Alzheimer’s Fund (private contribution) “Role of aberrant proteins in the pathogenesis of Alzheimer’s disease” Principal Investigator: Hans-Martin Jäck
2000 - 2002
German Research Community (DFG) Collaborative Research Project Grant SFB263 “Role of Notch-1 in cell type decisions and apoptotic cell death processes during development and differentiation of B lymphoid cells” Principal Investigators: Hans-Martin Jäck and Birgit Jehn
1999 - 2003
Roche Pharmaceuticals “In vitro translation using a bioreactor” Principal Investigator: Hans-Martin Jäck
1999 - 2006
German Research Community (DFG) Collaborative Research Project Grant SFB466 “Molecular mechanisms of pre-B cell receptor-mediated induction of proliferation and apoptosis in normal B cell precursor cells” Principal Investigator: Hans-Martin Jäck
1999 - 2003
Human Frontier Science Project (HFSP) “Molecular misreading, nonsense transcript stability and aberrant accumulation in Alzheimer disease” Principal Investigator(s): E. Hol, Hans-Martin Jäck, H. Dietz, M. Racchi, J. Verhaagen
1995 - 1998
Tobacco Research Council “The Role of Surrogate Light Chains During B Cell Development” Principal Investigator: Hans-Martin Jäck
1995 - 1997
American Cancer Society of America - Research Award “Biological Function of CD30” Principal Investigator: Thomas Ellis Co-Investigator: Hans-Martin Jäck
1995 - 1996
American Cancer Society, Illinois Division “The Role of Surrogate Light Chains during B Cell Development” Principal investigator: Hans-Martin Jäck
1994 - 1998
National Institute of Health (NCI), NIH R29 Grant “The Role of Endogenous Antigens in B Cell Tumor Formation” Principal Investigator: Hans-Martin Jäck
1994 - 1997
American Cancer Society of America Junior Faculty Research Award “The Role of Endogenous Antigens in B Cell Tumor Formation” Principal Investigator: Hans-Martin Jäck
1994 - 1997
Allergen Inc., San Francisco (contract) “Generation of a mouse/human chimeric anti-poison ivy
antibody” 1994 - 1997
American Cancer Society “Endogenous Antigens in B Cell Tumor Formation” Principal investigator: Hans-Martin Jäck (Due to scientific overlap with NIH R29 grant below, I did not accept this research award)
1992 - 1995
Schweppe Career Development Award Principal Investigator: Hans-Martin Jäck
1991 - 1994
National Cancer Institute, NIH R01 Grant “Biology and Treatment of AIDS Lymphomas” Principal Investigator: Richard Fisher Co-Investigator: Hans-Martin Jäck
1992 - 1993
Loyola Cancer Research Institute, Potts Foundation (intramural) "Mechanisms of Immunoglobulin mRNA Degradation" Principal Investigator: Hans-Martin Jäck
1992 - 1993
American Cancer Society, Illinois Division "The Role of Endogenous Antigens in B Cell Tumor Formation" Principal Investigator: Hans-Martin Jäck
1990 - 1991
Loyola Cancer Research Institute, Potts Foundation (intramural) "The Role of Endogenous Antigens in B Cell Tumor Formation" Principal Investigator: Hans-Martin Jäck
PROFESSIONAL ACTIVITIES • Member of Editorial Boards, Study Sections and Review Panels 2011-present
2010 - present
Member, advisory board (Kuratorium), Fraunhofer-Instituts für Zelltherapie und Immunologie (IZI), Leipzig Member, Editorial Board, Frontiers in Molecular Antigen Presenting Cell Biology Review Editor, Frontiers in B Cell Biology
2009 - present
Member, Editorial Board, European J. of Immunology
2004 - present 2005
Member, Editorial Board, Current Immunology Reviews Guest Editor, Seminars in Immunology
2001 - 2005
Associate Editor, Journal of Immunology
2002
Member, Evaluation Committee for the Heinrich-Pette Institute, Leibniz Society Germany
2011- present
1999 - present
Member, Committee on Animal Research, State of Bavaria, District, Lower Franconia, Germany
1996 - 1998
Member, Medical Advisory Board Leukemia Research Foundation Chicago
1996 - 1999
Member, Adhoc study section National Cancer Institute of Canada
1996
Member, Adhoc Immunology and Virology NIH study section
• Extramural Activities and Appointments 2013-present
President, German Society of Immunology (DGfI) Presidency starts January 2013)
2008 - present
Leading coordinator, Immunology Autumn School German Society of Immunology (DGfI)
2007 -present
Member, committee on education in immunology German Society of Immunology (DGfI)
2006 - present
Speaker of 11 research study groups of the German Society of Immunology (DGfI)
2006 - 2010
