Tab. 20.2 Sanità animale
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TAB. 20.2 - RICERCHE EFFETTUATE SANITA' ANIMALE Alborali° GL Pulizia e disinfezione degli allevamenti e dei mezzi di trasporto La biosicurezza in veterinaria / edito a cura della Fondazione Iniziative Zooprofilattiche e Zootecniche. - Brescia : Fondazione Iniziative Zooprofilattiche e Zootecniche, 2009. - (Atti delle giornate di Studio Fondazione Iniziative Zooprofilattiche e Zootecniche ; 74) p 161-174. - 4 bib ref [Nr. Estr. 4232]
Alborali° GL, Gradassi° M Biosicurezza negli allevamenti suini La biosicurezza in veterinaria / edito a cura della Fondazione Iniziative Zooprofilattiche e Zootecniche. - Brescia : Fondazione Iniziative Zooprofilattiche e Zootecniche, 2009. - (Atti delle giornate di Studio Fondazione Iniziative Zooprofilattiche e Zootecniche ; 74) p 47-62. - 9 bib ref [Nr. Estr. 4234]
Amadori° M, Farinacci M, Begni° B, Faita° R, Podavini ° D, Colitti M Effects of interferon-[alfa] on the inflammatory response of swine peripheral blood mononuclear cells J Interferon Cytokine Res. - Vol. 29 no 4 ( 2009). - p 241-247. - 35 bib ref [Nr. Estr. 4135] Interferon-a (IFN-a) at low concentrations had been previously shown to control the expression of inflammatory cytokine genes in swine pulmonary alveolar macrophages. In the first part of this study, cultured swine peripheral blood mononuclear cells (PBMCs) were supplemented with IFN-a at low/moderate concentrations, and then stimulated with lipopolysaccharide (LPS). The expression of IFN-a, IFN- , IL-1ß, TNF-a, and IL-6 genes was determined by real-time PCR. IFN-a at low/moderate concentrations did not significantly reduce the expression of any cytokine gene under study, with clear trends though to a concentration-dependent reduction of IL-1ß gene expression and to a concentration-dependent increase of IFN- gene expression. In vivo, orally administered IFN-a was shown instead to modulate the inflammatory response to early weaning in uncultured PBMCs of specific pathogen-free piglets. As opposed to the in vitro model, the oral IFN-a treatment reduced after weaning the expression of the IFN- gene (P < 0.08) and increased that of the IL-1ß gene (P < 0.05). There was also a trend to a reduced expression of both IL-6 and TNF-a. The above modulation of cytokine genes expression and the greater daily mean weight gain of treated piglets highlight important regulatory properties of oral IFN-a in the response to the weaning stress.
Amadori° M, Farinacci M, Colitti M Low-dose interferon-alpha treatment can modulate the stress of early weaning in pigs Third annual meeting Epizone : "Crossing borders" : 12-15 May 2009 Antalya, Turkey / [s.l. : s. n., 2009]. - 1 p. - 3 bib ref [Nr. Estr. 4148] Annual meeting Epizone (3rd : Antalya, Turkey : 12-15 May, 2009) Interferon-alpha (IFN-alpha) at low concentrations had been previously shown to control in vitro the expression of inflammatory cytokine genes in swine pulmonary alveolar macrophages. Owing to the above, we wondered if a similar control action could be exerted by IFN-alpha in piglets during a natural stressing event like early weaning, characterized by a high proflogistic potential. To this purpose, four Specific Pathogen Free (SPF) littermate piglets were given human lyrnphoblastoid
interferon-alpha for io days in a row in form of a freeze-dried preparation, mixed in the diet, starting on the day of early weaning at 21 days of age. The other four littermate piglets served as untreated controls; they received the same daily mass of placebo in a separate weaning cage. The expression of IFN-alpha, IFN-gamma, IL-1 beta, TNF-alpha and IL-6 genes was determined in uncultured PBMC by real time PCR. Orally administered IFN-alpha was shown to reduce alter weaning the expression of the IFN-gamma gene (p