Curriculum 2015/16 - Medizinische Hochschule Hannover

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Hannover Medical School Hannover Biomedical Research School

Curriculum MD/PhD Program “Molecular Medicine” PhD Programs “Infection Biology” and “DEWIN: Dynamics of Host-Pathogen Interactions” PhD Program “Regenerative Sciences” PhD Program “Auditory Sciences” PhD Program “Epidemiology” Marie Curie Initial Training Network ITN-TECAS: “Tissue Engineering for Cardiovascular Surgery”

Winter and Summer Semester 2015/2016

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Hannover Medical School Hannover Biomedical Research School

Curriculum MD/PhD Program “Molecular Medicine” PhD Programs “Infection Biology” and “DEWIN: Dynamics of Host-Pathogen Interactions” PhD Program “Regenerative Sciences” PhD Program “Auditory Sciences” PhD Program “Epidemiology” Marie Curie Initial Training Network ITN-TECAS: “Tissue Engineering for Cardiovascular Surgery”

Winter and Summer Semester 2015/2016 www.mh-hannover.de/hbrs.html

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PhD Curriculum

Hannover Medical School

Academic Year

Winter Semester 2015/2016 Start:

October 12th, 2015 (Opening ceremony October 19th)

End:

February 26th, 2016

MD/PhD “Molecular Medicine” intermediate examination: February 26th, 2016 (students organize date)

from January 15th to

PhD “Infection Biology” intermediate examination:

March 16th, 2016

PhD “Regenerative Sciences” intermediate examination:

by March 31st, 2016

PhD “Epidemiology” and PhD “Auditory Sciences” intermediate examination: To be decided on an individual basis, depending also on status of PhD thesis

Summer Semester 2016 Start:

April 4th, 2016

End:

July 8th, 2016

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Organization of Hannover Biomedical Research School

Members of the International Advisory Board: Prof. Dr. Nathalie Cartier (INSERM U986 MIRCen CEA, Fontenay aux Roses, France) Prof. Michael Carroll (Harvard Medical School, Childrens Hospital, Boston, USA) Prof. Joachim R. Kalden (University of Erlangen, Germany) Prof. Dr. Steve Keyse (University of Dundee, UK) Prof. Dr. Hans-Gustaf Ljunggren (Karolinska Institute, Stockholm, Sweden) Prof. Dr. Seppo Meri (University of Helsinki, Finland) Prof. Dr. Stanislas Pol (Département des maladies du foie Cochin, University Hospital Paris, France)

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Dean of the HBRS and chairman of MD/PhD program “Molecular Medicine”: Reinhold E. Schmidt, MD Professor of Medicine, Immunology and Rheumatology Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected]

Tel.: 0049-511-532-6656 Fax: 0049-511-532-9067

Coordination of HBRS and MD/PhD program “Molecular Medicine”: Dr. Susanne Kruse and Birgit Müller HBRS Office of the MHH Tel.: 0049-511-532-6011 Präsidalamt, OE 9117 Fax: 0049-511-532-2611 Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected]; [email protected] Web: www.mh-hannover.de/md-phd.html ------------------------------------------------------------------------------------Chairman of PhD programs “Infection Biology” and “DEWIN”: Prof. Dr. Reinhold Förster Tel.: 0049-511-532-9721 Institute of Immunology Fax: 0049-511-532-9722 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Coordination of PhD programs “Infection Biology” and “DEWIN”: Dr. Sabine Johann and Simone Zimmer Tel.: 0049-511-532-9742 Zentrum für Infektionsbiologie – ZIB Fax: 0049-511-532-9722 Institut für Immunologie, OE 5240 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Web: www.mh-hannover.de/zib.html

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Chairman of PhD program “Regenerative Sciences”: Prof. Dr. Ulrich Martin Tel.: 0049-511-532-8821 LEBAO Fax: 0049-511-532-8819 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Coordination of PhD program “Regenerative Sciences”: Dr. Daniela Pelz Tel.: 0049-511-532-5206 Steffi Gomm Tel.: 0049-511-532-5202 „REBIRTH“, OE 8880 Fax: 0049-511-532-5205 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Web: www.rebirth-hannover.de/en/phd-program.html ------------------------------------------------------------------------------------Chairman of PhD program “Auditory Sciences”: Prof. Dr. Andrej Kral Institut für AudioNeurotechnologie (VIANNA) & Abt. für experimentelle Otologie, HNO-Klinik Medizinische Hochschule Hannover Feodor-Lynen Str. 35 D-30625 Hannover E-mail: [email protected]

Tel: 0049-511-532-7272 Fax: 0049-511-532-7274

Coordination of PhD program “Auditory Sciences”: Dr. Odett Kaiser Tel.: 0049-511-532-7234 HNO Clinics, OE 6500 Medizinische Hochschule Hannover Carl-Neuberg Str. 1 D- 30625 Hannover E-Mail: [email protected] ------------------------------------------------------------------------------------Chairman of PhD program “Epidemiology”: Prof. Dr. Gérard Krause Tel: 0049-531-6181-3101 Head of Department of Epidemiology and Professor for Infectious Diesease Epidemiology at the Medical University Hannover Helmholtz Centre for Infection Research Inhoffenstr. 7 D-38124 Braunschweig E-mail: [email protected]

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Coordination of PhD program “Epidemiology”: Dr. Stefanie Castell & Dr. Jördis Ott Tel.: 0049-531-6181-3115 Helmholtz Centre for Infection Research Tel: 0049-531-6181-3104 Department of Epidemiology Inhoffenstr. 7 D- 38124 Braunschweig E-Mail: [email protected]; [email protected]; [email protected] Web: http://www.helmholtz-hzi.de/de/karriere/phd_studiengang_epidemiologie/ziele/

-------------------------------------------------------------------------------------Members of the MD/PhD program “Molecular Medicine” Commission: Prof. Dr. Reinhold E. Schmidt (Chairman) Prof. Dr. Georg Behrens Prof. Dr. Mathias Gaestel Prof. Dr. Axel Schambach Alexandra Ingendoh Natalie Weber

Prof. Dr. Thomas Thum (Vice Chairman) Prof. Dr. Armin Braun Prof. Dr. Dietmar Manstein Prof. Dr. Siegfried Weiss Katharina Lobschat NN

Contact/coordination: Dr. Susanne Kruse and Birgit Müller, Medizinische Hochschule Hannover, PhD Office, OE 9117, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-9844; Fax. -2611; [email protected]; [email protected]

Members of the PhD programs “Infection Biology” and “DEWIN” Commission: Prof. Dr. Reinhold Förster (Chairman) Prof. Dr. Susanne Häußler Dr. Matthias Lochner Prof. Dr. Reinhold E. Schmidt Prof. Dr. Sebastian Suerbaum (Vice Chairman) Bettina Buchmann

Dr. Günter Bernhardt Prof. Dr. Georg Herrler Prof. Dr. Thomas Pietschmann Prof. Dr. Thomas F. Schulz Prof. Dr. Peter Valentin-Weigand Brenda Raud

Contact/coordination: Dr. Sabine Johann and Simone Zimmer, Medizinische Hochschule Hannover. ZIB at Institute of Immunology, OE 5240, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-9742; Fax. -9722; [email protected]

Members of the PhD program “Regenerative Sciences” Commission: Prof. Dr. Ulrich Martin (Chairman) Prof. Dr. Tobias Cantz Prof. Dr. Birgit Glasmacher Prof. Dr. Axel Schambach, PhD Dr. Gerald Dräger Ralf Haller Janika Viereck Karsten Cirksena

Prof. Dr. Renata Stripecke (Vice Chairwoman) Prof. Dr. Boris Chichkov Prof. Dr. Heiner Niemann Prof. Dr. Dagmar Wirth PD Dr. Ina Gruh Christina Müller Hanna Möller

Contact/coordination: Dr. Daniela Pelz, Steffi Gomm, Medizinische Hochschule Hannover, REBIRTH Office, OE 8880, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-5206 / -5202; Fax. -5205, [email protected]

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Members of the PhD program “Auditory Sciences” Commission: Prof. Dr. Andrej Kral (Chairman) Prof. Dr. Andreas Büchner Prof. Dr. Holger Blume Prof. Dr. Lili Geworski (Vice Chairwoman) Christoph Kantzke Advisory: Dr. V. Hamacher, head, Advanced Bionics GmbH ERC

Prof. Dr. Thomas Lenarz Prof. Dr. Peter Behrens Prof. Dr. Reinhard Dengler PD Dr. Athanasia Warneke

Contact/coordination: Dr. Odett Kaiser, Medizinische Hochschule Hannover, OE 6500, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-7234; [email protected]

Members of the PhD program “Epidemiology” Commission: Prof. Dr. Gérard Krause (chairman) Prof. Dr. Rafael Mikolajczyk Prof. Dr. Marie-Luise Dierks Prof. Dr. Armin Koch Prof. Dr. Thomas Pietschmann (guest) Prof. Dr. Reinhold Schmidt (guest)

Dr. Stefanie Castell & Dr. Jördis Ott (coordinators) Nicole Rübsamen, Mahrrouz Hoodgarzadeh (students)

Programme Coordination: Dr. Stefanie Castell & Dr. Jördis Ott Helmholtz Centre for Infection Research, Department of Epidemiology, Inhoffenstr. 7, D- 38124 Braunschweig; [email protected]; [email protected] Programme Assistance: Helga Brink; Helmholtz Centre for Infection Research, Department of Epidemiology, Inhoffenstr. 7, D- 38124 Braunschweig; phd-epidemiology@helmholtz-hzi; phone: +49-531-6181-3105

Marie Curie Initial Training Network “ITN-TECAS: Tissue Engineering for Cardiovascular Surgery” Dr. Sotiris Korossis (Chairman) Department of Cardiac, Thoracic, Transplantation and Vascular Surgery Email: [email protected] Contact/coordination: Ms Eirini Chatzigeorgiou, TECAS-ITN Research Manager, Lower Saxony Centre for Biomedical Engineering Implant Research and Development, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Feodor-Lynen-Straße 31, Hannover, 30625, Germany, Tel: +49 511 532 7798, Email: [email protected]

Members of the Doctorate Training Programme ITN-TECAS Committee: Dr. Sotiris Korossis (Chairman) Prof. Dr. Axel Haverich (Vice Chairman) Prof. Dr. Christopher Baum Prof. Dr. Reinhold E. Schmidt Prof. Dr. Gino Gerosa (University of Padua) Prof. Dr. Stefan Jockenhoevel (University Hospital Aachen) Prof. Frank Baaijens (Eindhoven University of Technology) Prof. Demosthenes Mavrilas (University of Patras) Dr. Michael Harder (Corlife GbR)

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Content: Page Obligatory seminars for PhD programs ......................................................................... 14

1st Semester MD/PhD „Molecular Medicine“ ............................................................... 14 - in-depth seminars for medical students ...................................................................... 17 - in-depth seminars for life scientists............................................................................. 17

2nd Semester MD/PhD „Molecular Medicine“ ............................................................... 19 3rd Semester MD/PhD “Molecular Medicine” .......................................................... 22 - Focus Immunology ........................................................................................................ 22 - Focus Genetics and Cell Biology ................................................................................. 26

4th Semester MD/PhD “Molecular Medicine” .......................................................... 28 - Focus Infection and Immunity ...................................................................................... 28 - Focus Differentiation and Oncology ............................................................................ 30

1st Semester PhD “Infection Biology / DEWIN”.................................................... 32 2nd Semester PhD “Infection Biology / DEWIN” ................................................... 34 3rd Semester PhD “Infection Biology/ DEWIN”........................................................ 36 4th Semester PhD “Infection Biology/ DEWIN” ........................................................ 38 1st Semester PhD “Regenerative Sciences” ............................................................ 40 2nd Semester PhD “Regenerative Sciences” ........................................................... 43 3rd Semester PhD “Regenerative Sciences” ............................................................ 46 4th Semester PhD “Regenerative Sciences” ............................................................ 48 Additional Offers PhD “Regenerative Sciences” .................................................... 50 PhD program “Auditory Sciences” ........................................................................... 51 PhD program “Epidemiology” ................................................................................... 55 Obligatory program for Research Training Groups [(E)GRKs] .................................... 56 ITN-TECAS ........................................................................................................................ 56 Specific seminars ............................................................................................................ 59 - organized by HBRS........................................................................................................ 59 Optional courses .............................................................................................................. 60 Requirements and Rules ................................................................................................. 61 Map .................................................................................................................................... 67

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Curriculum MD/PhD “Molecular Medicine” 1st year 2nd sem.

1st sem. Immunology/Stem Cell Biology/ Bacteriology/ Virology

Basics in Molecular Medicine (Focus on Methods); Seminar, 2h

Cell Biology/ Genetics/ Biochemistry/ Methods

Tutorial, 1h

In parallel: special in-depth seminars for medical students and students from life sciences, respectively

2nd year

3rd sem.

Tutorial for the respective seminar/tutorial series

4th sem.

1. Focus: Immunology

or

2. Focus: Genetics & Cell Biology 3. Focus: Infection

or

4. Focus: Differentiation & Oncology For all: Seminar, 2h and Tutorial, 1h

3rd year: concentration on individual research projects

Structure of the MD/PhD program „Molecular Medicine“ Year 1

Year 2

Year 3

• Sem. + Lect. In basic sciences Monday (4.30 - 6.00 p.m.; 6 cp) • Tutorials Monday; till Christmas separate tutorials for edical students and life scientists (3.15 – 4.15 p.m.; 2 cp)

• Complex and clinical system; choice between the foci Immunology, Infection, Oncology and Differentiation, Cell Biology/Genetics, Biochemistry Mondays, Seminar and Tutorial (3.00 – 6.00 p.m.; 8 cp)

• 3-year PhD project work (125 cp) • Three presentations in department over three years (10 cp) • Three presentations of manuscripts at the departments Journal Club over three years (3 cp) • Public annual presentation/project report (10 cp) •Talk / presentation at international congress (2 cp) • Project-orientated seminars/courses; including practicals (80 h, 8 cp) • Participation in summer schools / interdisciplinary seminars (e.g. soft skills)/ congress (60 h, 6 cp) Intermediate exam after 18 months cp: credit points PhD thesis and final exam after 3 years

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Curriculum PhD “Infection Biology” and “DEWIN” 1st Year 1st Semester

2nd Semester

Weekly seminars: Immunology/Microbiology/ Virology/Cell Biology

Project Reports & Special topic lectures

2nd Year 3rd Semester

4th Semester

Presentation of original manuscripts & reviews

Project Reports

Structure of the PhD Program “Infection Biology“ and “DEWIN” Year 1 • Sem. + Lect.