Associate council member, German Society of Immunology
2004 - present
Speaker, research study group B Lymphocytes, German Society of Immunology http://www.molim.uni-erlangen.de/akb/
2000 - present
Council member, Biochemical Society Tübingen (MoBBEL), Germany
• University Programs and Committees (University of Erlangen, Germany) 2013 - present
Member, Coordination committee DFG Transregio TRR130 initiative
2010 - present
Director, DFG Doctoral Training Grant GRK1660 Key signals of adaptive immunity http://www.lymphozyten.de/
2006 - present
Co-Director, DFG research group FOR832 Regulators of humoral immunity http://www.for832.uni-erlangen.de/kontakte.html
2004 - present
Member, Committee on Research and postgraduate education, Medical School University of Erlangen-Nürnberg
2002 - present
Director, Immunology module Graduate programs in Molecular Medicine and Biology
2000 - 2009
Director, DFG Doctoral Training Grant GRK592 Lymphocytes http://www.lymphozyten.de/
1998 - 2002
Member, Intramural Research Grant Committee (ELAN) Medical School
1997 - 2002
Member, Committee on Research, Medical School
• Departmental Committees (Loyola University Chicago, Medical School) 1990 - 1997
Member, Graduate Admission Committee Graduate Program in Microbiology and Immunology
1992
Chair, Committee for the Evaluation of Graduate Affairs
1995
Chair, Faculty Search Committee
1996 - 1997
Member, Equipment Committee
1996 - 1997
Member, Committee for Public Education
• University Programs and Committees (Loyola University Chicago, Medical School) 1990 - 1997
Member, Interdepartmental Ph.D. Program in Molecular Biology
1995 - 1997
Member, Curriculum Committee, Molecular Biology program
1990 - 1997
Member, Cancer Research Institute (Director: Dr. Richard Fisher)
1991 - 1994
Member, AIDS/Lymphoma Committee, Loyola University (Chair: Dr. Richard Fisher)
1990 - 1992
Member of the Biomolecular Facility Committee, Loyola University (Chair: Dr. Robinson)
1993 - 1997
Member, Ad hoc committee, Reconstruction of Loyola's Animal Facility (Chair: Dr. G. Engelmann)
1992 - 1994
Member, Retreat Committee, Molecular Biology Program Loyola University
1995 - 1997
Member, Curriculum Committee, Molecular Biology Program, Loyola University
• Invited Reviews Manuscripts
• • • • • • • • • • • •
EMBO J J. Exp. Med Immunobiology Molecular and Cellular Biology Experimental Cell Research Proceedings of the National Academy of Sciences U.S.A. (PNAS) Journal of Immunology (Associate editor, 2000-2005) International Immunology Cancer Research Journal of Cranial-Maxillofacial Surgery Immunobiology European Journal of Immunology (Member of the Editorial Board since 2007)
Research Grant Applications
• • • • • • • • • • • • • • • •
Book reviews
• •
National Institute of Health (NIH, U.S.A.) German Research Community (DFG, Germany) European Research Council (ERC) National Cancer Institute (NCI) of Canada Welcome Trust Helmholtz Foundation, Germany Ministry of Research, State of Thuringia, Germany Ministry of Research, State of Tirol, Austria Leukemia Research Foundation (U.S.A.) Wilhelm-Sander-Foundation (Germany) Fonds zur Förderung der wissenschaftlichen Forschung (FWF, Austria) Charite Intramural Funding, Berlin, Germany Jubiläumsfonds, Oesterreichische Nationalbank (Austria) Minerva Foundation, Israel/Germany Human Science Frontier Project (HSFP) The Department of Veteran’s Affairs (U.S.A.) ”Bispecific Antibodies” by Michael W. Fanger, R.G. Landes Company ”Molecular Immunology”, edited by B.D. Hames and D.M. Glover, Doody Publishing
• Consulting 2004 - 2009 1998 - 2005 1992 - 1997
Picobella, Burlingame, California, U.S.A. Roche Molecular Diagnostics, Penzberg, Germany Allergen Inc., San Francisco, CA, U.S.A.
1994 - 1996
Abbott Laboratories, Chicago, IL, U.S.A.
• Membership in Professional Societies Society of Biological Chemistry (GBCH), Germany Signal Transduction Society, Germany Kunckel Society, Rockefeller University, USA German Society of Immunology (DGfI), Germany (Associate member of the council since 2005) Biochemical Society Tübingen (MoBBEL), Germany (member of the council since 2000) American Association for the Advancement of Science (AAAS), U.S.A. Illinois Society of Medical Research, U.S.A. American Society of Microbiology, U.S.A. American Association of Immunologists (AAI), U.S.A. Chicago Association of Immunologists (CAI), U.S.A.