Monday (16.30 - 18.00 hrs; 6 cp)

• Journal Club in students own department (15 h) + attendance of 15 scientific lect. At MHH/HZI/ TiHo (such as SFB-Sem. or Immunol. Colloquium; 2 cp)

Year 2

Year 3

• Seminar based on reviews and original manuscripts (Monday 16.15 or 16.30 – 18.00) (4 cp)

• Presentation of one review and one original manuscript during these seminars (4 cp) • Journal Club in students own department (15 h) + attendance of 15 scientific lect. at MHH/HZI/ TiHo (such as SFB-Sem. or Immunol. Colloquium; 2 cp)

• 3-year PhD project work (125 cp) • Public presentations/project reports (i.e. Retreat) (10 cp) • Three presentations in department over three years (10 cp) • Three presentations of manuscripts at the departments Journal Club over three years (3 cp) • Talk / presentation at international congress (2 cp) • Practical courses (80 hours) (10 cp) • Participation in summer schools / interdisciplinary seminars (e.g. soft skills) / congress (20h) (2 cp)

cp: credit points

Intermediate exam after 18 months PhD thesis and final exam after 3 years

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Structure of the PhD-Program “Regenerative Sciences”

Year 1

Year 2

Year 3



Seminars + Lectures in basic sciences Thursday (4.15 - 5.45 p.m.)



Seminars + Lectures in basic sciences Thursday (4.15 - 5.45 p.m.)



Tutorials Thursday (3.00 – 4.00 p.m.)



Tutorials Thursday (3.00 – 4.00 p.m.)

• • •

3-year PhD project work

• • • •

Focus on experimental work

Three presentations in department within three years (regular attendance) 3 Presentations of manuscripts at the department’s Journal Club within three years (regular participation, i.e. 10 times per year) Public annual presentation/project report (i.e. retreat) Talk/presentation at international congress Project-orientated seminars/courses; including practicals and summer schools (80 h) Participation in interdisciplinary seminars (e.g. soft skills/congresses) (40h)

Intermediate exam after 18 months

PhD thesis and final exam after 3 years

You may replace up to 30 hours of the Thursday seminars and tutorials by the additional offers ”Meet the Investigator” or “Method based seminar” see page 50

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      - three year research project - three project presentations over the three year time period - active participation in Journal Clubs, i.e. presentation of manuscripts or workshop outcomes - active participation in scientific conferences, i.e. poster or oral presentation - annual PhD-Retreats - soft skill courses - program modules (lectures, field work, and courses) Æ total accompanying program of a minimum of 300 hrs.

 

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Obligatory MD/PhD ”Molecular Medicine” 1st Semester Note: The curriculum of the first year is more orientated towards basics and methods in the different diciplines. MD/PhD “Molecular Medicine”: There are some alternative in-depth seminars/ tutorials on Mondays for medical students and students from life sciences till Christmas (see pages 17/18) and the respectives tutorial for the seminars.

1.) General Immunology Episode I: The hematopoetic wonderland

Monday,

12.10.15

HBRS Opening Ceremony Lecture Hall “R”

Monday,

19.10.15 5.00 p.m.

What innate immune cells can do for you

Monday,

26.10.15

4.30 – 6 p.m. 2 hrs

Monday,

02.11.15

4.30 – 6 p.m. 2 hrs

Monday,

09.11.15

4.30 – 6 p.m. 2 hrs

Monday,

16.11.15

4.30 – 6 p.m. 2 hrs

Monday

23.11.15

4.30 – 6 p.m. 2 hrs

Andreas Krüger Lecture hall B (building J2)

Immo Prinz

B-cells and antibody responses Georgios-Leandros Moschovakis

Multiple choices: Induction and function of T helper cells

4.30 – 6 p.m. 2 hrs

Matthias Lochner Divide and Conquer: Antigen presentation and cytotoxic T cells Georg Behrens

2.) General Bacteriology Introduction to Medical Microbiology: Common themes in bacterial pathogenesis Sebastian Suerbaum

15

Paradigms of Infection Biology: Mycobacteria

Monday,

30.11.15 4.30 – 6 p.m.

2 hrs

Monday,

07.12.15 4.30 – 6 p.m.

2 hrs

Paradigms of Infection Biology: The gastrointestinal Monday, habitat and its microbiota; Helicobacter and Campoylobacter as specific pathogens of the niche

14.12.15 4.30 – 6 p.m.

2 hrs

Monday,

04.01.16 4.30 – 6 p.m.

2 hrs

Monday

11.01.16 4.30 – 6 p.m.

2 hrs

Monday,

18.01.16 4.30 – 6 p.m.

2 hrs

Monday,

25.01.16 3.15 – 4.15 p.m.

1 hr

Monday,

25.01.16 4.30 – 6 p.m.

2 hrs

Monday,

01.02.16 3.15 – 4.15 p.m.

1 hr

Monday,

01.02.16 4.30 – 6 p.m.

2 hrs

Monday,

08.02.16 3.15 – 4.15 p.m.

1 hr

Monday,

08.02.16 4.30 – 6 p.m.

2 hrs

Franz Bange Paradigms of Infection Biology: Chlamydia and Listeria Andreas Klos

Christine Josenhans Paradigms of Infection Biology: Salmonella Guntram Graßl Metabolism and Virulence Dirk Hofreuter

3.) General Virology Different Viruses and Viral Diseases Anke Kraft Tutorial Kraft (Viral Disease) (HBRS seminar room 1140, J4) Virus Entry and Structural Virology Thomas Krey Tutorial Krey (HCV, Fusion proteins) HBRS seminar room 1140, J4) Virus Assembly, Maturation and Egress Eike Steinmann (TwinCore) Tutorial Steinmann (NOT FLAVIVIRIDAE) (HBRS seminar room 1140, J4) Transcription and Replication of DNA Viruses Jens Bohne

16

Tutorial Bohne (Journal Club, Replication of HIV)

Monday,

15.02.16 3.15 – 4.15 p.m.

1 hr

Monday,

15.02.16 4.30 – 6 p.m.

2 hrs

Monday,

22.02.16 3.15 – 4.15 p.m.

1 hr

Monday,

22.02.16 4.30 – 6 p.m.

2 hrs

(HBRS seminar room 1140, J4) Transcription and Replication of RNA Viruses Thomas Pietschmann Tutorial Pietschmann (NOT FLAVIVIRIDAE) (HBRS seminar room 1140, J4) Pathogenesis, Host defense and viral interference Abel Viejo-Borbolla

Location

Hannover Biomedical Research School, Lecture hall B, I 2

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*only for MD/PhD “Molecular Medicine” medical students: Some more basics in Life Sciences As there are not many medical students this year, we will arrange an individual program for you! Or you visit the tutorials for life scientists or PhD “Infection Biology” Mondays, 3.15 – 4.15 p. m. [Microbiology, Developmental Biology (Kispert), Biochemistry (Kotlyarov), Virology (Verhagen), Genetics (Schubert)] Location ask at PhD office

** only for PhD students from life sciences: Some basics in Medicine/Techniques Opening ceremony, October 19th ONLY for PhD “Molecular Medicine”:

Monday,

12.10.15 3.15 - 4.15 p.m. 1 hr

No tutorial because of opening ceremony

Monday,

19.10.15

Clinical Immunology: pathogenesis of an autoimmune disease (Lupus erythematosus)

Monday,

26.10.15 3.15 - 4.15 p.m. 1 hr

Monday,

02.11.15 3.15 - 4.15 p.m. 1 hr

Monday,

09.11.15 3.15 - 4.15 p.m. 1 hr

No tutorial because of Animal course

Monday,

16.11.15

Protein tyrosine kinases and human cancer

Monday,

23.11.15 3.15 - 4.15 p.m. 1 hr

Monday,

30.11.15 3.15 - 4.15 p.m. 1 hr

Monday,

07.12.15 3.15 - 4.15 p.m. 1 hr

Monday,

14.12.15 3.15 - 4.15 p.m. 1 hr

General introduction, lectures, expectations etc.; answering of all last questions, election of class speaker Susanne Kruse

Torsten Witte Hematology: pathogenesis of malignant diseases Matthias Eder Gene Technology and Biosafety Ruth Knorr

Zhixiong Li Super resolution light microscopy Rudolf Bauerfeind Electron Microscopy Stephanie Groos FACS analysis Roland Jacobs

18

Chip cytometry

Monday,

04.01.16 3.15 - 4.15 p.m. 1 hr

Monday,

11.01.16 3.15 - 4.15 p.m. 1 hr

Monday,

18.01.16 2.15 - 3.15 p.m. 1 hr

Christian Hennig Cell Sorting Mathias Ballmaier Is it Allergy? Clinical presentations and diagnostic workups Ulrike Raap

Location (level 01)

Hannover Biomedical Research School, HBRS seminar room 1140, I 4, 2nd floor

19

2nd Semester Curriculum MD/PhD Molecular Medicine MD/PhD MM: please attend the whole of the seminars and tutorials listed below.

4. ) General Cell Biology Tutorial Borbolla (Neurotropic Viruses)

Monday

04.04.16

3.15 – 4.15 p.m.

1 hr

Monday

04.04.16

4.30 – 6 p.m.

2 hrs

Monday,

11.04.16

3.15 – 4.15 p.m

1 hr

Monday

11.04.16

4.30 – 6 p.m.

2 hrs

Monday,

18.04.16

3.15 – 4.15 p.m.

1 hr

Monday,

18.04.16

4.30 – 6 p.m.

2 hrs

Tutorial Stradal

Monday,

25.04.16

3.15 – 4.15 p.m.

1 hr

Next generation sequencing

Monday,

25.04.16

4.30 – 6 p.m.

2 hrs

Monday,

02.05.16

3.15 – 4.15 p.m.

1 hr

Using genome wide screening methods to identify the Monday, genetic basis of syndromic cancer predisposition

02.05.16

4.30 – 6 p.m.

2 hrs

(HBRS seminar room 1140, J4) The cell cycle and its implication in disease Hans J. Hauser Lecture hall B Tutorial Hauser (HBRS seminar room 1140, J4) Intracellular trafficking Melanie Brinkmann Lecture hall B Tutorial Brinkmann (HBRS seminar room 1140, J4) The structure of the cell’s interior Theresia Stradal (HZI) Lecture hall B

(Now only for MD/PhD MM)

All seminars and tutorials in HBRS seminarroom

5.) Biochemistry and Genetics; methods

Robert Geffers (HZI) No tutorial

Ruthild Weber

20

Tutorial Weber

Monday,

09.05.16

3.15 – 4.15 p.m.

1 hr

Strategies to analyse gene function in vivo

Monday,

09.05.16

4.30 – 6 p.m.

2 hrs

No seminar and tutorial, public holiday!

Monday

16.05.16

Tutorial Gossler

Monday

23.05.16

3.15 – 4.15 p.m.

1 hr

Mass spectrometry and protein analysis

Monday

23.05.16

4.30 – 6 p.m.

2 hrs

Monday,

30.05.16

3.15 – 4.15 p.m.

1 hr

Monday,

30.05.16

4.30 – 6 p.m.

2 hrs

Tutorial Tiedje

Monday,

06.06.16

3.15 – 4.15 p.m.

1 hr

Transcriptomics

Monday,

06.06.16

4.30 – 6 p.m.

2 hrs

Monday,

13.06.16

3.15 – 4.15 p.m.

1 hr

Monday,

13.06.16

4.30 – 6. p.m.

2 hrs

Achim Gossler

Andreas Pich Tutorial Shot gun and targeted mass spectrometry Pich The complex world of RNA Christopher Tiedje (Mathias Gaestel)

Oliver Dittrich-Breiholz Building J3, Level 1, Room 2020 Tutorial Dittrich-Breiholz Building J3, Level 1, Room 2020 Physical Methods in Biochemistry: Spectroscopy, hydrodynamics, structure

Ute Curth Building J3, Level 1, Room 2020

21

Tutorial Curth

Monday,

20.06.16

3.15 – 4.15 p.m.

1 hr

Stem cells

Monday,

20.06.16

4.30 – 6. p.m.

2 hrs

Tutorial Schambach

Monday,

27.06.16

3.15 – 4.15. p.m. 1 hr

Techniques of miRNAs and lncRNAs

Monday,

27.06.16

4.30 – 6.30 p.m.

Jan Fiedler

seminar + tutorial (or 2 sessions?)

Axel Schambach

Location Hannover Biomedical Research School, I 4, 2nd floor, HBRS seminar room 1140 (HBRS seminar room)

2 hrs

22

MD/PhD program “Molecular Medicine” 3rd Semester Note: The curriculum of the second year is more orientated towards research and applied aspects in the different diciplines. Every student has the choice between two major foci each semester. You may vary in the choice of modules between the two foci. Please, choose the ones most appropriate for you and your project!

1. Focus: Immunology 1. Immune cells and organs Regulation and function of NK cells

Monday,

12.10.15

3 – 5 p.m.

2 hrs

Monday,

12.10.15

5 – 7 p.m.

2 hr

Opening ceremony of HBRS

Monday,

19.10.15

5 p.m.

HS R

No seminar

Monday

26.10.15

3 – 5 p.m.

2 hrs

Tutorial Jacobs

Monday

26.10.15

5 - 6 p.m.

1 hr

Calcium signaling and autoimmune inflammation (topic 2)

Monday,

02.11.15

3 – 5 p.m.

2 hrs

Tutorial Berod de Sparwasser

Monday,

02.11.15

5 – 6 p.m.