TEACHING • Graduate Courses (Loyola University) MICRO 413: MICRO 420: MBIO 417: MICRO 411: MICRO 414: MICRO 431: MICRO 471: MICRO 443:
Basic Concepts of Immunology Course Director: Jäck Methods in Molecular Biology Course directors: Jäck and Gallagher Introduction into Molecular Biology (Course Director: Dr. M. Kelley) Lectures: - Control of mRNA turnover Introduction into Microbiology (Course Director: Dr. W. Yotis) Lectures: - Protein synthesis in prokaryotes General Virology (Course Director: Dr. T. Gallagher) Lectures: Viral pathogens, virokines, and immunity against viruses Molecular Virology (Course Director: Dr. S. Baker) Lectures: Biology and Immunology of HIV Molecular Microbial Genetics (Course Director: Dr. Alan Wolfe) Lecture: Somatic Mutation in Mammalian Cells Molecular Biology of B Cell Differentiation (Course Directors : Knight & Jäck)
• Graduate Courses (University of Erlangen, Germany) MOLIM-S1: MOLIM-S2: MOLIM-P1: MOLIM-P2: MOLIM-S3: MEDBIO-S2:
Concepts of Immunology (Course Director: Jäck, Beuscher) Aspects of humoral immunity (Course Director: Jäck) Laboratory course in Molecular Immunology (4 weeks) (Course Director: Jäck) Advanced laboratory course in Molecular Immunology (6 weeks) (Course Director: Jäck) Special topics in humoral immunity (Course Directors: Jäck) Seminar in Biochemistry for medical students (Course Director: Becker)
SUPERVISION OF STUDENTS AND POSTDOCTORAL FELLOWS
Erlangen
7 Postdoctoral fellows 20 PhD students 3 MD students 30 MS students 20 BS students
Chicago
4 Postdoctoral fellows
6 PhD student 1 MD/PhD student 5 Undergraduate students I am currently a member of 8 PhD advisory committees in the graduate programs of Molecular Medicine and Cellular Biology in Erlangen
HONORS & AWARDS 2013-2014 since 2010 1994 1992 - 1994
1992 1989 1989 1988 1984
President, German Society for Immunology Member, Henry-Kunkel Society, Rockefeller University New York Junior Faculty Research AwardAmerican Cancer Society, U.S.A. Member, Scientist-Educator Team (SET) Program, sponsored by the National Science Foundation and the American Society of Microbiology Schweppe Career Development Award MoBBEL Prize, Biochemical Society Tübingen, Germany (Outstanding Ph.D. thesis in Biochemistry) Günther-Weitzel Lecture 3rd International Autumn Meeting of the Biochemical Society Summa cum laude (Ph.D.) Department of Biology, University of Tübingen, Germany Max-Planck Fellowship, Max-Planck Society, Germany
INVITED SPEAKER 2014
Symposium B cells, German Society of Immunology, Bonn
2014
Guest Symposium , American Association of Immunologists, Pittsburgh
2014
German-Argentinian Workshop
2014
Workshop - miRNA in immunity Zürich, Switzerland
2013
Study Group B Cells, Schluchsee, Germany
2013
Spring School of Immunology, Ettal, Germany
2013
European Workshop on Rheumatic Disease, Prague
2012
Department of Immunology, University of Basel
2012
International Symposium on Adaptive Humoral Immunity, Erlangen
2012
Department of Biochemistry, University of Tübingen
2012
Hofmann La Roche, Penzberg, Germany
2012
1st German-Italien Workshop on miRNA and Immunity, Lake Garda (organizer)
2012 2012
Department of Chemical Pharmacy, University of Frankfurt Annual European Congress of Rheumatology
2012
Kunkel Society Annual Meeting, Berlin, Germany
2012
Midwestern Immunology Conference, Birmingham, Alabama
2012
Department of Rheumatology, University of Freiburg, Germany
2012
Guest symposium, 99th Annual Meeting, American Association of Immunologist, Boston, USA
2012
Department of Veternary Medicine, Vienna
2012
Department of Rheumatology, University of Freiburg
2012
International IZKF Symposium, Kloster Banz
2012
B Cell Forum, Arbeitskreis B-Zelle, Kloster Banz
2012
Spring School of Immunology, Ettal
2012
1. Gradute Student Symposium, University of Turku, Finland
2012
Division of Experimental Immunology, University of Amsterdam
2011
Study Group B Cells, Bad Sooden
2011
Department of Immunology, LMU München, Germany
2010
Department of Immunology, University of Tübingen
2010
Graduiertenkolleg-Symposium, Essen
2010
8th German-Japanese Symposium, Cuxhaven, Germany
2010
1st German-Chinese Symposium, Burg Wanzleben, Magdeburg, Germany
2010
Annual Meeting DGfI Study Group 'B cells', Dresden, Germany
2010
Graduiertenkolleg - Symposium, Hamburg, Germany
2010
Department of Clinical Immunology, Necker Hosptital, Paris, France
2010 2010
Kunkel Society Annual Meeting, The Rockefeller University, New York, USA Advances in Targeted Therapies, Mandelieu, France
2010
30th European Workshop of Rheumatology, EWRR, Bamberg, Germany
2010
Babraham Research Institute, Cambridge, England
2010
Biotechnikum, Erlangen, Germany
2010
AR:O.S.A. V Expert Workshop: Current Rheumatology, Berlin, Germany
2009
Department of Surgery University of Michigan, Ann Arbor, USA
2009
Department of Immunology, Loyola University Chicago, USA
2009
Department of Immunology, University of Jena, Germany
2008
Medical University of Tokio, Japan
2008
German-Japanese Immunology meeting, Fukuoka, Japan
2008
Department of Cell Biology, University of Bern, Switzerland
2008
5th B Cell Forum, Eibsee, Germany
2008
Immunology Spring School 2008 Cloister Ettal, Bavaria
2008
Department of Immunology, University of Göttingen, Germany
2007
Department of Surgery, University of Minnesota, Rochester, USA
2007
Roche Forum: The B Cell Interdisciplinary, Castle Wernberg-Köblitz, Germany
2007
Immunology Spring School 2007, Cloister Ettal, Bavaria