1 hr

T and B cell differentiation

Monday,

09.11.15

3 – 6 p.m.

3 hrs

Fritz Melchers (Berlin/Basel)

Seminar+Tutorial

Roland Jacobs Metabolic regulation of immune cells Luciana Berod de Sparwasser

Georgios Sogkas

2. Autoimmunity Major histocompatibility complex in tolerogenic cell therapies

Monday

16.11.15

3 – 5 p.m.

2 hrs

Monday

16.11.15

5 – 6 p.m.

2 hr

Constanza Figueiredo Tutorial Sogkas

23

Transplantation, Tolerance and Tregs

Monday,

23.11.15

3 – 5 p.m.

2 hrs

Monday,

23.11.15

5 – 6 p.m.

1 hr

Monday,

30.11.15

3 – 5 p.m.

2 hrs

Tutorial Hardtke-Wolenski

Monday,

30.11.15

5 – 6 p. m.

1 hr

Allergic skin diseases

Monday

07.12.15

3 – 5 p.m.

2 hrs

Tutorial Dijkstra

Monday

07.12.15

5 – 6 p.m.

1 hr

Neuroimmune interactions in asthma bronchiale

Monday,

14.12.15

3 – 5 p.m.

2 hrs

Tutorial Werfel

Monday,

14.12.15

5 – 6 p.m.

1 hr

Studying allergic airway inflammation: of mice and man

Monday,

04.01.16

3 – 5 p.m.

2 hrs

Tutorial Braun

Monday,

04.01.16

5 – 6 p.m.

1 hr

Primary Immunodeficiencies in humans – what can they teach us about the immune system?

Monday

11.01.16

3 – 5 p.m.

2 hrs

Monday

11.01.16

5 – 6 p.m.

1 hr

Monday,

18.01.16

3 – 5 p.m.

2 hrs

Monday,

18.01.16

5 – 6 p.m.

1 hr

Matthias Hardtke-Wolenski Tutorial Figueiredo

3. Allergy and Asthma, Immunological diseases Basophils revisited Dorrit Dijkstra

Thomas Werfel

Armin Braun (Fraunhofer Institute)

Melanie Albrecht / Anna-Maria Dittrich

Almut Meyer-Bahlburg Tutorial Albrecht/Dittrich

5. Signaling and therapy Immune Checkpoints as therapeutic target for cancer Engin Gürlevik Tutorial Meyer-Bahlburg

24

Regulation of immune responses by CD45 molecules Monday,

25.01.16

3 – 5 p.m.

2 hrs

Reinhard Schwinzer Tutorial Gürlevik

Monday,

25.01.16

5 – 6 p.m.

1 hr

The complement system and its regulation

Monday

01.02.16

3 – 5 p.m.

2 hrs

Tutorial Schwinzer

Monday

01.02.16

5 – 6 p.m.

1 hr

Acute renal failure – mechanisms of disease

Monday,

08.02.16

3 – 5 p.m.

2 hrs

Tutorial Klos

Monday,

08.02.16

5 – 6 p.m.

1 hr

Tumor immunity and oncogenic signaling

Monday,

15.02.16

3 – 5 p.m.

2 hrs

Tutorial Güler

Monday,

15.02.16

5 – 6 p.m.

1 hr

Tutorial Falk

Monday,

22.02.16

5 – 6 p.m.

1 hr

Andreas Klos

Faikah Güler

Christine Falk

Location entrance)

Building I4, level SO (ground floor), seminar room S1400 (right to the main

25

2. Focus: Genetics and Cell Biology 1. Techniques and diagnostics/therapy Embryonic and somatic cloning in mammals

Monday

12.10.15

3 – 5 p.m.

2 hrs

No tutorial

Monday

12.10.15

Opening ceremony

Monday,

19.10.15

5 p.m.

HS R

Signal-dependent regulation of mRNA translation and non-coding RNAs by RNA-binding proteins

Monday,

26.10.15

3 – 5 p.m.

2 hrs

Tutorial Niemann

Monday,

26.10.15

5 – 6 p.m.

1 hr

Molecular mechanisms of vascular aging in health and disease

Monday,

02.11.15

3 – 5 p.m.

2 hrs

Monday,

02.11.15

5 – 6 p.m.

1 hr

Monday

09.11.15

3 – 5 p.m.

2 hrs

Tutorial Kiyan

Monday

09.11.15

5 – 6 p.m.

2 hrs

Molecular mechanisms of heart failure

Monday,

16.11.15

3 – 5 p.m.

2 hrs

Tutorial Emmrich

Monday,

16.11.15

5 – 6 p.m.

1hrs

Molecular biology of heart failure

Monday,

23.11.15

3 – 5 p.m.

2 hrs

Monday,

23.11.15

5 –6 p.m.

1 hr

Heiner Niemann

Christopher Tiedje (Matthias Gaestel)

Yulia Kiyan Tutorial Tiedje

2. Genetics Cell tracing strategies with fluorescent proteins Stephan Emmrich

Arash Haghikia

Denise Hilfiker Tutorial Haghikia

26

3. Transmembrane Signaling Functions of Syndecans in inflammatory diseases

Monday

30.11.15

3 – 5 p.m.

2 hrs

Tutorial Hilfiker

Monday

30.11.15

5 – 6 p.m.

1 hr

Small GTPases as targets of bacterial toxins

Monday,

07.12.15

3 – 5 p.m.

2 hrs

Tutorial Echtermeyer

Monday,

07.12.15

5 – 6 p.m.

1 hr

Glycosylation and diseases

Monday,

14.12.15

3 – 5 p.m.

2 hrs

Tutorial Genth

Monday,

14.12.15

5 – 6 p.m.

1 hr

Membrane domains

Monday

04.01.16

3 – 5 p.m.

2 hrs

Monday

04.01.16

5 – 6 p.m.

1 hr

Looking closely at the lung and its surfactant system Monday, (refers to topic 1)

11.01.16

3 – 5 p.m.

2 hrs

Frank Echtermeyer

Harald Genth

Hans Bakker

Robert Lindner Tutorial Bakker

4. Cell Biology and disease

Matthias Ochs / Elena Lopes-Rodriguez Tutorial Lindner

Monday,

11.01.16

5 – 6 p.m.

2 hr

How molecular motors work

Monday,

18.01.16

3 – 5 p.m.

2 hrs

Tutorial Ochs / Lopes-Rodriguez

Monday,

18.01.16

5 - 6 p.m.

2 hr

Pathophysiology of arteriosclerosis

Monday

25.01.16

3 – 5 p.m.

2 hrs

Tutorial Manstein

Monday

25.01.16

5 – 6 p.m.

1 hr

Micro RNAs from disease mechanisms to therapeutic approaches

Monday,

01.02.16

3 – 5 p.m.

2 hrs

Monday,

01.02.16

5 – 6 p.m.

1 hr

Dietmar Manstein

Daniel Sedding

Thomas Thum Tutorial Sedding

27

Genomic Alterations and Cancer Predisposition

Monday,

08.02.16

3 – 5 p.m.

2 hrs

Tutorial Jan Fiedler

Monday,

08.02.16

5 – 6 p.m.

1 hr

Stem cells in renal injury

Monday,

15.02.16

3 – 5 p.m.

2 hrs

Tutorial Steinemann

Monday,

15.02.16

5 – 6 p.m.

1 hr

Tutorial Schmitt

Monday,

22.02.16

5 – 6 p.m.

1 hr

Doris Steinemamn

Roland Schmitt

Location

Building I4, 2nd floor (Ebene 1), seminar room 1031 (Master program)

28

MD/PhD program “Molecular Medicine” 4th Semester 3. Focus: Infection and Immunity 1. Innate Immunity; Infection and disease Evolutionary aspects of the Immune System

Monday

04.04.16

3 – 5 p.m.

2 hrs

No tutorial

Monday,

04.04.16

5 – 6 p.m.

1 hr

From Virus pathogenesis to viral therapy

Monday,

11.04.16

3 – 5 p.m.

2 hrs

Tutorial Weiss

Monday,

11.04.16

5 – 6 p.m.

1 hr

Innate Immunity to Viral Infections

Monday,

18.04.16

3 – 5 p.m.

2 hrs

Monday,

18.04.16

5 – 6 p.m.

1 hr

Acute and chronic bacterial infection of the lung Monday (Location: Experimental Pneumology, Feodor-LynenStraße 21; building M05, level 2, room 213)

25.04.16

3 – 5 p.m.

2 hrs

Siegfried Weiss (HZI)

Thomas Pietschmann

Christine Goffinet Tutorial Pietschmann/ Gerold

Ulrich Maus Tutorial Goffinet

Monday

25.04.16

5 – 6 p.m.

1 hr

Immune response in HIV

Monday,

02.05.16

3 – 5 p.m.

2 hrs

Tutorial Maus ditto location

Monday,

02.05.16

5 – 6 p.m.

1 hr

Inflammasomes and Autoinflammation

Monday,

09.05.16

3 – 5 p.m.

2 hrs

Tutorial Schmidt

Monday,

09.05.16

5 – 6 p.m.

2 hrs

No seminars, public holiday

Monday 16.05.16

Reinhold E. Schmidt

Lukas Bossaller

29

2. Genetics and disease Genetic susceptibility of infectious disease

Monday

23.05.16

3 – 5 p.m.

2 hrs

Tutorial Bossaller

Monday

23.05.16

5 – 6 p.m.

1 hr

Genetic engineering of cells and mice for development of disease models

Monday,

30.05.16

3 – 5 p.m.

2 hrs

Monday,

30.05.16

5 – 6 p.m.

1 hr

Monday,

06.06.16

3 – 5 p.m.

2 hrs

Tutorial Wirth

Monday,

06.06.16

5 – 6 p.m.

1 hr

Basic concepts in vaccinology

Monday

13.06.16

3 – 5 p.m.

2 hrs

Tutorial Stripecke

Monday

13.06.16

5 – 6 p.m.

1 hr

Innate lymphoid cells and their role in viral infection and vaccine design

Monday,

20.06.16

3 – 5 p.m.

2 hrs

Tutorial Guzman (HZI)

Monday,

20.06.16

5 – 6 p.m.

1 hr

Host-pathogen interactions

Monday,

27.06.16

3 – 5 p.m.

2 hrs

Tutorial Riese (HZI)

Monday,

27.06.16

5 – 6 p.m.

1 hr

Tutorial Medina

Monday,

04.07.16

5 – 6 p.m.

1 hr

Burkhard Tuemmler

Dagmar Wirth (HZI) Tutorial Tuemmler 3. Infection and immune system Viral vectors for gene transfer in vitro and vivo Renata Stripecke

Carlos Guzman (HZI)

Peggy Riese (HZI)

Eva Medina (HZI)

Location entrance)

Building I4, level SO (ground floor), seminar room S1400 (right to the main

30

4. Focus: Differentiation and Oncology 1. Development and cancer Cellular senescence as a barrier for cancer development

Monday

04.04.16

3 – 5 p.m.

2 hrs

No tutorial

Monday

04.04.16

Liver organogenesis and hepatic stem cell differentiation

Monday,

11.04.16

3 – 5 p.m.

2 hrs

Tutorial Yevsa

Monday,

11.04.16

5 – 6 p.m.

1 hr

Epigenetics in cancer

Monday,

18.04.16

3 – 5 p.m.

2 hrs

Monday,

18.04.16

5 – 6 p.m.

1 hr

Monday

25.04.16

3 – 5 p.m.

2 hrs

Tutorial Lehmann

Monday

25.04.16

5 – 6 p.m.

1 hr

Metabolism and Cancer: Concept, Players,Therapy

Monday,

02.05.16

3 – 5 p.m.

2 hrs

Monday,

02.05.16

5 – 6 p.m.

1 hr

Adoptive T cell therapies in hematopoietic stem cell Monday, transplantation

09.05.16

3 – 5 p.m.

2 hrs

09.05.16

5 – 6 p.m.

1 hr

Tetyana Yevsa

Michael Ott

Ulrich Lehmann Tutorial Ott

2. Stem cells and cancer Tumor stem cells Matthias Christgen

Anuhar Chaturvedi Tutorial Christgen

Martin Sauer Tutorial Chaturvedi

Monday,

No seminars, public holiday

Monday 16.05.16

T-box genes in development and disease

Monday

23.05.16

3 – 5 p.m.

2 hrs

Monday

23.05.16

5 – 6 p.m.

1 hr

A. Kispert Tutorial Sauer

31

3. Signaling (and cancer) Oncogenes and myeloproliferation

Monday,

30.05.16

3 – 5 p.m.

2 hrs

Monday,

30.05.16

5 – 6 p.m.

1 hr

Fibulin-G affects TGF signalling in context of cardiac Monday, remodelling

06.06.16

3 – 5 p.m.

2 hrs

Matthias Eder Tutorial Kispert

Christine Herzog Tutorial Eder

Monday,

06.06.16

5 – 6 p.m.

1 hr

Molecular mechanisms of senescence and their importance for aging in vivo

Monday

13.06.16

3 – 5 p.m.

2 hrs

Tutorial Herzog

Monday

13.06.16

5 – 6 p.m.

1 hr

Physiological functions of the septin cytoskeleton

Monday,

20.06.16

3 – 5 p.m.

2 hrs

Tutorial Hömme

Monday,

20.06.16

5 – 6 p.m.

1 hr

Molecular basis of leukemogenesis

Monday,

27.06.16

3 – 5 p.m.

2 hrs

Tutorial Menon

Monday,

27.06.16

5 – 6 p.m.

1 hr

Tutorial Schwarzer

Monday,

04.07.16

5 – 6 p.m.

1 hr

Meike Hömme

Manoj Menon

Adrian Schwarzer

Location

building I4, 2nd floor (Ebene 1), seminar room 1031 (Master program)

32

PhD programs “Infection Biology / DEWIN” 1st Semester Tutorials: Mondays, 15:15-16:15 hrs Location: Room 1140, Building J4, level1

Seminars: Mondays, 16:30-18:00 hrs Location: Lecture Hall B, Building J2

DATE

TYPE

FOCUS

LECTURER

SUBJECT

12.10.2015

Seminar

Immunology I

Krueger

Episode I - The hematopoetic wonderland

19.10.2015

HBRS Opening: 17:00 - 19:00 hrs (Building J6, Level S0, Lecture Hall R)

26.10.2015

Seminar

Immunology II

Prinz

What innate immune cells can do for you

02.11.2015

Seminar

Immunology III

Moschovakis

B cells and antibody responses

09.11.2015

Seminar

Immunology IV

Lochner

Multiple Choices - Induction and function of T helper cells

16.11.2015

Seminar

Immunology V

Behrens

Divide and Conquer - Antigen presentation and cytotoxic T cells

23.11.2015

Seminar

Microbiology I

Suerbaum

Introduction to Medical Microbiology Common themes in bacterial pathogenesis

30.11.2015

Seminar

Microbiology II

Bange

Paradigms of Infection Biology: Mycobacteria

07.12.2015

Seminar

Microbiology III

Klos

Paradigms of Infection Biology

33

DATE

TYPE

FOCUS

LECTURER

SUBJECT Paradigms of Infection Biology: The gastrointestinal habitat and its microbiota; Helicobacter and Campylobacter as specific pathogens of the niche

14.12.2015

Seminar

Microbiology IV

Josenhans

04.01.2016

Seminar

Microbiology V

Graßl

Paradigms of Infection Biology Salmonella

11.01.2016

Seminar

Microbiology VI

Hofreuter

Metabolism and Virulence

18.01.2016

Seminar

Virology I

Kraft

25.01.2016

Seminar

Virology II

Krey

Virus Entry and Structural Virology

01.02.2016

Seminar

Virology III

Steinmann

Virus Assembly, Maturation and Egress

08.02.2016

Seminar

Virology IV

Bohne

Transcription and Replication of DNA Viruses

15.02.2016

Seminar

Virology V

Pietschmann

Transcription and Replication of RNA Viruses

22.02.2016

Seminar

Virology VI

Viejo-Borbolla

Pathogenesis, Host defense and viral interference

Different Viruses and Viral Diseases

34

PhD Programs “Infection Biology / DEWIN” 2nd Semester Tutorials: Mondays, 15:15-16:15 hrs Location: Room 1140, Building J4, level1

Seminars: Mondays, 16:30-18:00 hrs Location: Lecture Hall B, Building J2

DATE

TYPE

FOCUS

LECTURER

SUBJECT

04.04.2016

Seminar

Cell Biology I

Hauser

The cell cycle and its implications in disease

11.04.2016

Seminar

Cell Biology II

Brinkmann

Intracellular trafficking

18.04.2016

Seminar

Cell Biology III

Stradal

The structure of the cell's interior

Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420 DATE

FOCUS Project Presentation

25.04.2016

Project Presentation

Project Presentation 02.05.2016

Project Presentation

Project Presentation 09.05.2016

17.05.2016 Tuesday!!

Topic Focus

Project Presentation Project Presentation

Project Presentation 23.05.2016

Project Presentation

SUPERVISOR

STUDENT

Sodeik

Otoo

Schulz

Nivia

Wedemeyer

Aregay

Wedemeyer

Soon

Prinz

Wilharm

Prinz

Martins

Tümmler

Pienkowska

Goffinet

Franz

von Hahn

Zapatero

SUBJECT Characterization of functional domains in the large tegument protein pUL36 of Herpes-Simplex Virus Type 1 Developing Inhibitors of the Kaposi Sarcoma-associated Herpesvirus LANA protein Effect of anti-viral therapy and liver transplantation on T and NK cells during chronic hepatitis C Role of hepatitis E virus (HEV) infection in the induction of autoimmune hepatitis (AIH) Sentinels of the Oral Epithelium - Elucidating the Development and Function of Oral γδ T Cells and their Interplay with Langerhans Cells How γδ T cells regulate immune responses and immune tolerance Co-evolution of the intestinal and airways microbial metagenomes in people with cystic fibrosis Impact of Type I Interferons on Maintaining HIV-1 Latency Definition of a minimal set of cell surface molecules required for filovirus cell entry

35

DATE

FOCUS Project Presentation

30.05.2016

Project Presentation

Project Presentation 06.06.2016

Project Presentation

Project Presentation 13.06.2016

Project Presentation

Project Presentation 20.06.2016

Topic Focus

Project Presentation 27.06.2016

Topic Focus

SUPERVISOR

STUDENT

SUBJECT

Graßl

Sharma

Bleich

Meier

Josenhans

Ludwig

Environmental dynamics of Helicobacter pylori in novel rodent models

Förster

Eckert

Role of CCRL1 in controlling intestinal immunity

Krey

Naniima

Molecular characterization of the capsid vertex specific component of herpesviruses

Kalinke

Ghita

Virus control and pathology in herpes simplex encephalitis

N.N.

Identification of novel natural compounds as modulators of Dendritic cell activation

Susceptibility of toll like receptor-11 deficient mice to Salmonella infections Cdcs1-determined colitis susceptibility: microbial factors

Josenhans

Kalinke

Sparwasser

36

PhD Programs “Infection Biology / DEWIN” 3rd Semester Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420 DATE

FOCUS

SUPERVISOR

STUDENT

Topic

Förster

Raud

12.10.2015 Schirdewahn

Original Paper

19.10.2015

26.10.2015

Costa Steinmann

Original Paper

09.11.2015

16.11.2015

Topic focus Topic Focus Topic Original Paper Topic Topic focus

Hickford

23.11.2015

Weiß

Goffinet

Nikolova

B cell responses during infection

Venugopalan

Dejnirattisai et al., Nature Immunology

Bhushal

Functions of IFN-Lambda

Nahrevanian Sodeik

Original Paper

Zhu Joecks

Topic 30.11.2015

Ciesek Original Paper

Topic Topic Focus

Novel HCV inhibitors: from basic mechanisms to clinical use Gerold et al., Cell Reports, Quantitative proteomics identifies

Krey Graßl

Topic

07.12.2015

Differentiation and function of T-helper cells during infection Kashem et al., Immunity, Candida albicans Morphology

HBRS Opening: 17:00 - 19:00 hrs (Building J6, Level S0, Lecture Hall R)

Topic

02.11.2015

SUBJECT

Villalvazo

Bange

Estibariz

Assembly and maturation of herpesvirus capsids Rosato et al., PLOS Pathogens, Neuronal Interferon Signaling Epidemiology of HCV and its transmission Jurgeit et al., PLOS Pathogens, Niclosamide is a proton carrier Horizontal gene transfer in pathogenic bacteria and within the gastrotintestinal microbiota – mechanisms and biological relevance

37

DATE

14.12.2015

STUDENT

SUBJECT

Schirdewahn

Activation and modulation of PAMPs + inflammasome during infection

Original Paper

Nikolova

Härtlova et al., Immunity, DNA damage

Topic

Hickford

FOCUS

Topic

04.01.2016

SUPERVISOR

Sparwasser

Schulz Original Paper

Costa

Topic

Samarina

11.01.2016

Cicin-Sain Kutle

Original Paper Topic 18.01.2016

Original Paper

Kalinke

Topic 25.01.2016

Original Paper

Hühn

Topic 01.02.2016

08.02.2016

Restriction factors interfering with HSV infection Sheahan et al., Cell Host & Microbe, Interferon Lambda Alleles Molecular mechanisms of herpesvirus reactivation Stanton et al., Cell Host & Microbe, HCMV pUL135 Remodels

Zhu Joecks

Postherpetic neuralgia – underlying patho-mechanisms Ren et al., Scientific Reports, A DualReporter system

Venugopalan

Limiting the immune response

Raud

Kalia et al., Immunity, Quiescence of Memory CD8+ T Cells

Villalvazo Viejo-Borbolla

Cellular Entry Pathways used by different virus families van der Linden et al., PLOS Pathogens, The RNA Template

Original Paper

Nahrevanian

Original Paper

Bhushal

Yang et al., Nature, Mesenchymal stem cells

Estibariz

LeRoux et al., eLife, Kin cell lysis is a danger signal

Kutle

Viral interference with the cellular ubiquitination system

Hauser

Topic focus

15.02.2016

22.02.2016

Original Paper Topic focus Topic Original Paper

Suerbaum

Brinkmann

38

PhD Programs “Infection Biology / DEWIN” 4th Semester Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420 DATE

04.04.2016

11.04.2016

18.04.2016

FOCUS

SUPERVISOR

STUDENT

SUBJECT

Project Presentation

Pietschmann

Joecks

Pathways of Intracellular Lipoprotein Recruitment During Hepatitis C Virus Assembly and Maturation

Topic Focus

Pietschmann

Project Presentation

Sparwasser

Raud

Metabolic influences that regulate CD4 T cell function

Topic Focus

Sparwasser

Project Presentation

Ciesek

Costa

Impact of host variation in the SCARB1 gene on the development and maintenance of chronic hepatitis C

Topic Focus

Ciesek

Project Presentation

Förster

Nikolova

Project Presentation

Förster

Venugopalan

Project Presentation

Schulz

Samarina

A genetic approach to identifying host factors involved in herpesviral reactivation in humans

Topic Focus

Schulz

Project Presentation

Suerbaum

Estibariz

The dynamics of the methylome of Helicobacter pylori during human infection

Topic Focus

Suerbaum

Project Presentation

Wedemeyer

Schirdewahn

The role of NK cells and T cells in the pathogenesis of hepatitis delta

Topic Focus

Wedemeyer

Project Presentation

Messerle

Kutle

Project Presentation

Messerle

Nahrevanian

25.04.2016

02.05.2016

09.05.2016

17.05.2016 Tuesday!!!

23.05.2016

Role of memory T cells in adaptive immune responses Immune mechanisms controlling latent MCMV infections in mice

Role of tegument proteins on acute and chronic mouse cytomegalovirus infection Strategies for identification and characterization of antivirals against cytomegalovirus

39

DATE

30.05.2016

06.06.2016

FOCUS

SUPERVISOR

STUDENT

SUBJECT

Project Presentation

Hauser

Bhushal

Dynamics of IFN-virus interplay

Topic Focus

Hauser

Project Presentation

Viejo-Borbolla

Zhu

Modulation of the immune and nervous system mediated by human alphaherpesviruses

Topic Focus

Viejo-Borbolla

Topic Focus

Sodeik

HickfordMartinez

Topic Focus

Sodeik

VillalvazoGuerrero

Topic Focus

N.N.

N.N.

Topic Focus

N.N.

N.N.

Topic Focus

N.N.

N.N.

13.06.2016

20.06.2016

27.06.2016

Retreats: November 11th, 2015 for the Class of 2014 February 3rd, 2016 for the Class of 2013 Intermediate Exam for the Class of 2014: March 16th, 2016 PhD Final Exams: January 22nd, 2016 June 17th, 2016

Cell-type specific cytosolic host factors interacting with HSV1 capsids Molecular characterization of small chemical compounds blocking HSV1 replication

40

PhD Program “Regenerative Sciences” Chairman of program committee: Vice-chairwoman:

Professor Ulrich Martin Professor Renata Stripecke

Times (in general): Tutorials Thursday, 3.00 – 4.00 pm Seminars Thursday, 4.15 – 5.45 pm 5th May 2016 is Ascension Day (‘Christi Himmelfahrt’) which is a public holiday. Therefore, this week’s teaching is changed to 3rd May 2016 (4th semester) or cancelled (2nd semester). Exceptions in day and time are printed in bold. Locations (in general) Semester 1 & 2 MHH, building I/J 04, level 01, HBRS seminar room 1140 Semester 3 & 4 MHH, building I/J 11, Hans-Borst-Zentrum (HBZ), level S0, seminar room 6040 Exceptions in location are marked * and **. 1st semester Introductory lecture 1 Welcome address, the curriculum of REBIRTH & HBRS, Q & A

seminar *

Thursday, 15.10.2015

4.15 – 5.45 pm

Ulrich Martin

Introductory lecture 2 Principles of regenerative sciences and the REBIRTH approach

Seminar

Thursday, 22.10.2015

2.30– 4.00 pm

Ulrich Martin

Seminar

Thursday, 22.10.2015

4.15 – 5.45 pm

Andreas Kispert

Tutorial

Thursday, 29.10.2015

3.00 – 4.00 pm

Andreas Kispert

Seminar

Thursday, 29.10.2015

4.15 – 5.45 pm

Thomas Thum

Tutorial

Thursday, 05.11.2015

3.00 – 4.00 pm

Jan Fiedler

Seminar

Thursday, 05.11.2015

4.15 – 5.45 pm

Amar Deep Sharma

Tutorial

Thursday, 12.11.2015

3.00 – 4.00 pm

Amar Deep Sharma

Principles of developmental biology and organogenesis 1 - Commitment, differentiation, apoptosis, patterning - Morphogenetic gradients and cell-cell communication - Genetic and epigenetic mechanisms Principles of cell engineering 1 - MicroRNAs (miRNA) and downstream targets - technical approaches - Use of miRNA target identification software - Design of miRNA - Luciferase-gene reporter assays (tutorial)

Principles of stem cell biology 1 - Tumor stem cells and mechanisms of transformation - Principles of cell cycle regulation

41

Principles of stem cell biology 2 - Embryonic derivation of stem cells - Culture methods

Principles of developmental biology and organogenesis 2 - Model systems in developmental biology - Embryogenesis and fetal development