2007
4th B Cell Forum, Banz, Germany
2007
Max-Planck-Institute for Immunobiology, Freiburg, Germany
2006
IZKF Symposium on Tissue and Inflammation, Bamberg, Germany
2006
ESF-EMBO Symposium on B Cells Cross the Divide: From In Silico to the Whole Person, Sant Feliu de Guixols, Spain
2006
University of Marburg, Department of Microbiology, Germany
2006
University of Würzburg, Department of Immunology, Germany
2005
3rd B Cell Forum, Bad Breisig, Germany
2004
University of Marseille, Department of Pathology, France
2004
Laudatio, 150th Birthday of Emil von Behring, Emil-von-Behring High School, Erlangen
2004
2st German B Cell Forum, Potsdam, Germany
2003
1st German B Cell Forum, Titisee, Germany
2003
Autumn Meeting of the Signal Transduction Society (STS) Weimar
2003
Symposium on B Lymphopoiesis II, 70th Birthday of Max Cooper Birmingham, Alabama, USA
2003
Annual Congress of the American Association of Nephrologists, San Diego, USA
2002
University of Essen, Department of Cell Biology, Germany
2001
Max-Planck-Institute, Martinsried, Division of Neuroimmunology
2001
Württemberger Rheumatology Days, University of Tübingen, Germany
1999
University of Freiburg, Division of Rheumatology, Germany
1999
2. Signaltransduction Meeting, Signal Transduction Society, Berlin
1998
University of München, Institute of Immunology, Germany
1998
EMBO Symposia: Signaling in B cell development, Sweden
1997
10th International Autumn Meeting of MoBBEL, Tübingen, Germany
1997
Minisymposium: B Cell Development, FASEB, San Francisco, USA
1997
Chicago Association of Immunologists, Chicago, USA
1996
University of Toronto, Department of Immunology, Canada
1996
University of Illinois at Chicago, Department of Microbiology, USA
1996
University of Erlangen-Nürnberg, Department of Medicine, Germany
1996
Wabash College, Indiana, USA
1996
Rush University Medical School, Department of Immunology, USA
1995
University of Heidelberg, Department of Biochemistry, Germany
1995
University of Erlangen, Department of Internal Medicine, Germany
1995
University of Health Sciences, Chicago Medical School, Chicago, USA
1995
Illinois Institute of Technology, Department of Biology, Chicago, USA
1994
University of Heidelberg, Department of Biochemistry, Germany
1994
University of Erlangen, Institute of Rheumatology, Germany
1993
University of Health Sciences, Chicago Medical School, Chicago, USA
1993
American Heart Transplantation Meeting, Atlanta, USA (Antibodies as a tool to prevent graft rejections)
1993
University of Heidelberg, Department of Biochemistry, Germany
1993
3rd European Congress on Lupus Erythrematodes, Erlangen, Germany
1993
First Symposium in Molecular Medicine, Loyola University, USA
1993
Northeastern Illinois University, Department of Biology, Chicago, USA
1993
University of Erlangen, Department of Immunology, Germany
1992
Symposium ”30 Year: Ph.D. Program in Biochemistry”, University of Tübingen, Germany
1991
6th International Autumn Meeting of MoBBEL, Perugia, Italy.
1990
5th International Autumn Meeting of MoBBEL Prague, C.S.F.R.
1990
University of Erlangen, Department of Immunology, Germany
1990
University of South Carolina, Columbia, U.S.A.
1990
University of Illinois, Chicago, U.S.A.
1990
Iowa State University, Ames, U.S.A.
1990
Northwestern University Chicago, U.S.A.
1990
University of Toronto, Canada
1989
2nd UCSF/UCB Immunology Conference Asilomar, U.S.A.
1989
4th International Autumn Meeting of MoBBEL Thannheim, Austria
1989
University of Freiburg, Fed. Rep. of Germany
1989
University of München, Fed. Rep. of Germany
1989
Basel Institute of Immunology, Basel, Switzerland
1989
University of Tübingen, Fed. Rep. of Germany
1989
University of Erlangen, Fed. Rep. of Germany
1989
Schering Inc., Berlin, Fed. Rep. of Germany
PEER-REVIEWED PUBLICATIONS Hans-Martin JÄCK, Ph.D. Professor of Immunology
1. Winkelmann R, Sandrock L, Kirberg J, Jäck HM, Schuh W. (2014). KLF2-a negative regulator of pre-B cell clonal expansion and B cell activation. PLoS One. May 29;9(5):e97953. 2. Gabler J, Wittmann J, Porstner M, Renz H, Jäck HM, Abram M, Zemlin M. (2013). Contribution of microRNA 24-3p and Erk1/2 to interleukin-6-mediated plasma cell survival. Eur J Immunol. 43(11):3028-37. 3.
Brachs S, Lang C, Buslei R, Purohit P, Fürnrohr B, Kalbacher H, Jäck HM, Mielenz D. (2013). Monoclonal Antibodies to Discriminate the EF Hand Containing Calcium Binding Adaptor Proteins EFhd1 and EFhd2. Monoclon Antib Immunodiagn Immunother. 32(4):237-45.
4.
Metzner, M., Jäck, H.-M. and Wabl, M. (2012). LINE-1 Retroelements Complexed and Inhibited by Activation-Induced Cytidine Deaminase PloS ONE 7(11):e49358.
5.
Newrzela S. Al-Ghaili N, Heinrich, T, Petkova M., Hartmann S, B Rengstl B, Kumar A, Jäck HM, Gerdes S, Roeder I, Hansmann ML, and von Laer D (2012). T-cell receptor diversity prevents T-cell lymphoma development. Leukemia (12):2499-507.
6.
Preussner, M.; Schreiner, S.; Hung, L-.H.; Porstner, M.; Jäck, H.-M.; Benes, V.; Bindereif, A. (2012). HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing. Nucl Acids Res 40(12):5666-78 .
7.
Thiele S, Wittmann J, Jäck H-M, Pahl A (2012). miR-9 enhances IL-2 production in activated human CD4+ T cells by repressing Blimp-1. Eur J Immunol 42(8):2100-8.
8.
Buettner M., Lang A, Tudor CS, Meyer B, Cruchley A. Barros M, Farrell P, Jäck H-M, Schuh W, Niedobitek G (2012). Lytic EBV infection in epithelial cells but not in B lymphocytes is dependent on Blimp1. J Gen Virol 93(Pt 5):1059-64.
9.
Wittmann J, Jäck H-M, Mashreghi MF. [MicroRNAs in B-cells and T-cells as regulators of inflammation]. (2011). Z Rheumatol Aug;70(6):507-10. German.
10. Dedman AM, Majeed Y, Tumova S, Zeng F, Kumar B, Munsch C, Bateson AN, Wittmann J, Jäck H-M, Porter KE, Beech DJ. (2011). TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells. BMC Mol Biol. 12;12:30. 11. Lutz J, Müller W, Raman C, Jäck H-M (2011). Immunoglobulin Heavy Chain mRNA Controls VDJ Rearrangement. Proc Natl Acad Sci USA 108(26):10644-9. 12. Vettermann, C, Castor D, Mekker A, Gerrits B, Karas M and Jäck H-M (2011). Proteome profiling suggests a pro-inflammatory role for plasma cells through release of high-mobility group box 1 protein. Proteomics (7):1228-37. 13. Wittmann J & Jäck H-M (2011). microRNAs in rheumatoid arthritis: midget RNAs with a giant impact. Ann Rheum Dis. 2011; 70(Suppl_1): p. i92-96i 14. Winkelmann R, Sandrock L, Porstner M, Roth E, Mathews M, Hobeika E, Reth M, Kahn ML, Schuh W, Jäck HM (2011). B cell homeostasis and plasma cell homing controlled by Kruppel-like factor 2. Proc Natl Acad Sci U S A. Dec 27. [Epub ahead of print].
15. Lang VR, Mielenz D, Neubert K, Böhm C, Schett G, Jäck HM, Voll RE, Meister S. (2010). The early marginal zone B cell-initiated T-independent type 2 response resiststhe proteasome inhibitor bortezomib. J Immunol. 185(9):5637-47. Epub2010 Oct 4. 16. Wittmann J, Jäck HM (2010). Serum microRNAs as powerful cancer biomarkers. Biochim Biophys Acta. 1806(2):200-7. Epub 2010 Jul 13. 17. Wittmann J, Jäck HM. New surprises from the deep--the family of small regulatory RNAs increases (2010). ScientificWorldJournal. 10:1239-43. Review. 18. Danke C, Grünz X, Wittmann J, Schmidt A, Agha-Mohammadi S, Kutsch O, Jäck HM, Hillen W, Berens C (2010). Adjusting transgene expression levels in lymphocytes with aset of inducible promoters. J Gene Med. 12(6):501-15. 19. Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon SM, Polo JM, Valls E, Klemm L,Shojaee S, Cerchietti L, Schuh W, Jäck HM, Hurtz C, Ramezani-Rad P, Herzog S,Jumaa H, Koeffler HP, de Alborán IM, Melnick AM, Ye BH, Müschen M (2010). BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med. 207(6):1209-21. Epub 2010 May 24. 20. Vettermann C, Jäck HM (2010). The pre-B cell receptor: turning autoreactivity into selfdefense. Trends Immunol. 31(5):176-83. Epub 2010 Mar 30. 21. Brandl A, Wittmann J, Jäck HM (2010). A facile method to increase titers of miRNAencoding retroviruses by inhibition of the RNaseIII enzyme Drosha. Eur J Immunol. 2010 Nov 29. [Epub ahead of print]. 22. Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, Nitschke L, Feller SM, Jäck HM, Mielenz D (2010). Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts. J Immunol. 184(7):3665-76. Epub 2010 Mar 1. 23. Metzner, M., W. Schuh, E. Roth, E., Jäck, H.-M., and M. Wabl (2010). Two forms of AID differing in their ability to bind agarose. PlosONE, Jan 27;5(1):e8883.. 24. Beck-Engeser, G., Eilat, D., Harrer, T., Jäck, H.-M. & M. Wabl, M. (2009). Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir. Proc Nat Acad Sci USA. 106(49):20865-20870. 25. Trageser, D., Iacobucci, I., Chang, M.-S., Duy1, C, Nahar, R., Klemm, L., Park, E., Schuh, W., Gruber, T., Herzog, S., Kim, Y., Hofmann, W.-K., Li, A., Storlazzi, T., Groffen1, J., Jäck, H.-M., Martinelli, G., Jumaa, H., Heisterkamp, N. and Müschen, M. (2009). Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosomepositive acute lymphoblastic leukemia requires IKAROS function. J. Exp. Med. 206(8):1739-1753. 26. Eberle, A.B. Herrmann, K., Jäck, H.-M. and Oliver Mühlemann, O. (2009). Equal transcription rates of productively and nonproductively rearranged immunoglobulin µ heavy chain alleles in a pro-B cell line. RNA, published online 10 April 2009. 27. Rahul Nahar, R., Trageser, D., Klemm, L., Duy, C., van Essen, P., Kim, Y., Heisterkamp, N., Martinelli, G., Hofmann, W.-K., Jäck, H.-M., Jumaa, H. and Müschen, M. (2008). The Pre-B Cell Receptor Suppresses Leukemogenesis by Censoring MYC Expression. Blood (ASH Annual Meeting Abstracts). 112(11): p. 1918. 28. Dawid Eckert, Katharina Biermann, Daniel Nettersheim, Ad J.M., Gillis, Klaus Steger, H.-M. Jäck, Annette M. Müller, Leendert H.J., Looijenga and Hubert Schorle. (2008).
Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC Dev. Biol. 8:106. 29. Vettermann, C, Herrmann, K, Albert, C., Roth, E, Bösl, M & Jäck, H.-M. (2008). A unique role for the lambda5 nonimmunoglobulin tail in early B lymphocyte development. J. Immunol. 181(5):3232-42. 30. Wittmann, J. and Jäck, H.-M. (2008). Chapter 13. Identifying substrates of mRNA decay factors by a combined RNA interference and DNA microarray approach. Methods Enzymol 449:263. 31. Schuh, W., Meister, S., Herrmann, K., Bradl, H., and Jäck, H.-M. (2008). Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor, Mol. Immunol., 45(2): 362-375. Epub 2007 Aug 2. 32. Avramidou, A., Kroczek, C., Christiane Lang, C., Schuh, W., Jäck, H.-M. and Mielenz, D. (2007). The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis, Cell Death & Diff., 14(11): 1936-47. 33. Geraldes, P., Rebrovich, M., Herrmann, K., Wong, J., Jäck, H.-M., Wabl., M. and Cascalho, M. (2007). Ig heavy chain promotes mature B cell survival in the absence of light chain. J. Immunol., 179(3):1659-68. 34. Christelle Morris, C., Wittmann, J., Jäck, H.-M., & Jalinot, P. (2007). Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Reports, 8(6):596602. 35. Meister, S., Schubert, U., Neubert, K., Herrmann, K., Burger, R., Gramatzki, M., Hahn, S., Schreiber, S., Wilhelm, S., Herrmann, M., Jäck, H.-M. & Voll, R. (2007). Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Research, 67(4): 1783-1792. 36. Bradl, H. Vettermann, C, Schuh, W., Meister S. & Jäck, H.-M. (2007). The Pre-B Cell Receptor and Its Ligands: It Takes Two to Tango, Signal Transduction, 7 (4): 299-310. 37. Franz S, Herrmann K, Führnrohr B, Sheriff A, Frey B, Gaipl US, Voll RE, Kalden JR, Jäck H.-M., Herrmann M. (2006). After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes. Cell Death Diff. 14(4):733-42. 38. Lutz, J., Müller, W. and Jäck, H.-M. (2006). VH Replacement Rescues Pro-B cells with Two Non-Productive VDJ Alleles. J. Immunol., 177(10):7007-7014. 39. Vettermann, C, Lutz, J., Bösl, M. and Jäck, H.-M. (2006). Dominant suppression of murine B29/Ig-beta promoter-driven transgenes. Eur. J. Immunol., 36(12):3324-33. 40. Cattoretti, G., Shaknovich, R., Smith P.M., Jäck, H.-M., Murty V.V: and Alobeid, B. (2006) Stages of GC transit are defined by B-cell transcription factors co-expression and relative abundance. J. Immunol 177(10): 6930-6939. 41. Krueger, C, Pfleiderer, K., Danke, C., Wolfgang Schuh, W. Jäck, H.-M., Lochner, S., Gmeiner, P., Hillen, W. & Berens C. (2006). A gene regulation system with four distinct expression levels. J. Gen. Med. 18(1):44-55. 42. Wittmann, J. & Jäck, H.-M. (2006). UPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol. Cell. Biol., 26(4):1272-1287. 43. Jäck, H.-M. (2006). Editorial: The ins and outs of early B cell development. Sem. Immunol. 18(1):1.
44. Vettermann, C., Herrmann, K. & H.-M. Jäck (2006). Powered by pairing: The Surrogate light chain amplifies immunoglobulin heavy chain signaling and preselects the antibody repertoire. Sem. Immunol. 18(1):44-55. 45. Hampel,M., Sehnert,B., Karas,M., Jäck,H.-M. und Mielenz,D. (2006). Double staining of SDS gels with Ruthenium Bathophenantroline Disulfonate and Silver is compatible with MALDI-TOF mass spectrometry. Signal Transduction, 6(3):185-189. 46. Buettner, A. Greiner, A. Avramidou, H.-M. Jäck & Niedobitek, G. (2005). Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Hematological Oncology, 23(3-4):127-32. 47. Mielenz, D., Vettermann, C., Lang, C, Hampel, M, Karas, M., Jäck, H.-M. (2005). Lipid rafts associate with the B cell receptor during surface transport and exhibit a B cell stage specific protein composition J. Immunol., 174(6):3508-17. 48. Bradl, H, W. Schuh & H.-M. Jäck (2004). CD44 Is Dispensable for B Lymphopoiesis. Immunol Lett, 95 (1):71-75. 49. Lanig, H., H. Bradl & H.-M. Jäck (2004). Three-dimensional modeling of a pre-B-cell receptor. Mol. Immunol. 40:1263–1272. 50. Jäck, H.-M., W. Schuh, S. Meister,E. Roth (2004). The Authors Respond: Signaling and Cell Surface Expression of µH Chains in the Absence of Surrogate and Conventional Light Chains. J Immunol 172(1):4-5; author reply 5. 51. Martin, D. A., H. Bradl, T. J. Collins, H.-M. Jäck, G. E. Wu. (2003). Selection of immunoglobulin heavy chains by CDR3 length is dependent on surface µ expression. J. Immunol., 171(9):4663-4671. 52. Schuh, W., S. Meister,E. Roth, and H.-M. Jäck (2003). Cutting Edge: Signaling and Cell Surface Expression of a µH Chain in the Absence of λ5: A Paradigm Revisited. J. Immunol. 171 (7): 3343–3347. 53. Mielenz, D., Ruschel, A., Vettermann, C., and Jäck, H.-M. (2003). Immunoglobulin micro Heavy Chains Do Not Mediate Tyrosine Phosphorylation of Igalpha from the ERcis-Golgi. J. Immunol. 171(6):3091-101. 54. Bradl H., J. Wittmann J, D. Milius D, C. Vettermann, and H.-M. Jäck (2003). Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda5 and stroma cell-associated heparan sulfate. J. Immunol. 171(5):2338-48. Discussed in News & Views in J. Immunol. & Faculty 1000 (http://www.f1000biology.com/article/12928380/evaluation) 55. Romer, S., U. Saunders, H.-M. Jäck and B.M. Jehn. (2003). Notch1 enhances B-cell receptor-induced apoptosis in mature activated B cells without affecting cell cycle progression and surface IgM expression. Cell Death Diff. 10(7):833-44. 56. Vettermann, C, Jäck, H.-M., Mielenz, D. (2002). A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns. Anal. Biochem. 308(2):381-7. 57. Carastro, L.M., Tan, C.-M., Selg, M., Jäck H.-M., Antero G., So, A.G. Downey, K.M. (2002). Identification of delta helicase as the bovine homologue of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta. Nucleic Acids Research 30(10):2232-43.