Seminar

Thursday, 12.11.2015

4.15 – 5.45 pm

Thomas Müller

Tutorial

Thursday, 19.11.2015

3.00 – 4.00 pm

Thomas Müller

Seminar

Thursday, 19.11.2015

4.15 – 5.45 pm

Achim Gossler

Tutorial

Thursday, 26.11.2015

3.00 – 4.00 pm

Achim Gossler

Seminar

Thursday, 26.11.2015

4.15 – 5.45 pm

Axel Schambach

Tutorial

Thursday, 03.12.2015

3.00 – 4.00 pm

Axel Schambach

Seminar

Thursday, 03.12.2015

4.15 – 5.45 pm

Siegfried Weiß

Tutorial

Thursday, 10.12.2015

3.00 – 4.00 pm

Siegfried Weiß

Seminar

Thursday, 10.12.2015

4.15 – 5.45 pm

Rainer Niedenthal

Tutorial

Thursday, 17.12.2015

3.00 – 4.00 pm

Rainer Niedenthal

Seminar

Thursday, 17.12.2015

4.15 – 5.45 pm

Michael Morgan

Tutorial

Thursday, 07.01.2016

3.00 – 4.00 pm

Michael Morgan

Seminar

Thursday, 07.01.2016

4.15 – 5.45 pm

Dagmar Wirth

Tutorial

Thursday, 14.01.2016

3.00 – 4.00 pm

Dagmar Wirth

Seminar

Thursday, 14.01.2016

4.15 – 5.45 pm

Wolfgang Ziegler

Tutorial

Thursday, 21.01.2016

3.00 – 4.00 pm

Wolfgang Ziegler

Seminar

Thursday, 21.01.2016

4.15 – 5.45 pm

Gudrun Göhring

Tutorial

Thursday, 28.01.2016

3.00 – 4.00 pm

Gudrun Göhring

Principles of cell engineering 2 - Transient DNA delivery - Episomal maintenance - Stable DNA delivery - Homologous recombination

- Site-specific DNA modification Basic mechanisms of inflammation 1 - Innate and adaptive immunity

Principles of growth factor signalling 1 - Paracrine and juxtacrine signalling - Signalling pathways involved in the regulation of growth and differentiation Principles of growth factor signalling 2 - Cytokines, hormones, and their receptors

Synthetic biology and options for regeneration

Cell polarity & cytoskeleton

Principles of chromosomal instability

42

Basic mechanisms of inflammation 2 Infection & cancer

Seminar

Thursday, 28.01.2016

4.15 – 5.45 pm

Ulrich LehmannMühlenhoff

Tutorial

Thursday, 04.02.2016

3.00 – 4.00 pm

Ulrich LehmannMühlenhoff

Principles of cell engineering 3 - Cell expansion - Bioreactors

Seminar

Thursday, 04.02.2016

4.15 – 5.45 pm

Thomas Scheper

tutorial**

Thursday, 11.02.2016

3.00 – 4.00 pm

Thomas Scheper

Seminar

Thursday, 11.02.2016

4.30 – 6.00 pm

Anette Melk / Meike Hömme

Tutorial

Thursday, 18.02.2016

3.00 – 4.00 pm

Anette Melk / Meike Hömme

Cellular senescence, tumor suppression and organismal aging

Please note the following changes: * The seminar (Ulrich Martin) on Thursday, 15th October 2015 will take place at MHH building I/J 11 (TPFZ), level S0, seminar room 1420. ** The tutorial (Thomas Scheper) on Thursday, 11th February 2016 will NOT take place at MHH but at the Institute of Technical Chemistry Leibniz Universität Hannover (LUH) Callinstr. 3 30167 Hannover Callinstr. 3 (LUH) can easily be reached by tram no. 4 directly from MHH to stop Schneiderberg/Wilhelm-BuschMuseum (20 minutes tram)

43

PhD Program “Regenerative Sciences” 2nd semester Principles of growth factor engineering - Engineering growth factors and their receptors for regenerative medicine - Molecular and structural approaches (tutorial) Principles of materials sciences for regenerative medicine 1 Introduction to biomaterials - Ceramic materials (seminar) - Chemistry (tutorial) Principles of materials sciences for regenerative medicine 2 - Nanoparticles (NPs) in medicine (seminar) - Nano-manufacturing & nanoanalytics using lasers (tutorial) Laser technology in medicine 1 Imaging - Basics of microscopy - Contrast mechanisms - Modern approaches in imaging - Superresolution microscopy Laser technology in medicine 2 Laser manipulation/machining - Surface treatment, structuring, polymerization - Laser-tissue interaction - Laser manipulation of cells

Cardiovascular tissue engineering: Principles Principles of materials sciences for regenerative medicine 3 - Polymeric and metallic materials (seminar) - Cell-biomaterial interactions (seminar) - Cell technologies (tutorial)

seminar*

Thursday, 07.04.2016

3.00 – 4.30 pm

Michael Morgan

tutorial*

Thursday, 07.04.2016

4.45 – 5.45 pm

Michael Morgan / Trevor Huyton

seminar*

Thursday, 14.04.2016

3.00 – 4.30 pm

Peter Behrens

tutorial*

Thursday, 14.04.2016

4.45 – 5.45 pm

Peter Behrens

seminar*

Thursday, 21.04.2016

3.00 – 4.30 pm

Laszlo Sajti

tutorial**

Thursday, 21.04.2016

4.45 – 5.45 pm

Laszlo Sajti

seminar*

Thursday, 28.04.2016

3.00 – 4.30 pm

Alexander Heisterkamp

tutorial**

Thursday, 28.04.2016

4.45 – 5.45 pm

Alexander Heisterkamp

seminar*

Thursday, 12.05.2016

3.00 – 4.30 pm

Boris Chichkov

tutorial**

Thursday, 12.05.2016

4.45 – 5.45 pm

Boris Chichkov

seminar

Thursday, 19.05.2016

4.15 – 5.45 pm

Andres Hilfiker

tutorial

Thursday, 26.05.2016

3.00 – 4.00 pm

Andres Hilfiker

seminar*

Monday, 23.05.2016

3.00 – 4.30 pm

Birgit Glasmacher

tutorial*

Monday, 23.05.2016

4.45 – 5.45 pm

Birgit Glasmacher

seminar

Thursday, 26.05.2016

4.15 – 5.45 pm

Willem Wolkers

tutorial

Thursday, 02.06.2016

3.00 – 4.00 pm

Willem Wolkers

Tissue processing and preservation

44

Animal models of human disease 1 - Murine models of human disease

Animal models of human disease 2 - Primate models - Humanized mouse models

Principles of organ transplantation 1 - Heart, lung, and vessels

Animal models of human disease 3 - Transgenic pigs - Xenotransplantation - Donor animal engineering

seminar

Thursday, 02.06.2016

4.15 – 5.45 pm

Achim Gossler

tutorial

Thursday, 09.06.2016

3.00 – 4.00 pm

Achim Gossler

seminar

Thursday, 09.06.2016

4.15 – 5.45 pm

Thomas Moritz / Nico Lachmann

tutorial***

Tuesday, 14.06.2016

4.45 – 5.45 pm

Thomas Moritz / Nico Lachmann

seminar***

Tuesday, 14.06.2016

3.00 – 4.30 pm

Axel Haverich et al.

tutorial

Thursday, 23.06.2016

3.00 – 4.00 pm

Axel Haverich et al.

seminar*

Thursday, 16.06.2016

3.00 – 4.30 pm

Heiner Niemann

tutorial*

Thursday, 16.06.2016

4.45 – 5.45pm

Heiner Niemann

seminar

Thursday, 30.06.2016

4.15 – 5.45 pm

Michael Ott

tutorial

Thursday, 07.07.2016

3.00 – 4.00 pm

Michael Ott

seminar

Thursday, 07.07.2016

4.15 – 5.45 pm

Robert Zweigerdt

tutorial

Thursday, 14.07.2016

3.00 – 4.00 pm

Robert Zweigerdt

Principles of organ transplantation 2 - Liver, pancreas, and ß-cells

Stem cell based organ regeneration - Heart and ß-cells, and clinical translation

Please note the following changes * The seminars on 7th, 14th, 21st, 28th April 2016 and 12th, 23rd May 2016 and 16th June 2016 will be immediately followed by the associated tutorial. The seminars and tutorials on 14th, 21st , 28th April and 12th and 23rd May 2016 will NOT take place at MHH, please find the respective addresses below. ** Teaching taking place at the Laser Centre requires registration one week in advance, i.e. Register until April 14th for the seminar on April 21st (Laszlo Sajti) Register until April 21st for the seminar on April 28th (Alexander Heisterkamp) Register until April 26th for the seminar on May 12th (Boris Chichkov) Please register with [email protected]; you may of course register for all 3 seminars at the same time. *** The seminar and tutorial will take place at building I/J 11 (HBZ) level S0, seminar room 6040.

45 Additional information on ‘Principles of materials sciences for regenerative medicine’, part 1, 2 and 3 General topics: - materials engineering, biomaterials in medicine - ex vivo and in vivo application - degradable materials - cell-biomaterial interactions Literature: Biomaterials Science (Third Edition), BD Ratner, AS Hoffman, FJ Schoen, JE Lemons (eds.) Elsevier Amsterdam 2013; available online, MHH library Lecturers and locations of lectures and tutorials: 14.04.2016 Prof. Dr. Peter Behrens Leibniz Universität Hannover (LUH) Institute for Inorganic Chemistry Callinstrasse 9, 30167 Hannover Tel.: +49 (0) 511 762 3660 Secr.: +49 (0) 511 762 3697; Fax: +49 (0) 511 762 3006 Email: [email protected] Callinstrasse 9 (LUH) can easily be reached by tram no. 4 directly from MHH to stop Schneiderberg/WilhelmBusch-Museum (20 minutes tram) 21.04.2016 PD Dr. Laszlo Sajti Laser Zentrum Hannover e.V. (LZH) Department: Nanotechnology Hollerithallee 8, 30419 Hannover Tel. +49 (0) 511 2788 149; Fax: +49 (0) 511 2788 100 Email: [email protected] LZH can easily be reached by tram no. 4 directly from MHH to stop Marienwerder/Wissenschaftspark (35 minutes tram) 28.04.2016 Prof. Dr. Alexander Heisterkamp Leibniz Universität Hannover (LUH) Institut für Quantenoptik Welfengarten 1, 30167 Hannover Tel. +49 (0) 0511 762 2231; Fax: +49 (0) 0511 762 2211 Email: [email protected] LUH can easily be reached by tram no. 4 directly from MHH to stop Leibniz Universität (20 minutes tram), Main Building, Building 1101, Room F 442 12.05.2016 Prof. Dr. Boris Chichkov Laser Zentrum Hannover e.V. (LZH) Department: Nanotechnology Hollerithallee 8, 30419 Hannover Tel. +49 (0) 511 2788 316; Fax: +49 (0) 511 2788 100 Email: [email protected] LZH can easily be reached by tram no. 4 directly from MHH to stop Marienwerder/Wissenschaftspark (35 minutes tram) 23.05.2016 Prof. Dr. Birgit Glasmacher Leibniz Universität Hannover (LUH) Institute for Multiphase Processes & Centre for Biomedical Engineering (zbm) Callinstraße 36, 30167 Hannover Secr.: Tel. +49 (0) 511 762 3828 ; Fax: +49 (0) 511 762 3031 Email: [email protected] Callinstrasse 36 (LUH) can easily be reached by tram no. 4 directly from MHH to stop Schneiderberg/WilhelmBusch-Museum (20 minutes tram)

46

PhD Program “Regenerative Sciences” 3rd semester Regenerative approaches: Blood and immunity 1 - Embryonic stem cell derived hematopoiesis Regenerative approaches: Blood and immunity 2 - Thymus and T-cell development - B-cell development - Flow cytometry Regenerative approaches: Blood and immunity 3 - Principles of hematopoietic stem cell transplantation and lymphocyte infusions - HLA system and HLA compatibility (tutorial) Regenerative approaches: Blood and immunity 4 - Genetic disorders of hematopoiesis - Leukemia and leukemogenic stem cells Regenerative approaches: Liver 1 - Physiology and pathophysiological changes of the liver - Liver cell therapy, basics in translation

seminar

Thursday, 08.10.2015

4.15 – 5.45 pm

Bernhard Schiedlmeier

tutorial

Thursday, 15.10.2015

3.00 – 4.00 pm

Bernhard Schiedlmeier

seminar

Thursday, 15.10.2015

4.15 – 5.45 pm

Siegfried Weiß

tutorial

Thursday, 22.10.2015

3.00 – 4.00 pm

Siegfried Weiß

seminar

Thursday, 22.10.2015

4.15 – 5.45 pm

Matthias Eder

tutorial

Thursday, 29.10.2015

3.00 – 4.00 pm

Constanca Figueiredo

seminar

Thursday, 29.10.2015

4.15 – 5.45 pm

Axel Schambach

tutorial

Thursday, 05.11.2015

3.00 – 4.00 pm

Axel Schambach

seminar

Thursday, 05.11.2015

4.15 – 5.45 pm

Michael Ott

tutorial

Thursday, 12.11.2015

3.00 – 4.00 pm

Michael Ott

seminar

Thursday, 12.11.2015

4.15 – 5.45 pm

Michael Rothe

tutorial

Thursday, 19.11.2015

3.00 – 4.00 pm

Michael Rothe

seminar

Thursday, 19.11.2015

4.15 – 5.45 pm

Christine Falk

tutorial

Thursday, 26.11.2015

3.00 – 4.00 pm

Christine Falk

seminar*

Thursday, 03.12.2015

3.00 – 4.30 pm

André Bleich

tutorial*

Thursday, 03.12.2015

4.45 – 5.45 pm

André Bleich

seminar

Thursday, 26.11.2015

4.15 – 5.45 pm

Clemens Dasenbrock

tutorial**

Thursday, 10.12.2015

2.45 – 3.45 pm

Clemens Dasenbrock

Genotoxicity and monitoring

Immunotoxicity and immunomonitoring

Animal experiments 1 - Introduction to animal experiments - Presentation of the animal house

Animal experiments 2 - Toxicity testing (inhalation) of biopharmaceuticals (seminar) - Animal house and equipment for inhalation toxicity testing (tutorial)

47 Measuring through the microscope: Quantitative structural assessment of organs, tissues and cells - Basic principles of design-based stereology (seminar) - Applications of stereology to the lung (tutorial)

seminar

Thursday, 10.12.2015

4.15 – 5.45 pm

Matthias Ochs

tutorial

Thursday, 17.12.2015

3.00 – 4.00 pm

Matthias Ochs

seminar

Thursday, 17.12.2015

4.15 – 5.45 pm

Matthias Ballmaier

tutorial

Thursday, 07.01.2016

3.00 – 4.00 pm

Matthias Ballmaier

seminar

Thursday, 07.01.2016

4.15 – 5.45 pm

Renata Stripecke

tutorial

Thursday, 14.01.2016

3.00 – 4.00 pm

Renata Stripecke

Regenerative approaches: Liver 2 - Liver regeneration and stem cells - Stem cell-derived hepatocytes

seminar

Thursday, 14.01.2016

4.15 – 5.45 pm

Michael Ott

tutorial

Thursday, 21.01.2016

3.00 – 4.00 pm

Tobias Cantz

Regenerative approaches: Liver 3 - Liver tissue engineering - Artificial liver / extracorporal devices

seminar

Thursday, 21.01.2016

4.15 – 5.45 pm

Tobias Cantz

tutorial

Thursday, 28.01.2016

3.00 – 4.00 pm

Tobias Cantz

Regenerative Approaches: Pancreas 1 - Biochemistry/pathobiochemistry of pancreatic ß-cells

seminar

Thursday, 28.01.2016

4.15 – 5.45 pm

Ortwin Naujok

tutorial

Thursday, 04.02.2016

3.00 – 4.00 pm

Ortwin Naujok

Regenerative approaches: Pancreas 2 - Differentiation of ES cells into insulinproducing cells

seminar

Thursday, 04.02.2016

4.15 – 5.45 pm

Ortwin Naujok

tutorial

Thursday, 11.02.2016

3.00 – 4.00 pm

Ortwin Naujok

MicroRNAs in cardiovascular diseases - Regeneration and therapeutic approaches

seminar

Thursday, 11.02.2016

4.15 – 5.45 pm

Thomas Thum

tutorial

Thursday, 18.02.2016

3.00 – 4.00 pm

Thomas Thum / Sandor Batkai

Cell sorting - Method based seminar - Visit to MHH sorter lab – instrumentation (tutorial)

Regenerative approaches: Blood and immunity 5 - Antigen presenting cells

Please note the following change * The seminar on 3rd December 2015 will be immediately followed by the associated tutorial. ** Tutorial: ‘Animal house and equipment for inhalation toxicity testing’ on 10th December 2015, 2.45 - 3:45 pm, location: Fraunhofer ITEM, Nikolai-Fuchs-Str. 1, Main entrance: Stadtfelddamm, seminar room S 1a

48

PhD Program “Regenerative Sciences” 4th semester Molecular biology of heart failure (seminar) Physiological measurements at mouse heart (tutorial)

seminar

Thursday, 07.04.2016

4.15 – 5.45 pm

Jörg Heineke

tutorial

Thursday, 14.04.2016

3.00 – 4.00 pm

Jörg Heineke

Regenerative approaches: Heart and vessels 1 Angiogenesis und arteriogenesis in development and disease

seminar

Thursday, 14.04.2016

4.15 – 5.45 pm

Florian Limbourg

tutorial

Thursday, 21.04.2016

3.00 – 4.00 pm

Florian Limbourg

Regenerative approaches: Heart and vessels 2 Cardiac differentiation of pluripotent stem cells & myocardial TE

seminar

Thursday, 21.04.2016

4.15 – 5.45 pm

Ina Gruh

tutorial

Thursday, 28.04.2016

3.00 – 4.00 pm

Ina Gruh

seminar

Thursday, 28.04.2016

4.15 – 5.45 pm

Kai Wollert

tutorial

Tuesday, 03.05.2016

3.00 – 4.00 pm

Kai Wollert

seminar

Tuesday, 03.05.2016

4.15 – 5.45 pm

Ruth Olmer

tutorial

Thursday, 12.05.2016

3.00 – 4.00 pm

Ruth Olmer

seminar

Thursday, 12.05.2016

4.15 – 5.45 pm

Ruth Olmer

tutorial

Thursday, 19.05.2016

3.00 – 4.00 pm

Ruth Olmer

seminar

Thursday, 19.05.2016

4.15 – 5.45 pm

Michael Jagodzinski

tutorial

Thursday, 26.05.2016

3.00 – 4.00 pm

Michael Jagodzinski

seminar

Thursday, 26.05.2016

4.15 – 5.45 pm

Susanne Petri

tutorial

Thursday, 02.06.2016

3.00 – 4.00 pm

Susanne Petri

Regenerative approaches: Heart and vessels 3 Cell therapy for myocardial infarction: basic concepts and clinical applications

Regenerative approaches: Lung 1

Regenerative approaches: Lung 2

Regenerative approaches: Cartilage, bone and tendon - mesenchymal stem cells, mesenchymal tissues - signaling pathways - autologous/ allogenic/ xenogenic/ prosthesis/ tissue engineering - animal models - translation: from basic research to clinical therapies - treatment options for bone fractures, osteoarthritis (articular cartilage damage), tendon ruptures Regenerative approaches: Nerve - Degeneration and regeneration in the

central and peripheral nervous system - Animal models of acute and chronic neurotoxicity - Cell therapy in the nervous system: neuronal and non-neuronal cells - Application modes - Clinical trials

49

seminar

Thursday, 02.06.2016

4.15 – 5.45 pm

Christine Radtke

tutorial

Thursday, 09.06.2016

3.00 – 4.00 pm

Christine Radtke

seminar

Thursday, 09.06.2016

4.15 – 5.45 pm

Heiko von der Leyen HCTC

tutorial

Thursday, 16.06.2016

3.00 – 4.00 pm

Heiko von der Leyen HCTC

seminar

Thursday, 16.06.2016

4.15 – 5.45 pm

Ralf Cordes / Torben Söker Ascenion GmbH

tutorial

Thursday, 23.06.2016

3.00 – 4.00 pm

Ralf Cordes / Torben Söker Ascenion GmbH

seminar

Thursday, 23.06.2016

4.15 – 5.45 pm

Marc Barthold / Christoph Priesner

tutorial

Thursday, 30.06.2016

3.00 – 4.00 pm

Marc Barthold / Christoph Priesner

seminar

Thursday, 30.06.2016

4.15 – 5.45 pm

Ulrike Köhl / Stephan Klöss

tutorial

Thursday, 07.07.2016

3.00 – 4.00 pm

Ulrike Köhl / Stephan Klöss

seminar

Thursday, 07.07.2016

4.15 – 5.45 pm

Felix Hermann apceth GmbH & Co. KG

seminar*

Thursday, 14.07.2016

3.00 – 4.30 pm

Cornelia Blume

tutorial*

Thursday, 14.07.2016

4.45 – 5.45 pm

Cornelia Blume / Antonia Lavrentieva

Regenerative approaches: Skin

Design of clinical trials & regulation

Patent Protection of academic inventions

Quality Management – QM

Good Manufacturing Practice (GMP), Advanced Therapy Medicinal Products (ATMP)

Marketing and industrial partnerships

Cell culture for production, testing, and tissue engineering*

* The seminar on 14th July will be immediately followed by the associated tutorial.

50 Additional offers: Meet The Investigator

Name

Department

Location

Jörg Heineke

Experimental Cardiology

I/J 11, level S0, room 2nd June 6080 2016

Date

Ulrich Martin*

LEBAO

MHH

Elena LopezRodriguez 

Institute of Functional and Applied Anatomy

MHH

Laszlo Sajti

LZH, Nanotechnology

LZH

Jan Fiedler

IMTTS, IFB-Tx

I/J 03, level 03, room 2040

Lung surfactant biology and methods in lung surfactant research

Elena LopezRodriguez

Institute of Functional and Applied Anatomy

MHH

RNA and DNA-basic methods

Jörg Heineke

Experimental Cardiology

I/J 11, level S0, room th 9 June 2016 6080

Scientific working with Endnote and Reference Manager

Ortwin Naujok

Institute of Clinical Biochemistry

IFB-Tx, MHH

Real-time PCR & Analysis*

Ortwin Naujok

miRNA in thrombocytes

Seema Dangwal

Time

Method Based Seminar

Institute of Clinical Biochemistry Institute of Molecular and Translational Therapeutic Strategies (IMTTS)

Basics of pathology in laboratory Susanne Rittinghausen Fraunhofer ITEM rodents *max. 8 participants

Date and time for all semesters on appointment (registration required).

14th January 2016 or 21st January 2016

MHH

MHH

17th February 2.00 pm 2016

Microscopy Room (ITEM)

17th November 2015

10.1511.45 am and 1.152.45 pm

51

PhD Program ”Auditory Sciences: Physics and Engineering, Physiology and Therapy of Hearing” For further information and registration please contact (if not noted elsewhere): [email protected] / [email protected] / [email protected] Obligatory courses: red: obligatory courses for all students; black: electives for UOL and LUH, obligatory for MHH Title

Course organiser

Credit

Time and place

1.1 Clinic, Diagnostic and Therapy of Peripheral and Central Hearing Disorders

Prof. Thomas Lenarz

25 hours 3 CP

MHH building K6, node B, 6th floor, seminar room S66

1.2 Audiology and Physics of Hearing

Prof. Hannes Maier

10 hours 1 CP

MHH

1.3 Sensory Neuroscience

Prof. Andrej Kral

25 hours 3 CP

MHH

1.4 Imaging Methods in Medicine

Prof.’in Lilli Geworski

25 hours 3 CP

MHH building K7, floor S0, seminar room 1321 Participants: 5-20 students

1.5 Psychophysical Methods in Hearing Research

Prof. Andreas Büchner

10 hours 1 CP

MHH Seminar room “DHZ”, Hannover

1.6 Introduction to Biomaterials, Laser Spectroscopy and Microelectronics 1.7 Fundamentals of Auditory Physiology

Prof. Peter Behrens Prof. Andreas Heisterkamp Prof. Holger Blume Prof.’in Christine Köppl Prof. Georg Klump

25 hours 3 CP

LUH

30 hours 3 CP

UOL

1.8 Summer School and Internal Retreat

N.N.

20 hours 2 CP

15.-19.08.2016 Location tba

52

Elective courses at MHH: 2.1 Nanotechnology in Medicine

Prof. Theo Doll

2.4 Sound Coding Strategies Jun.-Prof. Waldo Nogueira and Signal Processing Methods for Cochlear Implants and Hearing Aids 2.5 Anatomy of the Auditory Jun.-Prof.’in Simone Kurt System

12 hours 1 CP

15 hours 1.5 CP 10 hours 1 CP

2.6 Biomedical Technology

PD Dr. Omid Majdani

10 hours 1 CP 12 hours 1-1.5 CP

2.7 Medical Image Processing for Medical Applications

PD Dr. Omid Majdani Thomas Rau Georg-Jakob Lexow

2.8.1 Modulation of Basal Ganglia Activity in Movement Disorders by Functional Neurosurgery

Prof. Joachim Krauss

1.5 hours

2.8.2 Animal Models for Psychiatric Disorders

Prof.’in Kerstin Schwabe

1.5 hours

2.9 Auditory Plasticity

Prof. Andrej Kral

25 hours 3 CP

2.10 Audiological Practical Course (incl. Stem Cell- and Molecular Biology of Hearing)

Prof. Günter Reuter Prof.’in Andrea Hoffmann

25 hours 3 CP

2.11 Scientific Writing

Prof. Andrej Kral

30 hours 3 CP

2.12 Lab Meeting Otolaryngology

N.N.

1 hour / meeting

MHH Conference room, 2nd floor, “HZH GmbH” (VIANNAbuilding), tba MHH On request NogueiraVazquez.Waldo@mh -hannover.de MHH On request Min. 4 students MHH On request MHH On request [email protected] MHH building K6, node B, 05th floor, seminar room 65 18.11.2015, 4:30 – 6:00 pm; [email protected] deadline: 13.11.2015 MHH building K6, node B, 05th floor, seminar room 65 02.12.2015, 4:30 – 6:00 pm; [email protected] deadline: 30.11.2015 MHH Conference room, 2nd floor, “HZH GmbH” (VIANNAbuilding), On request MHH, building K5, node F, 3rd floor, seminar room and labs, WS 2015 MHH VIANNA Starting 18.12.13 15:00-16:30; on request MHH Conference room, 2nd floor, “HZH GmbH” (VIANNAbuilding) Wednesdays 5-6pm

53

2.13 Journal Club (Neuroscientific Studies on Humans)

N.N.

2 hours / meeting

2.14 Hearing(4all) Research N.N. Seminar

1 hour / meeting

2.15 Colloquium Medical Physics

Prof.’in Lilli Geworski

1 hour / meeting

2.16 Lunchseminar Radiology

Prof.’in Lilli Geworski

1 hour / meeting

2.17 Colloquium Radiology

Prof.’in Lilli Geworski

1 hour / meeting

2.18 HNO-Meeting

Prof.’in Lilli Geworski

1 hour / meeting

MHH, building K5, node B, 3rd floor, seminar room 63, last Wednesday of the month 11am-1pm MHH Wednesdays every second month; 5 - 6pm; Place: tba Contact: [email protected] MHH, building K7, floor S0, seminar room 1321 Every second Tuesday 3 - 4pm, Registration required MHH Radiology Wednesdays, 12am - 1pm Registration required MHH Radiology Tuesdays 08:15 - 09:00am Registration required MHH Neuroradiology Date per request Registration required

Elective courses at the University of Veterinary Medicine Hannover, Foundation: 2.19 Neurobiology of Acoustic Communication and Orientation

Prof.’in Elke Zimmermann PD Dr. Sabine Schmitt

25 hours 3 CP

TiHo, Bünteweg 17, Summer 2016 [email protected] participants: 4-8 students

Prof. Holger Blume

12 hours 1 CP

LUH / IMS Seminar room 335 Appelstr. 4, 3rd floor Hannover

Elective courses at LUH: 2.20 Basics of Digital Systems

Two days in spring 2016 10am - 1pm, 2pm - 5pm (each day)

54

2.21 Application-Specific Instruction-Set Processors for Hearing Aid Systems

2.22 Principles of Signal Processing in MATLAB

Jun.-Prof. Guillermo Payá Vayá

Jun.-Prof. Guillermo Payá Vayá

12 hours 1 CP

12 hours 1 CP

LUH / IMS Seminar room 335 Appelstr. 4, 3rd floor Hannover Two days in spring 2016 10am - 1pm, 2pm - 5pm (each day) LUH / IMS Seminar room 335 Appelstr. 4, 3rd floor Hannover Two days in spring 2016 10am - 1pm, 2pm - 5pm (each day)

Elective courses at UOL: 2.23 Signal Processing and Prof. Simon Doclo Acoustics I

40 hours 4 CP

UOL Tba (February/March 2016)

2.24 Signal Processing and Prof. Simon Doclo Acoustics II

25 hours 3 CP

UOL Tba (February/March 2016)

2.25 Methods in Hearing Research - Introduction to Biomedical Physics and Acoustics

25 hours 3 CP

UOL Thursday: 4 - 6 pm, weekly, beginning 16.04.2015

25 hours 3 CP

UOL 30.09.-01.10.2015

Prof. Birger Kollmeier, Prof. Simon Doclo

2.26 Neurophysiological Prof.’in Christiane Thiel Imaging and Data Analysis Prof. Stefan Debener (in Hearing Research) EEG and fMRI

Combined electives: 2.27 Combined Hot Topic Seminar (Web Conference)

Odett Kaiser Jacqueline LeßigOwlanj

2 h/seminar

Dates: tba

55

PhD Program “Epidemiology” Chairman of program committee:

Prof. Dr. Gérard Krause

Coordination:

Dr. Jördis Ott & Dr. Stefanie Castell

Location:

Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany Study Centre of German National Cohort and of the Helmholtz Centre for Infection Research, Hannover, Germany

Epidemiologic Fieldwork:

Module*

Type

Outbreak investigation and surveillance Good Epidemiological Practice and its practical application Data Analysis I

Lectures, exercises, practical application Lecture and exercise

Data Analysis II Data Analysis III Epidemiologic field work

Laboratory methods in infectious disease epidemiology (“Spring School”) Journal Club

Dates Semester 2015/16 Spring/summer 2016

Duration

Lecturer/organizer

30 hrs (one week module)

Gérard Krause and team.