58. Hess, J., Werner, A., Wirth, T., Melchers, F, Jäck, H.-M. und Winkler, T. (2001). Induction of Pre-B Cell Proliferation Following De Novo Synthesis of the Pre-B Cell Receptor. Proc. Natl. Acad. Sci. U.S.A. 13;98, 1745-50. 59. Bradl, H. and H.-M. Jäck (2001). Surrogate light chain mediated interaction of the soluble pre-B cell receptor with adherent cell lines. J. Immunol. 167,6403-11. 60. Donohoe, M.E., Beck-Engeser, G., Lonberg, N., Karasuyama, H., Riley, R.L., Jäck, H.M., and Blomberg B.B. (2000). Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. J. Immunol 164, 5269-5276 61. Cascalho M, Wong, J., C, Brown, J., Jäck, H.-M., Steinberg, and Wabl. M. A B220negative, CD19-negative population of B cells in peripheral blood of quasimonoclonal mice (2000). Int. Immunol., 12 (1), 29-35 62. C. Amshoff , Jäck H.-M. and I.G. Haas (1999). Cycloheximide, a new tool to dissect specific steps in ER-associated degradation of different substrates. Biol. Chem. 380(6), 669-77 63. Swanson, B.J., Jäck, H.-M., and Lyons, G.E. (1998). Characterization of MEF2 Expression in B and T cells: MEF2C is a B cell restricted Transcription factor in Lymphocytes. Mol. Immunology 35(8), 445-58. 64. Kline, G.H., Hartwell, L., Beck-Engeser, G.B., Keyna, U., Zaharevitz, S., Klinman, N.R., and Jäck, H.-M.. (1998). Pre-B Cell Receptor-Mediated Selection of Pre-B Cells Synthesizing Functional µ Chains. J. Immunol., 161,1608-1618. 65. Powell, I.F., Li, T., Jäck, H.-M., Ellis, T.M. (1998). Construction and expression of a soluble form of human CD30 ligand with functional activity. Leukoc. Biol ., 63(6), 52757. 66. Siemasko, K, Chong, A, Jäck, H.-M., Gong, H., Williams, J.W., and Finnegan, A. (1998). Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Lefunomide Leads to a Block in IgG1 Production. J. Immunol., 160, 1581-1588. 67. Weiss, A., Waiser, J., Serfling, E., Nebl, G., Samstag, Y, Jäck, H.-M., Gessner, A., Röllinghof, M., and Lohoff, M. (1998). A dominant mechanism coordinately suppresses the expression of Th2 lymphokines. Int. Immunology 9, 1347-1353. 68. Rowley, A.H., Eckerly, C.A., Knight, K., Jäck, H.-M., Shulman, S.T., and Baker, S.-C. (1997). Prominent IgA B-cell response within vascular tissue in patients with fatal Kawasaki syndrome. J. Immunology 159, 5946-5955. 69. Applequist, S.E., Selg, M, Raman, C, and Jäck, H.-M. (1997). Cloning and characterization of HUPF1, a human homologue of the S. cerevisiae nonsense mRNAreducing UPF1 protein. Nucleic Acids Res. 25, 814-821. 70. Napolitano, E.W., Villar, H.O, Kauvar, L.M., Higgins, D.L., Roberts, D., Mandac, J., Lee, S.K., Engqvist-Goldstein, A., Bukar, R., Calio, B.L., Jäck, H.-M., and Trainer, J.A. (1996). Glubodies: randomized libraries of glutathione transferase enzymes. Chemistry & Biology 3, 359-367. 71. Alzona, M, Jäck H.-M., Simms P. E., and T. M. Ellis (1996), Interleukin-12 Activates Interferon- Production by Targeted Activation of CD30+ T Cells. Annals New York Acad. Sci. 795, 12
72. Keyna, U., Beck-Engeser, G., Jongstra, J., Applequist, S.E., and Jäck, H.-M. (1995). Surrogate light chain-mediated selection of Ig heavy chain variable regions. J. Immunol. 155, 5536-5542. 73. Applequist, S.E., Keyna, U., Calvin, M., Raman, C., Beck-Engeser, G., and Jäck, H.-M. (1995). Cloning and sequence of the rabbit glycaldehyde-3-phosphate dehydrogenase cDNA. Gene 163, 325-326. 74. Bornemann, K., Brewer, J., Beck-Engeser, G., Corley, R., Haas, I.G. and Jäck, H.-M. (1995). The Roles of Heavy and Light Chains in IgM Polymerization. Proc. Natl. Acad. Sci. U.S.A. 92, 4912-4916. 75. Keyna, U., Beck-Engeser, G. Applequist, S.E., and Jäck, H.-M. (1995). Immunoglobulin µ heavy chains with VH81X variable regions do not associate with surrogate L-chain. Annals New York Acad. Sci. 764, 39-42. 76. Alzona, M, Jäck, H.-M., Fisher, R., and Ellis, T. (1995). IL-12 activates IFN- production through the preferential activation of CD30+ T cells. J. Immunol, 154, 1, p. 916. 