July 2016

5 hrs

Stefanie Castell Jördis Ott

Lectures and exercises Lectures and exercises Lectures and exercises Practical work in the study center of the German National Cohort or at other field locations. Lectures and practical laboratory work including site visits.

15-16 Oct 2015 22-23 Oct 2015 Summer 2016

30 hrs 30 hrs

Rafael Mikolajczyk and team Rafael Mikolajczyk

Summer/Fall 2016

30 hrs

Rafael Mikolajczyk

Individual dates for each student.

One week module.

Yvonne Kemmling and team.

May 2016

30 hrs (one week module)

Claudia Sievers

Presentations by students.

Ongoing on a monthly basis.

1 hr (monthly)

Jördis Ott Stefanie Castell

* Teaching modules in the PhD Programme Epidemiology are organized as compact courses, taught on subsequent days.

Students of the PhD Programme Epidemiology and located at the HZI can attend courses and symposia offered by the HZI Grad School. Students of the PhD Programme Epidemiology are encouraged to attend courses at institutes of the MHH and of the HBRS at the MHH. CPs/hours can be accredited after consulting with the coordinating team and in line with the requirements of the program. The annual PhD retreat of the Programme Epidemiology takes place on 18 September 2015 in Braunschweig. Attendance is mandatory for all PhD students in the programme.

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TECAS European Doctoral Academy in Regenerative Engineering Marie Curie Initial Training Network “Tissue Engineering Solutions for Cardiovascular Surgery” Chairman of program committee: Vice-chairman:

Dr. Sotiris Korossis Prof. Dr. Axel Haverich

Modules/activities compulsory for Marie Curie Fellows are listed in the table below (see notes 1 and 2). Courses will be delivered on the condition that there are at least 5 registered participants. Location: Building M07, level 1, seminar room Title A rookie’s guide to the PhD Degree

Type

Lecture

Lecture Statistical analysis Tutorial

Principles of material mechanics - Loading and Lecture/Tutorial support - Free body diagrams - Stress/strain concept - Elastic properties Lecture/Tutorial - Viscoelastic properties

Biomaterials for tissue engineering - Biological scaffolds - Polymeric scaffolds

TE bioreactors - Bioreactor types - Bioreactor design - Case studies

Lecture

Tutorial

Lecture

Date Tuesday, 10.11.2015 AND Tuesday, 17.05.2016 Tuesday, 10.11.2015 AND Tuesday, 17.05.2016 Wednesday, 11.11.2015 AND Wednesday, 18.05.2016 Wednesday, 11.11.2015 AND Wednesday, 18.05.2016 Friday, 13.11.2015 AND Friday, 20.05.2016 Tuesday, 17.11.2015 AND Tuesday, 24.05.2016 Wednesday, 18.11.2015 AND Wednesday, 25.05.2016 Tuesday, 17.11.2015 AND Tuesday, 24.05.2016

Time/Duration

Lecturer/Organiser

14.00 – 15.00 Sotiris Korossis

15.00 – 18.00

Sotiris Korossis Daniele Dipresa

10.00 – 13.00

Sotiris Korossis Daniele Dipresa

14.00 – 17.00

14.00 – 17.00

Sotiris Korossis

Sotiris Korossis

10.00 – 13.00

Sotiris Korossis Lucrezia Morticelli

15.00 – 18.00

Sotiris Korossis Lucrezia Morticelli

14.00 – 17.00 Sotiris Korossis

57 Friday, 20.11.2015 AND Friday, 27.05.2015

Tutorial

Title

Type

Exchange Secondment 1 3 Laboratory practical

Exchange Secondment 2 3 Seminar

Clinical Secondment 4

Laboratory practical

External Secondment 5

Laboratory practical

Industrial Secondment 6

Industrial placement

Transferable Skills Workshop 7 Translation, Commercialisation and Standardisation Workshop 8

Semester(s) To be individually arranged for each Fellow To be individually arranged for each Fellow To be individually arranged for each Fellow To be individually arranged for each Fellow To be individually arranged for each Fellow

Lecture Tutorial

04.12.2015

Lecture 03.12.2015 Tutorial

14.00 – 17.00 Sotiris Korossis

Duration

Organiser

max 3 months Sotiris Korossis

max 1 month

Sotiris Korossis

1 month

Sotiris Korossis

max 2 weeks

Sotiris Korossis

1 month

Sotiris Korossis

Sotiris Korossis 09.00 – 17.00 RWTH Aachen University, Aachen Sotiris Korossis, Michael Harder 09.00 – 17.00 RWTH Aachen University, Aachen

58 IMPORTANT NOTES 1. TECAS Marie Curie Fellows are required to attend 300 hours of lectures and seminars from the TECAS Curriculum offered by the TECAS Partners (HBRS; Eindhoven University of Technology; RWTH Aachen University; University of Padua; University of Patras). In addition, TECAS Marie Curie Fellows are required to attend the annual Women in Science & Engineering Days and the Annual Work-in-Progress Meetings organized by the TECAS-ITN. 2. TECAS modules are offered at both Winter and Summer Semester. 3. Exchange Secondments can be organised for a maximum of 4 non-TECAS students per year after consultation and agreement with their project supervisors, provided that their travel and living expenses are covered by them. TECAS Marie Curie Fellows are required to undertake 2 Exchange Secondments to other TECAS-ITN academic partners (University Hospital Aachen, Eindhoven University of Technology, University of Padua, University of Patras) to gain training in projectspecific techniques or equipment (Exchange Secondment #1) and transferable skills (Exchange Secondment #2) not available in Hannover Medical School. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 4. Clinical Secondments can be organised for a maximum of 2 non-TECAS students per year after consultation and agreement with their project supervisors provided that their travel and living expenses are covered by them. TECAS Marie Curie Fellows are required to undertake 1 Clinical Secondment with one of the affiliated hospitals (Hanover Medical School, Padua University Hospital, Aachen University Hospital). The Clinical Secondment will be undertaken in the transplant services of the affiliated hospitals and will familiarise the Fellows with standard practices and methodologies used for retrieval, storage, processing and issue of human tissues for transplantation purposes. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 5. This Secondment is only available to TECAS Marie Curie Fellows. Depending on the their research and training needs, TECAS Marie Curie Fellows are required to undertake 1 External Secondment to an academic or industrial institution outside the TECAS-ITN. This scheme will offer access to specialised equipment and techniques not available among the TECAS-ITN partners. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 6. This Secondment is only available to TECAS Marie Curie Fellows. TECAS Marie Curie Fellows are required to undertake 1 Industrial Secondment with one of the industrial TECAS-ITN partners (Corlife, ROWIAK, 3T). The Industrial Secondment will provide the Fellows with experience of working in the medical implant industry, and familiarise them with aspects and issues relevant to clinical translation, standardisation and/or commercialisation of their research. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 7. The Transferable Skills Workshop will be hosted at RWTH Aachen University, Aachen. The workshops will be delivered in the form of lectures, tutorial and interactive activities and will focus on research ethics, leadership and team work, entrepreneurship, time management, networking skills, media training, writing for non-scientific press, public awareness & engagement, presentation skills, and event organisation. Students that wish to participate in the Workshop are required to notify the organizer at least two months in advance. 8. The Translation, Commercialisation and Standardisation Workshop will be hosted in Eindhoven University of Technology, Netherlands and it is open to all HBRS students. The workshop will aim to deepen the understanding on the commercialisation and standardisation challenges facing regenerative medicine along the innovation pipeline from the bench to the bedside. The workshop will comprise lectures and Q&A sessions on preclinical testing, tissue sterilisation, preservation and banking, risk assessment and quality management, European regulation, and ISO standards. Students that wish to participate in the Translation, Commercialisation and Standardisation Workshop are required to notify the organizer at least two months in advance.

59

Specific seminars and practicals (see special announcements provided by the HBRS office, program offices and the respective departments)

Organized by the HBRS Office: Presentation of projects/retreat (weekend, 2 days; for MD/PhD MM: March 3rd/4th, 2016) Gene Technology Security (September 2016, in English) Translation workshop (Drug development, Patenting, Clinical Studies etc.: May 2016) Career Day (March 18th, 2016) GMP/ GLP workshop (December 9th, 2016, Fleischauer & further representatives of ITEM) Scientific communication/writing, “tipps and tricks” (January 15th, 2016, Kruse) Scientific writing, advanced (February 2016 John Chandler) Animal Experiments (3 days, in the week November 16th-20th, 2016, Bleich/ Dorsch) Conflict Management (December 1st/2nd, 2016, G. Kümmele, Berlin) and Stress Management (January 12th/13th 2016, G. Kümmele) Time Management (April 6th, 2016 Golin) Team Work and Leadership (April 20th, 2016 Golin) Intercultural communication (weekend, June 10th-12th 2016; A. and S. Petersen, Aachen; together with MSc/PhD programs in Göttingen) Seminars on career perspectives (continuously) Further courses: Assessment Center, Job hunting, Project Management, Team Building, Weekend workshop German culture etc. will be announced in course of the year.

Seminars offered by Helmholtz Centre for Infection Research Braunschweig, Twincore, Fraunhofer Institute or TiHo: see announcements

Lectures (see special announcements and websites) Interdisciplinary Seminars of the IRTG Seminars of the SFBs Seminars of Clusters of Excellence” Immunological Colloquium Biochemical Colloquium Gastroenterology Colloqium Microbiological Colloquium, Virological Colloqium Biological and Biochemical Questions (BBQ)

60

In the departments (a must!!) -

Lab-Seminars Journal-Clubs

(these should be in English!)

Internal practical courses The supervisors will provide you with special practical trainings if needed. You might also ask your cosupervisors or fellow PhD students for help. Program offices and HBRS will offer a number of short practical courses (see announcements).

German Classes Tuesdays: 4.00 p.m. – 6.00 p.m. (beginners, Gudrun Dettmar), HBRS seminar room 1140 (building I 4, level 01); Tuesdays: 5.00 p.m. – 7.00 p.m. (advanced, Mrs Gesine Mann) Fridays Mrs Gudrun Dettmar (on demand)

Scientific English Mondays: 6.15 p.m. – 7.30 p.m.; Mrs Lydia Lange; HBRS seminar room 1140 (I 4, level 01)

Optional Note: You are welcome to visit most of the seminars/courses organized for the German Biology and Biochemistry students, as well as medical students. You are also welcome to visit seminars/courses offered by all programs of HBRS [including the Graduate School at the University of Veterinary Medicine Hannover (TiHo)].

http://www.mh-hannover.de/hbrs.html http://www.helmholtz-hzi.de

61

Rules and Requirements for Postgraduate (PhD) Studies and Examinations in structured doctoral programs of Hannover Biomedical Research School (HBRS), Hannover Medical School On December 15th, 2000 the Senate of the Hannover Medical School approved the following Rules and Requirements for Postgraduate (PhD) Studies and Examinations in structured doctoral programs of Hannover Biomedical Research School (HBRS) (alternatively Dr.rer.nat. for life scientists). (Modifications on June 4th 2002, February 11th 2004, April 21st 2005, March 14th 2007, April 15th 2009, November 9th 2011, November 14th 2012 and June 18th 2014)

§1

Objective of PhD Studies Research studies at the Hannover Medical School (MHH) for the purpose of obtaining a PhD degree (hereinafter referred to as PhD studies) shall facilitate postgraduate training with a focus on specific research projects with a view to enabling the candidate to do in-depth scientific work on his or her own and to provide him or her with additional professional qualifications for future assignments in research or related areas of work. PhD studies shall foster the development of outstandingly gifted up-andcoming academics. The standard time allowed for completing PhD studies shall be three years. Once these PhD studies have been successfully completed, and the PhD examination has been passed, the MHH will award the degree of a Doctor of Philosophy (PhD) to medical students (including dentists), veterinarians, pharmacists, engineers, life scientists, and graduates with biomedical or health science related focus or Dr. rer. nat. to natural scientists and pharmacists (not to medical students).

§2

Requirements for Access and Admission (1) Anybody having successfully completed university studies in medicine, veterinary medicine, engineering, pharmacy, natural sciences or biomedical/ health science focus (normally Master, Diploma or Staatsexamen) shall have access to PhD studies. (2) Applicants are required to render evidence of above-average results obtained at university. The applicant’s past career must reveal his or her particular qualification for and dedication to scientific work. Decision on whether or not a candidate qualifies for access to PhD studies is up to the PhD Program Committee (§ 4).

§3

Admission to PhD Studies (1) The number of applicants that can be admitted to PhD studies is limited; the number depends on the respective program. The respective PhD Program Committee shall select the applicants to be admitted (§ 4). As a rule, the President of the MHH will give notice of the date of commencement of PhD studies once a year. (2) Details of the as a rule three-step selection process (written application, written test in home countries or selection by program committee, interview) are regulated in the respective program ‘rules of admission’. (3) Application papers shall be submitted to the chairperson of the PhD Program Committee. Details of current application procedures are described on the website of HBRS. (4) On the basis of this application the PhD Program Committee shall decide on admission to PhD studies. (5) At MHH, candidates are enrolled as PhD students for the whole duration of their PhD work. Matriculation is done at the beginning of studies (usually winter semester).

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§4

PhD Program Committee (1) The respective PhD Program Committee shall be responsible for the conduct of PhD studies according to the Rules and Requirements for postgraduate studies and examinations to obtain a PhD (Dr.rer.nat.) degree. (2) As a rule, the PhD Program Committee shall be composed of four professors (or competent habilitated/senior scientists), a university scientist with a doctoral degree, and student representatives of every study year who have a joint vote. Members of the PhD Program Committee shall be appointed by the scientists of a respective program for a period of four years, or two years in case of student members. Re-election shall be possible. The PhD students shall suggest candidates from among their ranks. The respective PhD Program Committee shall be affirmed by the Research Committee of MHH. The PhD Program Committee is then constituted by the Dean of HBRS and shall elect a professor from among its ranks as chairman. (3) The PhD Program Committee will meet regularly. (4) The PhD Program Committee will evaluate proposed projects (open projects) according to quality (with external referees if necessary), financial support, guarantee of independence for PhD students. (5) The PhD Program Committee shall appoint a team of co-supervisors (thesis advisory board) for each PhD student. Team members shall be habilitated or equally qualified. The team of co-supervisors shall be composed of the student’s personal supervisor at the MHH or partner institutes, and two further scientists qualified as university teachers whose professional activity shall be closely related to the subject of the project. In case of several PhD students doing research in the same line, the respective cosupervisors’ teams can be composed of the same individuals.

§5

Contents of Studies (1) The contents to be learned shall be conveyed to the students through their experimental or equivalent theoretical research work and through project-related as well as inter-disciplinary research-oriented courses and seminars. For that purpose, the PhD Program Committee shall prepare and submit, after consultation with the university institutions or partner institutes involved in these studies, a curriculum indicating compulsory and recommended courses or seminars for each discipline. The courses and seminars shall be held by the teachers and professors of the MHH as well as partner institutes, including visiting professors. Teaching shall be in English. Lectures and seminars of different programs are mutually acknowledged. PhD students may also register for suitable courses or seminars offered by other scientific schools (Leibniz University, University of Veterinary Medicine, etc.). Students are encouraged to do active teaching themselves, e.g. by giving lectures at seminars or postgraduate research training programs [Doktorandenkolleg]. Each student’s individual progress at PhD courses and seminars shall be monitored and consistently assessed by the respective teachers, with teachers preparing written reports on the results obtained by the student.

(2) PhD students shall design, after consultation concert with their co-supervisors, their respective individual schedules pursuant to the curriculum established by the PhD Program Committee. Such individual schedule shall require approval by the respective co-supervisors’ team. The student must complete a minimum of 300 hours at courses and seminars during his or her PhD studies; as a rule, at least 80% thereof must be taken at project-related courses and seminars and up to 20% may be spent on interdisciplinary learning (e.g. experimental techniques and bio-informatics, molecular biology, biostatistics, scientific communication etc.). During the first year of PhD studies, courses for physicians, dentists and veterinarians are intended to provide participants with a chance to consolidate their knowledge of the fundamental principles of natural sciences and courses for natural scientists are intended to consolidate their knowledge in medical aspects.

63 (3) PhD students could apply for a leave if justified (e.g. in case of pregnancy), but for no more than 12 months. Short time stays abroad are very much appreciated and will be supported. If students take seminars and courses abroad, they could be acknowledged for the respective PhD program.

§6

Supervision (1) PhD students shall supervised by the members of their respective thesis advisory board (§ 4) appointed by the PhD Program Committee. The responsibilities of the team shall be: a) To act as co-supervisors and to give individual expert advice to PhD students all through their PhD studies. b) To evaluate PhD students’ progress during their studies by receiving their reports (annually) and conducting exams; and to assess their written final examination papers. c) Within a time of probation of 6 months, PhD students are evaluated. Within this time peroid, student status can be changed easily on both sides in agreement with the team of co-supervisors and PhD Program Committee. The PhD Program Committee can upon request decide about the termination of collaboration with the student. d) Within the scope of their research project, students have to work with appropriate methods on a clearly defined subject so that, with some realistic prospect of success, scientific knowledge can be expected to be incremented and the results of such research should be published in international peer-review journals. The co-supervisors shall make sure, and satisfy the PhD Program Committee to that effect, that students are not entrusted with any tasks unrelated to their PhD studies.

(2) The co-supervisors shall be responsible for the financing of the respective research project and shall make efforts, during the standard period of PhD studies (three years), to raise the money needed for the PhD students they are in charge of. Any scholarships available at the MHH shall be awarded by resolution of the HBRS Committee of MHH. (3) Co-supervisors should assist PhD students in planning their further professional career. (4) The responsibilities of co-supervisors for PhD students shall end upon the date when the latter pass their PhD examination (§ 10), which is normally three years but no later than five years after commencement of PhD studies.

§7

Scientific Colloquia (retreats) PhD students shall be invited annually by the PhD Program Committee to attend a public colloquium (retreat), giving them an opportunity to give a presentation on the current status of their research (§5). The contents of such presentation, constituting an interim report, shall be submitted in writing by the PhD student to the PhD Program Committee. The PhD Program Committee shall decide whether or not this progress report constitutes a sufficient step towards the successful completion of the student’s research. If the Committee’s comment is negative, such result shall be communicated in writing to the student and his or her co-supervisors’ team, indicating the reasons. Pursuant to a period of one month, the student shall submit a modified work plan for the next year of his research, giving due consideration to the recommendations made.

64

§8

Intermediate Examination The oral intermediate examination shall be held no later than 18 months after commencement of PhD studies. By way of exception, which must be well-founded, the intermediate examination can be taken at a later date. If a student wishes such exception, he shall apply in writing to the PhD Program Committee adding a comment prepared by his co-supervisors’ team. The dates for intermediate examinations shall be determined by the PhD Program Committee. The intermediate examination shall be held by a member of the PhD Program Committee and an expert (chairman) in the special field and shall cover topics from the student’s research project and from the courses and seminars the student has registered for. The examination usually is held in English. If the student fails the intermediate examination he shall be allowed to retake it once, pursuant to a period of at least three and no more than six months as the examiners may decide. If the student fails again, he or she shall be deemed to have finally and absolutely failed. Following such final and absolute failure the student shall be taken off the register. The “chairman” shall report the result of the intermediate examination to the PhD Program Committee. The result of the exam will account for 20% of the final mark (PhD or Dr.rer.nat.).

§9

Requirements for Signing up for PhD Examination After completion of PhD studies, which is normally at the end of the third year, the PhD examination shall be held. The PhD student shall submit the following documents when signing up for the PhD examination: 1. Certificate of regular attendance at and completion of courses and seminars according to the curriculum, i.e. a total of at least 300 hours, and of three colloquia pursuant to § 7; 2. Certificate of intermediate examination; 3. A scientific thesis (dissertation) prepared in English or German by the PhD student on the research project the student worked on during his or her PhD studies, with introduction, materials and methods, results, discussion and summary. The thesis shall constitute an essential original scientific contribution to the discipline the student’s research project pertains to; 4. Alternatively (instead of thesis), usually two first author publications in internationally peer review science journals. The PhD student’s personal contribution to such publications shall be clearly identified. In that context, “accepted” shall be deemed equivalent to “published”. As for this publication requirement, exceptions are possible with reasons to be given by the supervisor. The publications must be in one scientific context, and shall be supplemented by a detailed description under a joint title in English or German of the research subject, including an overall summary and a discussion of results. The final version of the dissertation should be submitted in six printed copies as well as a digital version. To assess the thesis or the publications, the PhD Program Committee shall procure at least one external expert’s opinion, as well as one internal expert’s opinion. To be on the save side, one expert shall be nominated as substitute in case of unforeseen drop outs. For the Dr. rer. nat., at least one of the experts has to have a natural scientist qualification. In addition, the co-supervisors’ team shall prepare an expert report on the dissertation or the publications, and such report together with the external and internal expert’s opinion shall serve to make the final assessment. If one of the expert reports detects any shortcomings in the dissertation, the PhD Program Committee can be requested to have such shortcomings eliminated or remedied as a precondition for acceptance of the thesis. The chairperson can allow a reasonable period for the PhD candidate to remedy the shortcomings and recommend that he or she submit the thesis anew. In that respect, the chairperson of the PhD Program Committee can extend this period once only. The experts shall assess the thesis again once the shortcomings have been remedied.

65 If, based on such second experts’ vote, the PhD Program Committee declines to accept the thesis, the candidate shall be deemed to have failed the PhD examination finally and absolutely. In that case, the PhD student shall be taken off the register.

§ 10

PhD Examination The PhD examination consists of a public presentation (usually 15-20 min, in English) held by the PhD student at the Hannover Medical School on the subject of his research, a subsequent public disputation of the project of at least 30 minutes of duration to assess the knowledge acquired by the student on the subject of his specific area of research as well as on interdisciplinary subjects. The interview also serves to assess whether the candidate has acquired, and is able to apply, any knowledge and skills relating to the scientific environment of the subject of his research. The examination is taken by the external and internal examiner. The final mark results from: the intermediate exam (20%), the written dissertation/ the two experts’ opinions (60%), the oral examination (20%). In justified exceptional cases, the examination committee may deviate from the latter rule. The oral examination shall be taken on record in abridged form and shall indicate: the grade earned for the oral examination, the grade earned for the thesis, the overall grade average earned for the PhD examination. It shall be signed by the chairman of the board of examiners.

The following grades can be awarded: Excellent/ very good/ good / satisfactory (Failed) Equivalent to excellent / summa cum laude, very good / magna cum laude, good / cum laude, passed / rite. If the candidate fails the final examination, he or she shall be allowed to retake it once, pursuant to a period of at least three and no more than six months as the co-supervisors’ team may decide. Should the student then fail again, he or she shall be deemed to have finally and absolutely failed the PhD examination. Following such final and absolute failure the student shall be taken off the register. The result of the PhD examination shall be communicated to the PhD Program Committee and the President’s office (in case of failure with reasons and instructions about a person's available legal remedies).

§ 11 and § 12

Publication and Award of the Academic Degree of a Doctor of Philosophy (PhD) PhD students are obliged to publish their dissertation. Once the student has passed the PhD examination and has distributed six copies of the dissertation (plus one electronic version), he or she shall be awarded the academic degree of a Doctor of Philosophy (PhD) or a Dr. rer. nat. degree by the MHH (latest one year after the PhD exam). Formatting has to be done according to the rules of MHH library. The publication in form of a monograph is allowed if it is clearly indicated that the dissertation has been published by MHH. A document as shown in Appendix 1 shall be issued to him or her in evidence of such award. The award shall authorize the candidate to use the academic title of a PhD or Dr. rer. nat..

66

§ 13

Withdrawal of PhD exam registration The registration for the PhD exam (submission of PhD thesis) can be withdrawn by a written declaration to the program committee.

§ 14

Resumption of PhD exam (1) If a candidate ultimately fails a PhD exam all German universities have to be notified. (2) A new registration for PhD exam can only be done once, only after three and at the most eight months. This also applies when a failed PhD exam has been taken at another German university.

§ 15

Abrogation of PhD If by error requirements for PhD registration have been taken for granted or if the candidate has strongly violated the rules of “good scientific practise”, the president of MHH can abrogate the PhD title after having consulted the PhD committee.

§ 16

Revocation of PhD title The PhD title is revocated in cases of criminal conviction or strong violation against the rules of “good scientific practise” in the PhD thesis. The decision is to be delivered to the aggrieved party.

§ 17

Coming into Effect The Rules and Requirements for Postgraduate Studies and Examinations in structured doctoral programs of Hannover Biomedical Research School (HBRS) to obtain a PhD degree (or Dr. rer. nat.), as approved by me, are hereby published within the Hannover Medical School and are coming into effect.

Hannover, The President Professor Dr. Christopher Baum Appendix 1 (MHH Logo) Hannover Medical School under the presidency of Professor Firstname Lastname awards to Firstname Lastname Born on DD Month YYYY in town, country the degree of Doctor rerum naturalium (Dr. rer. nat.) / Doctor of Philosophy (PhD) in recognition of his/her successful participation in the Hannover Biomedical Research School and the PhD Program XXX, the scientific standard of his/her research thesis TITEL, performed at the Institute at University and its public defense showing his/her ability for profound independent scientific work with the overall mark excellent (summa cum laude) / very good (magna cum laude) / good (cum laude) / sufficient (rite) Hannover, DD Month YYYY Signature Signature Chairman/woman PhD ProgramPresident

5 3J 2 1 4 6 Twincore ITEM

1: Building J4 (Forschungswerkstätten) MD/PhD/ HBRS Office; HBRS seminar room 1140; Seminar room 1031, level 1, Seminar room S1400 (ground), Seminar room Cell Biology (level H)

2: TPFZ Research building (for entrance see arrows) PhD Infection Biology Office and DEWIN, level 2 Seminar room 1420, ground floor

3: HBZ Building (Hans Borst Zentrum, J11) PhD Regenerative Science Office, level 2 Seminar room, ground floor

4: Main lecture hall building (F-N), Library, student secretary 5: Lecture halls Q, R 6: Lecture halls A-E

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