77. Alzona, Fisher, R., Jäck, H.-M., and Ellis, T. (1994). CD30 defines a subset of activated CD45RO+ T cells which express IL-5 and IFN-γ. J. Immunol 153, 7, p. 2861-2867, 1994 78. Ellis, T.M., Simms, P.E., Helfrich, B.A., Slivnick, D.S., Jäck, H.-M., and Fisher, R.I. (1993). CD30 is a signal-transducing molecule expressed by a subset of activated human CD45RO+ T cells. J. Immunol 151, 2380. 79. Jäck, H.-M., Sloan, B., Grisham, G., Reason, D., and Wabl, M. (1993). An immunoglobulin light chain with unusual intrachain disulfide bonding. J. Immunol. 150, 4928-4933. 80. Jäck, H.-M., Beck-Engeser, G., Lee, G., and Wabl., M. (1992). Tumorigenesis mediated by an antigen receptor. Proc. Natl Acad. Sci. USA 89, 8482-8486. 81. Jäck, H.-M., Beck-Engeser, G., Sloan, B., Li, M., Wofsy, D., and Wabl, M. (1992). A leukemia cell line with an unusual Mott cell phenotype. Proc. Natl. Acad. Sci. USA 89, 11688-11691. 82. Berg, J., Lötscher, E., Steimer, K., Capron, D., Baenzinger, J., Jäck, H.-M., and Wabl, M. (1991). Cytotoxic lymphocytes of any specificity can be targeted to kill cells infected with HIV of any strain. Proc. Natl. Acad. Sci. U.S.A., 88, 4723-4727. 83. von Schwedler, U., Jäck, H.-M., and Wabl, M (1990). Circular DNA is a product of the immunoglobulin class switch. Nature, 345, 452-456. 84. von Schwedler, U., Jäck, H.-M., and Wabl, M. (1990). Beswitched: The looping out model for immunoglobulin class switching. The New Biologist, 2, 8, 1-6. 85. Berg, J., McDowell, M., Jäck, H.-M., and Wabl, M. (1990). Immunoglobulin λ gene rearrangement can precede κ gene rearrangement. Dev. Immunol., 1, 53-57. 86. Jäck, H.-M., Berg, J. and Wabl, M. (1989). Translation affects immunoglobulin mRNA stability. Eur. J. Immunology 19, 843-847. 87. Wabl, M, Jäck, H.-M., von Borstel, R. C. and Steinberg, C.M. (1989). Scope of action of the immunoglobulin mutator system. Genome 31, 118-121.
88. Jäck, H.-M. and Wabl, M. (1988). Immunoglobulin mRNA stability varies during B lymphocyte differentiation. EMBO J. 7, 1041-1046. 89. Jäck, H.-M., McDowell, M., Steinberg, C.M., and Wabl, M. (1988). Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch. Proc. Natl. Acad. Sci. USA 85-1581-1585. 90. Jäck, H.-M. and Wabl, M. (1987). High rates of deletions in the constant region segment of the immunoglobulin µ gene. Proc. Natl. Acad. Sci. USA 84-4934-4938. 91. Wabl, M., Jäck, H.-M., Meyer, J., Beck-Engeser, G., von Borstel, R. C., and Steinberg, C.M. (1987). Measurements of mutation rates in B lymphocytes. Immunological Reviews 96, 91-107. 92. Beck-Engeser, G., Jäck, H.-M., and Wabl, M. (1987). Allelic inclusion in a pre-B cell line that generates immunoglobulin heavy-chain genes in vitro. Proc. Natl. Acad. Sci. USA 84, 1060-1064. 93. Meyer, J., Jäck, H.-M., Ellis, N., and Wabl, M. (1986). High rate of somatic point mutations in vitro in and near the variable-region segment of an immunoglobulin heavychain gene. Proc. Natl. Acad. Sci. USA 83, 6950-6953. 94. Pantelias, G., Jäck, H.-M., and Wabl, M. (1986). Possible target of Abelson virus phosphokinase in cell transformation. Experientia 42, 1036-1038. 95. Koch, R., Deger, A., Jäck, H.-M., Klotz, K.-N., Schenzle, D., Kelm, S., Krämer, H., Müller, G., Rapp, R., and Weber, U. (1986). Characterization of the solubilized insulin receptor from rat liver membranes. Existence of two receptor species with different binding properties. Eur. J. Biochem. 154, 282-287. 96. Jäck, H.-M., Koch, R., Krämer, H., Deger, A., Rapp, R., Müller, G., & Weber,U. (1984). Purification of the insulin receptor by ion-exchange chromatography. Hoppe-Seyler's Z. Physiol. Chem. 365, 1008. 97. Rapp, R., Koch, R. Deger, A., Jäck, H.-M., Klotz, K.-N., Müller, P.H., and Eggstein, M. (1984). Radiorezeptortest für die quantitative Bestimmung von Insulin aus Serum. Akt. Endokrin. 5, 115.
